h_RELAPathway

Acetylation and Deacetylation of RelA in The Nucleus

BioCarta

CREBBP, EP300, NFKB1, RELA, TNF, TNFRSF1B, TRADD, RIPK1, FADD, HDAC3

h_RNApol3Pathway

RNA polymerase III transcription

BioCarta

SSB, GTF3C4

h_RacCycDPathway

Influence of Ras and Rho proteins on G1 to S Transition

BioCarta

AKT1, RHOA, CDK2, CDK4, E2F1, NFKB1, PIK3CA, PIK3R1, MAPK1, MAPK3, RAC1, RAF1, RB1, RELA, TFDP1, CDK6, CDKN1A, CDKN1B

h_SARSpathway

SARS Coronavirus Protease

BioCarta

MAPK14, EIF4E, LDHA, LDHB

h_TPOPathway

TPO Signaling Pathway

BioCarta

FOS, GRB2, JUN, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, SOS1, JAK2, MAPK3, MAP2K1, RAF1, RASA1, STAT3, STAT5A, STAT5B

h_WNVpathway

West Nile Virus

BioCarta

CASP9, EEF1A1, TIA1

h_aMANpathway

Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

BioCarta

MAN1A1, MAN2A2, MAN2B1, MAN1C1, FUT4, FUT7, ST3GAL4, ST8SIA4, B3GALT2

h_ace2Pathway

Angiotensin-converting enzyme 2 regulates heart function

BioCarta

AGT, AGTR1, AGTR2, COL4A2, COL4A3, COL4A6, ACE

h_achPathway

Role of nicotinic acetylcholine receptors in the regulation of apoptosis

BioCarta

AKT1, BAD, FOXO3, MUSK, PIK3CA, PIK3CG, PIK3R1, PTK2, YWHAH, CHRNB1

h_acrPathway

Ahr Signal Transduction Pathway

BioCarta

ARNT, HSP90AA1, AHR, AIP

h_actinYPathway

Y branching of actin filaments

BioCarta

NTRK1, RAC1, WASL, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, ABI2, WASF2

h_agpcrPathway

Attenuation of GPCR Signaling

BioCarta

GNAS, GNB1, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB

h_agrPathway

Agrin in Postsynaptic Differentiation

BioCarta

CDC42, EGFR, NRG1, ITGB1, JUN, PAK2, MAPK1, MAPK3, MAPK8, PTK2, RAC1, DAG1, DMD, CTTN, LAMA2, LAMA3, LAMA4, MUSK, PAK3, GIT2, PAK7

h_ahspPathway

Hemoglobin's Chaperone

BioCarta

ALAD, CPOX, HBA1, HBB, UROD

h_aifPathway

Opposing roles of AIF in Apoptosis and Cell Survival

BioCarta

PARP1, AIFM1, CYCS

h_akap13Pathway

Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation

BioCarta

RHOA, GNA12, PRKAG1, PRKAR2A, PRKAR2B, AKAP13

h_akap95Pathway

AKAP95 role in mitosis and chromosome dynamics

BioCarta

CCNB1, CDK1, PPP1CA, PRKAG1, PRKAR2A, PRKAR2B, DDX5, NCAPD2

h_akapCentrosomePathway

Protein Kinase A at the Centrosome

BioCarta

RHOA, CDK1, PPP1CA, PRKAG1, PRKAR2A, PRKAR2B, PKN1, MAP2, PCNT, NUP85

h_aktPathway

AKT Signaling Pathway

BioCarta

AKT1, BAD, CASP9, FOXO3, GH1, GHR, HSP90AA1, FOXO4, NFKB1, PIK3CA, PIK3CG, PIK3R1, RELA, YWHAH, FOXO1

h_alkPathway

ALK in cardiac myocytes

BioCarta

APC, CTNNB1, GATA4, GSK3B, SMAD1, SMAD4, SMAD5, MEF2C, MAP3K7, HNF1A, TGFB1, TGFB2, TGFBR1, TGFBR2, TGFBR3, AXIN1, ACVR1, BMP2, BMP4, BMPR1A, BMPR2, SMAD6, NPPB, BMP10

