hsa00072

Synthesis and degradation of ketone bodies

KEGG

HMGCL, HMGCS1, ACAT2, OXCT1, BDH2

hsa00100

Steroid biosynthesis

KEGG

EBP, CYP2R1, CYP27B1, CYP51A1, DHCR7, DHCR24, FDFT1, LIPA, LSS, NSDHL, HSD17B7, MSMO1, SC5D, SOAT1, SQLE, TM7SF2

hsa00120

Primary bile acid biosynthesis

KEGG

ACOT8, CYP8B1, HSD17B4, SCP2, HSD3B7, ACOX2, CH25H

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis

KEGG

NQO1, GGCX, COQ2, COQ3, VKORC1

hsa00140

Steroid hormone biosynthesis

KEGG

COMT, CYP1A1, CYP1B1, CYP3A7, CYP2E1, CYP3A4, CYP3A5, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP21A2, AKR1C1, AKR1C2, HSD3B1, HSD3B2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, STS, HSD17B12, HSD17B7, SRD5A1, SRD5A2, SULT1E1, UGT2B4, UGT2A3, HSD17B6, AKR1C3

hsa00190

Oxidative phosphorylation

KEGG

COX17, TCIRG1, ATP5H, ATP5L, UQCR11, NDUFA11, COX5B, COX6A1, COX6B1, COX6C, COX7B, COX7C, COX11, CYC1, COX7B2, ATP6V1C2, PPA2, UQCRQ, UQCR10, UQCRHL, NDUFA1, NDUFA2, NDUFA4, NDUFA5, NDUFA7, NDUFA10, NDUFAB1, NDUFB4, NDUFB6, NDUFB7, NDUFB8, NDUFB10, NDUFS1, NDUFS2, NDUFS4, NDUFS6, NDUFS8, NDUFV2, NDUFV3, ATP12A, ATP5C1, NDUFA13, ATP5D, ATP6V1D, ATP5E, ATP6V1H, ATP5G2, ATP5G3, ATP5I, ATP5J, ATP6V1B2, ATP6V1C1, ATP6V1G2, ATP6V0A1, ATP5O, NDUFB11, SDHA, SDHB, SDHC, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, ATP6V0E1, ATP6V0D1, ATP6V1F, COX5A, ATP6V1G1

hsa00220

Arginine biosynthesis

KEGG

GLS, GLUD2, GOT2, ASS1, NOS3, GPT2

hsa00230

Purine metabolism

KEGG

ADA, NME6, PAICS, POLR3F, POLR3G, POLR3C, POLD3, ADCY3, NUDT5, ADCY7, ADCY9, ADSSL1, NUDT16, ADSL, AK8, ADSS, DCK, DGUOK, AK1, AK4, FHIT, ENPP4, POLA2, POLR2J2, POLR1A, GART, PDE7B, AMPD3, GMPR, GUK1, NME7, GUCY2D, NT5C, ZNRD1, APRT, NME1, NME4, PNP, NPR2, NT5E, AK3, POLR1D, PDE3A, PDE3B, PDE4C, PDE4D, PDE6D, PDE7A, PDE8A, PDE9A, ENPP1, ENPP3, POLR3K, PFAS, PGM1, PKM, NUDT9, POLE3, POLA1, POLD1, POLE, POLE2, POLR2A, POLR2B, POLR2D, POLR2E, POLR2G, POLR2I, POLR2J, POLR2K, POLR2L, PPAT, PGM2, PRIM1, PRIM2, POLR3B, PRPS1, PRPS2, POLE4, POLD4, PRUNE, RRM1, RRM2, POLR1E, NME2, XDH, POLR3GL, PDE8B, PDE5A, PNPT1, GMPS, PAPSS2, POLR1C, ENTPD6, ENTPD3

hsa00232

Caffeine metabolism

KEGG

CYP2A6, XDH

hsa00240

Pyrimidine metabolism

KEGG

NME6, POLR3F, POLR3G, POLR3C, POLD3, CMPK2, UPRT, CTPS1, UPP2, DCK, DCTD, DHODH, DPYD, DTYMK, DUT, TYMP, POLA2, POLR2J2, POLR1A, NME7, NT5C, ZNRD1, NME1, NME4, PNP, NT5E, POLR1D, ENPP1, ENPP3, CMPK1, POLR3K, POLE3, POLA1, POLD1, POLE, POLE2, POLR2A, POLR2B, POLR2D, POLR2E, POLR2G, POLR2I, POLR2J, POLR2K, POLR2L, UCKL1, PRIM1, PRIM2, POLR3B, CTPS2, POLE4, POLD4, RRM1, RRM2, POLR1E, NME2, TK1, TK2, TXNRD1, TYMS, UCK2, UMPS, UPP1, CAD, DCTPP1, UCK1, POLR3GL, PNPT1, POLR1C, ENTPD6, ENTPD3

hsa00250

Alanine, aspartate and glutamate metabolism

KEGG

ADSSL1, ADSL, ADSS, ABAT, AGXT, GFPT1, GLS, GLUD2, GOT2, ASNS, ASS1, PPAT, RIMKLB, CAD, GPT2

hsa00260

Glycine, serine and threonine metabolism

KEGG

CTH, DLD, SARDH, AGXT, PHGDH, GATM, GCSH, DMGDH, PSAT1, AOC2, MAOA, MAOB, ALDH7A1, PIPOX, PGAM1, SHMT1, BPGM, AOC3, CBS, GRHPR

