GO:0051537

MF

2 iron, 2 sulfur cluster binding

Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.

FDX1, NDUFV2, SDHB, NDUFS1, UQCRFS1, XDH, AOX1, FXN, FDX1L, CISD2, ISCA1, GLRX2, CISD1

GO:0051538

MF

3 iron, 4 sulfur cluster binding

Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing.

SDHB, ACO2

GO:0051539

MF

4 iron, 4 sulfur cluster binding

Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

NDUFS8, REV3L, NDUFS2, POLA1, ERCC2, SDHB, NDUFS1, POLD1, PRIM2, DNA2, NTHL1, PPAT, POLE, DPYD, ETFDH, CDKAL1, NUBPL, ACO2, ISCA1, MUTYH, NFU1

GO:0051541

BP

elastin metabolic process

The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.

HIF1A

GO:0051545

BP

negative regulation of elastin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.

HBEGF

GO:0051546

BP

keratinocyte migration

The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another.

KRT16, PPARD, FERMT1

GO:0051549

BP

positive regulation of keratinocyte migration

Any process that activates or increases the frequency, rate or extent of keratinocyte migration.

MMP9, FGF7, ADAM9, HAS2, HBEGF, EPB41L4B

GO:0051552

BP

flavone metabolic process

The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).

PPARGC1A

GO:0051560

BP

mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.

ANXA6, MICU2

GO:0051561

BP

positive regulation of mitochondrial calcium ion concentration

Any process that increases the concentration of calcium ions in mitochondria.

TGM2, BCAP31, RAP1GDS1, MICU2, MCUR1

GO:0051562

BP

negative regulation of mitochondrial calcium ion concentration

Any process that decreases the concentration of calcium ions in mitochondria.

MICU2

GO:0051563

BP

smooth endoplasmic reticulum calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings.

APP, PSEN1

GO:0051567

BP

histone H3-K9 methylation

The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.

EHMT2, SETDB2

GO:0051568

BP

histone H3-K4 methylation

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

KDM6A, RBBP5, KMT2E, KMT2C, ASH1L, ASH2L, KMT2B

GO:0051569

BP

regulation of histone H3-K4 methylation

Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

CTCFL, PYGO2, ZNF335, KMT2B

GO:0051570

BP

regulation of histone H3-K9 methylation

Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.

SETD7

GO:0051571

BP

positive regulation of histone H3-K4 methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

OGT, GCG, DNMT1, CTNNB1, BRCA1, SMAD4, RTF1, DNMT3B

GO:0051572

BP

negative regulation of histone H3-K4 methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

KDM1A, H2AFY, BRCA1

GO:0051573

BP

negative regulation of histone H3-K9 methylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.

KDM1A, DNMT1, BRCA1, DNMT3B

GO:0051574

BP

positive regulation of histone H3-K9 methylation

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.

BRCA1

GO:0051575

MF

5'-deoxyribose-5-phosphate lyase activity

Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site.

POLQ, XRCC5, HMGA2

GO:0051582

BP

positive regulation of neurotransmitter uptake

Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.

PARK2

GO:0051583

BP

dopamine uptake involved in synaptic transmission

The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

PARK2, SNCA

GO:0051584

BP

regulation of dopamine uptake involved in synaptic transmission

Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell.

TOR1A, DRD2

GO:0051585

BP

negative regulation of dopamine uptake involved in synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.

SNCA

GO:0051586

BP

positive regulation of dopamine uptake involved in synaptic transmission

Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell.

DRD2, RAB3B

GO:0051591

BP

response to cAMP

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.

PER1, NDUFS4, PAX4, LDHA, FOS, COL1A1, JUN, SPARC, TYR, FOSL1, AREG, NME1, PFKFB1, JUNB, JUND, SDC1, AGXT, DUSP1, BSG, SREBF1, PLA2G5, FOSB, TEK, CREM, RELA, PDE3A, CDO1, CARM1, PPARGC1B, MMP19, CITED1, DUOX2, DUOX1

GO:0051592

BP

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

PTGES, AHCYL1, PDCD6, ENTPD6, SLC25A12, SEC31A, EGFR, PENK, FGA, FGB, FGG, IL6, THBS1, SPARC, SDC1, CAPN3, DUSP1, SLC6A1, GDI1, TRPC1, ANXA11, CALM2, CAV1, PPP3CA, KCNMA1, ADAM9, TRPC3, HNRNPD, ITPR3, HOMER1, TPH2, TTN, AQP3, BAD, S100A16, TRPV6, TXNIP, SLC25A13

GO:0051593

BP

response to folic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.

TYMS, EEF2, MTHFR, ASCL1

GO:0051597

BP

response to methylmercury

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.

S100B, ALAD, ARSB, CPOX, ANK2

GO:0051598

BP

meiotic recombination checkpoint

A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.

RAD1

GO:0051599

BP

response to hydrostatic pressure

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.

NTRK1, KRT8, ATP2B4, COL18A1

GO:0051601

BP

exocyst localization

Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.

