| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0050667 | BP | homocysteine metabolic process | The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. |
CBS, MTHFR, NOX4 |
GO:0050668 | BP | positive regulation of homocysteine metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. |
COMT |
GO:0050671 | BP | positive regulation of lymphocyte proliferation | Any process that activates or increases the rate or extent of lymphocyte proliferation. |
IL12A, ZNF335 |
GO:0050672 | BP | negative regulation of lymphocyte proliferation | Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. |
GAL |
GO:0050673 | BP | epithelial cell proliferation | The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. |
KIT, COL8A2, PSEN1, C6orf89, EHF |
GO:0050678 | BP | regulation of epithelial cell proliferation | Any process that modulates the frequency, rate or extent of epithelial cell proliferation. |
SERPINB5, SMAD3, HES1, FRS2 |
GO:0050679 | BP | positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
TBX1, EGFR, MYC, TGFA, TGFB1, ERBB2, IGF1, IL6, LAMB1, LAMC1, BMP4, CCL5, NME1, VEGFA, C5AR1, FGF7, FGFR2, BMP6, NME2, FGF9, BMPR1A, ID1, NOTCH1, SOX9, DLX5, MAP2K5, TWIST1, SFRP1, WDR48, OSR1, NR4A3, HTRA1, BAD, ESRP2 |
GO:0050680 | BP | negative regulation of epithelial cell proliferation | Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
EREG, MTSS1, TGFB1, RB1, AR, BMP4, FGFR2, PBLD, WNT5A, CDKN2B, GDF5, SOX9, CDKN1C, HRSP12, PTEN, TGFB2, CDK6, TGFBR3, PPARD, MEF2C, DLG1, PTCH1, RUNX3, RGN, SFRP1, MARVELD3, IFT74, IFT122, WFDC1 |
GO:0050681 | MF | androgen receptor binding | Interacting selectively and non-covalently with an androgen receptor. |
TGFB1I1, TCF21, KDM1A, PRKCB, RB1, DDX5, CALR, CTNNB1, BRCA1, NRIP1, CDK7, SMARCA4, EP300, NCOA4, NCOA1, PKN1, WIPI1, FOXP1, PPARGC1A, RNF14, RNF6, NCOA3 |
GO:0050682 | MF | AF-2 domain binding | Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. |
PPARGC1B |
GO:0050683 | MF | AF-1 domain binding | Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. |
HEYL |
GO:0050684 | BP | regulation of mRNA processing | Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. |
CDK11B, SUPT6H, SRPK1, SLTM, CDK11A |
GO:0050687 | BP | negative regulation of defense response to virus | Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. |
TRIM38, PPM1B, C1QBP, HTRA1, ITCH |
GO:0050689 | BP | negative regulation of defense response to virus by host | Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
MICB |
GO:0050690 | BP | regulation of defense response to virus by virus | Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. |
AP2A2, CD4, FYN, CD28, AP2S1, AP1S2, B2M, AP1S1, RAC1, AP2B1, ARF1, AP1B1, PAK2, ELMO1, DOCK2, AP2M1, ATP6V1H |
GO:0050691 | BP | regulation of defense response to virus by host | Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. |
TNFAIP3, RNF216 |
GO:0050692 | MF | DBD domain binding | Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors. |
PROX1 |
GO:0050693 | MF | LBD domain binding | Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. |
PROX1, CITED1, CITED2 |
GO:0050699 | MF | WW domain binding | Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. |
CDC25C, SCNN1A, SCNN1G, TNK2, TCEAL1, ENAH, TCEAL3, PMEPA1, TCEAL4, KIF20B, LITAF, NDFIP2 |
GO:0050700 | MF | CARD domain binding | Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. |
RIPK2, MAVS, CARD19 |
GO:0050702 | BP | interleukin-1 beta secretion | The regulated release of interleukin 1 beta from a cell. |
TLR4, ABCA1, CD36, F2RL1 |