hsa00270

Cysteine and methionine metabolism

KEGG

CDO1, AHCYL1, CTH, DNMT1, DNMT3B, AHCY, AMD1, GCLC, GCLM, MAT2B, GOT2, LDHA, LDHB, MAT2A, MDH1, MDH2, MPST, MTAP, MTR, ADI1, BCAT1, SRM, CBS

hsa00280

Valine, leucine and isoleucine degradation

KEGG

HIBADH, DBT, DLD, ABAT, ECHS1, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, HIBCH, HSD17B10, HADHB, HADH, HMGCL, HMGCS1, AOX1, ACADSB, ACAT2, ALDH6A1, ALDH7A1, OXCT1, PCCA, AUH, MCCC1, BCAT1, BCKDHA, BCKDHB, MCCC2, AACS, MCEE

hsa00290

Valine, leucine and isoleucine biosynthesis

KEGG

BCAT1

hsa00300

Lysine biosynthesis

KEGG

ALDH7A1

hsa00310

Lysine degradation

KEGG

AASS, EHMT2, DLST, ECHS1, EZH1, EZH2, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, HADH, KMT5A, ACAT2, OGDH, ALDH7A1, KMT5B, PIPOX, PLOD1, PLOD2, WHSC1L1, ASH1L, KMT2E, KMT2C, WHSC1, PRDM2, SUV39H2, SETD7, SETDB2, KMT5C, PHYKPL, PRDM6, KMT2B

hsa00330

Arginine and proline metabolism

KEGG

SAT2, L3HYPDH, CKB, CKMT2, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, AMD1, GATM, GOT2, MAOA, MAOB, NOS3, ODC1, ALDH7A1, P4HA1, LAP3, CKMT1A, PRODH, ALDH18A1, SAT1, PYCRL, SRM, AGMAT, P4HA2

hsa00340

Histidine metabolism

KEGG

ALDH2, ALDH1B1, ALDH1A3, ALDH3B2, ALDH9A1, ALDH3A2, HNMT, MAOA, MAOB, ALDH7A1

hsa00350

Tyrosine metabolism

KEGG

ADH1B, ADH7, COMT, FAH, ALDH1A3, ALDH3B2, GOT2, GSTZ1, HGD, AOC2, AOX1, MAOA, MAOB, MIF, PNMT, TH, TYR, AOC3

hsa00360

Phenylalanine metabolism

KEGG

ALDH1A3, ALDH3B2, GOT2, AOC2, MAOA, MAOB, MIF, AOC3

hsa00380

Tryptophan metabolism

KEGG

TPH2, CYP1A1, CYP1B1, ECHS1, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, HADH, AOX1, ACAT2, MAOA, MAOB, OGDH, ALDH7A1, KMO, KYNU

hsa00400

Phenylalanine, tyrosine and tryptophan biosynthesis

KEGG

GOT2

hsa00410

beta-Alanine metabolism

KEGG

ABAT, DPYD, ECHS1, ALDH2, ALDH1B1, ALDH1A3, ALDH3B2, ALDH9A1, ALDH3A2, HIBCH, AOC2, ALDH6A1, ALDH7A1, SRM, AOC3

hsa00430

Taurine and hypotaurine metabolism

KEGG

CDO1, GGT7, CSAD

hsa00440

Phosphonate and phosphinate metabolism

KEGG

CEPT1, PCYT1A, PCYT2, EPT1, PCYT1B

hsa00450

Selenocompound metabolism

KEGG

CTH, SEPHS1, MTR, SEPSECS, SCLY, TXNRD1, PAPSS2

hsa00471

D-Glutamine and D-glutamate metabolism

KEGG

GLS, GLUD2

hsa00480

Glutathione metabolism

KEGG

GSTO2, G6PD, GGT7, OPLAH, GCLC, GCLM, GPX1, GPX3, GPX4, GPX7, GSR, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, IDH1, IDH2, GSTK1, MGST1, MGST2, MGST3, GPX8, ODC1, LAP3, PGD, RRM1, RRM2, SRM, GSTO1

hsa00500

Starch and sucrose metabolism

KEGG

AGL, G6PC, GAA, GBE1, AMY2B, GPI, GYS1, GYS2, HK1, ENPP1, ENPP3, PGM1, PGM2, PYGB, PYGM, UGP2, HKDC1, GYG2, MGAM, G6PC3

hsa00510

N-Glycan biosynthesis

KEGG

MAN1B1, MGAT4B, MGAT4A, ALG10B, MGAT5B, DAD1, DDOST, STT3B, GANAB, FUT8, B4GALT1, ALG6, STT3A, MAN1A1, MAN2A2, MGAT2, DPM3, MAN1C1, ST6GAL1, ALG8, ALG9, ALG13, ST6GAL2

hsa00511

Other glycan degradation

KEGG

MAN2B2, FUCA1, FUCA2, HEXA, MAN2B1, NEU1, GBA2, ENGASE

hsa00512

Mucin type O-glycan biosynthesis

KEGG

GALNT5, GALNT15, GALNT1, GALNT2, GALNT7, GALNT10, ST3GAL1, ST3GAL2, GALNT14, GALNT4, B4GALT5

hsa00514

Other types of O-glycan biosynthesis

KEGG

POMT1, B4GALT1, RFNG, ST6GAL1, ST3GAL3, ST6GAL2, OGT

hsa00515

Mannose type O-glycan biosynthesis

KEGG

POMT1, B4GAT1, MGAT5B, FUT4, B4GALT1, ST3GAL3, FKRP, POMK, POMGNT2, LARGE

hsa00520

Amino sugar and nucleotide sugar metabolism

KEGG

GNPDA1, GNE, CHIT1, CYB5R3, GALE, GALT, GFPT1, GMDS, GPI, GMPPB, HEXA, HK1, PGM1, PMM2, PGM2, CMAS, UAP1, UGDH, UGP2, UXS1, HKDC1, NPL

