GO:0046822

BP

regulation of nucleocytoplasmic transport

Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.

PPP1R12A, PPP1CC, RBM4

GO:0046825

BP

regulation of protein export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.

XPO1, IFI27, PTPN11, UHMK1

GO:0046826

BP

negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.

TXN, SP100, RANGAP1, CDK5, SOX4, BARD1

GO:0046827

BP

positive regulation of protein export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.

IL1B, TP53, TPR, PRKACA, SFN, GSK3B, EMD, MDM2, CAMK1, GAS6, ANP32B, XPO4, TCF7L2, GTSE1

GO:0046831

BP

regulation of RNA export from nucleus

Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.

KHDRBS1

GO:0046832

BP

negative regulation of RNA export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.

TPR, NUP153

GO:0046833

BP

positive regulation of RNA export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.

KHDRBS1

GO:0046834

BP

lipid phosphorylation

The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.

DGKZ, SPHK1

GO:0046835

BP

carbohydrate phosphorylation

The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.

PFKFB2, PFKFB1, HK1, GALK2, PFKFB3, PFKFB4, HKDC1, TKFC, GNPTAB, GNPTG, GNE

GO:0046836

BP

glycolipid transport

The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NPC2, GLTP

GO:0046838

BP

phosphorylated carbohydrate dephosphorylation

The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it.

G6PC

GO:0046839

BP

phospholipid dephosphorylation

The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.

PLPP1, PLPP3, PLPPR4, PLPP5, PLPPR2

GO:0046847

BP

filopodium assembly

The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

EZR, ITGA6, CDC42, FGD6, FGD2, FGD4, SPATA13, TTYH1, ARHGEF4

GO:0046848

MF

hydroxyapatite binding

Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin.

BGLAP

GO:0046849

BP

bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

LRP5, IL6, NOTCH2, SPP2, LGR4

GO:0046850

BP

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

LRP5, GJA1, LEP, LEPR

GO:0046851

BP

negative regulation of bone remodeling

Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.

GREM1, SFRP1

GO:0046854

BP

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

PIK3CD, PIK3C2A, EREG, PIP5K1B, PIP5K1C, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, FGF2, PDGFRB, KIT, CD28, FGFR1, VAV1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, PIK3R1, IMPA1, FGF9, BTC, IRS1, PIK3CA, PIK3CB, PIK3CG, INPP1, GRB2, PIP4K2B, NRG1, PTPN11, GAB1, ERBB4, TMEM150A, TTC7B, PIK3C3, FRS2, SMG1, HBEGF, PI4KB, KL, IP6K2, PIKFYVE, IRS2

GO:0046855

BP

inositol phosphate dephosphorylation

The process of removing a phosphate group from any mono- or polyphosphorylated inositol.

SYNJ1, IMPA1, INPP1, PTEN, MTMR2, INPP5A, INPP5K, INPP5E

GO:0046856

BP

phosphatidylinositol dephosphorylation

The process of removing one or more phosphate groups from a phosphatidylinositol.

SYNJ2, SYNJ1, PTEN, OCRL, MTM1, MTMR1, MTMR2, INPP5A, INPP5D, INPP5K, INPP5E

GO:0046870

MF

cadmium ion binding

Interacting selectively and non-covalently with cadmium (Cd) ions.

MT3, NOS3, SLC11A2, MT1X

GO:0046872

MF

metal ion binding

Interacting selectively and non-covalently with any metal ion.

