| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0051047 | BP | positive regulation of secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. |
GPLD1 |
GO:0051048 | BP | negative regulation of secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. |
ERBB3, NPY2R, NRG1 |
GO:0051053 | BP | negative regulation of DNA metabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. |
GPER1 |
GO:0051054 | BP | positive regulation of DNA metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. |
PFN1, ANXA3 |
GO:0051055 | BP | negative regulation of lipid biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. |
STK11, SERPINA12, GPER1 |
GO:0051056 | BP | regulation of small GTPase mediated signal transduction | Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
RHOD, ARHGAP33, ARHGAP6, PLEKHG5, FAM13A, A2M, BCR, RAC2, VAV1, CHN1, RHOQ, GDI1, ARHGAP25, TSC2, GDI2, ARHGDIA, ARHGDIB, RAC3, CDC42, RHOA, RHOB, RAC1, OCRL, SOS1, SOS2, AKAP13, ABR, TIAM1, ARHGAP5, MYO9B, ARHGEF7, ARHGAP19, RALBP1, TRIP10, ITSN1, ARHGAP31, RALGAPA2, AMOT, ARHGAP29, ARHGEF16, RALGAPA1, ARHGAP11A, SYDE1, RHOU, ARHGAP22, NET1, SRGAP1, ARHGAP30, FGD2, RALGAPB, TAGAP, ARHGAP24, ARHGAP18, DEPDC1B, ARAP3, ARAP2, STARD8, ARHGEF2, FGD4, ARAP1, DLC1, RACGAP1, RHOJ, PLEKHG2, ECT2, ARHGEF4, ARHGEF3, FAM13B, ARHGAP23, ARHGAP20, SIPA1L2, VAV3, ARHGAP26, STARD13 |
GO:0051057 | BP | positive regulation of small GTPase mediated signal transduction | Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. |
SOS1, SOS2 |
GO:0051058 | BP | negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. |
SLIT2 |
GO:0051059 | MF | NF-kappaB binding | Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
HDAC3, BCL10, NPM1, ANXA4, GSK3B, PPARD, RELA, HDAC1, TP53BP2, COMMD6, MTDH, SETD6, HDAC2, FOXP3, FAF1 |
GO:0051066 | BP | dihydrobiopterin metabolic process | The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions. |
QDPR |
GO:0051068 | BP | dihydrolipoamide metabolic process | The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor. |
DLD |
GO:0051081 | BP | nuclear envelope disassembly | The controlled breakdown of the nuclear envelope in the context of a normal process. |
NDEL1 |
GO:0051082 | MF | unfolded protein binding | Interacting selectively and non-covalently with an unfolded protein. |
AIP, TOR1A, CLGN, PFDN6, DNAJA2, DNAJB6, SRSF10, RP2, CLPX, CRYAB, APCS, SCG5, NPM1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPD1, HSPA5, HSP90B1, HSPA6, TCP1, PPIB, DNAJB1, DNAJB2, CALR, CANX, LRPAP1, DNAJA1, HSPA1L, CCT6A, CCT3, SERPINH1, CCT8, HSPE1, PPIA, TUBB4B, CCT2, CHAF1A, CHAF1B, CLN3, PTGES3, TOMM20, CDC37, SYVN1, ERO1B, NUDCD2, DNAJA4, PFDN5, TTC1, NAP1L4, CCT7, GRPEL1, DNAJC4, MKKS, PFDN4, MDN1, UGGT1, DNAJB4, RUVBL2 |
GO:0051083 | BP | de novo' cotranslational protein folding | The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. |
HSPA14 |
GO:0051084 | BP | de novo' posttranslational protein folding | The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. |
SELENOF, UGGT1 |
GO:0051085 | BP | chaperone mediated protein folding requiring cofactor | The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. |
TOR1A, CD74, HSPD1, DNAJB1, HSPE1, TOR2A, TOR2A, HSPH1, ERO1A |
GO:0051086 | BP | chaperone mediated protein folding independent of cofactor | The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release. |
CCT2 |
GO:0051087 | MF | chaperone binding | Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