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

KEGG

HK1, HKDC1

hsa00531

Glycosaminoglycan degradation

KEGG

HPSE, HGSNAT, GALNS, GNS, HEXA, ARSB, NAGLU, SGSH, SPAM1, HYAL2

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

KEGG

CHSY1, DSE, CHSY3, CHST11, CHST15, CSGALNACT1, CHST7, XYLT2, CHST3

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

KEGG

CHST4, B3GNT2, FUT8, B4GALT1, CHST6, ST3GAL1, ST3GAL2, ST3GAL3, B4GALT4, B3GNT7, CHST2

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

KEGG

EXT1, EXT2, NDST1, XYLT2, HS6ST2, HS6ST1, HS2ST1, HS3ST3B1, HS3ST1

hsa00561

Glycerolipid metabolism

KEGG

MGLL, MBOAT2, GPAT4, DGKK, DGKH, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, AKR1B1, LPIN1, LCLAT1, TKFC, GK, LPL, ALDH7A1, AGPAT3, AGPAT4, PNPLA2, GPAM, PNPLA3, DGAT2, GPAT3, DGKZ, PLPP1, PLPP3, LIPG

hsa00562

Inositol phosphate metabolism

KEGG

PIKFYVE, PLCB1, PIP5K1C, IMPA1, INPP1, INPP4A, INPP5A, INPP5D, ITPK1, ITPKA, ALDH6A1, MTM1, OCRL, ISYNA1, INPP5K, PIK3C2A, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PI4KB, PIP4K2A, PLCD1, PLCG2, MIOX, INPP5E, PTEN, TPI1, PIP5K1B, PIP4K2B, MTMR1, INPP4B, SYNJ1, SYNJ2, MTMR2, MTMR4, MINPP1

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

KEGG

PIGK, PIGU, GPLD1, PIGW, PIGT, PIGA, PIGC, PIGF, PIGH, PIGG, PIGX, PGAP1, PIGY

hsa00564

Glycerophospholipid metabolism

KEGG

LPCAT3, CEPT1, CDS1, PEMT, LYPLA1, PLA2G16, CHKA, CHKB, LYPLA2, MBOAT2, GPAT4, DGKK, DGKH, LPIN1, LCLAT1, GPD2, PCYT1A, PLA2G2A, PLA2G4A, PLA2G5, PLD1, CRLS1, LPCAT2, ETNK1, AGPAT3, AGPAT4, GPAM, PCYT2, MBOAT7, PLA2G12A, GNPAT, GPAT3, DGKZ, EPT1, PLA2G4C, PLPP1, PLPP3, CDS2, PCYT1B, PGS1, PTDSS1, LPGAT1

hsa00565

Ether lipid metabolism

KEGG

CEPT1, PLA2G16, PAFAH1B2, PAFAH1B3, ENPP2, PLA2G2A, PLA2G4A, PLA2G5, PLD1, LPCAT2, PLA2G7, PLA2G12A, AGPS, EPT1, PLA2G4C, PLPP1, PLPP3

hsa00590

Arachidonic acid metabolism

KEGG

PTGES3, PLA2G16, CYP2U1, CYP2B6, CYP2C9, CYP2E1, ALOX5, ALOX15, GPX1, GPX3, GPX7, GPX8, PLA2G2A, PLA2G4A, PLA2G5, PTGDS, PTGIS, PTGS1, PTGS2, PLA2G12A, PLA2G4C, AKR1C3, CBR1, PTGES

hsa00591

Linoleic acid metabolism

KEGG

PLA2G16, CYP2C9, CYP2E1, CYP3A4, ALOX15, PLA2G2A, PLA2G4A, PLA2G5, PLA2G12A, PLA2G4C

hsa00592

alpha-Linolenic acid metabolism

KEGG

PLA2G16, ACOX1, PLA2G2A, PLA2G4A, PLA2G5, PLA2G12A, ACOX3, PLA2G4C, FADS2

hsa00600

Sphingolipid metabolism

KEGG

SGPP2, SGMS2, CERS6, GALC, SGMS1, ARSA, ASAH1, NEU1, SMPD4, GBA2, UGCG, CERS4, PLPP1, PLPP3, SPHK1, CERS5, B4GALT6, SPTLC2