GO:0050703 | BP | interleukin-1 alpha secretion | The regulated release of interleukin-1 alpha from a cell. |
S100A13 |
GO:0050706 | BP | regulation of interleukin-1 beta secretion | Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell. |
FOXP1 |
GO:0050707 | BP | regulation of cytokine secretion | Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. |
TLR4, SOCS1, TLR5, TLR2, LYN, TLR1, GPAM |
GO:0050708 | BP | regulation of protein secretion | Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. |
INS, SAA1, PAM, ARFIP1, STXBP5, PIK3C3, RHBDF1, DNAJC1, STXBP5L |
GO:0050709 | BP | negative regulation of protein secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. |
INS, DRD2, ERP29, RHBDF1, DPH3 |
GO:0050710 | BP | negative regulation of cytokine secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. |
IL6, SRGN, TNFSF4, PTGER4, BTN2A2, LGR4, FOXP3, RGCC |
GO:0050711 | BP | negative regulation of interleukin-1 secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell. |
GAS6 |
GO:0050712 | BP | negative regulation of interleukin-1 alpha secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell. |
IL1R2 |
GO:0050713 | BP | negative regulation of interleukin-1 beta secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell. |
APOA1 |
GO:0050714 | BP | positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
APBB1, TGFB1, IL1A, FGA, FGB, FGG, ANG, IGF1, EZR, BMP6, VEGFC, TGFB2, PPIA, ADAM8, ARF1, PPID, ADAM9, ANKRD1, EXPH5, SYTL4, ATP13A2, EXOC1, RPH3AL, STXBP5L |
GO:0050715 | BP | positive regulation of cytokine secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. |
INS, TNF, IL1A, CD14, FGR, SAA1, MIF, IL10, PTGER4, HTR2B, SYK, AGTR2, GLMN, C1QTNF3, CADM1, RGCC |
GO:0050716 | BP | positive regulation of interleukin-1 secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. |
HMGB1, SAA1 |
GO:0050717 | BP | positive regulation of interleukin-1 alpha secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell. |
CASP1, PANX1 |
GO:0050718 | BP | positive regulation of interleukin-1 beta secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell. |
CCL3, IFNAR1, CASP1, WNT5A, PANX1, PYCARD |
GO:0050725 | BP | positive regulation of interleukin-1 beta biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta. |
EGR1 |
GO:0050726 | BP | positive regulation of interleukin-1 alpha biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha. |
CCL20 |
GO:0050727 | BP | regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
JAK2, BRD4, SEMA7A, AHSG, ESR1, ANXA1, LYN, IL1R1, SELE, TNFAIP3, TNFSF4, AGTR1, PTGS2, BCL6, CASP4, SLC7A2, ADAMTS12, XIAP, RELA, MTA1, BIRC3, NR1D2, ZYX, DUOXA1, DUOXA2, RICTOR, SETD6, PGLYRP2, MGLL, FANCD2, FOXP1, TBC1D23, SHPK, PYCARD |
GO:0050728 | BP | negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
SOCS3, KLF4, SOCS5, ADA, APOA1, APOE, KRT1, SAA1, BCR, HGF, ETS1, PTPN2, NFKB1, TNFRSF1B, TNFAIP3, NT5E, RORA, PTGER4, CHRNA7, SERPINF1, SMAD3, TNFAIP6, TEK, PPARD, MVK, PRKCD, TYRO3, PPARA, ABR, NR1H3, MAPK7, ADIPOQ, PTGIS, CD276, GHSR, PBK, NR1H4, GPER1, VIMP, FEM1A, NDFIP1, C1QTNF3, WFDC1, MMP26, GHRL, RABGEF1 |
GO:0050729 | BP | positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
TLR4, MAPK13, TLR3, TLR2, JAK2, IL33, EGFR, AGT, LDLR, S100A8, SERPINE1, S100A9, LPL, CCL3, HSPD1, CCL4, CCL2, CCL5, PLA2G2A, ETS1, FABP4, ITGA2, ZP3, TGM2, TNFSF4, AGTR1, PTGER4, WNT5A, STAT5B, CCL8, IL1RL1, CD47, HYAL2, PLA2G7, IL18, CDK19, TRPV4, IL17RB, GPRC5B |
