| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0051280 | BP | negative regulation of release of sequestered calcium ion into cytosol | Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
TGFB1 |
GO:0051281 | BP | positive regulation of release of sequestered calcium ion into cytosol | Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
F2, CAPN3, F2R, SRI, SNCA, TRPC1, BAX, AKAP6, CEMIP, GPER1 |
GO:0051282 | BP | regulation of sequestering of calcium ion | Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. |
SLC25A23 |
GO:0051284 | BP | positive regulation of sequestering of calcium ion | Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. |
RYR2 |
GO:0051286 | CC | cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
EZR, RDX, RAB8B |
GO:0051287 | MF | NAD binding | Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
PHGDH, IDH3B, UGDH, NDUFS2, IDH1, LDHA, CYB5R3, GAPDH, LDHB, DLD, PARP1, HPGD, ME2, AHCY, HIBADH, MDH1, IDH2, CTBP2, HSD11B2, SORD, AOX1, ME3, GLYR1, BDH2, GRHPR |
GO:0051289 | BP | protein homotetramerization | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
ACACB, GLS, ALDOA, SOD2, TK1, FBP1, IDE, PFKL, GPX3, MIP, CTH, SHMT1, ACTN2, DHPS, PPAT, CRYZ, GOLGA2, KCNJ12, RYR3, DECR1, CRTC3, DCXR, TRPV1, HM13, SYT11, DCTPP1, ACOT13, EVL, SAMHD1 |
GO:0051290 | BP | protein heterotetramerization | The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. |
INSR, ANXA2, RRM1, RRM2, S100A10, HIST1H4A, HIST1H3D, PDSS1, PDSS2, NLGN1, NUP58, FARSA |
GO:0051291 | BP | protein heterooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
TMEM120B, CLDN3, CHMP2A, CLDN1, BCL10, IDE, JUP, MAT2A, YWHAB, CTNNA1, LIMS1, GLRB, GRB2, HBB, HBA1, FADD, ILK, BIRC3, SQSTM1, RIPK1, ITPR3, CASP8, TRADD, SEPT7, MAGI2, SCUBE3, MCCC1, TMEM120A, MCCC2, CAB39 |
GO:0051292 | BP | nuclear pore complex assembly | The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. |
NUP153, NUP107, NUP93, TMEM170A, AHCTF1, NUP205, NDC1, RTN4 |
GO:0051293 | BP | establishment of spindle localization | The directed movement of the spindle to a specific location in the cell. |
DYNC1H1 |
GO:0051294 | BP | establishment of spindle orientation | Any process that set the alignment of spindle relative to other cellular structures. |
SPAG5 |
GO:0051295 | BP | establishment of meiotic spindle localization | The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs. |
MYH9, FMN2 |
GO:0051297 | BP | centrosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
PPP1R12A, HAUS5, PLK1, GOLGA2, CKAP5, KIAA0101, PCM1, CROCC, HAUS6, SDCCAG8, CEP120, HAUS1, HAUS7, HAUS4, HAUS2, UXT, SSX2IP |
GO:0051298 | BP | centrosome duplication | The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
ARHGEF10, ROCK2, CEP152, CDK2, BRCA2, PKD2, STIL, TUBGCP3, NDE1 |
GO:0051299 | BP | centrosome separation | The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. |
NEK2, CNTROB |
GO:0051301 | BP | cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
STRA13, CDC7, WASL, UBE2C, NDC80, AURKA, CETN3, BIRC5, OIP5, ZNF207, BUB1, BUB3, ENSA, RAD21, CCNT1, BUB1B, CCNT2, PRPF40A, TACC1, CDC123, RNF8, HAUS5, CCNB2, ZWINT, TNKS, SMC2, LATS1, PTTG1, CCNE2, NR3C1, GNAI2, RB1, CDK1, TUBB, GNAI3, CDK4, TPR, CCNB1, RCC1, LIG1, CCNA2, CDK2, CCND2, CCND3, WEE1, CDC25A, CDC25B, CDC25C, CKS2, PPP1CC, CCNF, NCAPD3, BRCC3, CSNK1A1, CENPF, CDK7, KNTC1, ANXA11, NEK2, NEK3, NEK4, CCNG1, KIF11, HMGA2, IST1, TERF1, ARPP19, CKS1B, PPP1CA, PPP1CB, GNAI1, DYNLT1, UBE2I, TUBA1B, CCNA1, CDK3, CDK6, CDK5, CENPE, CENPC, NSUN2, CDC20, MAD2L1, ITGB3BP, CKAP5, NEDD9, SMC1A, NCAPH, FAM175B, SEPT2, NCAPD2, KIF14, MAPRE2, MAPRE1, PKN2, CCNG2, UBE2S, PDS5A, ERCC6L, CDCA8, SGOL2, CENPW, SGOL1, CDCA2, REEP3, MIS18BP1, PSRC1, BORA, TUBA1A, MAEA, HAUS6, WAPL, CENPV, NCAPG2, ANKLE2, KIF18B, TEX14, SKA3, SIRT2, SMC5, SPG20, APITD1, SPC24, PAPD5, NUP43, NUP37, CASC5, MPLKIP, NEK9, SKA2, ARHGEF2, SKA1, ARL8A, HAUS1, ANAPC16, SPDL1, SEH1L, CDCA5, MASTL, SENP5, BOD1, NSL1, ZFYVE19, MARK4, NEK1, KIF20B, SPAG5, SETDB2, CDCA3, KIF2C, CDC6, CIB1, HAUS7, VRK1, NCAPG, PELO, FAM64A, KATNB1, TIPIN, KIFC1, PARD6B, NUF2, LRRCC1, USP44, ANAPC1, TRIOBP, DSN1, FAM83D, HAUS4, ZWILCH, SPC25, CENPJ, PARD6A, KMT5A, LATS2, HELLS, PDS5B, SMC4, ARL8B, HAUS2, NDE1, MIS18A, KLHL42, FBXL7, CDC23, ANAPC5, ANAPC4, FBXO5, TPX2, FZR1, ANAPC10, CDC14A, TIMELESS, MAPRE3, SMC3, RUVBL1, KNSTRN, MAD1L1 |