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

KEGG

ST3GAL6, B3GNT2, FUT1, FUT2, FUT4, FUT7, GCNT2, B4GALT1, ST3GAL4, ST3GAL3, B3GNT5, B4GALT4, B3GALT2

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

KEGG

FUT1, FUT2, HEXA, ST3GAL1, ST3GAL2

hsa00604

Glycosphingolipid biosynthesis - ganglio series

KEGG

ST6GALNAC4, HEXA, ST3GAL1, ST3GAL2, ST6GALNAC5, B3GALT4, SLC33A1

hsa00620

Pyruvate metabolism

KEGG

ME3, DLAT, DLD, ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, FH, GLO1, HAGH, ACACB, ACAT2, LDHA, LDHB, MDH1, MDH2, ME2, ALDH7A1, PC, PCK1, PCK2, PDHA1, PDHB, PKM, ACSS2, ACSS1, GRHPR, ACYP1

hsa00630

Glyoxylate and dicarboxylate metabolism

KEGG

DLD, AGXT, GCSH, ACAT2, MDH1, MDH2, ACO2, PCCA, HAO2, SHMT1, MCEE, GRHPR

hsa00640

Propanoate metabolism

KEGG

DBT, DLD, ABAT, ECHS1, HIBCH, ACACB, ACAT2, LDHA, LDHB, ALDH6A1, PCCA, ECHDC1, ACSS2, BCKDHA, BCKDHB, ACSS3, ACSS1, MCEE, SUCLG1, SUCLA2

hsa00650

Butanoate metabolism

KEGG

ABAT, ECHS1, HADH, HMGCL, HMGCS1, ACAT2, OXCT1, BDH2, ACSM3, AACS

hsa00670

One carbon pool by folate

KEGG

MTHFS, MTHFD2, ALDH1L1, MTFMT, ALDH1L2, DHFR, MTHFD1L, GART, MTHFD2L, MTHFD1, MTHFR, MTR, SHMT1, TYMS

hsa00730

Thiamine metabolism

KEGG

AK8, AK1, AK4, ALPL, TPK1

hsa00740

Riboflavin metabolism

KEGG

ENPP1, ENPP3, RFK, BLVRB

hsa00750

Vitamin B6 metabolism

KEGG

PSAT1, AOX1, PDXK

hsa00760

Nicotinate and nicotinamide metabolism

KEGG

NAMPT, NADK2, QPRT, NT5C, AOX1, NMNAT3, NNMT, PNP, NT5E, ENPP1, ENPP3, NMRK1, NADSYN1

hsa00770

Pantothenate and CoA biosynthesis

KEGG

DPYD, ENPP1, ENPP3, BCAT1, AASDHPPT, PANK3, PANK2, COASY, VNN1

hsa00785

Lipoic acid metabolism

KEGG

LIPT1

hsa00790

Folate biosynthesis

KEGG

GPHN, DHFR, ALPL, QDPR, GGH

hsa00830

Retinol metabolism

KEGG

DHRS9, DHRS4, ADH1B, ADH7, CYP1A1, CYP2A6, CYP3A7, CYP2B6, CYP2C9, RDH10, CYP3A4, CYP3A5, CYP26A1, ALDH1A1, AOX1, RDH11, CYP26B1, UGT2B4, UGT2A3, HSD17B6, ALDH1A2, DHRS3

hsa00860

Porphyrin and chlorophyll metabolism

KEGG

EARS2, CPOX, EPRS, ALAD, FXN, HCCS, HMOX1, MMAB, BLVRB, UGT2B4, UROD, UGT2A3, HEPH

hsa00900

Terpenoid backbone biosynthesis

KEGG

FDPS, ICMT, PDSS1, HMGCR, HMGCS1, IDI1, ACAT2, MVD, MVK, PCYOX1, PDSS2, IDI2, RCE1

hsa00910

Nitrogen metabolism

KEGG

GLUD2, CA13, CA2, CA3, CA4, CA8, CA12

hsa00920

Sulfur metabolism

KEGG

ETHE1, MPST, CYCS, SUOX, PAPSS2

hsa00970

Aminoacyl-tRNA biosynthesis

KEGG

FARS2, MTFMT, EARS2, DARS, EPRS, FARSA, LARS2, HARS2, PARS2, GATC, HARS, KARS, SEPSECS, GATB, QRSL1, RARS, SARS, TARS, YARS

hsa00980

Metabolism of xenobiotics by cytochrome P450

KEGG

GSTO2, ADH1B, ADH7, CYP1A1, CYP1B1, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, AKR1C1, EPHX1, ALDH1A3, ALDH3B2, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, HSD11B1, GSTK1, MGST1, MGST2, MGST3, SULT2A1, UGT2B4, UGT2A3, AKR7A2, CBR1, GSTO1

hsa00982

Drug metabolism - cytochrome P450

KEGG

GSTO2, ADH1B, ADH7, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, ALDH1A3, ALDH3B2, FMO2, FMO4, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, AOX1, GSTK1, MAOA, MAOB, MGST1, MGST2, MGST3, UGT2B4, UGT2A3, GSTO1

