GO:0060024

BP

rhythmic synaptic transmission

Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.

PTEN

GO:0060025

BP

regulation of synaptic activity

Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.

MEF2C

GO:0060026

BP

convergent extension

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.

LRP6, PTK7

GO:0060027

BP

convergent extension involved in gastrulation

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.

NPHP3, MKKS

GO:0060028

BP

convergent extension involved in axis elongation

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.

WNT5A, TRIM28

GO:0060029

BP

convergent extension involved in organogenesis

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ.

WNT5A

GO:0060032

BP

notochord regression

The developmental process in which the stucture of the notochord is destroyed in an embryo.

GLI2

GO:0060033

BP

anatomical structure regression

The developmental process in which an anatomical stucture is destroyed as a part of its normal progression.

LRP5, CD248

GO:0060037

BP

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

TBX1, PLXNA2, TGFBR1, ECE1, ACVR1, PTCH1

GO:0060038

BP

cardiac muscle cell proliferation

The expansion of a cardiac muscle cell population by cell division.

BMP10, PRKAR1A, NOTCH1, TGFB2, TGFBR3, FOXC1, SMAD1, TENM4, NDRG4

GO:0060039

BP

pericardium development

The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.

BMP2, SMAD3, SMAD2, CCM2, HEG1

GO:0060041

BP

retina development in camera-type eye

The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

NPHP1, GRM6, PAX4, SKI, RRM1, SERPINF1, SOX9, LHX2, SOX8, GNB1, RPL24, BAX, MERTK, NECTIN1, NTRK2, JMJD6, PAPD4, ZNF513, MDM1, PFDN5, CHD7, LAMC3

GO:0060042

BP

retina morphogenesis in camera-type eye

The process in which the anatomical structure of the retina is generated and organized.

LRP5, PROX1, NECTIN3

GO:0060043

BP

regulation of cardiac muscle cell proliferation

Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.

BMPR1A, TGFBR1

GO:0060044

BP

negative regulation of cardiac muscle cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.

RBP4, GJA1, TGFBR2, PTEN

GO:0060045

BP

positive regulation of cardiac muscle cell proliferation

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.

BMP10, CDK1, FGF2, WNT2, FGFR1, CCNB1, FGFR2, FGF9, BMPR1A, NOTCH1, TGFBR3, MEF2C, ERBB4, MAPK14, ZFPM2, GATA6

GO:0060046

BP

regulation of acrosome reaction

Any process that modulates the frequency, rate or extent of the acrosome reaction.

SPINK1, B4GALT1

GO:0060047

BP

heart contraction

The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.

GPX1, ACE, TNNI3, CDC42, ACTC1, RPS6KA2, SGCD, SGCZ

GO:0060048

BP

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

ATP1B1, TPM1, GAA, DMD, MYL4, TNNI3, PIK3CA, VEGFB, ATP1A2, MAP2K6, ACTC1, SRSF1, KCNH2, PPP1R13L, TTN, RYR2, SMAD5

GO:0060049

BP

regulation of protein glycosylation

Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

MT3

GO:0060050

BP

positive regulation of protein glycosylation

Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

RAMP1, GOLGA2, CHP1

GO:0060052

BP

neurofilament cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins.

NDEL1

GO:0060053

CC

neurofilament cytoskeleton

Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.

NDEL1

GO:0060054

BP

positive regulation of epithelial cell proliferation involved in wound healing

Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.

FZD7, B4GALT1

GO:0060055

BP

angiogenesis involved in wound healing

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.

ITGB3, GPX1, ETS1, B4GALT1, PIK3CB, HPSE

GO:0060056

BP

mammary gland involution

The tissue remodeling that removes differentiated mammary epithelia during weaning.

IGFBP5, ELF3, CAV1

GO:0060058

BP

positive regulation of apoptotic process involved in mammary gland involution

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.

VDR, B4GALT1, BAX

GO:0060059

BP

embryonic retina morphogenesis in camera-type eye

The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.

LRP6, RBP4, PROX1, HIPK2

GO:0060064

BP

Spemann organizer formation at the anterior end of the primitive streak

Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan.

WNT3

GO:0060065

BP

uterus development

The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.

RBP4, ESR1, HOXA10, WNT5A, CDKN1C, FOXL2, TGFB2, SMAD4

GO:0060066

BP

oviduct development

The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.

