| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0048791 | BP | calcium ion-regulated exocytosis of neurotransmitter | The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. |
SYT1, SYTL5, SYTL4, SYT11, RIMS4, RIMS2 |
GO:0048793 | BP | pronephros development | The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. |
PAX8, OSR1 |
GO:0048806 | BP | genitalia development | The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. |
WNT5A, PKD1, PTPN11, DNAJC19, CHD7 |
GO:0048807 | BP | female genitalia morphogenesis | The process in which the anatomical structures of female genitalia are generated and organized. |
RBP4 |
GO:0048808 | BP | male genitalia morphogenesis | The process in which the anatomical structures of male genitalia are generated and organized. |
AR |
GO:0048812 | BP | neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
EGFR, NGF, GJA1, WEE1, NBL1, NEK3, DYNLT1, ILK, CTTN, SLC9A6, ANKRD27, ALS2, KIF20B, PACSIN1, ZNF335, ZSWIM6, DICER1, EPB41L3 |
GO:0048813 | BP | dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. |
DCLK1, RBFOX2, KLF7, ITGB1, FYN, MAP2, CTNNA2, SDC2, SLC11A2, RAC1, VLDLR, CDK5, MEF2A, MAPK8IP2, PICALM, SEMA3A, PREX2, ABI1, MINK1, TMEM106B, RERE, KIDINS220, BTBD3, FARP1 |
GO:0048814 | BP | regulation of dendrite morphogenesis | Any process that modulates the frequency, rate or extent of dendrite morphogenesis. |
PQBP1, RAP2A, SDC2, STK11, SARM1, NSMF, KNDC1, TNIK, LZTS1 |
GO:0048820 | BP | hair follicle maturation | A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. |
ERCC2 |
GO:0048821 | BP | erythrocyte development | The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. |
BPGM, SOX6, BCL6, SLC11A2, RPS6, JMJD6 |
GO:0048822 | BP | enucleate erythrocyte development | The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
MAEA |
GO:0048839 | BP | inner ear development | The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. |
MAF, LGR5, CXCL14, TGFB1, SPARC, PDGFRB, BMP2, MPV17, CDKN1B, MAPKAPK2, HOXA1, CEBPD, TGFB2, PTPN11, PLPPR4, LRP10, BMPER, ANP32B, CCM2, DUOX2 |
GO:0048841 | BP | regulation of axon extension involved in axon guidance | Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. |
PLXNC1, PLXNA2, PLXNA3, SEMA3A, PLXNA1, PLXND1 |
GO:0048842 | BP | positive regulation of axon extension involved in axon guidance | Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. |
NRP1, VEGFA, CXCL12, SEMA5A, BMPR2 |
GO:0048843 | BP | negative regulation of axon extension involved in axon guidance | Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. |
NRP1, SEMA3E, SEMA3D, WNT5A, PLXNA3, WNT3, SEMA3B, SEMA5A, SEMA3A, SEMA6D, SEMA3C, SEMA6A, SEMA4A, SEMA6B |
GO:0048844 | BP | artery morphogenesis | The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. |
NRP1, SMAD7, TBX1, APOE, APOB, VEGFA, GJA5, TGFBR1, HOXA1, FOXC1, HES1, ZMIZ1 |
GO:0048845 | BP | venous blood vessel morphogenesis | The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. |
EFNB2, CCBE1, PROX1, CCM2, HEG1 |
GO:0048846 | BP | axon extension involved in axon guidance | The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
NRP1, NRP2, SLIT2, ALCAM, SEMA3A |
GO:0048850 | BP | hypophysis morphogenesis | The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. |
WNT5A |
GO:0048853 | BP | forebrain morphogenesis | The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
PTEN, HHEX, UCHL5 |
GO:0048854 | BP | brain morphogenesis | The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
FOXO3, CDH2, CTNNA2, PSEN1, PTEN, BBS2, FANCD2, ZNF335, MKKS |
GO:0048855 | BP | adenohypophysis morphogenesis | The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. |
DUOX2 |
GO:0048856 | BP | anatomical structure development | The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. |
SPARCL1 |
GO:0048858 | BP | cell projection morphogenesis | The process in which the anatomical structures of a cell projection are generated and organized. |
NES |
GO:0048859 | BP | formation of anatomical boundary | The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. |
SMAD4 |
GO:0048861 | BP | leukemia inhibitory factor signaling pathway | Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
LIF, IL6ST, LIFR, CTF1 |
GO:0048863 | BP | stem cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
PSMD11, A2M, KIT, LIF, EPCAM, HMGA2, FOXO4, RUNX2, PUM1, OSR1, SETD6, LIN28A, MTF2 |
GO:0048864 | BP | stem cell development | The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. |
PTPRC, MSI2 |
GO:0048866 | BP | stem cell fate specification | The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. |