GO:0051302 | BP | regulation of cell division | Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. |
RACK1, KIF18B, CIB1 |
GO:0051303 | BP | establishment of chromosome localization | The directed movement of a chromosome to a specific location. |
NDEL1, NDE1 |
GO:0051304 | BP | chromosome separation | The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). |
TTK, NCAPD3, NCAPD2, SMARCAD1 |
GO:0051306 | BP | mitotic sister chromatid separation | The process in which sister chromatids are physically detached from each other during mitosis. |
PPP2R1A, TEX14 |
GO:0051307 | BP | meiotic chromosome separation | The process in which chromosomes are physically detached from each other during meiosis. |
ESPL1 |
GO:0051310 | BP | metaphase plate congression | The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. |
MEIOC, NDC80, CENPF, GEM, CENPE, KIF22, CENPQ, KIF2C, FAM83D |
GO:0051315 | BP | attachment of mitotic spindle microtubules to kinetochore | The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression. |
NDC80, CENPE, SEH1L, CHAMP1, KIF2C, MAD1L1 |
GO:0051321 | BP | meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
BUB3, NBN, H2AFX, NEK2, PIWIL4, SIRT2, MNS1, RSPH1, PSMC3IP, EXO1, SPIN1 |
GO:0051343 | BP | positive regulation of cyclic-nucleotide phosphodiesterase activity | Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. |
CALM2, RACK1 |
GO:0051344 | BP | negative regulation of cyclic-nucleotide phosphodiesterase activity | Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. |
AIP, MAPK7, RGN |
GO:0051345 | BP | positive regulation of hydrolase activity | Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. |
APOA1, GM2A |
GO:0051346 | BP | negative regulation of hydrolase activity | Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. |
SERPINA5, NOS3, LEPR |
GO:0051347 | BP | positive regulation of transferase activity | Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. |
RPS2 |
GO:0051349 | BP | positive regulation of lyase activity | Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. |
FXN |
GO:0051350 | BP | negative regulation of lyase activity | Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. |
PHPT1 |
GO:0051351 | BP | positive regulation of ligase activity | Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. |
XRCC4, MID1IP1 |
GO:0051353 | BP | positive regulation of oxidoreductase activity | Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. |
CCS, ABL2 |
GO:0051354 | BP | negative regulation of oxidoreductase activity | Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. |
HP, MT3, HDAC6 |
GO:0051365 | BP | cellular response to potassium ion starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions. |
JUN, PCK1 |
GO:0051371 | MF | muscle alpha-actinin binding | Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. |
LDB3, PKD2, PALLD, TTN, PDLIM2, SYNPO2 |
GO:0051373 | MF | FATZ binding | Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. |
ACTN2, MYOZ1 |
GO:0051378 | MF | serotonin binding | Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
HTR2C, HTR2B |
GO:0051379 | MF | epinephrine binding | Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. |
ADRB2, ADRB1, ADRB3, ADRA2B |
GO:0051380 | MF | norepinephrine binding | Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. |
ADRB2, ADRB1, ADRB3 |
GO:0051382 | BP | kinetochore assembly | The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
STRA13, CENPA, CENPF, CENPE, CENPC, CENPW, APITD1, CENPH |
GO:0051383 | BP | kinetochore organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
SMC2, CENPH, SMC4 |
GO:0051384 | BP | response to glucocorticoid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
KRAS, TNF, APOA2, BGLAP, S100B, TYMS, ALPL, IL6, SPARC, BCL2, HSPD1, ANXA3, ALAD, CPN1, AREG, PFKFB1, IGFBP2, IL1RN, SDC1, PAM, AGXT, MDK, BMP6, IL10, FAS, DUSP1, ADM, PTGS2, PTGDS, HNMT, UCP3, HSD11B2, PAPPA, ADAM9, ADIPOQ, CDO1, PPARGC1B, TPH2, BAD |