CTNNB1

GO:0060067

BP

cervix development

The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure.

WNT5A

GO:0060068

BP

vagina development

The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.

RBP4, ESR1, WNT5A, TYRO3, BAX, MERTK

GO:0060070

BP

canonical Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.

AXIN1, KDM6A, KLF4, SNAI2, TBL1X, FZD7, LRP5, LRP6, MYC, WNT2, SDC1, APC, CTNNB1, WNT5A, NR4A2, PSEN1, GSK3B, WNT3, PTEN, CDC42, UBE2B, SMAD3, NDP, SOX4, PTK7, DIXDC1, STK11, SFRP1, RYR2, MED12, WNT2B, PYGO2, TBL1XR1, FZD8, SOX17, CHD8, TCF7L1, TCF7L2, FZD4

GO:0060071

BP

Wnt signaling pathway, planar cell polarity pathway

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.

PSMD11, PSMD12, PSMD3, FZD6, FZD7, GPC4, PSMD10, AP2A2, PFN1, UBC, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, WNT5A, PSMC4, PSMB3, PSMD7, AP2S1, CDC42, PSME3, RHOA, PSMC1, PSMC6, RPS27A, UBA52, RAC1, AP2B1, ROR1, TIAM1, PSMD2, PSME4, MED12, CTHRC1, AP2M1, PRICKLE1, SMURF2, PARD6A, CELSR3, FZD4, DAAM1, GPC6

GO:0060072

MF

large conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.

KCNMA1

GO:0060073

BP

micturition

The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.

ADRA1A, KCNMA1

GO:0060074

BP

synapse maturation

The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.

PTEN

GO:0060075

BP

regulation of resting membrane potential

Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.

KCNK1, PSEN1, KCNK6

GO:0060076

CC

excitatory synapse

A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.

SRPX2, SYT1, FGFR2, ITGA3, DLG4, NLGN4X, SYT11

GO:0060077

CC

inhibitory synapse

A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.

SYT11, IGSF9B

GO:0060078

BP

regulation of postsynaptic membrane potential

Any process that modulates the potential difference across a post-synaptic membrane.

PKD2, SCN9A, FGF14

GO:0060079

BP

excitatory postsynaptic potential

A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.

ADORA1, SNCA, CDK5, MEF2C, PPP3CA, GRIN2A, MAPK8IP2, RAB3GAP1, SLC29A1, GHRL

GO:0060081

BP

membrane hyperpolarization

The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.

CFTR, CASP1, ADIPOQ

GO:0060083

BP

smooth muscle contraction involved in micturition

The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.

KCNMA1, TRPV1

GO:0060086

BP

circadian temperature homeostasis

Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.

NR1D1, TNFRSF11A

GO:0060087

BP

relaxation of vascular smooth muscle

A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.

ADORA2B, ADORA1, RGS2

GO:0060088

BP

auditory receptor cell stereocilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.

CLIC5

GO:0060090

MF

binding, bridging

The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

PDCD6, GAS6, TRADD

GO:0060091

CC

kinocilium

A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.

DCDC2

GO:0060100

BP

positive regulation of phagocytosis, engulfment

Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

CD36, ITGA2, PPARG, F2RL1, ANO6

GO:0060112

BP

generation of ovulation cycle rhythm

The process which controls the timing of the type of sexual cycle seen in female mammals.

CHRNA7, KISS1, NPY5R

GO:0060113

BP

inner ear receptor cell differentiation

The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.

BMP4

GO:0060117

BP

auditory receptor cell development

The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

FGFR1

GO:0060119

BP

inner ear receptor cell development

The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

ATP8B1, GABRA5, NAGLU

GO:0060122

BP

inner ear receptor stereocilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.

SDC4, HES1, TRIP11, CTHRC1, IFT27, MKS1

GO:0060123

BP

regulation of growth hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.

CHD7

GO:0060124

BP

positive regulation of growth hormone secretion

Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.

GHRH, DRD2, ARHGEF7, KISS1, GHRL

GO:0060125

BP

negative regulation of growth hormone secretion

Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.

PTPN11

GO:0060126

BP

somatotropin secreting cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.

PITX2

GO:0060127

BP

prolactin secreting cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin.

PITX2

GO:0060128

BP

corticotropin hormone secreting cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.

