GO:0052833

MF

inositol monophosphate 4-phosphatase activity

Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0052834

MF

inositol monophosphate phosphatase activity

Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0052835

MF

inositol-3,4,6-trisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).

ITPK1

GO:0052836

MF

inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.

IP6K2

GO:0052839

MF

inositol diphosphate tetrakisphosphate kinase activity

Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.

IP6K2

GO:0052840

MF

inositol diphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052841

MF

inositol bisdiphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052842

MF

inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052843

MF

inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052844

MF

inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052845

MF

inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052846

MF

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052847

MF

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052848

MF

inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052851

MF

ferric-chelate reductase (NADPH) activity

Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ .

STEAP4

GO:0052852

MF

very-long-chain-(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons.

HAO2

GO:0052853

MF

long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity

Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons.

HAO2

GO:0052854

MF

medium-chain-(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons.

HAO2

GO:0052855

MF

ADP-dependent NAD(P)H-hydrate dehydratase activity

Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate.

CARKD

GO:0052858

MF

peptidyl-lysine acetyltransferase activity

Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.

NAA50

GO:0052890

MF

oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.

ACOX3, ACADSB, ACADVL, ACOX1, ACOX2

GO:0052906

MF

tRNA (guanine(37)-N(1))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.

TRMT5

GO:0052907

MF

23S rRNA (adenine(1618)-N(6))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.

METTL16

GO:0052909

MF

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.

DIMT1

GO:0052918

MF

dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

ALG9

GO:0052926

MF

dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

ALG9

GO:0052927

MF

CTP:tRNA cytidylyltransferase activity

Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate.

TRNT1

GO:0052928

MF

CTP:3'-cytidine-tRNA cytidylyltransferase activity

Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.

TRNT1

GO:0052929

MF

ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity

Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.

TRNT1

GO:0055001

BP

muscle cell development

The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.

AXIN1, KDM1A, NFATC4, SGCD, MEGF10, SGCZ

GO:0055002

BP

striated muscle cell development

The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.

SDC1

GO:0055003

BP

cardiac myofibril assembly

The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.

OBSL1, PDGFRB, PDGFRA, ACTC1, TTN

GO:0055005

BP

ventricular cardiac myofibril assembly

The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.

MEF2A, PROX1

GO:0055007

BP

cardiac muscle cell differentiation

The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

ARID1A, ITGB1, BMP2, BMP4, CALR, SOX6, SIK1, NRG1, AKAP13, PROX1, GATA6, CACYBP, NOX4

GO:0055008

BP

cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac muscle tissue are generated and organized.

BMP2, NOTCH1, ACTC1, ANKRD1, TTN

GO:0055009

BP

atrial cardiac muscle tissue morphogenesis

The process in which the anatomical structure of cardiac atrium muscle is generated and organized.

BMP10, WNT2, PROX1, PITX2

GO:0055010

BP

ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.

SMAD7, BMP10, TGFB1, TPM1, COL11A1, TNNI3, FGFR2, TGFBR3, FOXC1, PROX1, PKP2

GO:0055012

BP

ventricular cardiac muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

MEF2C

GO:0055013

BP

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

ACTN2, HNRNPU, SGCB

GO:0055015

BP

ventricular cardiac muscle cell development

The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

BMP10, LMNA, CDK1, CCNB1, PITX2

GO:0055017

BP

cardiac muscle tissue growth

The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.

HEG1

GO:0055020

BP

positive regulation of cardiac muscle fiber development

Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.

BMP4

GO:0055025

BP

positive regulation of cardiac muscle tissue development

Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.

CREB1, ERBB3

GO:0055037

CC

recycling endosome

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

WASH1, KCNK1, DYNC1I1, RAB29, STX7, SLC31A1, SLC31A2, TBC1D12, ATP9A, RAB11FIP3, FCHSD2, TNF, TFRC, TF, ITGB1, RAP2A, CFTR, TUBG1, USP6, AQP2, SLC11A2, RAB4B, RAB11A, EEA1, RABEP1, VAMP3, RAB11B, HFE, LDLRAP1, RAB11FIP1, TUBA1A, VPS52, COMMD1, SH3TC2, SORL1, SGK3, OPTN, GPER1, SYT11, ACKR4, TBC1D14, VTI1B, RABGEF1, TNIK, MYO5B, ATP11B, NISCH, MYO5A, ARFGEF2

GO:0055038

CC

recycling endosome membrane

The lipid bilayer surrounding a recycling endosome.