h_alternativePathway

Alternative Complement Pathway

BioCarta

CFB, C3, C6, C7, CFP

h_amiPathway

Acute Myocardial Infarction

BioCarta

SERPINC1, COL4A2, COL4A3, COL4A6, F2, F2R, FGA, FGB, FGG, PLAT, PLG, TFPI

h_anthraxPathway

Anthrax Toxin Mechanism of Action

BioCarta

MAP2K1, MAP2K2, BLOC1S6

h_antisensePathway

RNA polymerase III transcription

BioCarta

NONO, SFPQ, MATR3

h_appPathway

Generation of amyloid b-peptide by PS1

BioCarta

APP, PSEN1, ADAM10

h_arapPathway

ADP-Ribosylation Factor

BioCarta

ARF1, COPA, GPLD1, GBF1, ASAP2, CYTH3, CYTH2, ARFGEF2, KDELR1, KDELR3, ARFGAP3, ASAP1, ARAP2, ARAP1

h_arenrf2Pathway

Oxidative Stress Induced Gene Expression Via Nrf2

BioCarta

CREB1, MAPK14, FOS, HMOX1, JUN, PRKCA, PRKCB, MAPK1, MAPK8, CRYZ, MAFG, AKR7A2, MAFF

h_arfPathway

Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

BioCarta

E2F1, MDM2, MYC, PIK3CA, PIK3CG, PIK3R1, RAC1, RB1, TP53, TWIST1, POLR1C, POLR1A, POLR1D

h_argininecPathway

Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline

BioCarta

GLS, PRODH

h_asbcellPathway

Antigen Dependent B Cell Activation

BioCarta

FAS, CD4, CD28, CD40LG, HLA-DRA, HLA-DRB1, IL10

h_atmPathway

ATM Signaling Pathway

BioCarta

BRCA1, CDKN1A, CHEK1, GADD45A, JUN, MDM2, MRE11A, NBN, NFKB1, MAPK8, RAD51, RELA, TP53, RAD50

h_atrbrcaPathway

Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility

BioCarta

BRCA1, CHEK1, FANCD2, FANCE, FANCG, TP53, BRCA2, MRE11A, NBN, RAD1, RAD9A, RAD51, RAD50

h_bArrestin-srcPathway

Roles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling

BioCarta

GNAS, GNB1, KCNA1, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, PLCB1, FGR

h_bArrestinPathway

�-arrestins in GPCR Desensitization

BioCarta

AP2M1, GNAS, GNB1, PPARA, PLCB1, KCNA1

h_badPathway

Regulation of BAD phosphorylation

BioCarta

AKT1, BAD, BAX, BCL2, IGF1, IGF1R, KIT, KITLG, PIK3CA, PIK3CG, PIK3R1, PRKAR1A, PRKAR2A, PRKAR2B, MAPK1, MAPK3, RPS6KA1, YWHAH

h_bard1Pathway

BRCA1-dependent Ub-ligase activity

BioCarta

BRCA1, BARD1, FANCD2, FANCE, FANCG

h_barr-mapkPathway

Role of ?-arrestins in the activation and targeting of MAP kinases

BioCarta

GNAS, GNB1, KCNA1, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, PLCB1

h_bbcellPathway

Bystander B Cell Activation

BioCarta

FAS, CD4, CD28, CD40LG, HLA-DRA, HLA-DRB1

h_bcellsurvivalPathway

B Cell Survival Pathway

BioCarta

AKT1, XIAP, FOS, ITGB1, JUND, PIK3CA, PIK3CG, PIK3R1, BIRC5, ZBTB7A

h_bcrPathway

BCR Signaling Pathway

BioCarta

CALM2, CALM3, MAPK14, ELK1, FOS, GRB2, JUN, LYN, NFATC1, NFATC2, NFATC4, PPP3CA, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAC1, RAF1, SOS1, SYK, VAV1, BLNK

h_biopeptidesPathway

Bioactive Peptide Induced Signaling Pathway

BioCarta

AGT, AGTR2, CALM2, CALM3, CAMK2D, CDK5, MAPK14, F2, FYN, GNAI1, GNB1, GRB2, JAK2, KNG1, MAPT, MYLK, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAP2K1, MAP2K2, RAF1, SOS1, STAT3, STAT5A, GNA11