TMEM129, ZC3H12D, ZNF320, ZNF233, SOBP, ZNF785, PHF20L1, NUDT19, ZNF879, NDUFS8, CDC7, PPP6C, NME4, FBP2, ACACB, TRAFD1, CTDSP2, UTY, ENPP3, ADAM10, RIOK3, ZNF213, TPP1, NRP1, ZNF646, ZBTB5, PFAS, SMAD7, ANGPT2, MUSK, CTDSPL, SMAD9, SIVA1, PPM1G, BIRC5, FOXP2, NUPL2, ZSCAN9, KDM6A, ASAP2, ZBTB24, CYB5B, ADAM12, ZNHIT1, MAP3K13, B4GALT5, ZNF264, RASA4, ERI3, CBFA2T2, OIP5, B4GAT1, SMAD6, SNAI2, ASNA1, ADCY3, NUAK1, ZNF862, ZFC3H1, ZEB2, NRP2, ADCY9, B4GALT4, PDE8A, REV3L, JAK2, PRMT3, YPEL1, EIF5B, DNAJA2, FAM20B, ROCK2, ZNF623, ZC3H11A, NDUFS2, ZNF217, NME6, ITGA10, USP2, ADAP1, RNASEH2A, ZNF189, PAK3, CLPX, PDE5A, PDE9A, DDAH1, SORBS2, PDE8B, ZBTB7A, PARN, NPTXR, STAMBP, ECEL1, EYA4, WIZ, ZBED1, CYB5A, F13A1, TIMP1, GH1, COL1A1, COL3A1, CRYAB, FGA, FGG, RAF1, CYBB, GNAI2, ITGB2, CFI, MPO, PCCA, ALPL, ITGB1, COL5A2, FYN, ITGAV, PRSS1, ZFY, COL1A2, CYC1, ITGA5, GNAI3, STS, FBP1, HMOX1, POLA1, FURIN, ZNF688, ZNF853, MT1HL1, GLI3, TROVE2, COX5B, KIT, EGR2, ITGAM, PC, COL11A1, BCKDHA, COL11A2, FDPS, VAV1, GNS, ZNF44, ZNF250, HIVEP1, ARSB, CHN1, RAG1, TIMP2, NQO2, ZNF823, PRLR, FAH, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF23, ZKSCAN1, ZNF25, ZNF43, ITGA2, ATF7, PFKL, IGFBP3, ERCC2, LIG1, NDUFV2, TNNI3, AMY2B, ATP2B1, COX5A, ITGAX, COL9A1, COL5A1, NT5E, SDHB, TGM2, GART, NME2, XPA, PTGS1, ITGA6, ME2, JAK1, ATP2B4, POLR2A, CDK2, ITGA3, ZFP36, ACVR2A, NDUFS1, POLD1, MZF1, TKT, GNA11, SLC6A1, CLIP1, POLR2B, MAT2A, RRM2, HIVEP2, DNAJA1, GALNS, PTGS2, CBS, TIMP3, HMGCL, MAP2K2, NUDT1, PPP1CC, BMPR1A, ACVR1B, TGFBR1, GMPR, TGFBR2, ITGAE, CDKN1A, COL18A1, BCL6, CSK, PRKCI, HELZ, ECE1, ATRX, NSF, BRCC3, NPTX2, ZFP36L2, UQCRFS1, TGM4, PPM1F, PRIM1, PRIM2, MCM2, MTHFS, GNAQ, METAP2, TNFSF10, ZNF83, DNA2, SGSH, ARSD, CLCNKA, CLCNKB, ADCY7, NEK2, NEK3, AGFG1, ZNF133, ZNF136, ZNF140, ZNF138, THOP1, HCCS, CACNA2D1, PRKAA2, ATP12A, MAZ, PRDM15, KLF3, ANTXR2, YBEY, ZNF445, ELOF1, PPP4C, YPEL3, RPL37A, HSPE1, RPL37, PPP1CA, PPP1CB, PPP2CB, RPS27A, ADAM17, NTHL1, ADARB1, MT1