| Pathway ID | Pathway Term | Pathway Source |
Proteins |
h_p38mapkPathway | p38 MAPK Signaling Pathway | BioCarta |
CDC42, MAPK14, ELK1, GRB2, MEF2A, MEF2C, MEF2D, MYC, PLA2G4A, MAP2K6, RAC1, MAP3K7, TGFB1, TGFB2, TGFBR1, TRADD, RIPK1, CREB1, DDIT3, HSPB1, HSPB2, MAP3K5, MKNK1, RPS6KA5, MAPKAPK2 |
h_p53Pathway | p53 Signaling Pathway | BioCarta |
BCL2, CDK2, CDK4, CDKN1A, E2F1, MDM2, RB1, TIMP3, TP53, BAX, GADD45A, PCNA |
h_p53hypoxiaPathway | Hypoxia and p53 in the Cardiovascular system | BioCarta |
AKT1, BAX, CDKN1A, CSNK1A1, CSNK1D, GADD45A, EP300, HIF1A, HSPA1A, HSP90AA1, DNAJB1, MDM2, MAPK8, TP53, NQO1, IGFBP3 |
h_parkinPathway | Role of Parkin in the Ubiquitin-Proteasomal Pathway | BioCarta |
PARK2, SNCA, GPR37, UBE2E2, SNCAIP |
h_pcafpathway | The information-processing pathway at the IFN-beta enhancer | BioCarta |
CREBBP, JUN, NFKB1, POLR2A, RELA, KAT2B, HMGB1, IRF1 |
h_pdgfPathway | PDGF Signaling Pathway | BioCarta |
ELK1, FOS, GRB2, JAK1, JUN, PDGFA, PDGFRA, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAF1, RASA1, SOS1, STAT3, STAT5A |
h_pelp1Pathway | Pelp1 Modulation of Estrogen Receptor Activity | BioCarta |
CREBBP, EP300, MAPK1, MAPK3, ESR1 |
h_pepiPathway | Proepithelin Conversion to Epithelin and Wound Repair Control | BioCarta |
CXCL8, GRN, SLPI, CELA2B, CELA2A |
h_pgc1aPathway | Regulation of PGC-1a | BioCarta |
CALM2, CALM3, CAMK2D, PPARA, PPP3CA, YWHAH, PPARGC1A, ESRRA, MEF2A, MEF2C, MEF2D, SLC2A4, CAMK1, HDAC5 |
h_pitx2Pathway | Multi-step Regulation of Transcription by Pitx2 | BioCarta |
APC, CREBBP, CTNNB1, EP300, GSK3B, HDAC1, AXIN1, PITX2, TRRAP |
h_pkcPathway | Activation of PKC through G protein coupled receptor | BioCarta |
GNAQ, NFKB1, PRKCA, PRKCB, RELA, PLCB1 |
h_plateletAppPathway | Platelet Amyloid Precursor Protein Pathway | BioCarta |
COL4A2, COL4A3, COL4A6, F2, APP, SERPINE1, PLAT, PLAU, PLG |
h_plcPathway | Phospholipase C Signaling Pathway | BioCarta |
AKT1, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, VAV1, PLCB1 |
h_plcdPathway | Phospholipase C d1 in phospholipid associated cell signaling | BioCarta |
PRKCA, PRKCB, ADRA1B, PLCD1, TGM2 |
h_plcePathway | Phospholipase C-epsilon pathway | BioCarta |
GNAS, PRKAR1A, PRKAR2A, PRKAR2B, ADRB2, RAP2B |
h_plk3Pathway | Regulation of cell cycle progression by Plk3 | BioCarta |
CDC25C, CHEK1, TP53, YWHAH |
h_pmlPathway | Regulation of transcriptional activity by PML | BioCarta |
FAS, CREBBP, RB1, TNF, TNFRSF1B, TP53, SP100 |
h_pparPathway | Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression | BioCarta |
PPARA, PPARD, PPARG |
h_pparaPathway | Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) | BioCarta |
CREBBP, DUSP1, EP300, HSPA1A, HSP90AA1, JUN, LPL, MYC, PIK3CA, PIK3CG, PIK3R1, PPARA, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, MAPK1, MAPK3, RB1, RELA, STAT5A, STAT5B, TNF, NCOA1, NCOR1, NCOR2, PPARGC1A, ACOX1, APOA1, APOA2, DUT, HSD17B4, PDGFA, NRIP1, NR0B2, SRA1, NR1H3, CITED2 |