h_blymphocytePathway

B Lymphocyte Cell Surface Molecules

BioCarta

HLA-DRA, HLA-DRB1, ICAM1, ITGB2, PTPRC, CR1, FCGR2B

h_botulinPathway

Blockade of Neurotransmitter Relase by Botulinum Toxin

BioCarta

SNAP25, VAMP2

h_btg2Pathway

BTG family proteins and cell cycle regulation

BioCarta

PRMT1, NGF, RB1, TP53, CHAF1A, BTG1, BTG2, CHAF1B

h_calcineurinPathway

Effects of calcineurin in Keratinocyte Differentiation

BioCarta

CALM2, CALM3, CDKN1A, GNAQ, NFATC1, NFATC2, NFATC4, PPP3CA, PRKCA, PRKCB, SP3, MARCKS

h_cardiacegfPathway

Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

BioCarta

AGT, RHOA, EDN1, EGFR, FOS, JUN, MYC, NFKB1, PRKCA, PRKCB, RELA, AGTR2, EDNRA, ADAM12

h_carm-erPathway

CARM1 and Regulation of the Estrogen Receptor

BioCarta

BRCA1, CREBBP, EP300, ESR1, GTF2A1, GTF2F1, HDAC1, HDAC2, MEF2C, POLR2A, NRIP1, HDAC3, NCOR2, HDAC4, SRA1, HDAC6, HDAC5, CARM1, PPARGC1A, NR0B1, PHB2, SPEN

h_carm1Pathway

Transcription Regulation by Methyltransferase of CARM1

BioCarta

CREB1, CREBBP, EP300, PRKAR1A, PRKAR2A, PRKAR2B, CARM1

h_caspasePathway

Caspase Cascade in Apoptosis

BioCarta

PARP1, BIRC3, XIAP, ARHGDIB, CASP1, CASP6, CASP8, CASP9, DFFA, LMNA, LMNB1, CEP104, CYCS, LMNB2, CASP4

h_cb1rPathway

Metabolism of Anandamide, an Endogenous Cannabinoid

BioCarta

PLD1, CNR1

h_cblPathway

CBL mediated ligand-induced downregulation of EGF receptors

BioCarta

CSF1R, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB, SH3GLB1

h_cd40Pathway

CD40L Signaling Pathway

BioCarta

CD40LG, DUSP1, NFKB1, RELA, TNFAIP3, IKBKAP

h_cdMacPathway

Cadmium induces DNA synthesis and proliferation in macrophages

BioCarta

FOS, JUN, MYC, NFKB1, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, RAF1, RELA, TNF, PLCB1

h_cdc25Pathway

cdc25 and chk1 Regulatory Pathway in response to DNA damage

BioCarta

CDK1, CDC25A, CDC25B, CDC25C, CHEK1, WEE1, YWHAH

h_cdc42racPathway

Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration

BioCarta

RHOA, CDC42, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2

h_cdk5Pathway

Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway

BioCarta

CDK5, KLK2, NGF, NGFR, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, EGR1