GO:0050730 | BP | regulation of peptidyl-tyrosine phosphorylation | Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
EGFR, PDGFA, ITGB2, IFNAR1, EFNA1, PPP2R5B, PDGFD, PDCL3, PDGFC |
GO:0050731 | BP | positive regulation of peptidyl-tyrosine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
HAX1, PLPP3, NRP1, RIPK2, JAK2, AGT, PDGFB, TGFB1, GH1, INS, IGF2, CD4, VTN, CD74, TP53, IGF1, ITGB3, IL6, ICAM1, CCK, ITGA5, IL6R, GHR, TDGF1, MIF, HGF, HCLS1, LIF, VEGFA, CD44, CD36, IL11, EFNA1, KITLG, FGF7, THBS4, SYK, VEGFC, EFNA5, CD81, NRG1, TNK2, CNTN1, PAK2, ENPP2, ANGPT1, STK11, ADIPOQ, RICTOR, CSPG4, ARHGEF2, MLST8, EHD4 |
GO:0050732 | BP | negative regulation of peptidyl-tyrosine phosphorylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
SPINK1, PRKCD, SFRP1, SAMSN1 |
GO:0050733 | MF | RS domain binding | Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. |
SRSF10, SON, SRSF1, SRSF5, LUC7L |
GO:0050746 | BP | regulation of lipoprotein metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. |
DGAT2, LIPG |
GO:0050747 | BP | positive regulation of lipoprotein metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. |
PEMT |
GO:0050748 | BP | negative regulation of lipoprotein metabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. |
ITGB3, ITGAV |
GO:0050750 | MF | low-density lipoprotein particle receptor binding | Interacting selectively and non-covalently with a low-density lipoprotein receptor. |
DKK1, APOE, CRP, APOB, HSP90B1, SYT1, LRPAP1, DNAJA1, LDLRAP1, APOA5, PCSK9, AP2M1 |
GO:0050755 | BP | chemokine metabolic process | The chemical reactions and pathways involving chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
TREM1 |
GO:0050760 | BP | negative regulation of thymidylate synthase biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. |
APBB1 |
GO:0050764 | BP | regulation of phagocytosis | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. |
ITGAV, FGR, SYK, SCARB1 |
GO:0050765 | BP | negative regulation of phagocytosis | Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. |
SNX3, TGFB1, CSK, PTEN, RACK1, ADIPOQ, SYT11 |
GO:0050766 | BP | positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
TNF, IL1B, AHSG, MBL2, BCR, PTX3, CALR, SLC11A1, RAB27A, RAP1A, CD47, MERTK, ABR, GAS6, CAMK1D, DOCK2, PYCARD |
GO:0050767 | BP | regulation of neurogenesis | Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons. |
ARNTL, HMGB2, CTNNB1, BCL6, YAP1, DOCK7, DLL4, CHD7 |
GO:0050768 | BP | negative regulation of neurogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons. |
BRINP1, BMPR1A, NOTCH1, DYNLT1, PCM1, HOOK3, SORL1, ARHGEF2 |
GO:0050769 | BP | positive regulation of neurogenesis | Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons. |
WNT2, XRCC5, SERPINF1, STAR, NUMB, SPEN, GPER1, ZNF335 |
GO:0050770 | BP | regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
CHN1, EFNA1, EPHA4, SSH2, SSH3, KIF13B |
GO:0050771 | BP | negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
DAB1, NGFR, MAG, EPHB2, GDI1, PSEN1, ARHGDIA, PTEN, RHOA, PTK2, RUFY3, SYNGAP1, RTN4 |
GO:0050772 | BP | positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
PLXNB2, SHOX2, SLIT2, NGF, NGFR, SKIL, ARHGDIA, RHOA, MAP2K1, TIAM1, STK11, NTRK2, ROBO2 |
GO:0050773 | BP | regulation of dendrite development | Any process that modulates the frequency, rate or extent of dendrite development. |
CDC20, DBN1, CAMK1D, RTN4IP1 |
GO:0050774 | BP | negative regulation of dendrite morphogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. |
ID1, YWHAH, PPP3CA, NFATC4, TRPC6 |