h_ppargPathway | Role of PPAR-gamma Coactivators in Obesity and Thermogenesis | BioCarta |
CREBBP, EP300, LPL, PPARG, NCOA1, NCOA2, PPARGC1A |
h_prc2Pathway | The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails | BioCarta |
HDAC1, EZH1, EZH2, HDAC2, RBBP4, RING1, YY1, SUZ12, SYNC |
h_prionPathway | Prion Pathway | BioCarta |
BCL2, HSPA5, DNAJB1, LAMB1, LAMC1, RPSA, PRNP, DNAJB6, TMEM135 |
h_ps1Pathway | Presenilin action in Notch and Wnt signaling | BioCarta |
APC, CTNNB1, GSK3B, HNF1A, AXIN1, BTRC, NOTCH1, PSEN1, ADAM17 |
h_ptc1Pathway | Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle | BioCarta |
CCNB1, CDK1, CDC25A, CDC25B, CDC25C, CDK7, PTCH1, XPO1 |
h_ptdinsPathway | Phosphoinositides and their downstream targets | BioCarta |
AKT1, BAD, GSK3B, RAB5A, RAC1, JAG1, ARF1, AP2M1, LYN, PFKL, EEA1, ARHGEF2 |
h_ptenPathway | PTEN dependent cell cycle arrest and apoptosis | BioCarta |
AKT1, CDKN1B, GRB2, ITGB1, PIK3CA, PIK3R1, MAPK1, MAPK3, PTK2, SOS1, FOXO3, ILK, PTEN |
h_pyk2Pathway | Links between Pyk2 and Map Kinases | BioCarta |
CALM2, CALM3, MAPK14, GNAQ, GRB2, JUN, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAP2K1, RAC1, RAF1, SOS1, CRKL, MAP2K2 |
h_rabPathway | Rab GTPases Mark Targets In The Endocytotic Machinery | BioCarta |
RAB1A, RAB2A, RAB5A, RAB27A, RAB7A, RAB11A, RAB9A |
h_rac1Pathway | Rac 1 cell motility signaling pathway | BioCarta |
CDK5, CFL1, MYLK, PPP1R12B, PIK3CA, PIK3CG, PIK3R1, PLD1, RAC1, VAV1, RALBP1, CHN1, NCF2, PDGFRA |
h_raccPathway | Ion Channels and Their Functional Role in Vascular Endothelium | BioCarta |
GNB1, NOS3, GNAS, TRPC3, TRPV4 |
h_ranMSpathway | Role of Ran in mitotic spindle regulation | BioCarta |
RCC1, RANBP1, RANGAP1, KPNB1, KPNA2, AURKA, TPX2, KIF15 |
h_ranPathway | Cycling of Ran in nucleocytoplasmic transport | BioCarta |
RCC1, RANBP1, RANBP2, RANGAP1 |
h_ranbp2Pathway | Sumoylation by RanBP2 Regulates Transcriptional Repression | BioCarta |
HDAC1, RANBP2, RANGAP1, MDM2, HDAC9, HDAC4, HDAC6 |
h_ranklPathway | Bone Remodelling | BioCarta |
FOS, NFKB1, MAPK8, RELA, FOSL2, IFNAR1, IFNAR2, FOSL1, TNFSF11, TNFRSF11A, IRF9 |
h_rarPathway | Degradation of the RAR and RXR by the proteasome | BioCarta |
CDK7 |
h_rarrxrPathway | Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells | BioCarta |
POLR2A, NCOA3, NCOA1, HDAC3, KAT2B, NCOA2, GTF2A1, GTF2B, GTF2F1, NCOR2 |
h_rasPathway | Ras Signaling Pathway | BioCarta |
AKT1, RHOA, BAD, CASP9, CDC42, ELK1, NFKB1, PIK3CA, PIK3CG, PIK3R1, MAPK3, MAP2K1, RAC1, RAF1, RELA, FOXO4, PLD1, RALA, RALGDS, RALBP1 |
h_rbPathway | RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage | BioCarta |
CDK1, CDC25A, CDC25B, CDC25C, CDK2, RB1, TP53, CDK4, CHEK1, WEE1, YWHAH |
h_reckPathway | Inhibition of Matrix Metalloproteinases | BioCarta |