hsa00983

Drug metabolism - other enzymes

KEGG

UPP2, CYP2A6, CYP3A4, DPYD, TYMP, UCKL1, TK1, TK2, TPMT, UGT2B4, UCK2, UMPS, UPP1, XDH, UGT2A3, UCK1, GMPS

hsa01040

Biosynthesis of unsaturated fatty acids

KEGG

ACOT7, ACOT4, HACD2, FADS1, HACD4, ACOX1, HSD17B12, HACD3, ELOVL5, SCD, ELOVL6, SCD5, ACOX3, HACD1, FADS2

hsa01100

Metabolic pathways

KEGG

ADA, ACOT8, GNPDA1, GNE, PIGK, COX17, NAMPT, AASS, DHRS9, NME6, GPHN, TCIRG1, CDO1, CEPT1, CDS1, PEMT, ST3GAL6, ATP5H, POMT1, MTHFS, PAICS, POLR3F, POLR3G, POLR3C, ATP5L, B3GNT2, EBP, POLD3, PTGES3, AHCYL1, MTHFD2, HPSE, ME3, DHRS4, UQCR11, B4GAT1, HIBADH, PLA2G16, CHIT1, CHKA, CHKB, GALNT5, SAT2, MAN1B1, MGAT4B, MGAT4A, MGLL, CYP2U1, CKB, CKMT2, GALNT15, CYP2R1, TPH2, ADSSL1, ACOT4, EARS2, ADH1B, NDUFA11, PIGU, CMPK2, MBOAT2, ADH7, COMT, COX5B, NADK2, COX6A1, COX6B1, COX6C, COX7B, COX7C, COX11, CPOX, GPAT4, HGSNAT, DGKK, UPRT, ALG10B, MGAT5B, CTH, CTPS1, UPP2, CYC1, CYP1A1, CYP2A6, CYP3A7, CYP2B6, CYP2C9, CYP2E1, RDH10, CYP3A4, CYP3A5, ADSL, AK8, CYP8B1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP21A2, ADSS, CYP26A1, CYP27B1, CYP51A1, DAD1, DGKH, DBT, DCK, DCTD, DDOST, SGMS2, COX7B2, DGUOK, DHCR7, DHCR24, DHFR, DHODH, DLAT, DLD, DLST, SARDH, AGL, DNMT1, DNMT3B, ABAT, DPYD, DTYMK, DUT, AGXT, TYMP, ECHS1, AHCY, STT3B, ENO1, ENO2, ENO3, AK1, AK4, EPRS, ALAD, EXT1, EXT2, ALDH1A1, ALDH2, ACSL1, ACSL4, FAH, ALDH1B1, FASN, ALDH1A3, FBP1, ALDH3B2, FDFT1, FDPS, ALDH9A1, ALDH3A2, ALDOA, FH, CHSY1, SEPHS1, ALDOC, AKR1B1, LPIN1, GANAB, PLCB1, ACSL6, PIP5K1C, QPRT, POLA2, ALOX5, ATP6V1C2, ALOX15, POLR2J2, ALPL, FUT1, FUT2, FUT4, FUT7, FUT8, LCLAT1, CERS6, G6PC, G6PD, GAA, PGLS, GALC, GALE, GALNS, POLR1A, GALNT1, GALNT2, MTHFD1L, GALT, SGMS1, GAPDH, TKFC, GART, AMD1, PHGDH, HIBCH, GATM, GBE1, GCNT2, GCSH, GFPT1, B4GALT1, GGT7, TPK1, UQCRQ, ST6GALNAC4, GK, AMPD3, COQ2, GCLC, GCLM, MAT2B, GLS, GLUD2, GMDS, GNS, AMY2B, GOT2, GPI, GATC, PIGW, GSTZ1, UQCR10, GUK1, NME7, GMPPB, ALG6, DSE, DMGDH, PSAT1, GYS1, GYS2, HSD17B10, HADHB, HADH, HEXA, HGD, NT5C, ZNRD1, HK1, AOC2, HMGCL, HMGCR, HMGCS1, AOX1, HMOX1, ACACB, MMAB, HSD3B1, HSD3B2, HSD11B1, HSD17B1, HSD17B2, HSD17B4, NDST1, CHSY3, IDH1, IDH2, IDH3B, IDI1, NMNAT3, APRT, ACADSB, IMPA1, INPP1, INPP4A, INPP5A, ACADVL, STT3A, ITPK1, ITPKA, ACAT2, LAMA3, LCT, LDHA, LDHB, LSS, ARSB, MAN1A1, MAN2A2, MAOA, MAOB, IDNK, MAT2A, MDH1, MDH2, MGAT2, ASAH1, ALDH6A1, MPST, ASNS, UQCRHL, MTHFD2L, ASS1, MTAP, MTHFD1, MTHFR, MTM1, MTR, MVD, MVK, NAGLU, NDUFA1, NDUFA2, NDUFA4, NDUFA5, NDUFA7, NDUFA10, NDUFAB1, NDUFB4, NDUFB6, NDUFB7, NDUFB8, NDUFB10, NDUFS1, NDUFS2, NDUFS4, NDUFS6, NDUFS8, NDUFV2, NDUFV3, NME1, NME4, NNMT, NOS3, PNP, NT5E, OCRL, ODC1, OGDH, ACO2, ALDH7A1, P4HA1, PAFAH1B2, PAFAH1B3, NSDHL, ATP5C1, PC, PCCA, ACOX1, PCK1, LAP3, PCK2, NDUFA13, POLR1D, CRYL1, MECR, RDH11, HSD17B12, HAO2, DCXR, PIPOX, ATP5D, PCYT1A, CSAD, ATP6V1D, ATP5E, ISYNA1, HSD17B7, SCLY, PDHA1, LIPT1, PIGT, ATP6V1H, PDHB, ENPP1, ENPP3, ATP5G2, CMPK1, POLR3K, INPP5K, ATP5G3, COQ3, GALNT7, GATB, PFAS, ATP5I, PFKL, ATP5J, PGAM1, PGD, PGK1, PGM1, ATP6V1B2, PIGA, PIGC, ATP6V1C1, PIGF, PIGH, PIK3C2A, PIK3C3, PI4KB, PKM, PLA2G2A, PLA2G4A, PLA2G5, PLCD1, PLCG2, PLD1, ATP6V1G2, ATP6V0A1, PMM2, ATP5O, PNMT, POLE3, CYCS, POLA1, POLD1, POLE, POLE2, POLG, POLR2A, POLR2B, POLR2D, POLR2E, DPM3, POLR2G, POLR2I, POLR2J, POLR2K, POLR2L, PON1, NDUFB11, CRLS1, PPAT, CKMT1A, AUH, LPCAT2, UCKL1, PIGX, NMRK1, NADSYN1, ADI1, PGM2, QRSL1, RFK, PPT1, ETNK1, GALNT10, PRIM1, PRIM2, SMPD4, POLR3B, CSGALNACT1, ACSS2, CMAS, PRODH, PRPS1, PRPS2, CTPS2, CYP26B1, INPP5E, POLE4, AGPAT3, AGPAT4, BDH2, MCCC1, PNPLA2, MAN1C1, PTGDS, PTGIS, PTGS1, PTGS2, RIMKLB, GPAM, GBA2, POLD4, ALDH18A1, PCYT2, PYGB, PYGM, BCAT1, QDPR, BCKDHA, BCKDHB, REV3L, RRM1, RRM2, ACSM3, SAT1, MSMO1, SC5D, SCP2, SDHA, SDHB, SDHC, MCCC2, XYLT2, POLR1E, SGSH, BLVRB, SHMT1, ST6GAL1, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL3, PYCRL, NME2, TRAK2, SORD, UAP1, SPAM1, BPGM, SQLE, SRM, SUOX, TALDO1, TH, TK1, TK2, TKT, TM7SF2, TPI1, TYMS, TYR, UGCG, UGDH, UGP2, UGT2B4, UCK2, UMPS, UPP1, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UROD, XDH, CAD, ALG8, DCTPP1, FKRP, PLA2G7, CERS4, ACSS3, GALNT14, PANK3, ALG9, UGT2A3, AGMAT, ALG13, PANK2, PGAP1, UXS1, HKDC1, HSD3B7, PNPLA3, COASY, PLA2G12A, ST6GALNAC5, ACOX2, ACOX3, UCK1, PIP5K1B, B3GNT5, POMK, POLR3GL, ACSS1, ST6GAL2, DGAT2, MCEE, GPT2, GPAT3, POMGNT2, PIGY, PHYKPL, DGKZ, AGPS, EPT1, KMO, PDXK, PLA2G4C, PLPP1, PLPP3, HSD17B6, AOC3, AKR1C3, HYAL2, GALNT4, B4GALT4, B3GALT4, B3GALT2, CBR1, CBS, CDS2, MTMR1, FBP2, SUCLG1, SUCLA2, INPP4B, GMPS, ALDH1A2, SYNJ1, SYNJ2, SPHK1, MTMR2, GYG2, KYNU, MGAM, P4HA2, ATP6V0E1, PAPSS2, CERS5, RGN, MTMR4, ATP6V0D1, IDI2, SLC33A1, LARGE, DHRS3, G6PC3, ATP6V1F, B4GALT6, KL, PPT2, COX5A, GRHPR, LIPG, PCYT1B, PGS1, SPTLC2, POLR1C, PTGES, ATP6V1G1, MINPP1, H6PD, PRDX6, PTDSS1