WASH1, SCAMP1, SCAMP2, RAB11FIP3, RAP2A, RAP2B, RAB11A, RAB11B, RAB12, SLC39A4, RAB11FIP2, RFFL, SLC9A6, NDRG1, PLEKHB2, EHD4, EHD3, ZDHHC2, LAMP5, ATP11B

GO:0055056

MF

D-glucose transmembrane transporter activity

Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other.

SLC2A10, SLC2A1, SLC2A3, SLC2A4, SLC2A6

GO:0055059

BP

asymmetric neuroblast division

The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.

TEAD3

GO:0055062

BP

phosphate ion homeostasis

Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.

SFRP4

GO:0055064

BP

chloride ion homeostasis

Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell.

CA12

GO:0055065

BP

metal ion homeostasis

Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell.

SLC7A8

GO:0055069

BP

zinc ion homeostasis

Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.

PARK2, MT3, ATP13A2

GO:0055070

BP

copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.

XIAP, COMMD1

GO:0055072

BP

iron ion homeostasis

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

TF, FTL, MFI2, HMOX1, SLC11A1, B2M, PICALM, HFE, STEAP4, SFXN4, TMPRSS6, EPAS1, BDH2, SFXN3, SFXN1, SLC25A37, TFR2

GO:0055073

BP

cadmium ion homeostasis

Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell.

MT3

GO:0055074

BP

calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.

TNFSF11, CYP27B1, CAV1, CCDC47, TRPV6, SEPN1, KL

GO:0055075

BP

potassium ion homeostasis

Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.

CYP11B2, KCNH2

GO:0055077

MF

gap junction hemi-channel activity

A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.

GJA5, PANX2, PANX1

GO:0055078

BP

sodium ion homeostasis

Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.

CYP11B2, SCNN1A, SCNN1G

GO:0055085

BP

transmembrane transport

The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other

SLC22A23, SLC33A1, ABCD4, ABCC4, ABCC5, ABCA8, APOA1, SLC25A5, EIF2S1, BCL2, SLC25A4, CFTR, SLC25A16, MAL, AZGP1, ABCD3, SLC6A1, ABCC1, GJA5, EIF2S3, VDAC2, PEX3, ABCE1, SEC61A1, RNASEL, SLC18A2, SLC10A7, SLC14A1, KCNJ11, RALBP1, SLC15A2, NDUFAF6, PDZD11, MFSD14B, ABCC10, SLC18B1, SLC23A3, SV2A, SV2B, SLC16A14, SLC16A9, SLC44A2, ABCA6, SLC44A3, SLC15A4, MFSD2A, SLC43A3, SLC44A5, ABCF1, NUP35, MFSD8, SLC25A43, SLC44A1, SLC5A11, ABCA5, SLC25A36, SLC47A1, SLC41A3, SLC25A44, SLC41A2, MFSD14A, PANX2, SLC46A2, SLC25A18, ABCG8, TMEM245, MFSD1, SLC25A19, ANKH, MRS2, ABCB6, ABCB10, ADD3, FLVCR2, VDAC3

GO:0055088

BP

lipid homeostasis

Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.

ACOX3, PPARG, ACADSB, ACADVL, NR1H3, NR1D2, USF2, PNPLA5, PNPLA2, ACOX2, PKP2, PNPLA3, IRS2

GO:0055089

BP

fatty acid homeostasis

Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.

INS, APOE, XBP1, POLD1, PRKAA2, DGAT2, NR1H4, GPAM

GO:0055090

BP

acylglycerol homeostasis

Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell.

APOA5

GO:0055091

BP

phospholipid homeostasis

Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.

ABCA1, APOA1, FABP3, GPAM, LIPG

GO:0055092

BP

sterol homeostasis

Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.

XBP1, NR1H3

GO:0055093

BP

response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

COL1A1, CYP1A1, PDGFRB, CDK4, CDKN1A, POLG, BNIP3, HDAC1, HDAC2

GO:0055094

BP

response to lipoprotein particle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus.