X, ABAT, GNAS, ZBED6, ZXDB, ZNF200, ATP2C1, CYCS, INSM1, AMPD3, BNC1, OGDH, SP3, CREB5, GNA12, COL10A1, ZNF85, PRKCQ, ACVR1, EGR4, ZBTB16, PRKCD, RNASEL, PPAT, ZNF33A, EGR3, ZFP36L1, TNK2, DDR1, PDE4C, PDE4D, ZNF844, ZNF616, DMPK, ZNF763, ZNF816, KCNMA1, AKAP13, DPYD, TRIM26, ZBTB17, KLF10, MAP2K5, PDE3B, ZNF211, IKZF1, ADAM9, MYO9B, SMAD4, DGKZ, ACVR2B, ITGA9, BMPR2, KLF9, IDI1, CACNA1C, PDE7A, VEZF1, GIT2, PDE3A, ZNF345, ZNF268, ZNF273, RASA3, ZNF846, MTF1, CLCA4, SUZ12, KARS, ACAP2, POSTN, PRKD1, RASA2, RHEB, FCN2, TESK1, ZNHIT3, JMJD1C, MYLK, MPPED2, SMAD2, SMAD1, ZIC1, ZNF141, ZNF77, ZNF124, ETFDH, PDCD2, EXT1, ZSCAN26, AMHR2, HAGH, ME3, PCK2, UGP2, TATDN3, ZNF423, ZNF630, ZNF791, TKFC, ZSCAN23, MGAT5B, ZNF568, ZNF404, MMEL1, ZFP69, ZBED5, FLYWCH1, ATP13A5, ARHGAP29, ACSM3, TAF1B, CYBRD1, ESCO2, PAN3, ZNF326, ZNF789, ZNF766, ZNF667, ZC3H12B, ZNF506, GNAS, DGKK, COLEC12, ZBTB41, HIVEP3, ZC3H13, PDSS1, ZNF684, ZNF648, ZNF618, RBM26, ZC2HC1B, ZNF658, CDKAL1, MBNL2, TNS2, STEAP4, ZNF776, ZNF57, ZNF518A, ZNF787, PLAG1, ASPHD2, ADNP2, ZNF280D, FAAP20, TATDN1, ZNF529, ZNF585A, FDX1L, ALKBH5, CYB5D1, ZNF449, ZNF880, HAGHL, PAPD4, ZC3H14, ZNF474, ARSK, ZNF562, BNC2, DEF8, ZNF600, ZNF621, TSHZ1, FGD6, PHLPP2, NEK10, MOB3C, CHSY3, RPS27L, ZNF534, ASXL2, RHOU, ZNF765, ZNF771, MCM10, ZNF627, ZNF367, ERMP1, TRMT1L, ZNF550, ZFYVE16, ZNF804A, IRF2BP2, FGD2, CMC1, ZNF467, ZSCAN2, GALNT5, GALNT7, NEK8, GALNT10, ZBTB33, MOB3B, PRUNE, STK32C, NT5DC3, CASZ1, ADIPOR2, TRABD2A, TAX1BP1, JAZF1, ZSCAN30, CHSY1, DGKH, ZNF677, FRAS1, ZNF573, ZNF280B, FOXP4, ZC3H7A, ZBTB8OS, ADHFE1, ZC3H3, ZNF440, ZNF101, ZNF654, ZFP82, ZNF567, ARHGEF28, PPM1K, GALNT15, GTPBP8, ZNF843, PNKD, GALNT4, ZNF808, CISD2, ARFGAP2, ZNF655, ZNF283, ZNF513, ZNF615, CYB561D1, ZNF709, ZNF557, ZNF565, ZNF610, THAP8, ZNF579, ZBTB38, ZNF511, SUMF1, DAGLB, ZNF485, ZBTB34, PAPD5, ZNF248, GLIS3, ZNF548, PDZD8, ZNF555, TRPV1, ZNF397, NUDT10, NEK11, ZFP28, PPTC7, CTCFL, RP9, RHEBL1, ZNF420, OSR1, NUBPL, THAP6, ZSCAN18, ZNF