EXOC3, TNFAIP2, STXBP6, EXOC1

GO:0051602

BP

response to electrical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.

MSTN, NTRK1, IL6, TH, CD14, BTG2, EEF1A2, HNRNPD, S100A13

GO:0051603

BP

proteolysis involved in cellular protein catabolic process

The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

CLPX, CTSL, CTSB, CTSH, IDE, CTSS, CTSK, CTSC, ADAMTS12, DNAJC3, CASP8, CLPP, SCPEP1, CTSZ, CTSF, ADAMTS7

GO:0051604

BP

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

SNAPIN, HSPD1, SERPINH1, TSPAN5, TSPAN14, SORL1, LMF1, STUB1

GO:0051606

BP

detection of stimulus

The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.

CADM1

GO:0051607

BP

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

PLSCR1, POLR3G, TLR3, BNIP3L, CRCP, IL33, IFNA1 , IFNA16, ISG15, IL6, PTPRC, BCL2, IRF1, IFITM1, IFNAR1, GBP1, IFNAR2, STAT2, F2RL1, ADARB1, IRF9, IFITM3, RELA, RNASEL, IL10RB, BST2, HYAL2, ILF3, BNIP3, FADD, DNAJC3, IFIT5, SERINC3, PMAIP1, TRIM25, IFI16, MICA, NCBP3, IFI44L, MAVS, SERINC5, NLRC5, IFNE, TRIM22, LILRB1, ISG20, ITCH, LYST, SPON2, POLR3C, TRIM34, GBP3, POLR3F, APOBEC3G, GPAM, EXOSC4, POLR3B, DDIT4, EIF2AK4, DMBT1, APOBEC3B, TBK1, PYCARD, POLR3K, SAMHD1, ZNF175

GO:0051612

BP

negative regulation of serotonin uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.

SNCA, GPM6B

GO:0051615

BP

histamine uptake

The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

SLC22A3

GO:0051622

BP

negative regulation of norepinephrine uptake

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.

SNCA

GO:0051638

BP

barbed-end actin filament uncapping

The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits.

LRRC16A

GO:0051639

BP

actin filament network formation

The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.

COBL, ACTN1, LCP1, PLS1, COBLL1, LRRC16A

GO:0051640

BP

organelle localization

Any process in which an organelle is transported to, and/or maintained in, a specific location.

STX7

GO:0051641

BP

cellular localization

A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

MYO1D

GO:0051642

BP

centrosome localization

Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.

AURKA, DYNC1LI2, PLXNA2, NIN, SYNE2, NDEL1, NDE1, SUN2

GO:0051643

BP

endoplasmic reticulum localization

Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.

MYO5A

GO:0051645

BP

Golgi localization

Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.

DAB1, STK11, HOOK3

GO:0051646

BP

mitochondrion localization

Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.

MFN2, PLIN5, BRAT1, HDAC6

GO:0051647

BP

nucleus localization

Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.

BIN1

GO:0051649

BP

establishment of localization in cell

Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.

ZWINT

GO:0051650

BP

establishment of vesicle localization

The directed movement of a vesicle to a specific location.

RAB11A

GO:0051651

BP

maintenance of location in cell

Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.

APOE

GO:0051653

BP

spindle localization

Any process in which is the spindle is transported to, and/or maintained in, a specific location.

WASL, ACTR3, ACTR2, ASPM

GO:0051654

BP

establishment of mitochondrion localization

The directed movement of the mitochondrion to a specific location.

FEZ1

GO:0051656

BP

establishment of organelle localization

The directed movement of an organelle to a specific location.

CROCC

GO:0051659

BP

maintenance of mitochondrion location

Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere.

ALB

GO:0051660

BP

establishment of centrosome localization

The directed movement of the centrosome to a specific location.

EZR, DLG1

GO:0051661

BP

maintenance of centrosome location

Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere.

GPSM2, ASPM, TBCCD1

GO:0051665

BP

membrane raft localization

Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.

RALA

GO:0051668

BP

localization within membrane

Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.

CDH13, RAC1

GO:0051683

BP

establishment of Golgi localization

The directed movement of the Golgi to a specific location.

CDC42, YWHAZ, ARHGAP21, PDCD10, COPG1

GO:0051684

BP

maintenance of Golgi location

Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere.

ARHGAP21, TBCCD1

GO:0051693

BP

actin filament capping

The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

SPTBN1, SPTBN4

GO:0051694

BP

pointed-end actin filament capping

The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

TMOD1, LMOD1

GO:0051695

BP

actin filament uncapping

The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits.

ACTN2

GO:0051702

BP

interaction with symbiont

An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.

GPX1

GO:0051707

BP

response to other organism

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.

KRT8

GO:0051716

BP

cellular response to stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.

EIF2B1, EIF2B3, EIF2B4

GO:0051717

MF

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.

PTEN, MINPP1

GO:0051718

MF

DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA).

DNMT3B

GO:0051721

MF

protein phosphatase 2A binding

Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.