HMGCS1

GO:0055096

BP

low-density lipoprotein particle mediated signaling

A series of molecular signals mediated by the detection of low-density lipoprotein particle.

CD36, CDH13

GO:0055098

BP

response to low-density lipoprotein particle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.

ABCA1, PPARG, SREBF2

GO:0055099

BP

response to high density lipoprotein particle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus.

ADAM17

GO:0055100

MF

adiponectin binding

Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.

CDH13, ADIPOR2, ADIPOR1

GO:0055102

MF

lipase inhibitor activity

Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.

APOA1, APOA2, APOC1, APOC3, FAF2

GO:0055103

MF

ligase regulator activity

Modulates the activity of a ligase.

CAPN3

GO:0055105

MF

ubiquitin-protein transferase inhibitor activity

Stops, prevents or reduces the activity of a ubiquitin-protein transferase.

GLMN

GO:0055106

MF

ubiquitin-protein transferase regulator activity

Modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.

TRIB2, TRIB3, TRIB1

GO:0055108

BP

Golgi to transport vesicle transport

The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.

ARF1

GO:0055114

BP

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

DHRS12, SH3PXD2B, AGPS, PLOD2, SCD, UTY, CCS, HSD17B6, KMO, ABCC4, P4HA2, CYP27B1, KDM6A, CYB5B, CYP26A1, PHGDH, PRODH, AKR7A2, KDM1A, FADS1, UGDH, AOC2, CREG1, SC5D, ALDH1L1, DHRS3, TM7SF2, ALDH1A2, MICAL2, KDM4B, H6PD, DUS4L, CRYZL1, AIFM1, FADS2, CH25H, CYB5A, LDHA, DHFR, CYB5R3, GSR, F8, FTH1, HMGCR, SOD2, CYP1A1, CYBB, CYP17A1, CYP11A1, MPO, CYP2E1, TH, LDHB, UQCRH, SOD3, CYP3A4, CYP21A2, QDPR, ALOX5, FDX1, TXN, MGST1, CYP2D6, G6PD, CYP2A6, CYP19A1, MTHFD1, CYP2C9, BMP2, BCKDHA, P4HA1, MTHFD2, HSD3B1, HSD17B1, TYR, UQCRB, AKR1B1, HPGD, CYP11B1, NQO1, ALOX15, NQO2, CBR1, SRD5A1, PAM, CYP11B2, VCAM1, NCF2, CYP2B6, MAOA, BCKDHB, GPX3, PTGS1, ME2, RRM1, CHM, CHML, HSD3B2, MAOB, LOX, HSD11B1, KDM5A, NOS3, PRDX6, BLVRB, PDIA3, SDHA, GDI1, SRD5A2, RRM2, FMO4, UQCRC1, HIBADH, PRDX2, PTGS2, CBS, GLRX, CPOX, GMPR, GPX4, HSD17B2, FDFT1, SNCA, ADH7, AKR1C3, MTHFR, GPD2, ALDH1A3, XDH, ALDH3B2, ALDH9A1, FASN, ALDH7A1, GLUD2, GDI2, ALDH3A2, PGD, AKR1C2, HCCS, ALDH18A1, GFER, CTBP2, HSD17B7, SESN3, GSTO1, HSD11B2, MRPS36, SORD, DHODH, ALDH6A1, PLOD1, AKR1C1, AOX1, PRDX1, PIGF, CRYZ, LOXL1, ASPH, DPYD, PRDX4, SQLE, PDIA5, PTGR1, NCF4, DHCR24, JMJD1C, NSDHL, MSMO1, PTGIS, CYP1B1, ME3, CYP51A1, AOC3, CDO1, TXNRD1, ALDH1L2, GLYR1, HSD17B12, PYCRL, CYBRD1, TECRL, ASPHD1, MARC1, STEAP4, ASPHD2, JMJD6, FDX1L, OGFOD3, MTHFD1L, MOXD1, DHRS13, CYP2R1, HSDL2, KDM7A, QSOX2, FA2H, AAED1, CYP2U1, DCXR, SCD5, ERO1B, MINA, P3H2, TPH2, ADHFE1, DNAJC10, MSRB3, ALDH16A1, RDH10, ZADH2, OXR1, CYB561D1, SUMF1, RDH13, HSD17B11, CYP2W1, RDH11, ENOX1, MICAL1, GPX8, STAB2, RTN4IP1, DIO2, HGD, KIAA1191, ERO1A, HPDL, LOXL4, FAR2, DHRS1, NOX5, HHIP, GPX7, SDHC, HSD17B10, TXN2, DHRS9, VKORC1, HEPH, AIFM2, FAM213A, ALKBH7, DHRS4, DOHH, HTATIP2, ADI1, MECR, C1orf43, NMES1, TMX4, SH3BGRL3, ALDH8A1, HSD3B7, GSTO2, EGLN3, MTHFD2L, CYP3A43, NOX4, CYP26B1, DUOX2, DUOX1, GLRX2, STAB1, SEPN1, PIPOX, DHCR7, GRHPR, AASS, MIOX, KDM5B, PCYOX1, DMGDH, OSGIN1, SARDH, CYP8B1, HIGD1A, KDM2A, GSTK1, CRYL1, DHRS7, LOXL2, SESN1