SOX17 |
GO:0048870 | BP | cell motility | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. |
SRPX2, SKI, ETS1, ITGB4, TGFBR1, MMP14, RAC1, ADAM17, MAP2K1, DST, PTK2, PLD1, CTTN, FSCN1, PDPN, IER2 |
GO:0048871 | BP | multicellular organismal homeostasis | Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. |
TNS2, PPP1R13L |
GO:0048872 | BP | homeostasis of number of cells | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. |
IL7R, CDH2, SART3, WDR48, RRN3 |
GO:0048873 | BP | homeostasis of number of cells within a tissue | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. |
SASH3, KRAS, PTH, FH, BCL2, F2R, CORO1A, LIPA, RAC3, RAC1, PTPN11, BAX, GIGYF2, ILDR2, TEX15 |
GO:0048875 | BP | chemical homeostasis within a tissue | Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. |
HOMER1 |
GO:0048880 | BP | sensory system development | The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. |
SEMA3A |
GO:0048935 | BP | peripheral nervous system neuron development | The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. |
HOXD10, ETV1, RUNX1, RUNX3, NTRK2 |
GO:0048936 | BP | peripheral nervous system neuron axonogenesis | Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. |
NEFH |
GO:0050023 | MF | L-fuconate dehydratase activity | Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. |
ENOSF1 |
GO:0050031 | MF | L-pipecolate oxidase activity | Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. |
PIPOX |
GO:0050038 | MF | L-xylulose reductase (NADP+) activity | Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH. |
DCXR |
GO:0050046 | MF | lathosterol oxidase activity | Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2. |
SC5D |
GO:0050062 | MF | long-chain-fatty-acyl-CoA reductase activity | Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. |
FAR2 |
GO:0050072 | MF | m7G(5')pppN diphosphatase activity | Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. |
NUDT3, DCP2, NUDT10, NUDT16, NUDT11 |
GO:0050104 | MF | L-gulonate 3-dehydrogenase activity | Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. |
CRYL1 |
GO:0050113 | MF | inositol oxygenase activity | Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). |
MIOX |
GO:0050115 | MF | myosin-light-chain-phosphatase activity | Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. |
PPP1CB |
GO:0050119 | MF | N-acetylglucosamine deacetylase activity | Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate. |
NDST1 |
GO:0050145 | MF | nucleoside phosphate kinase activity | Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate. |
DTYMK, AK4, CMPK1 |
GO:0050178 | MF | phenylpyruvate tautomerase activity | Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. |
MIF |
GO:0050197 | MF | phytanate-CoA ligase activity | Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. |
SLC27A2 |
GO:0050220 | MF | prostaglandin-E synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). |
PTGES, PTGES3 |
GO:0050221 | MF | prostaglandin-E2 9-reductase activity | Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. |
CBR1 |
GO:0050252 | MF | retinol O-fatty-acyltransferase activity | Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. |
DGAT2 |
GO:0050262 | MF | ribosylnicotinamide kinase activity | Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide. |
NMRK1 |
GO:0050265 | MF | RNA uridylyltransferase activity | Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). |
ZCCHC6 |
GO:0050277 | MF | sedoheptulokinase activity | Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate. |
SHPK |
GO:0050290 | MF | sphingomyelin phosphodiesterase D activity | Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). |
SMPD4 |
GO:0050291 | MF | sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
CERS6, CERS5, CERS4 |
GO:0050294 | MF | steroid sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. |
SULT2A1 |
GO:0050313 | MF | sulfur dioxygenase activity | Catalysis of the reaction: sulfur + O2 + H2O = sulfite. |
ETHE1 |
GO:0050321 | MF | tau-protein kinase activity | Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. |
CSNK1D, GSK3B, CDK5, MARK4, MARK1 |
GO:0050346 | MF | trans-L-3-hydroxyproline dehydratase activity | Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+). |
L3HYPDH |
GO:0050347 | MF | trans-octaprenyltranstransferase activity | Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate. |
PDSS1, PDSS2 |
GO:0050354 | MF | triokinase activity | Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+). |
TKFC |
GO:0050405 | MF | [acetyl-CoA carboxylase] kinase activity | Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. |