ENSA, HMGCR, TP53, BCL2, AKT1, ARPP19, IGBP1, FOXO1, STRN3, EIF4EBP1, PPP2R4, ANKLE2, MASTL, STRN4, SPHK1, CTTNBP2NL, SMG5, PPME1

GO:0051722

MF

protein C-terminal methylesterase activity

Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.

PPME1

GO:0051724

MF

NAD transporter activity

Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH.

SLC25A17

GO:0051725

BP

protein de-ADP-ribosylation

The process of removing one or more ADP-ribose residues from a protein.

MACROD2, ADPRH, MACROD1

GO:0051726

BP

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

CLIC1, ARNTL, GADD45B, RAD51D, CCNB2, GADD45G, INHA, JUN, ITGB1, PTPRC, MYBL2, IRF1, BCR, CCNB1, JUNB, JUND, SON, MAK, CDK11B, RBL1, WEE1, CDC25A, CDC25C, GRK5, STAT3, LEP, CDK8, CENPF, TSC2, PLK1, RACK1, ADARB1, CDK3, CDK16, ID3, FOXM1, RBBP4, EP300, TARDBP, SRSF5, SKP2, CCNI, BOP1, E2F2, PUM1, KIAA0101, CCNG2, LIN52, SIRT2, PHACTR4, BAP1, MASTL, LIN37, PRR11, UHRF2, MNT, PKMYT1, CDK19, BEX2, HIPK2, TXLNG, CDK12, DTL, CDK11A, L3MBTL1

GO:0051754

BP

meiotic sister chromatid cohesion, centromeric

The cell cycle process in which centromeres of sister chromatids are joined during meiosis.

RAD21, PPP2R1A, SGOL2

GO:0051758

BP

homologous chromosome movement towards spindle pole involved in homologous chromosome segregation

The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, that contributes to meiosis I.

FMN2

GO:0051764

BP

actin crosslink formation

The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.

ACTN1, LCP1, FLNA, EPS8, DPYSL3, PLS1, BAIAP2L1

GO:0051770

BP

positive regulation of nitric-oxide synthase biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.

TLR4, TLR2, JAK2, CCL2, NAMPT, MAP2K6, CCL20

GO:0051771

BP

negative regulation of nitric-oxide synthase biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.

EDN1, GSTP1, PGGT1B, VIMP

GO:0051775

BP

response to redox state

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.

ARNTL, SIRT2, RYR2, NPAS2, VIMP, GLRX2

GO:0051781

BP

positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.

ITGB1BP1, EREG, PDGFB, TGFA, TGFB1, IGF2, IL1A, IL1B, PPBP, PDGFA, FGF2, VEGFA, TAL1, MDK, FGF7, FGFR2, FGF9, BTC, THBS4, HTR2B, PGF, VEGFB, VEGFC, TGFB2, YBX1, CSPP1, SIRT2, PDGFD, GAREM1, PDGFC

GO:0051782

BP

negative regulation of cell division

Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.

MYC, BLM, PTCH1, TXNIP, INTU

GO:0051787

MF

misfolded protein binding

Interacting selectively and non-covalently with a misfolded protein.

TOR1A, HSPD1, CLU, HSPA5, DNAJC3, DNAJC10, EDEM1, HDAC6, DNAJB9, STUB1

GO:0051788

BP

response to misfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.

CLU, HDAC6

GO:0051791

BP

medium-chain fatty acid metabolic process

The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12.

CROT

GO:0051792

BP

medium-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12.

ACOT7

GO:0051795

BP

positive regulation of catagen

Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle.

GAL, TGFB2

GO:0051797

BP

regulation of hair follicle development

Any process that modulates the frequency, rate or extent of hair follicle development.

SMAD4, HPSE

GO:0051798

BP

positive regulation of hair follicle development

Any process that activates or increases the frequency, rate or extent of hair follicle development.

TNF, FST, KRT17, TRADD, HPSE

GO:0051800

MF

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate.

PTEN

GO:0051823

BP

regulation of synapse structural plasticity

Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.

DRD2, CTNNA2, DMPK

GO:0051835

BP

positive regulation of synapse structural plasticity

Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.

CDC42, CAMK1, FRMPD4

GO:0051861

MF

glycolipid binding

Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.

GLTP

GO:0051864

MF

histone demethylase activity (H3-K36 specific)

Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.

KDM7A, KDM2A

GO:0051865

BP

protein autoubiquitination

The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.

WWP2, PARK2, TRIM13, RNF8, TRIM37, UBE4B, CNOT4, RAG1, BRCA1, UBE2A, UBE2D3, UBE2B, RNF141, UHRF2, UHRF1, UBE2T, RAD18, RNF146, RNF181, AMFR, STUB1

GO:0051866

BP

general adaptation syndrome

General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses.

NR4A2

GO:0051867

BP

general adaptation syndrome, behavioral process

The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus.

PENK

GO:0051870

MF

methotrexate binding

Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

DHFR, FOLR1