502, ZNF564, ZNF596, NT5C, ZNF507, NEK9, CSGALNACT1, NEK7, ZNF721, ZNF526, ZNF384, THAP3, ZC3H15, HDAC7, PRUNE2, NUDT8, DNAJA4, ARAP3, RASSF5, ZNF606, PPM1E, ARAP2, GTF3A, TANK, RAD50, EXT2, HGD, RFK, ZNF566, ADIPOR1, ZUFSP, EME1, ISG20, ZNF669, ZNF689, OPTN, ZBTB10, OMA1, ZNF503, STAMBPL1, GALNT14, DPH3, NUDT11, ZNF274, AURKB, FAHD2A, ZC2HC1A, ZNF486, ZNF764, ZNF419, ZNF625, ZNF845, HPDL, ZBED3, HIC2, ZNF333, ZNF462, CHAMP1, ZFP91, ZFYVE19, ZBTB45, ZC3H10, ZNF521, ZNF512B, ZSCAN31, FGD4, ZNF75A, ZNF578, ZNF641, ZNF285, ZFP3, ARAP1, AGAP4, MCEE, ZNF317, NEK1, SMG1, YPEL2, PPP1R10, TRPM7, ZNF300, MCCC1, ZNF347, ZNF607, ZNF587, ZNF382, YME1L1, STAC, KLF6, PKMYT1, SDHC, SMAD5, NPAS2, MIPEP, ZFYVE21, ELAC2, ZNF559, CPPED1, PELO, AGMAT, ESYT1, ALKBH7, ZNF692, DOHH, SPON2, ZNF426, MLPH, REPIN1, PAPOLG, TRPM6, SALL3, CLEC7A, IDI2, HDAC8, HELZ2, NLN, PRKD2, FOXP3, INO80B, UNK, ZNF518B, ZC3H12C, EPT1, LNP, ZNF436, PEG3, CTDSP1, ZNF350, UBA5, ADAM19, RACGAP1, ZNF700, LMAN2L, THAP2, BCL11A, TRPV6, TNKS2, IKZF4, FOXP1, ZNF335, IKZF5, FAM96A, ZNF552, SMYD3, ATP13A3, NT5DC2, ZNF430, ZNF395, MOB1A, PLEKHF2, ELP3, SAP30L, EBF2, PATZ1, MKNK2, ZNF287, ZBTB20, SPON1, ZNF532, ZNF160, ZNF334, CD209, PDE7B, ARFGAP3, ADAP2, NGB, PRDM10, PRDM6, GPHN, ZNF71, ZNF302, MBNL1, SLC2A4RG, TSHZ2, ZNF277, LATS2, GLRX2, ZFP64, MBNL3, TRMT13, NUDT15, ARMC1, ZNF358, POLR3B, RBM22, RNF216, NMRK1, LYAR, SMPD4, ZNF586, MTMR4, MIS18A, ZNF226, CISD1, GDE1, ZNF224, PDP1, ZKSCAN7, ZBTB4, ZNF492, ANKFY1, SUCLA2, DNMT3B, ASH2L, VPS29, POLK, B4GALT6, ZC3H7B, NUFIP1, ZNF639, ZNF230, MUTYH, KLF15, CNOT7, ENPP5, ZFP69B, ZNF112, ZNF222, ZNF580, NOCT, GPATCH8, ADAM21, FBXO5, HDAC9, AGO2, VAV3, ITGA11, ZHX1, ZNF236, ZNF608, ASAP1, RIMKLB, ZBTB21, CNOT6, NOB1, MGAT4A, PLAGL1, NENF, POLI, AGAP1, ZC3H4, DICER1, RIMS2, MGAT4B, EXO1, HDAC5, ZNF148, GNE, POLH, EXOG, GIT1, KLF13, RTCB, ZNF337, ZNF330, ZNF175, ZNF451, HSPB11, NME7, TIMM10B, ZNF706, KLF2, CPQ, POMT1, SAR1B, STK24, XRCC6BP1, CEPT1, TNFRSF11A, MAP3K4, ENPP4