PFDN6, BIRC5, SLC25A17, PARK2, DNAJA2, DNAJB6, BAG2, FGB, ALB, PRNP, VWF, TP53, HSPD1, CLU, HSPA5, DNAJB1, DNAJB2, CALR, ERP29, DNAJA1, STIP1, CDKN1B, ATP1A2, CTSC, HSPE1, OGDH, DNAJC3, HES1, CDC37, AHSA2, SYVN1, DNAJC10, DNAJA4, USP13, DNAJC1, PACRG, TBCD, GRPEL1, PFDN4, DNAJB4, AMFR, BAG5, HYOU1 |
GO:0051088 | BP | PMA-inducible membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist. |
ADAM10, ADAM17, ADAM9 |
GO:0051089 | BP | constitutive protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. |
ADAM10 |
GO:0051090 | BP | regulation of sequence-specific DNA binding transcription factor activity | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
FOS, JUN, HMOX1, MAPK3, MAPK1, SYK, MAPK8, MAPK9, MAPK14, SGK3, FANCD2 |
GO:0051091 | BP | positive regulation of sequence-specific DNA binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
TRIM38, PLPP3, TNFSF11, KDM1A, JAK2, LRP5, LRP6, TRIM37, TNF, IL1B, ESR1, IL6, EDN1, WNT2, KIT, ANXA3, JUP, FOSL1, TCF3, IL10, AKT1, CTNNB1, PPARG, SMARCA4, GTF2A2, CEBPG, HDAC4, PTEN, NDP, PPP3CA, EP300, ARHGEF5, TRIM26, TRIM14, TRIM25, ARID5B, PPP2R5B, TAF12, MAVS, PPARGC1B, TRIM22, JMY, ESR2, PHB2, TRIM62, PINK1, TRIM34, PRKD2, TRIM8, HIPK2, RGCC, BEX1, PPARGC1A, FZD4, PYCARD, HDAC5, TNFRSF11A |
GO:0051092 | BP | positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
TLR4, TRIM38, TNFSF11, TLR3, CFLAR, IRAK2, MAP3K13, MAP3K7, RIPK2, GREM1, TLR2, TRIM13, RPS6KA5, TRIM37, BCL10, AGT, KRAS, TGFB1, INS, TNF, IL1B, AMH, NTRK1, ITGB2, S100A8, ICAM1, PRKCB, S100A9, NPM1, UBC, HSPA1A, HSPA1B, AR, CLU, NFKB1, CAPN3, CD40LG, CTH, WNT5A, PRKCI, IRAK1, MTPN, TIRAP, RPS27A, UBA52, ADAM8, RELA, PRKCQ, TRAF1, UBE2V1, RIPK1, TRIM14, TRIM25, PRKD1, TRADD, TAB1, LRRFIP1, MTDH, ERC1, TRIM22, TAB3, RHEBL1, ARHGEF2, CIB1, TRIM62, PRKD2, TRIM8, IL1RAP, SPHK1, PYCARD, IRAK3, TNFRSF11A |
GO:0051096 | BP | positive regulation of helicase activity | Any process that activates or increases the activity of a helicase. |
MSH3, MSH2, MSH6, SSBP1, POT1 |
GO:0051097 | BP | negative regulation of helicase activity | Any process that stops or reduces the activity of a helicase. |
TP53 |
GO:0051098 | BP | regulation of binding | Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
TGFB1, SMAD3, SMAD4, SMAD2 |
GO:0051099 | BP | positive regulation of binding | Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
ANXA2, PON1, S100A10, DPH3 |
GO:0051100 | BP | negative regulation of binding | Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
CYP2D6 |
GO:0051101 | BP | regulation of DNA binding | Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
TGFB1, BCL3, HJURP |
GO:0051103 | BP | DNA ligation involved in DNA repair | The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. |
HMGB1, PARP1, HMGB2, XRCC4, PARP2 |
GO:0051106 | BP | positive regulation of DNA ligation | Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. |
HMGB1, RAD51 |
GO:0051117 | MF | ATPase binding | Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
ATP6V1G1, UBE4B, ABCA1, ESR1, ATP1B1, PGR, AR, RALA, RALB, EZR, DNAJB1, PLN, RDX, ATXN3, ATP1B3, NR1H2, SNU13, FXYD4, GABARAPL2, ANK2, CAV1, PDE4D, SNTA1, TCIRG1, PKD2, NKAIN1, SYVN1, DNAJC10, SVIP, METTL21A, UFD1L, ATP6V0A1, VIMP, BBC3, NUFIP1, USP25, NSFL1C, TRPC6 |
GO:0051120 | MF | hepoxilin A3 synthase activity | Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3. |
ALOX15 |
GO:0051122 | BP | hepoxilin biosynthetic process | The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. |
ALOX15 |