GO:0055117

BP

regulation of cardiac muscle contraction

Any process that modulates the frequency, rate or extent of cardiac muscle contraction.

SMAD7, BMP10, PRKACA, ADRA1B, GJA5, CALM2, ANK2, RYR2, P2RX4, EHD3

GO:0055118

BP

negative regulation of cardiac muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.

PDE5A, ADORA1, PIK3CG

GO:0055119

BP

relaxation of cardiac muscle

The process in which the extent of cardiac muscle contraction is reduced.

PDE5A, ATP1B1, ATP2A2, PLN, GSTM2, RGS2, ATP1A2, CAMK2D, P2RX4

GO:0055123

BP

digestive system development

The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

CDKN1C

GO:0055129

BP

L-proline biosynthetic process

The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

ALDH18A1, PYCRL

GO:0055131

MF

C3HC4-type RING finger domain binding

Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.

HSPA1A, HSPA1B, DNAJA1, KCNH2, PINK1

GO:0060001

MF

minus-end directed microfilament motor activity

Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers.

MYO6

GO:0060002

MF

plus-end directed microfilament motor activity

Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers.

MYO19, MYO10

GO:0060004

BP

reflex

An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness.

SATB1

GO:0060005

BP

vestibular reflex

A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.

NR4A3

GO:0060008

BP

Sertoli cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.

TCF21, SOX9, NR0B1

GO:0060009

BP

Sertoli cell development

The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.

CST3, NTRK1, SDC1, ATRX, SOX9, HSD17B4, SOX8

GO:0060011

BP

Sertoli cell proliferation

The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.

FSHB, ACVR2A, BAX, BCL2L2

GO:0060012

BP

synaptic transmission, glycinergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.

GLRB

GO:0060013

BP

righting reflex

A reflex process in which an animal immediately tries to turn over after being placed in a supine position.

FOXP2, ALDH1A3, GLRB, USP46

GO:0060014

BP

granulosa cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.

FOXL2

GO:0060016

BP

granulosa cell development

The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate.

BMP15

GO:0060017

BP

parathyroid gland development

The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone.

HOXA3, TBX1, TGFBR1, CRKL

GO:0060018

BP

astrocyte fate commitment

The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte.

TAL1, SOX9, SOX8

GO:0060019

BP

radial glial cell differentiation

The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.

CDH2, STAT3

GO:0060020

BP

Bergmann glial cell differentiation

The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.

PLPP3, VIM, MAPK3, MAPK1, MAP2K1, PTPN11

GO:0060021

BP

palate development

The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.

INSIG1, SNAI2, TCF21, LRP6, DHRS3, GDF11, INHBA, GLI3, SKI, COL11A2, EPHB2, BMPR1A, TGFBR1, TGFBR2, WNT5A, DLX5, TGFB2, TGFBR3, MEF2C, SOS1, NPRL3, SMAD4, ACVR2B, ARID5B, TWIST1, SMAD2, BNC2, FRAS1, BBS7, OSR1, ANP32B, CSRNP1, PYGO2, PAK1IP1, CHD7

GO:0060022

BP

hard palate development

The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes.

DLG1, MMP25

GO:0060023

BP

soft palate development

The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate.

TBX1, COL11A2, TSHZ1