BMP2

GO:0060129

BP

thyroid-stimulating hormone-secreting cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin.

BMP2

GO:0060134

BP

prepulse inhibition

The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse.

DRD2, CTNNA2, PTEN, NRXN1

GO:0060135

BP

maternal process involved in female pregnancy

A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.

AGRP, ANGPT2, CCL2, AKR1B1, PAM, CNR1, ITGA3, UBE2A, ADCY7, PPAT, DSG2, APOL2

GO:0060136

BP

embryonic process involved in female pregnancy

A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.

ACSL4, JUNB, HSF1, SP3

GO:0060137

BP

maternal process involved in parturition

A reproductive process occurring in the mother that results in birth.

CYP1A1, EDN1, CCL2, OXTR

GO:0060139

BP

positive regulation of apoptotic process by virus

Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

BCL2L11, BAD

GO:0060143

BP

positive regulation of syncytium formation by plasma membrane fusion

Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

CAMK1

GO:0060154

BP

cellular process regulating host cell cycle in response to virus

Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus.

BCL2L11, BAD

GO:0060155

BP

platelet dense granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.

ABCA1, F2R, BLOC1S1, BLOC1S3

GO:0060156

BP

milk ejection

An automatic response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.

GJA1

GO:0060157

BP

urinary bladder development

The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion.

RBP4, WNT5A

GO:0060158

BP

phospholipase C-activating dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).

DRD2, GNA11, GNAQ

GO:0060160

BP

negative regulation of dopamine receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.

DRD2

GO:0060161

BP

positive regulation of dopamine receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.

CAV2, VPS35

GO:0060163

BP

subpallium neuron fate commitment

The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon.

ASCL1

GO:0060164

BP

regulation of timing of neuron differentiation

The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron.

HES1

GO:0060165

BP

regulation of timing of subpallium neuron differentiation

The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon.

ASCL1

GO:0060166

BP

olfactory pit development

The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.

ALDH1A3, ASCL1, DLX5

GO:0060168

BP

positive regulation of adenosine receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands.

ACPP

GO:0060169

BP

negative regulation of adenosine receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands.

ADA

GO:0060170

CC

ciliary membrane

The portion of the plasma membrane surrounding a cilium.

CASK, GPI, DRD2, SCNN1A, EPS15, EVC, PKD1, PKD2, PTCH1, SEPT2, TCTN3, BBS7, BBS1, TTC8, TCTN2, HHIP, BBS2

GO:0060171

CC

stereocilium membrane

The portion of the plasma membrane surrounding a stereocilium.

MYO1C, FAM65B

GO:0060173

BP

limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

GREM1, PAM, NR2F2, COMP, BMPR2, BBS7, LNP, RC3H2, IFT122, ZAK, CHD7, INTU

GO:0060174

BP

limb bud formation

The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.

PLXNA2, FGFR2, SOX9, WNT3, SOX4, SEMA3C

GO:0060175

MF

brain-derived neurotrophic factor-activated receptor activity

Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

NTRK2

GO:0060177

BP

regulation of angiotensin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin.

ACE

GO:0060178

BP

regulation of exocyst localization

Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.

RALB

GO:0060179

BP

male mating behavior

The specific behavior of a male organism that is associated with reproduction.

PTEN, NCOA1

GO:0060192

BP

negative regulation of lipase activity

Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

APOA1, APOA2, PLIN5

GO:0060193

BP

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

RHOA, PLIN5

GO:0060197

BP

cloacal septation

The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development.

BMP4

GO:0060201

CC

clathrin-sculpted acetylcholine transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.

SYT1

GO:0060203

CC

clathrin-sculpted glutamate transport vesicle membrane

The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle.

SYT1, VAMP2

GO:0060205

CC

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

ADA

GO:0060213

BP

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.

CNOT1, ZFP36, POLR2G, BTG2, CPEB3, TNRC6C, CNOT7, AGO2, TNRC6B

GO:0060214

BP

endocardium formation

Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

PROX1, SOX17

GO:0060215

BP

primitive hemopoiesis

A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.

STK4

GO:0060216

BP

definitive hemopoiesis

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

MEIS1, TAL1, ZFP36L2, SP3, TEK, TGFBR3, MFAP5, CBFB