hsa01200

Carbon metabolism

KEGG

ME3, DLAT, DLD, DLST, AGXT, ECHS1, ENO1, ENO2, ENO3, FBP1, ALDOA, FH, ALDOC, G6PD, PGLS, GAPDH, TKFC, PHGDH, HIBCH, GLUD2, GOT2, GPI, PSAT1, HK1, IDH1, IDH2, IDH3B, ACAT2, IDNK, MDH1, MDH2, ME2, ALDH6A1, MTHFR, OGDH, ACO2, PC, PCCA, HAO2, PDHA1, PDHB, PFKL, PGAM1, PGD, PGK1, PKM, ACSS2, PRPS1, PRPS2, SDHA, SDHB, SDHC, SHMT1, TALDO1, TKT, TPI1, HKDC1, ACSS1, MCEE, GPT2, FBP2, SUCLG1, SUCLA2, RGN, H6PD

hsa01210

2-Oxocarboxylic acid metabolism

KEGG

GOT2, IDH1, IDH2, IDH3B, ACO2, BCAT1, GPT2

hsa01212

Fatty acid metabolism

KEGG

CPT1A, CPT1B, ECHS1, HACD2, ACSL1, ACSL4, FASN, ACSL6, HADHB, HADH, ACADSB, ACADVL, ACAT2, FADS1, HACD4, ACOX1, MECR, HSD17B12, HACD3, PPT1, ELOVL5, SCD, ELOVL6, SCD5, ACOX3, HACD1, PPT2, FADS2

hsa01230

Biosynthesis of amino acids

KEGG

CTH, ENO1, ENO2, ENO3, ALDOA, ALDOC, GAPDH, PHGDH, MAT2B, GOT2, PSAT1, IDH1, IDH2, IDH3B, MAT2A, ASS1, MTR, ACO2, ALDH7A1, PC, PFKL, PGAM1, PGK1, PKM, PRPS1, PRPS2, ALDH18A1, BCAT1, SHMT1, PYCRL, TALDO1, TKT, TPI1, GPT2, CBS