GO:0051123 | BP | RNA polymerase II transcriptional preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. |
MED6, GTF2A2, TAF11, TAF9B, DACH1 |
GO:0051124 | BP | synaptic growth at neuromuscular junction | The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates. |
APP |
GO:0051126 | BP | negative regulation of actin nucleation | Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. |
CORO1A, ARPIN |
GO:0051127 | BP | positive regulation of actin nucleation | Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. |
WIPF3 |
GO:0051128 | BP | regulation of cellular component organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. |
COL5A1, STK38L |
GO:0051131 | BP | chaperone-mediated protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. |
PFDN6, APCS, HSP90AA1, HSPD1, CLU, HSPA4, CCT2, BBS12, BBS10, MKKS, THEG |
GO:0051135 | BP | positive regulation of NK T cell activation | Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. |
IL12A, HSPH1 |
GO:0051138 | BP | positive regulation of NK T cell differentiation | Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation. |
AP3D1, TGFBR2, ZBTB16 |
GO:0051139 | MF | metal ion:proton antiporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). |
SLC11A1 |
GO:0051142 | BP | positive regulation of NK T cell proliferation | Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation. |
IL18 |
GO:0051145 | BP | smooth muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. |
CTNNB1, ACVR1, MEF2C, NFATC4, GATA6, MKL2 |
GO:0051146 | BP | striated muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. |
SPAG9, KRAS, RB1, CDH2, IGFBP5, AKT1, MTPN, MAPK14 |
GO:0051147 | BP | regulation of muscle cell differentiation | Any process that modulates the frequency, rate or extent of muscle cell differentiation. |
CAMK1, SUPT6H, MEGF10 |
GO:0051148 | BP | negative regulation of muscle cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. |
PTBP1 |
GO:0051149 | BP | positive regulation of muscle cell differentiation | Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. |
SPAG9, TCF3, CDH2, CTNNA2, CTNNA1, CTNNB1, CDH15, CDC42, MEF2A, MEF2C, CAMK1, MAPK14, RBM4 |
GO:0051150 | BP | regulation of smooth muscle cell differentiation | Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. |
BMP4, FGFR2, ZEB1 |
GO:0051151 | BP | negative regulation of smooth muscle cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. |
EREG, FOXO4, RBPMS2, PRDM6 |
GO:0051152 | BP | positive regulation of smooth muscle cell differentiation | Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. |
TGFB1, SMARCD3 |
GO:0051153 | BP | regulation of striated muscle cell differentiation | Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. |
HDAC9 |
GO:0051154 | BP | negative regulation of striated muscle cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. |
YBX1, EZH2 |
GO:0051155 | BP | positive regulation of striated muscle cell differentiation | Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. |
NRG1, MORF4L2, HOPX |
GO:0051156 | BP | glucose 6-phosphate metabolic process | The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. |
GPI, G6PD, HK1, G6PC, HKDC1, G6PC3 |
GO:0051160 | BP | L-xylitol catabolic process | The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. |
SORD |
GO:0051164 | BP | L-xylitol metabolic process | The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. |
SORD |
GO:0051168 | BP | nuclear export | The directed movement of substances out of the nucleus. |
NEMF, HNRNPA1, ATXN1, NCBP1, AKAP13, RITA1, PHAX |