h_cell2cellPathway

Cell to Cell Adhesion Signaling

BioCarta

ACTN1, ACTN2, CSK, CTNNB1, PECAM1, PTK2, CTNNA1, CTNNA2

h_cellcyclePathway

Cyclins and Cell Cycle Regulation

BioCarta

CCNB1, CDK1, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2B, E2F1, RB1, RBL1, TFDP1, CCNA1, CCND2, CCND3, CDKN2C

h_ceramidePathway

Ceramide Signaling Pathway

BioCarta

BAD, BAX, BCL2, CASP8, NFKB1, MAPK1, MAPK3, MAPK8, MAP2K1, RAF1, RELA, TRADD, RIPK1, FADD, AIFM1, CYCS, NSMAF

h_cftrPathway

Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway

BioCarta

ADRB2, GNAS, PRKAR1A, PRKAR2A, PRKAR2B, EZR, CFTR

h_chemicalPathway

Apoptotic Signaling in Response to DNA Damage

BioCarta

PARP1, AKT1, BAD, BAX, BCL2, BID, CASP6, CASP9, EIF2S1, PRKCA, PRKCB, PTK2, TLN1, TP53, CYCS

h_chrebpPathway

ChREBP regulation by carbohydrates and cAMP

BioCarta

GNAS, GNB1, PRKAA2, PRKAG1, PRKAR1A, PRKAR2A, PRKAR2B, PRKAG3

h_circadianPathway

Circadian Rhythms

BioCarta

ARNTL, CRY1, CSNK1E, PER1

h_ck1Pathway

Regulation of ck1/cdk5 by type 1 glutamate receptors

BioCarta

CDK5, CSNK1D, PPP1CA, PPP3CA, PRKAR1A, PRKAR2A, PRKAR2B, PLCB1, DRD2

h_classicPathway

Classical Complement Pathway

BioCarta

C1QA, C1R, C1S, C3, C4A, C4B, C6, C7

h_compPathway

Complement Pathway

BioCarta

C3, C4A, C4B, C6, C7, MBL2, MASP2, CFB, C1QA, C1R, C1S

h_cpsfPathway

Polyadenylation of mRNA

BioCarta

CSTF3, PABPN1, PAPOLA, CPSF1, CPSF2

h_cptPathway

Mitochondrial Carnitine Palmitoyltransferase (CPT) System

BioCarta

CPT1A, ACSS2

h_crebPathway

Transcription factor CREB and its extracellular signals

BioCarta

AKT1, CAMK2D, CREB1, MAPK14, GNAS, GRB2, PIK3CA, PIK3R1, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, MAPK1, MAPK3, RAC1, RPS6KA1, SOS1, RPS6KA5

h_cremPathway

Regulation of Spermatogenesis by CREM

BioCarta

CREM, GNAS, XPO1, FSHB, FSHR

h_ctbp1Pathway

SUMOylation as a mechanism to modulate CtBP-dependent gene responses

BioCarta

UBE2I, SAE1, ZEB1

h_ctcfPathway

CTCF: First Multivalent Nuclear Factor

BioCarta

CDKN1B, SMAD1, SMAD4, SMAD5, MDM2, MYC, PIK3CA, PIK3CG, PIK3R1, PTEN, TGFB1, TGFB2, TGFBR1, TGFBR2, TGFBR3, TP53

h_ctlPathway

CTL mediated immune response against target cells

BioCarta

FAS, B2M, HLA-A, ICAM1, ITGB2

h_ctla4Pathway

The Co-Stimulatory Signal During T-cell Activation

BioCarta

CD28, GRB2, HLA-DRA, HLA-DRB1, PIK3CA, PIK3R1, PTPN11

h_cxcr4Pathway

CXCR4 Signaling Pathway

BioCarta

GNAI1, GNAQ, GNB1, NFKB1, PIK3CA, PIK3R1, PRKCA, PRKCB, MAPK1, MAPK3, MAP2K1, PTK2, RAF1, RELA, CXCR4, CXCL12

h_cytokinePathway

Cytokine Network

BioCarta

IL1A, IL6, CXCL8, IL10, IL12A, IL18, TNF

h_d4gdiPathway

D4-GDI Signaling Pathway

BioCarta

PARP1, ARHGAP5, ARHGDIB, CASP1, CASP8, CASP9, JUN, CYCS

h_dbpbPathway

Transcriptional activation of dbpb from mRNA

BioCarta

F2, YBX1, PDGFB, PROCR

h_dcPathway

Dendritic cells in regulating TH1 and TH2 Development

BioCarta

IL10, IL12A, TLR2, TLR4, CD33, ITGAX

h_deathPathway

Induction of apoptosis through DR3 and DR4/5 Death Receptors

BioCarta

BIRC3, XIAP, BCL2, BID, CASP6, CASP8, CASP9, DFFA, LMNA, NFKB1, RELA, TRADD, RIPK1, FADD, CFLAR, CEP104, CYCS, TNFRSF25, TNFSF10