GO:0051385 | BP | response to mineralocorticoid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. |
KRAS, CTGF |
GO:0051386 | BP | regulation of neurotrophin TRK receptor signaling pathway | Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. |
SLC9A6, DOK5 |
GO:0051387 | BP | negative regulation of neurotrophin TRK receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. |
SPRY2, SPRY1, AGT, AGTR2 |
GO:0051388 | BP | positive regulation of neurotrophin TRK receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. |
PPP2R5B |
GO:0051389 | BP | inactivation of MAPKK activity | Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK). |
IGF1R |
GO:0051393 | MF | alpha-actinin binding | Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. |
PPARG, CACNA1C, DAG1, MAGI1, MYOT |
GO:0051400 | MF | BH domain binding | Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. |
BCL2L2, BOK |
GO:0051402 | BP | neuron apoptotic process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. |
TNFRSF21, AIFM1, GAPDH, APP, RB1, BCL2, ERBB3, PSEN1, ATN1, BID, CDK5, BAX, BNIP3, NAE1, SIAH1, PIGT, FAM162A, BOK |
GO:0051403 | BP | stress-activated MAPK cascade | A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. |
MAP2K7, MAP3K7, AGT, CRYAB, UBC, NFKB1, MAP3K8, RPS27A, UBA52, SKP1, CCM2, RBM4, TAOK2, BTRC |
GO:0051409 | BP | response to nitrosative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. |
GCLC, GCLM, DUSP6 |
GO:0051410 | BP | detoxification of nitrogen compound | Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. |
MARC1 |
GO:0051412 | BP | response to corticosterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. |
FOS, TH, FOSL1, TRH, MAOB, CDKN1A, STAR, FOSB, CALM2 |
GO:0051414 | BP | response to cortisol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. |
SLIT2, CAD, IGFBP7 |
GO:0051415 | BP | interphase microtubule nucleation by interphase microtubule organizing center | The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. |
MZT1, TUBGCP3 |
GO:0051425 | MF | PTB domain binding | Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein. |
APP, INSR, NUP62, INPP5D |
GO:0051428 | MF | peptide hormone receptor binding | Interacting selectively and non-covalently with a receptor for peptide hormones. |
JAK2, PTH, FYN, PTHLH, LEP, PTPN11 |
GO:0051430 | MF | corticotropin-releasing hormone receptor 1 binding | Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. |
GNAS, GNAS |
GO:0051434 | MF | BH3 domain binding | Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. |
BCL2, BAX, MCL1 |
GO:0051436 | BP | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. |
PSMD11, PSMD12, UBE2C, PSMD3, BUB3, BUB1B, PSMD10, CDK1, UBC, CCNB1, PSMC3, PSMB1, CDK2, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, CDC20, PSMD2, MAD2L1, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10 |
GO:0051437 | BP | positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition. |
PSMD11, PSMD12, UBE2C, PSMD3, BUB3, BUB1B, PSMD10, CDK1, UBC, CCNB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PLK1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, SKP1, CDC20, PSMD2, MAD2L1, PSME4, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10, BTRC |
GO:0051438 | BP | regulation of ubiquitin-protein transferase activity | Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. |
FEM1A, FEM1B, BAG5 |
GO:0051439 | BP | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. |
UBE2C, CDK1, CCNB1, CDK2, CDC27, UBE2E1, PLK1, CDC20, ANAPC16, ANAPC1, CDC23, ANAPC5, ANAPC4, FBXO5, FZR1, ANAPC10 |
GO:0051443 | BP | positive regulation of ubiquitin-protein transferase activity | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. |
AXIN1, PLK1, ARRDC4, DCUN1D4, ARRDC3, DCUN1D1, TRIB3, PINK1, STUB1 |
GO:0051444 | BP | negative regulation of ubiquitin-protein transferase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. |
SMAD7, PSEN1, BAG5 |
GO:0051445 | BP | regulation of meiotic cell cycle | Any process that modulates the rate or extent of progression through the meiotic cell cycle. |
ASPM |
GO:0051446 | BP | positive regulation of meiotic cell cycle | Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. |
INSR |