MMP2, MMP9, MMP14, TIMP1, TIMP2, TIMP3, RECK |
h_reelinPathway | Reelin Signaling Pathway | BioCarta |
FYN, CDK5, DAB1, VLDLR |
h_rhoPathway | Rho cell motility signaling pathway | BioCarta |
RHOA, TLN1, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, ARHGAP5, ARHGAP6, CFL1, MYLK, PPP1R12B, PFN1, ARHGEF5, PIP5K1B |
h_rhodopsinPathway | Visual Signal Transduction | BioCarta |
SLC25A18 |
h_rnaPathway | Double Stranded RNA Induced Gene Expression | BioCarta |
EIF2S1, NFKB1, RELA, TP53, DNAJC3 |
h_s1pPathway | SREBP control of lipid synthesis, | BioCarta |
HMGCS1, LDLR, SREBF1, SREBF2, LIMA1 |
h_salmonellaPathway | How does salmonella hijack a cell | BioCarta |
RAC1, CDC42, WASL, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2 |
h_sam68Pathway | Regulation of Splicing through Sam68 | BioCarta |
CDK1, MAPK1, MAPK3, RASA1, KHDRBS1 |
h_setPathway | Granzyme A mediated Apoptosis Pathway | BioCarta |
CREBBP, DFFA, CEP104, HMGB2, SET, ANP32A |
h_shhPathway | Sonic Hedgehog (Shh) Pathway | BioCarta |
GSK3B, PRKAR1A, PRKAR2A, PRKAR2B, GLI2, GLI3, PTCH1, SUFU |
h_skp2e2fPathway | E2F1 Destruction Pathway | BioCarta |
RB1, CDC34, CDK2, E2F1, SKP1, SKP2, TFDP1, CCNA1 |
h_slrp2Pathway | Function of SLRP in Bone: An Integrated View | BioCarta |
TGFB1, TGFB2, TGFBR1 |
h_slrpPathway | Small Leucine-rich Proteoglycan (SLRP) molecules, | BioCarta |
BGN, DCN, EPYC, FMOD, LUM |
h_smPathway | Spliceosomal Assembly | BioCarta |
SRSF2, SNRPA, SNRPA1, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPF |
h_soddPathway | SODD/TNFR1 Signaling Pathway | BioCarta |
CASP8, TNF, TNFRSF1B, TRADD, RIPK1, FADD, BIRC3 |
h_sppaPathway | Aspirin Blocks Signaling Pathway Involved in Platelet Activation | BioCarta |
GNB1, ITGB1, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, PTK2, RAF1, PLCB1, F2, F2R, GNAI1, PLA2G4A, PTGS1, SYK |
h_spryPathway | Sprouty regulation of tyrosine kinase signals | BioCarta |
EGFR, GRB2, MAPK1, MAPK3, MAP2K1, RAF1, RASA1, SOS1, PTPRB, SPRY1, SPRY2, SPRY4 |
h_srcRPTPPathway | Activation of Src by Protein-tyrosine phosphatase alpha | BioCarta |
CCNB1, CDK1, GRB2, PRKCA, PRKCB, CDC25A, CDC25B, CDC25C, CSK |
h_stat3Pathway | Stat3 Signaling Pathway | BioCarta |
JAK2, MAPK1, MAPK3, STAT3, JAK1, JAK3 |
h_stathminPathway | Stathmin and breast cancer resistance to antimicrotubule agents | BioCarta |
PRKAR1A, PRKAR2A, PRKAR2B, CAMK2D, CCNB1, CDK1, HSPA5, STMN1, MAPK13, RB1CC1, UHMK1 |
h_stemPathway | Regulation of hematopoiesis by cytokines | BioCarta |
CD4, IL6, CXCL8, IL11 |
h_stressPathway | TNF/Stress Related Signaling | BioCarta |
MAPK14, JUN, NFKB1, MAPK8, MAP2K6, RELA, TNF, TRADD, RIPK1, CRADD, TANK, ATF1 |
h_sumoPathway | Basic Mechanisms of SUMOylation | BioCarta |
SUMO3, SUMO2, UBE2I, SAE1 |
h_tall1Pathway | TACI and BCMA stimulation of B cell immune responses | BioCarta |
MAPK14, NFKB1, MAPK8, RELA, TNFSF13, TNFSF13B |