GO:0050775 | BP | positive regulation of dendrite morphogenesis | Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. |
OBSL1, PTPRD, VAMP7, EPHA4, ILK, CUX1, CAPRIN1, CUL7, ANKRD27, RAB21 |
GO:0050776 | BP | regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
TYROBP, C3, HLA-B, COL1A1, COL3A1, ITGB2, ICAM1, ITGB1, COL1A2, FCGR1A, IFITM1, HLA-E, SELL, PVR, CD1D, HLA-G, VCAM1, CD33, KLRC1, CD40LG, HLA-A, HLA-F, FCGR2B, BCL6, CD200, KIR3DL2, CD81, B2M, CXADR, SMAD3, MICB, MICA, CD276, LAIR1, LAIR2, LILRB1, SPPL2A, CLEC2B, ULBP3, TREM1, COL17A1, SIGLEC7 |
GO:0050777 | BP | negative regulation of immune response | Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
COL3A1, AMBP, LYN, HLA-G, TGFB2, INPP5D, FOXP3 |
GO:0050778 | BP | positive regulation of immune response | Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
TGFB2 |
GO:0050779 | BP | RNA destabilization | Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. |
DXO, TNFRSF1B |
GO:0050780 | MF | dopamine receptor binding | Interacting selectively and non-covalently with a dopamine receptor. |
CLIC6 |
GO:0050786 | MF | RAGE receptor binding | Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. |
S100B, S100A8, S100A9, HMGB1, FPR1, S100P, S100A4, HMGB2, S100A7, S100A13 |
GO:0050790 | BP | regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
KRIT1, ZEB2, BAG2, CTSB, AR, CAPN3, BRCC3, RCAN1, GPSM2, RING1, DMPK, SEPT2, PPP1R7, PPP1R3B, ANKLE2, GPSM1, PCP2, TTN, MTMR9, GRPEL1, GOPC, BMP2K, MAT2B, SH3BP4, ATP6V1H, GPSM3 |
GO:0050792 | BP | regulation of viral process | Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. |
CHMP2A, VPS4B, CHMP4B |
GO:0050793 | BP | regulation of developmental process | Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
NOTCH2 |
GO:0050794 | BP | regulation of cellular process | Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. |
WNK1 |
GO:0050795 | BP | regulation of behavior | Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. |
MDK, HTR2B, HOXA1, AHI1 |
GO:0050796 | BP | regulation of insulin secretion | Any process that modulates the frequency, rate or extent of the regulated release of insulin. |
ARNTL, ENSA, GCG, TNF, IL1B, SLC25A5, SLC2A1, SLC25A4, CCL5, PRKCA, CNR1, MARCKS, SSTR5, LEP, MTNR1B, CPT1A, SNAP25, RAP1A, ICA1, CACNA1C, ITPR2, ITPR3, ITPR1, KCNJ11, CACNA1E, CARTPT, RAPGEF4, UQCC2 |
GO:0050798 | BP | activated T cell proliferation | The expansion of a T cell population following activation by an antigenic stimulus. |
FYN, SATB1 |
GO:0050801 | BP | ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
KLHL3 |
GO:0050803 | BP | regulation of synapse structure or activity | Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
APP, PPT1, SYNGAP1 |
GO:0050804 | BP | modulation of synaptic transmission | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. |
CSPG5, PRKACA, HRH1, PPP3CA, EIF4EBP2, PXK, BTBD9 |
GO:0050805 | BP | negative regulation of synaptic transmission | Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. |
PCDH17, GNAI2, GNAI1, ADIPOQ, TNR |
GO:0050806 | BP | positive regulation of synaptic transmission | Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. |
CLSTN1, CCL2, SYT1, SLC1A3, NMU, DLG4, KISS1, CLSTN2, RETN |
GO:0050807 | BP | regulation of synapse organization | Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
DKK1, IL10, ETV5 |
GO:0050808 | BP | synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
SEMA3E, PAK3, CTNNB1, SNCA, LRRTM4, NLGN4X, SLC9A6, TNR, RAB39B, PCDHGC3, MYO5A |