hsa01521

EGFR tyrosine kinase inhibitor resistance

KEGG

AKT3, BCL2L11, EGFR, EIF4E, EIF4EBP1, ERBB2, ERBB3, AKT1, AKT2, FGF2, FGFR2, FOXO3, GAB1, SHC2, GAS6, GRB2, GSK3B, HGF, NRG1, IGF1, IGF1R, IL6, IL6R, JAK1, JAK2, KRAS, MET, NRAS, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLCG2, PRKCA, PRKCB, MAPK1, MAPK3, PDGFC, MAP2K1, MAP2K2, BAD, PTEN, BAX, RAF1, BCL2, RPS6, SOS1, SOS2, STAT3, TGFA, VEGFA, PDGFD, EIF4E2

hsa01522

Endocrine resistance

KEGG

AKT3, CDK4, CDKN1A, CDKN1B, CDKN2C, CARM1, ADCY3, ADCY7, ADCY9, MAPK14, CYP2D6, JAG1, HBEGF, E2F1, E2F2, EGFR, ERBB2, AKT1, AKT2, ESR1, ESR2, FOS, SHC2, GNAS, GPER1, GRB2, IGF1, IGF1R, JUN, KRAS, MDM2, MMP2, MMP9, NOTCH1, NOTCH2, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3R1, DLL4, PRKACA, MAPK1, MAPK3, MAPK8, MAPK9, MAPK13, MAP2K1, MAP2K2, BAD, PTK2, BAX, RAF1, RB1, BCL2, SOS1, SOS2, TP53, NCOA3, NCOR1

hsa01523

Antifolate resistance

KEGG

ABCC5, ABCC4, SLC46A1, DHFR, FOLR1, GART, IL1B, IL6, ABCC1, MTHFR, NFKB1, RELA, SHMT1, SLC19A1, TNF, TYMS, GGH

hsa01524

Platinum drug resistance

KEGG

AKT3, CDKN1A, GSTO2, SLC31A1, ERBB2, ERCC1, AKT1, AKT2, BBC3, GSTA1, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTP1, GSTT1, GSTT2, MSH6, BIRC3, XIAP, BIRC5, FAS, MDM2, MAP3K5, MGST1, MGST2, MGST3, MLH1, MSH2, MSH3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PMAIP1, CYCS, POLH, MAPK1, MAPK3, BAD, BAX, BCL2, REV3L, BID, BRCA1, TOP2A, TP53, XPA, CASP8, CASP9, FADD, GSTO1

hsa02010

ABC transporters

KEGG

ABCC5, ABCB6, ABCC4, ABCA8, CFTR, ABCA1, ABCB10, ABCA6, ABCA5, ABCC1, ABCD3, ABCD4, ABCG8, ABCC10

hsa03008

Ribosome biogenesis in eukaryotes

KEGG

RCL1, POP7, EMG1, NXF1, NOP56, RPP30, TBL3, POP4, RPP40, WDR3, WDR36, RPP25L, DKC1, MDN1, REXO2, GNL3, RRP7A, NOB1, NXT1, EIF6, SNU13, FCF1, UTP18, SBDS, POP5, GAR1, XRN1, GNL3L, RPP25, NOP10, REXO1, TCOF1, XPO1, UTP15, UTP4

hsa03010

Ribosome

KEGG

RPL35, RPL22L1, FAU, MRPL21, RPL13A, RPL36, MRPL15, RPSA, RPL10A, RPS27L, MRPL4, MRPS2, MRPL30, MRPL35, MRPS21, MRPL16, MRPS18A, MRPS10, RPL4, RPL5, RPL7, RPL7A, RPL10, RPL11, RPL12, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23A, MRPL23, RPL24, RPL26, RPL27, RPL30, RPL27A, RPL28, RPL29, RPL31, RPL32, RPL34, RPL35A, RPL36AL, RPL37, RPL37A, RPL38, RPL41, RPL36A, RPLP0, RPLP1, RPLP2, MRPL12, MRPS12, RPS2, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS18, RPS20, RPS21, RPS25, RPS26, RPS27, RPS27A, MRPL17, MRPS14, MRPL14, MRPS5, MRPL36, MRPL34, MRPL32, MRPL1, UBA52, RPL14, MRPL33, MRPL19

hsa03013

RNA transport

KEGG

ALYREF, EIF1, POP7, SRRM1, SAP18, EIF1B, TACC3, NXF1, RPP30, PAIP1, NUP50, POP4, RPP40, RNPS1, NUPL2, DDX20, NUP35, RPP25L, EEF1A1, EEF1A2, EIF1AX, EIF2S1, EIF2B1, EIF2S3, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4EBP2, EIF5, NUP205, CYFIP1, NUP210, NUP160, FMR1, NUP62, GEMIN5, UPF2, CYFIP2, NXT1, NUP43, KPNB1, SUMO4, NCBP1, NUP88, PABPC3, GEMIN4, TRNT1, POP5, PHAX, PNN, RPP25, GEMIN8, NDC1, NUP107, THOC2, RANBP2, RANGAP1, ELAC2, SEC13, UPF3A, SUMO3, SUMO2, TPR, UBE2I, XPO1, NUP37, GEMIN6, NUP85, THOC7, PABPC1L, FXR1, SEH1L, THOC3, RAE1, EIF3A, EIF3B, EIF3J, EIF4G3, EIF2B4, EIF2B3, EIF2B5, EIF4E2, NUP155, EIF5B, NUP93, NUP58, RBM8A, NUP153