PRKAA2 |
GO:0050421 | MF | nitrite reductase (NO-forming) activity | Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. |
CBS |
GO:0050427 | BP | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. |
SULT1A3, ENPP1, SULT2A1, ABHD14B |
GO:0050428 | BP | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. |
PAPSS2, SLC26A2, SLC26A1 |
GO:0050431 | MF | transforming growth factor beta binding | Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. |
ITGAV, THBS1, CD36, TGFBR1, TGFBR2, TGFBR3, ACVR1, HYAL2, LTBP1, LTBP3 |
GO:0050434 | BP | positive regulation of viral transcription | Any process that activates or increases the frequency, rate or extent of viral transcription. |
SUPT5H, POLR2D, CCNT1, PFN1, GTF2F2, POLR2E, POLR2A, POLR2B, GTF2F1, POLR2I, NOTCH1, POLR2J, POLR2K, POLR2G, POLR2L, GTF2B, RSF1 |
GO:0050435 | BP | beta-amyloid metabolic process | The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). |
MME, ACE, IDE, PSEN2 |
GO:0050436 | MF | microfibril binding | Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material. |
LTBP1 |
GO:0050473 | MF | arachidonate 15-lipoxygenase activity | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. |
ALOX15, PTGS2 |
GO:0050482 | BP | arachidonic acid secretion | The controlled release of arachidonic acid from a cell or a tissue. |
ANXA1, NMB, ACE, DRD2, PLA2G2A, PLA2G5, PLA2G4A, PLA2G12A, PNPLA8 |
GO:0050501 | MF | hyaluronan synthase activity | Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. |
HAS2 |
GO:0050508 | MF | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. |
EXT1, EXT2 |
GO:0050509 | MF | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
EXT1, EXT2 |
GO:0050510 | MF | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity | Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
CHSY3, CHSY1 |
GO:0050528 | MF | acyloxyacyl hydrolase activity | Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. |
AOAH |
GO:0050543 | MF | icosatetraenoic acid binding | Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. |
FABP3 |
GO:0050544 | MF | arachidonic acid binding | Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
S100A8, S100A9, PPARG, STX3 |
GO:0050561 | MF | glutamate-tRNA(Gln) ligase activity | Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. |
EARS2 |
GO:0050567 | MF | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. |
GATC, GATB, QRSL1 |
GO:0050591 | MF | quinine 3-monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). |
CYP3A4 |
GO:0050610 | MF | methylarsonate reductase activity | Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. |
GSTO1, GSTO2 |
GO:0050613 | MF | delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
TM7SF2 |
GO:0050614 | MF | delta24-sterol reductase activity | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
DHCR24 |
GO:0050632 | MF | propionyl-CoA C2-trimethyltridecanoyltransferase activity | Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA. |
SCP2 |
GO:0050649 | MF | testosterone 6-beta-hydroxylase activity | Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. |
CYP3A4 |
GO:0050650 | BP | chondroitin sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. |
CSGALNACT1, PXYLP1, XYLT2 |
GO:0050651 | BP | dermatan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. |
CSGALNACT1 |
GO:0050653 | BP | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate. |
CSGALNACT1 |
GO:0050656 | MF | 3'-phosphoadenosine 5'-phosphosulfate binding | Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. |
ENPP1, CHST15 |
GO:0050658 | BP | RNA transport | The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
HNRNPA2B1, CKAP5, RBFOX1 |
GO:0050659 | MF | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity | Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
CHST15, CHST11 |
GO:0050660 | MF | flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
KMO, ACOX3, KDM1A, DUS4L, CYB5R3, GSR, CYBB, DLD, MAOB, NOS3, SDHA, FMO4, MTHFR, ACADSB, XDH, ACADVL, GFER, AOX1, DPYD, SQLE, ACOX1, DHCR24, ETFDH, TXNRD1, NOX5, ACOX2, FMO2, AIFM2, NOX4 |
GO:0050661 | MF | NADP binding | Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
IDH1, TM7SF2, H6PD, CRYZL1, GSR, GAPDH, G6PD, NOS3, FMO4, MTHFR, DPYD, NOX5, FMO2, DUOX1, DHCR7 |
GO:0050662 | MF | coenzyme binding | Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. |
HMGCR, GCLC |
GO:0050663 | BP | cytokine secretion | The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. |
AGT, LYN, NOX5, S100A13 |
GO:0050665 | BP | hydrogen peroxide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
CYP1A1, CYBB, MAOB, DUOX2, DUOX1 |