h_tcapoptosisPathway | HIV Induced T Cell Apoptosis | BioCarta |
CD4, CD28, FAS |
h_tcrPathway | T Cell Receptor Signaling Pathway | BioCarta |
CALM2, CALM3, ELK1, FOS, FYN, GRB2, JUN, NFATC1, NFATC2, NFKB1, PIK3CA, PIK3CG, PIK3R1, PPP3CA, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAC1, RAF1, RASA1, RELA, SOS1, NFATC4, VAV1 |
h_tcraPathway | Lck and Fyn tyrosine kinases in initiation of TCR Activation | BioCarta |
CD4, FYN, HLA-DRA, HLA-DRB1, PTPRC |
h_tcytotoxicPathway | T Cytotoxic Cell Surface Molecules | BioCarta |
CD28, ICAM1, ITGB2, PTPRC |
h_telPathway | Telomeres, Telomerase, Cellular Aging, and Immortality | BioCarta |
AKT1, EGFR, MYC, PRKCA, RB1, TP53, BCL2, HSP90AA1, IGF1R, KRAS, POLR2A, TEP1, TERF1, XRCC5, TNKS |
h_tercPathway | Overview of telomerase RNA component gene hTerc Transcriptional Regulation | BioCarta |
RB1, SP3, NFYB, NFYC |
h_tertpathway | Overview of telomerase protein component gene hTert Transcriptional Regulation | BioCarta |
HDAC1, MYC, TP53, WT1, SP3, MZF1 |
h_tffPathway | Trefoil Factors Initiate Mucosal Healing | BioCarta |
AKT1, RHOA, CASP9, CTNNB1, GRB2, ITGB1, PIK3CA, PIK3CG, PIK3R1, MAPK3, PTK2, SOS1, BAD, EGFR, ERBB2, GH1, GHR, MAPK1, CYCS |
h_tgfbPathway | TGF beta signaling pathway | BioCarta |
APC, CREBBP, EP300, SMAD3, SMAD4, MAPK3, MAP2K1, MAP3K7, TGFB1, TGFB2, TGFBR1, TGFBR2, TAB1, SMAD2, SMAD7, SKIL |
h_th1th2Pathway | Th1/Th2 Differentiation | BioCarta |
CD28, IFNGR1, IFNGR2, CD40LG, HLA-DRA, HLA-DRB1, IL4R, IL12A, IL12RB1, IL18, IL18R1 |
h_thelperPathway | T Helper Cell Surface Molecules | BioCarta |
CD4, CD28, ICAM1, ITGB2, PTPRC |
h_tidPathway | Chaperones modulate interferon Signaling Pathway | BioCarta |
JAK2, NFKB1, RB1, RELA, TNF, TNFRSF1B, HSPA1A, IFNGR1, IFNGR2, TP53, WT1, TAX1BP3 |
h_tnfr1Pathway | TNFR1 Signaling Pathway | BioCarta |
JUN, MAPK8, MAP3K7, TNF, RIPK1, PARP1, ARHGDIB, CASP8, DFFA, LMNA, LMNB1, PAK2, PRKDC, RB1, TRADD, CRADD, FADD, CEP104, LMNB2 |
h_tnfr2Pathway | TNFR2 Signaling Pathway | BioCarta |
NFKB1, RELA, DUSP1, TNFAIP3, TNFRSF1B, TRAF1, IKBKAP, RIPK1, TANK |
h_tob1Pathway | Role of Tob in T-cell activation | BioCarta |
SMAD4, CD28, SMAD3, TGFB1, TGFB2, TGFBR1, TGFBR2, TGFBR3, TOB2 |
h_tollPathway | Toll-Like Receptor Pathway | BioCarta |
MAPK14, FOS, JUN, NFKB1, RELA, MAP3K7, TAB1, CD14, ELK1, IRAK1, PPARA, MAPK8, MAP2K6, TLR2, TLR3, TLR4, TOLLIP, TIRAP |
h_trkaPathway | Trka Receptor Signaling Pathway | BioCarta |
PIK3CA, PIK3R1, PRKCA, PRKCB, AKT1, GRB2, KLK2, NGF, NTRK1, SOS1 |
h_tsp1Pathway | TSP-1 Induced Apoptosis in Microvascular Endothelial Cell | BioCarta |
CD36, MAPK14, FOS, FYN, JUN, THBS1 |
h_tubbyPathway | G-Protein Signaling Through Tubby Proteins | BioCarta |
GNAQ, GNB1, HTR2C, PLCB1 |
h_ucalpainPathway | uCalpain and friends in Cell spread | BioCarta |
PTK2, ACTN1, ACTN2, RHOA, ITGB1, ITGB3, RAC1, TLN1, EZR |
h_vdrPathway | Control of Gene Expression by Vitamin D Receptor | BioCarta |