GO:0051169 | BP | nuclear transport | The directed movement of substances into, out of, or within the nucleus. |
PSIP1, BANF1, HMGA1 |
GO:0051170 | BP | nuclear import | The directed movement of substances into the nucleus. |
HNRNPA1, SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, GEMIN5, GEMIN6, HTATIP2, DDX20 |
GO:0051174 | BP | regulation of phosphorus metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. |
FAM20C |
GO:0051180 | BP | vitamin transport | The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
APOA1, GC |
GO:0051181 | BP | cofactor transport | The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. |
PPT1 |
GO:0051183 | MF | vitamin transporter activity | Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
GC |
GO:0051186 | BP | cofactor metabolic process | The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. |
PPT1 |
GO:0051205 | BP | protein insertion into membrane | The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. |
EGFR, REEP1 |
GO:0051208 | BP | sequestering of calcium ion | The process of binding or confining calcium ions such that they are separated from other components of a biological system. |
HSP90B1, CALR |
GO:0051209 | BP | release of sequestered calcium ion into cytosol | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. |
PTPRC, FGF2, DRD2, PLCG2, F2R, HTR2C, DDIT3, HTR2B, PKD2, ITPR2, ITPR3, ITPR1, RASA3, RYR3, CHERP, TRPV1, TPCN2, RYR2, ERO1A |
GO:0051213 | MF | dioxygenase activity | Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. |
UTY, KDM6A, KDM4B, PTGS1, JMJD1C, ASPHD1, ASPHD2, OGFOD3, ALKBH7 |
GO:0051216 | BP | cartilage development | The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
SMAD9, HOXA3, TIMP1, TYMS, EDN1, HOXC4, ESRRA, BMP3, COL11A2, CD44, BMP6, ITGB8, MAPK3, BMP8B, SOX6, CHI3L1, ZEB1, WNT5A, SOX9, LUM, EVC, GNAS, PKD1, COL10A1, ZBTB16, DLX2, HYAL2, SMAD1, HIF1A, GNAS, BMP8A, SULF2, SULF1, CSGALNACT1, SMAD5, BBS2, MKKS, GHRL |
GO:0051219 | MF | phosphoprotein binding | Interacting selectively and non-covalently with a phosphorylated protein. |
MID1, TOX3, URI1, PLAT, RB1, LYN, IGF2R, PRKCSH, YWHAB, SFN, SNCA, YWHAE, FKBP4, PKD2, TRPV1, TBK1, THRAP3, TBL2 |
GO:0051220 | BP | cytoplasmic sequestering of protein | The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. |
LATS1, FLNA, YWHAB |
GO:0051222 | BP | positive regulation of protein transport | Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
TNF, CHP1 |
GO:0051223 | BP | regulation of protein transport | Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
DNAJA1, RAB11A |
GO:0051224 | BP | negative regulation of protein transport | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
WWP2, SNX3, NDFIP1, NDFIP2, SNX12 |
GO:0051225 | BP | spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
HDAC3, NCOR1, HAUS5, TNKS, TUBB, RCC1, CSNK1D, NEK2, GOLGA2, CHD4, HAUS6, NEK7, HAUS1, HAUS7, TUBB1, HAUS4, NEK6, HAUS2, STARD9 |
GO:0051228 | BP | mitotic spindle disassembly | The controlled breakdown of the spindle during a mitotic cell cycle. |
SPAST |
GO:0051232 | BP | meiotic spindle elongation | The lengthening of the distance between poles of the spindle during a meiotic cell cycle. |
PPP2R1A |
GO:0051233 | CC | spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
AURKA, BUB1B, APP, PLK1, GEM, CDC42, UNC119, KIF14, CDCA8, CENPV, ARL8A, AURKB, KIF20B, PKP4, CDC6, RACGAP1, ARL8B |
GO:0051238 | BP | sequestering of metal ion | The process of binding or confining metal ions such that they are separated from other components of a biological system. |