GO:0050810 | BP | regulation of steroid biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
DHH, TSPO, LEP, IGFBP7, DDX20 |
GO:0050811 | MF | GABA receptor binding | Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
TRAK2, GABRA5, GABARAPL2, PLCL1, GABARAPL1, PLCL2, TRAK1, ARFGEF2 |
GO:0050812 | BP | regulation of acyl-CoA biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. |
SNCA |
GO:0050815 | MF | phosphoserine binding | Interacting selectively and non-covalently with a phosphorylated serine residue within a protein. |
YWHAB, YWHAE |
GO:0050819 | BP | negative regulation of coagulation | Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. |
ANXA5, PROCR |
GO:0050820 | BP | positive regulation of coagulation | Any process that activates or increases the frequency, rate or extent of coagulation. |
PSEN1 |
GO:0050821 | BP | protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
USP27X, PLPP3, SMAD7, MDM4, ZNF207, PARK2, CREBL2, USP2, CRTAP, WIZ, APOA1, GAPDH, IGF1, ATP1B1, PFN1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPD1, CLU, LAMP1, LAMP2, CREB1, TCP1, FLNA, PPIB, MT3, CALR, PIK3R1, PHB, CDKN1A, CCT6A, CCT3, GNAQ, CCT8, ATP1B3, PTEN, STXBP1, UBE2B, CCT2, SMAD3, ANK2, PRKCD, SOX4, EP300, STK4, MORC3, CDC37, AAK1, TBRG1, SYVN1, USP13, ZBED3, PHB2, CHP1, CCT7, PDCD10, NAA15, PINK1, SOX17, TAF9B, IFT46, HPS4, GTSE1, NLK, PPARGC1A, SEL1L |
GO:0050829 | BP | defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
TLR4, TLR5, LYZL6, CD4, APP, SERPINE1, IL6, IL6R, DEFA4, HMGB2, S100A7, ADM, SLC11A1, LYZ, B2M, FCN2, MR1, OPTN, PYCARD |
GO:0050830 | BP | defense response to Gram-positive bacterium | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. |
RIPK2, TLR2, HIST1H2BK, LYZL6, TNF, CRP, ANG, APP, IL6, FGR, MBL2, DEFA4, HLA-E, PLA2G2A, CD36, C5AR1, HMGB2, IL12A, ADM, TIRAP, LYZ, B2M, HIST1H2BC, ADAM17, FCN2, HIST2H2BE, SEH1L, PGLYRP2, TBK1 |
GO:0050832 | BP | defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
S100A8, MPO, S100A9, DEFA4, HAMP, COTL1, SPON2 |
GO:0050833 | MF | pyruvate transmembrane transporter activity | Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other. |
SLC16A7 |
GO:0050839 | MF | cell adhesion molecule binding | Interacting selectively and non-covalently with a cell adhesion molecule. |
FGA, FGB, FGG, ITGB3, ITGB2, ITGB1, SELL, JUP, PVR, EZR, CD1D, DSP, CPE, VCAM1, PTPRD, CD200, CXADR, ADAM8, PTPN11, SMAGP, DSG2, POSTN, NECTIN1, TENM4, NLGN4X, NLGN1, CADM1, CDHR2, NECTIN3, TENM3, NRXN1, PKP3 |
GO:0050840 | MF | extracellular matrix binding | Interacting selectively and non-covalently with a component of the extracellular matrix. |
CYR61, VTN, ITGB3, ITGAV, DCN, SPARC, SPP1, COL11A1, VEGFA, BGN, FBLN2, SPARCL1, TGFBI, OLFML2A, GPR126, ADAMTS15, SPOCK2, CD248, ADAMTS5, ADGRG1 |
GO:0050847 | BP | progesterone receptor signaling pathway | Any series of molecular signals generated as a consequence of a progesterone binding to its receptor. |
UBR5, PHB |
GO:0050848 | BP | regulation of calcium-mediated signaling | Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. |
GBP1, RGN |
GO:0050849 | BP | negative regulation of calcium-mediated signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. |
ITPR1 |
GO:0050850 | BP | positive regulation of calcium-mediated signaling | Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. |
ADA, CD4, CCL3, CCL4, SYK, HINT1, CDH13, P2RX4 |
GO:0050851 | BP | antigen receptor-mediated signaling pathway | A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. |
RFTN2 |