CREBBP, HDAC1, ACTL6A, EP300, PRMT1, SMARCA4, SMARCC1, SMARCC2, SMARCD1, TSC2, VDR, NCOA3, ARID1A, NCOA1, KAT2B, BAZ1B, NCOR1, CHAF1A, CARM1, NCOA2, SUPT16H |
h_vegfPathway | VEGF, Hypoxia, and Angiogenesis | BioCarta |
ARNT, EIF1AX, EIF2S1, EIF2B1, EIF2S3, ELAVL1, FLT4, HIF1A, NOS3, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, PTK2, VEGFA, EIF2B4, EIF2B3, EIF2B5, EIF1 |
h_vifPathway | HIV-1 defeats host-mediated resistance by CEM15, | BioCarta |
CD4, CXCR4 |
h_vipPathway | Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells | BioCarta |
MYC, CALM2, CALM3, EGR2, EGR3, GNAQ, NFATC1, NFATC2, NFKB1, PPP3CA, PRKAR1A, PRKAR2A, PRKAR2B, RELA |
h_vitCBPathway | Vitamin C in the Brain | BioCarta |
COL4A2, COL4A3, COL4A6, P4HB, SLC2A1, SLC2A3, SLC23A2 |
h_vobesityPathway | Visceral Fat Deposits and the Metabolic Syndrome | BioCarta |
NR3C1, HSD11B1, LPL, PPARG, TNF, ADIPOQ, RETN |
h_wnt-lrp6Pathway | Wnt/LRP6 Signalling | BioCarta |
LRP6, DKK1, DKK2 |
h_wntPathway | WNT Signaling Pathway | BioCarta |
APC, CREBBP, CSNK1A1, CSNK1D, CTNNB1, GSK3B, HDAC1, SMAD4, MYC, PPARD, MAP3K7, HNF1A, TLE1, AXIN1, BTRC, TAB1, WIF1, NLK |
hsa00010 | Glycolysis / Gluconeogenesis | KEGG |
ADH1B, ADH7, DLAT, DLD, ENO1, ENO2, ENO3, ALDH2, ALDH1B1, ALDH1A3, FBP1, ALDH3B2, ALDH9A1, ALDH3A2, ALDOA, ALDOC, G6PC, GAPDH, GPI, HK1, LDHA, LDHB, ALDH7A1, PCK1, PCK2, PDHA1, PDHB, PFKL, PGAM1, PGK1, PGM1, PKM, PGM2, ACSS2, BPGM, TPI1, HKDC1, ACSS1, FBP2, G6PC3, MINPP1 |
hsa00020 | Citrate cycle (TCA cycle) | KEGG |
DLAT, DLD, DLST, FH, IDH1, IDH2, IDH3B, MDH1, MDH2, OGDH, ACO2, PC, PCK1, PCK2, PDHA1, PDHB, SDHA, SDHB, SDHC, SUCLG1, SUCLA2 |
hsa00030 | Pentose phosphate pathway | KEGG |
FBP1, ALDOA, ALDOC, G6PD, PGLS, GPI, IDNK, DERA, PFKL, PGD, PGM1, PGM2, PRPS1, PRPS2, TALDO1, TKT, FBP2, RGN, H6PD |
hsa00040 | Pentose and glucuronate interconversions | KEGG |
AKR1B1, CRYL1, DCXR, SORD, UGDH, UGP2, UGT2B4, UGT2A3, KL |
hsa00051 | Fructose and mannose metabolism | KEGG |
FBP1, ALDOA, ALDOC, AKR1B1, TKFC, GMDS, GMPPB, HK1, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PMM2, ENOSF1, SORD, TPI1, HKDC1, FBP2 |
hsa00052 | Galactose metabolism | KEGG |
AKR1B1, G6PC, GAA, GALE, GALT, B4GALT1, HK1, LCT, PFKL, PGM1, PGM2, UGP2, HKDC1, MGAM, G6PC3 |
hsa00053 | Ascorbate and aldarate metabolism | KEGG |
ALDH2, ALDH1B1, ALDH9A1, ALDH3A2, ALDH7A1, MIOX, UGDH, UGT2B4, UGT2A3, RGN |
hsa00061 | Fatty acid biosynthesis | KEGG |
ACSL1, ACSL4, FASN, ACSL6, ACACB |
hsa00062 | Fatty acid elongation | KEGG |
ACOT7, ACOT4, ECHS1, HACD2, HADHB, HADH, HACD4, MECR, HSD17B12, HACD3, PPT1, ELOVL5, ELOVL1, ELOVL4, ELOVL6, ELOVL7, HACD1, PPT2 |
hsa00071 | Fatty acid degradation | KEGG |
ECI2, ADH1B, ADH7, CPT1A, CPT1B, ECI1, ECHS1, ALDH2, ACSL1, ACSL4, ALDH1B1, ALDH9A1, ALDH3A2, ACSL6, HADHB, HADH, ACADSB, ACADVL, ACAT2, ALDH7A1, ACOX1, ACOX3 |