S100A7 |
GO:0051246 | BP | regulation of protein metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. |
CUL4A |
GO:0051247 | BP | positive regulation of protein metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. |
KLF4, MAPK8, MTPN, MAP2K5, MAPK7, KLF2 |
GO:0051250 | BP | negative regulation of lymphocyte activation | Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. |
TYRO3, MERTK |
GO:0051252 | BP | regulation of RNA metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. |
RASA1, NOVA1 |
GO:0051256 | BP | mitotic spindle midzone assembly | The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. |
KIF4A, KIF23, AURKB, RACGAP1, CDC14A |
GO:0051257 | BP | meiotic spindle midzone assembly | The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis. |
MLH1 |
GO:0051258 | BP | protein polymerization | The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. |
CHMP2A, FGA, FGB, FGG, VTN, MID1IP1 |
GO:0051259 | BP | protein oligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
NOL3, BCL10, NPM1, AR, GJA1, PFKL, TNFAIP3, NME2, STX2, GJA5, TMED10, IRAK1, CAV2, BLM, TEK, BAX, AHNAK, TRIM28, CAMK2D, NBR1, QPRT, HGSNAT, DGKH, CHP1, GRHPR, NUFIP1, AMFR, SH3GLB1 |
GO:0051260 | BP | protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
TOR1A, TNFSF11, SLC22A1, CLDN3, CHMP2A, SPAG9, PEX14, POLQ, FLOT1, CLDN1, BCL10, PEX11B, CRYAB, PRNP, VWF, NPM1, ANXA6, HMOX1, ALAD, IDE, PAM, SYT1, TGM2, FAS, PLN, STOM, SLC6A1, RBMX, CPT1A, VCP, BID, CAV1, AKR1C1, RAD51, BAX, KCNA1, TAF10, RIPK1, KCNC3, DPYSL3, ITPR3, ADIPOQ, CLPP, TOR2A, COLEC12, KCTD11, ATL3, OLFM4, KCTD1, CEP57, SCUBE1, SCUBE3, TOR2A, NLGN1, MUC20, KCTD6, ATL2, KCNG3, PNPT1, KCNV2, KCTD13, KCTD12, KCTD7, PEO1, P2RX4, NUP58, C1QTNF1, TMEM120A, MFF, EHD4, KCTD10, CHMP4B, SMARCAD1, ECT2, GOPC, EHD3, SPAST, KCNG1, PRND |
GO:0051261 | BP | protein depolymerization | The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. |
VPS4B |
GO:0051262 | BP | protein tetramerization | The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. |
NUDT21, HMGCR, TP53, FH, IGF1R, CCL5, ADSL, SHMT1, HMGCL, MTMR2, KCNC3, UXS1, TRPM7, DHRS4, TRPM6, AASS |
GO:0051264 | MF | mono-olein transacylation activity | Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. |
PNPLA3 |
GO:0051265 | MF | diolein transacylation activity | Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. |
PNPLA3 |
GO:0051267 | MF | CP2 mannose-ethanolamine phosphotransferase activity | Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. |
PIGG |
GO:0051270 | BP | regulation of cellular component movement | Any process that modulates the frequency, rate or extent of the movement of a cellular component. |
B4GALT1, ARAP1 |
GO:0051271 | BP | negative regulation of cellular component movement | Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component. |
ACTN4, ACTN1, SP100, CDKN1B, TGFBR3 |
GO:0051272 | BP | positive regulation of cellular component movement | Any process that activates or increases the frequency, rate or extent of the movement of a cellular component. |
ACTN4, LYN, ETS1, VEGFA, STMN1, TGFBR1, BCL6, ADAM17, PDPN |
GO:0051276 | BP | chromosome organization | A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. |
SMCHD1, PTTG1, MYC, SFPQ, YY1, GEM, CDCA8, CENPW, RAD54L, PELO |
GO:0051279 | BP | regulation of release of sequestered calcium ion into cytosol | Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
LYN, CORO1A, ANK2, PRKD1, UBASH3B |