hsa03015

mRNA surveillance pathway

KEGG

ALYREF, SRRM1, SAP18, NXF1, HBS1L, PAPOLA, RNPS1, NUDT21, MSI2, CSTF3, SMG1, SMG5, UPF2, DAZAP1, SSU72, NXT1, GSPT1, CPSF1, NCBP1, PABPC3, PELO, CPSF2, PNN, PPP1CA, PPP1CB, PPP1CC, PPP2CB, PPP2R1A, PPP2R1B, PPP2R3A, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PAPOLG, UPF3A, PABPC1L, PABPN1, FIP1L1, SYMPK, RBM8A

hsa03018

RNA degradation

KEGG

C1D, TOB2, LSM6, EXOSC8, EXOSC6, NUDT16, DCP2, DHX36, ENO1, ENO2, ENO3, PATL1, DIS3, EXOSC7, CNOT1, EXOSC2, SKIV2L2, LSM5, PAN3, LSM4, LSM3, CNOT7, HSPD1, CNOT3, CNOT4, PABPC3, PARN, EXOSC3, LSM7, LSM8, PFKL, EXOSC9, XRN1, EXOSC4, CNOT6, LSM2, PAPD5, BTG1, BTG2, EDC3, PABPC1L, ZCCHC7, PNPT1

hsa03020

RNA polymerase

KEGG

POLR3F, POLR3G, POLR3C, POLR2J2, POLR1A, ZNRD1, POLR1D, POLR3K, POLR2A, POLR2B, POLR2D, POLR2E, POLR2G, POLR2I, POLR2J, POLR2K, POLR2L, POLR3B, POLR1E, POLR3GL, POLR1C

hsa03022

Basal transcription factors

KEGG

CDK7, GTF2A1L, ERCC2, GTF2A1, GTF2A2, GTF2B, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H4, GTF2I, TAF9B, TAF5, TAF10, TAF11, TAF12, GTF2H2C_2, TAF15

hsa03030

DNA replication

KEGG

RNASEH2A, POLD3, DNA2, FEN1, POLA2, LIG1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, PCNA, POLE3, POLA1, POLD1, POLE, POLE2, PRIM1, PRIM2, POLE4, POLD4, RFC2, RFC3, RFC4, RFC5, RPA3, SSBP1, RNASEH2B

hsa03040

Spliceosome

KEGG

PQBP1, ALYREF, PPIE, PPIH, CHERP, SRSF10, SF3A3, SNRNP27, LSM6, ZMAT2, DDX5, DHX15, HNRNPA3, PUF60, U2SURP, LSM5, LSM4, PRPF31, LSM3, RBMX, PRPF19, TRA2A, HNRNPA1, HNRNPC, HNRNPU, HSPA1A, HSPA1B, HSPA1L, HSPA6, HNRNPM, NCBP1, SNU13, PCBP1, CRNKL1, CWC15, SF3B6, LSM7, LSM8, PLRG1, PRPF40A, RBM22, THOC2, LSM2, RBM25, RP9, SRSF1, SRSF2, SRSF5, SRSF6, TRA2B, SNRPA, SNRPA1, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPF, SF3B5, THOC3, DHX16, RBM17, PRPF18, SRSF9, BUD31, PRPF3, SNRNP40, DDX23, DDX46, CDC5L, RBM8A

hsa03050

Proteasome

KEGG

PSME3, ADRM1, PSME4, POMP, PSMA1, PSMA2, PSMA3, PSMA4, PSMB1, PSMB3, PSMB4, PSMB5, PSMB8, PSMB9, PSMB10, PSMC1, PSMC2, PSMC3, PSMC4, PSMC6, PSMD2, PSMD3, PSMD7, PSMD11, PSMD12, SHFM1

hsa03060

Protein export

KEGG

SEC63, SEC61G, SEC61A1, HSPA5, SEC61A2, SRPRB, SRP9, SRP14, SRP54, SRP72, SEC62, SEC11C, SPCS2

hsa03320

PPAR signaling pathway

KEGG

NR1H3, SORBS1, SLC27A4, SLC27A2, APOA5, PLIN2, CPT1A, CPT1B, CYP8B1, DBI, FABP4, FABP3, FABP5, FABP6, ACSL1, ACSL4, ACSL6, GK, SLC27A6, APOA1, APOA2, APOC3, ILK, SLC27A1, LPL, MMP1, PLIN5, OLR1, ACOX1, PCK1, PCK2, PLIN1, PPARA, PPARD, PPARG, RXRB, SCD, SCP2, PLIN4, UBC, UCP1, SCD5, ACOX2, ACOX3, ADIPOQ, FADS2, CD36

hsa03410

Base excision repair

KEGG

PARP2, POLD3, PARP1, FEN1, SMUG1, HMGB1, LIG1, MPG, MUTYH, NTHL1, PCNA, POLE3, POLD1, POLE, POLE2, NEIL3, POLE4, POLD4, TDG, UNG, MBD4

hsa03420

Nucleotide excision repair

KEGG

CDK7, POLD3, ERCC1, ERCC2, ERCC4, GTF2H1, GTF2H2, GTF2H4, LIG1, PCNA, POLE3, POLD1, POLE, POLE2, POLE4, POLD4, RAD23A, RAD23B, RFC2, RFC3, RFC4, RFC5, RPA3, GTF2H2C_2, XPA, XPC, CUL4B, CUL4A, RBX1

hsa03430

Mismatch repair

KEGG

POLD3, MLH3, MSH6, LIG1, MLH1, MSH2, MSH3, PCNA, POLD1, POLD4, RFC2, RFC3, RFC4, RFC5, RPA3, SSBP1, EXO1