h_dicerPathway

Dicer Pathway

BioCarta

DICER1, AGO2, AGO4

h_dreampathway

Repression of Pain Sensation by the Transcriptional Regulator DREAM

BioCarta

CREB1, FOS, JUN, POLR2A, PRKAR1A, PRKAR2A, PRKAR2B, MAPK3, CREM

h_dspPathway

Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases

BioCarta

MAPK14, DUSP1, MAPK3, MAPK8, DUSP2, DUSP6, DUSP8, DUSP9

h_ecmPathway

Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia

BioCarta

RHOA, ARHGAP5, FYN, ITGB1, MYLK, PFN1, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAP2K1, PTK2, RAF1, TLN1

h_edg1Pathway

Phospholipids as signalling intermediaries

BioCarta

AKT1, RHOA, GNAI1, GNB1, ITGB3, PDGFA, PDGFRA, PIK3CA, PIK3CG, PIK3R1, PRKCA, PRKCB, MAPK1, MAPK3, PTK2, RAC1, PLCB1, ASAH1, S1PR1, ITGAV, SPHK1, SPHKAP

h_eea1Pathway

The role of FYVE-finger proteins in vesicle transport

BioCarta

EGFR, RAB5A, EEA1, TF, TFRC

h_egfPathway

EGF Signaling Pathway

BioCarta

EGFR, ELK1, FOS, GRB2, JAK1, JUN, PIK3CA, PIK3R1, PRKCA, PRKCB, MAPK3, MAPK8, MAP2K1, RAF1, RASA1, SOS1, STAT3, STAT5A

h_egfr_smrtePathway

Map Kinase Inactivation of SMRT Corepressor

BioCarta

MAPK14, EGFR, MAP2K1, NCOR2, THRA, ZBTB16

h_eicosanoidPathway

Eicosanoid Metabolism

BioCarta

PLA2G4A, PTGS1, PLCB1, ALOX5, EPHX1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIS, PTGS2, PTGES

h_eif2Pathway

Regulation of eIF2

BioCarta

EIF2S1, EIF2S3, EIF5, GSK3B, EIF2B5, PPP1CA, EIF2AK4

h_eif4Pathway

Regulation of eIF4e and p70 S6 Kinase

BioCarta

AKT1, MAPK14, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, GHR, IRS1, PIK3CA, PIK3R1, PRKCA, PRKCB, MAPK1, MAPK3, PTEN, MKNK1, EIF4G3

h_eifPathway

Eukaryotic protein translation

BioCarta

EIF1AX, EIF2S1, EIF2S3, EIF4A1, EIF4A2, EIF4E, EIF3A, EIF4G3, EIF1, EEF2, EIF5, EIF6

h_eosinophilsPathway

The Role of Eosinophils in the Chemokine Network of Allergy

BioCarta

HLA-DRA, HLA-DRB1, CCL5

h_ephA4Pathway

Eph Kinases and ephrins support platelet aggregation

BioCarta

FYN, ITGB1, LYN, EPHA4, EPHB1

h_epoPathway

EPO Signaling Pathway

BioCarta

ELK1, FOS, GRB2, JAK2, JUN, MAPK3, MAPK8, MAP2K1, RAF1, SOS1, STAT5A, STAT5B, EPOR

h_eponfkbPathway

Erythropoietin mediated neuroprotection through NF-kB

BioCarta

ARNT, CDKN1A, EPOR, HIF1A, JAK2, NFKB1, RELA, SOD2

h_eradPathway

ER�associated degradation (ERAD) Pathway

BioCarta

SKP1, UBE2I, RBX1, SAE1, CANX, MAN1A1, MAN2A2, MAN2B1, EDEM1, GANAB, SEC61A1, UGGT1, MAN1C1

h_erbB4pathway

g-Secretase mediated ErbB4 Signaling Pathway

BioCarta

ERBB4, PRKCA, PRKCB, PSEN1, ADAM17

h_erk5Pathway

Role of Erk5 in Neuronal Survival

BioCarta

AKT1, CREB1, GRB2, MEF2A, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3CG, PIK3R1, MAPK1, MAPK3, MAPK7, RPS6KA1

h_erkPathway

Erk1/Erk2 Mapk Signaling pathway

BioCarta

EGFR, ELK1, GNAS, GNB1, MKNK2, GRB2, IGF1R, ITGB1, KLK2, MYC, NGF, NGFR, PDGFRA, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, RPS6KA1, SOS1, STAT3, MKNK1, RPS6KA5