GO:0051447 | BP | negative regulation of meiotic cell cycle | Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. |
NPR2, DUSP1 |
GO:0051450 | BP | myoblast proliferation | The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
IGF1, GPX1, HGF, ATOH8 |
GO:0051451 | BP | myoblast migration | The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
ITGB1BP1, THBS4, PLEKHO1, NET1 |
GO:0051452 | BP | intracellular pH reduction | Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. |
GPR89A, GPR89B |
GO:0051453 | BP | regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
CA2, SLC4A2, SLC26A2, SLC4A8, SLC26A11, SLC9A6, CHP1, SLC26A1, SLC9A2, SLC4A4 |
GO:0051454 | BP | intracellular pH elevation | Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. |
CFTR |
GO:0051456 | BP | attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. |
DSN1 |
GO:0051457 | BP | maintenance of protein location in nucleus | Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. |
SUPT7L, BCL3, SKP1, MORC3 |
GO:0051461 | BP | positive regulation of corticotropin secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell. |
RAB8B, GHRL, APLN |
GO:0051463 | BP | negative regulation of cortisol secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell. |
PTPN11 |
GO:0051464 | BP | positive regulation of cortisol secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell. |
GAL, GHRL |
GO:0051466 | BP | positive regulation of corticotropin-releasing hormone secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell. |
TNFSF11, APLN |
GO:0051480 | BP | regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
F2, PRKACA, CALB2, PLN, TRPC1, CAV1, CLN3, TMEM178A, RYR2, GPER1, TRPC6 |
GO:0051481 | BP | negative regulation of cytosolic calcium ion concentration | Any process that decreases the concentration of calcium ions in the cytosol. |
KCNK3, DRD2, ATP1A2, GTF2I, SMAD3, RYR3 |
GO:0051482 | BP | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. |
EDN1, S1PR1, TGM2, F2R, HTR2C, AGTR1, KISS1 |
GO:0051489 | BP | regulation of filopodium assembly | Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
GAP43, RAB5A, CDC42, FMR1, MYO10 |
GO:0051490 | BP | negative regulation of filopodium assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
CAPZB, PRKCD |
GO:0051491 | BP | positive regulation of filopodium assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
WASL, RALA, RHOQ, TGFBR1, FMR1, DPYSL3, FSCN1, FNBP1L, NLGN1, ARAP1 |
GO:0051492 | BP | regulation of stress fiber assembly | Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
ROCK2, PIK3R1, PTGER4, MKKS |
GO:0051493 | BP | regulation of cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
S100A8, S100A9, STMN1, MAPK3, MAPK1, DYNLT1, PTK2, NEXN, ARHGEF5, CRIPAK, STMN3 |
GO:0051495 | BP | positive regulation of cytoskeleton organization | Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
SORBS3, PLXNA3 |
GO:0051496 | BP | positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
ITGB1BP1, ARHGEF10, SORBS3, APOA1, PFN1, TPM1, CTGF, SDC4, NF2, TGFBR1, PPM1F, S100A10, RHOA, RAC1, SMAD3, ARHGEF5, LRRC16A, SFRP1, PPM1E, RGCC, NOX4, EVL, FHOD1 |
GO:0051497 | BP | negative regulation of stress fiber assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
ARHGAP6, PFN1, S1PR1, PHLDB2, ARAP1, DLC1, INPP5K, TMEFF2, WASF2 |
GO:0051500 | MF | D-tyrosyl-tRNA(Tyr) deacylase activity | Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. |
DTD2 |
GO:0051503 | BP | adenine nucleotide transport | The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
SLC25A23 |
GO:0051525 | MF | NFAT protein binding | Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. |
GATA4, PPARA, MAPK14, FOXP3 |
GO:0051531 | BP | NFAT protein import into nucleus | The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane. |
PIK3R1 |
GO:0051533 | BP | positive regulation of NFAT protein import into nucleus | Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. |
TNF, PPP3CA, AKAP6, CHERP, SPPL3 |
GO:0051534 | BP | negative regulation of NFAT protein import into nucleus | Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. |
GSK3B, MAPK7, DYRK2 |
GO:0051536 | MF | iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. |
ABAT, FXN, ELP3 |