GO:0046875

MF

ephrin receptor binding

Interacting selectively and non-covalently with an ephrin receptor.

SDCBP, FYN, CHN1, EFNA1, PIK3CG, EFNA4, EFNB2, EFNA5, EPHA4, GRB2, CDK5, ANKS1A

GO:0046879

BP

hormone secretion

The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.

ADM

GO:0046880

BP

regulation of follicle-stimulating hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHBA

GO:0046881

BP

positive regulation of follicle-stimulating hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHA, INHBA, INHBB, LEP, FOXL2, SMAD4

GO:0046882

BP

negative regulation of follicle-stimulating hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone.

INHA, INHBA, INHBB

GO:0046883

BP

regulation of hormone secretion

Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.

ANXA1, SCG5

GO:0046885

BP

regulation of hormone biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.

STC2

GO:0046886

BP

positive regulation of hormone biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.

KDM1A, EGR1, ARNT, HIF1A

GO:0046887

BP

positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.

EDN1, NMB, CREB1, NMU, PTPN11

GO:0046888

BP

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

IL6, EDN1, NMB, LIF, IL11, ADORA1, ADIPOQ

GO:0046889

BP

positive regulation of lipid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

CREBL2, INS, APOE, CREB1, AKT1, CCDC3, ABHD6, SORBS1

GO:0046890

BP

regulation of lipid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

MID1IP1

GO:0046899

MF

nucleoside triphosphate adenylate kinase activity

Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP.

AK4, AK3

GO:0046900

BP

tetrahydrofolylpolyglutamate metabolic process

The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.

GGH

GO:0046902

BP

regulation of mitochondrial membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

TP53, CNP, BCL2, PPIF, STAT3, BNIP3, PMAIP1, BAD

GO:0046903

BP

secretion

The controlled release of a substance by a cell or a tissue.

CA2, PRKCI, NPY2R, TPD52

GO:0046904

MF

calcium oxalate binding

Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi.

AMBP

GO:0046907

BP

intracellular transport

The directed movement of substances within a cell.

CSPG5, APOE, AFTPH, BBS7, APPBP2, SDCBP2, MKKS, FMN2

GO:0046911

MF

metal chelating activity

The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring.

APOE

GO:0046914

MF

transition metal ion binding

Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

APP, HRSP12, APLP2

GO:0046915

MF

transition metal ion transmembrane transporter activity

Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

SLC11A1, SLC11A2

GO:0046920

MF

alpha-(1->3)-fucosyltransferase activity

Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.

FUT4

GO:0046923

MF

ER retention sequence binding

Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.

KDELR3, CEMIP, KCNIP2

GO:0046928

BP

regulation of neurotransmitter secretion

Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.

SYN1, MEF2C, FMR1, SNCAIP

GO:0046929

BP

negative regulation of neurotransmitter secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.

PNKD, SYT11, SLC30A1

GO:0046930

CC

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

TOMM40, BCL2, NUP62, VDAC2, BAX, VDAC3

GO:0046931

BP

pore complex assembly

The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.

CCT3, CCT8, ANO6, BAD

GO:0046933

MF

proton-transporting ATP synthase activity, rotational mechanism

Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism.

ATP5H, ATP5D, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5G2

GO:0046934

MF

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

PIK3CD, EREG, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, FGF2, PDGFRB, KIT, CD28, FGFR1, VAV1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, PIK3R1, FGF9, BTC, IRS1, PIK3CA, PIK3CB, PIK3CG, GRB2, NRG1, PTPN11, GAB1, ERBB4, FRS2, HBEGF, KL, IRS2

GO:0046935

MF

1-phosphatidylinositol-3-kinase regulator activity

Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.

PIK3R1, CCKBR

GO:0046939

BP

nucleotide phosphorylation

The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.

DTYMK, GUK1, RAD50

GO:0046940

BP

nucleoside monophosphate phosphorylation

The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.

DTYMK, AK4, CMPK1

GO:0046942

BP

carboxylic acid transport

The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

AQP9

GO:0046943

MF

carboxylic acid transmembrane transporter activity

Enables the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

AQP9

GO:0046947

BP

hydroxylysine biosynthetic process

The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.

PLOD1

GO:0046950

BP

cellular ketone body metabolic process

The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.

OXCT1

GO:0046951

BP

ketone body biosynthetic process

The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.

HMGCL, AACS, BDH2

GO:0046952

BP

ketone body catabolic process

The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.

OXCT1

GO:0046958

BP

nonassociative learning

A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.

MAPK8IP2

GO:0046961

MF

proton-transporting ATPase activity, rotational mechanism

Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

ATP6V0E1, ATP6V1B2, ATP6V1C1, ATP5D, ATP5C1, ATP5E, TCIRG1, ATP6V1F, ATP6V0A1, ATP6V1H

GO:0046965

MF

retinoid X receptor binding

Interacting selectively and non-covalently with a retinoid X receptor.

VDR, HMGA1, FUS, PPARG, NR4A2, NRIP1, NR1H2, NR0B2, NCOA1, NR1H4

GO:0046966

MF

thyroid hormone receptor binding

Interacting selectively and non-covalently with a thyroid hormone receptor.

NCOR1, FUS, NUP62, GTF2B, NR0B2, TAF11, ZNHIT3, JMJD1C, TRIP6, MED12, MED30, MED4, MED17, THRAP3, MED16, NCOA3

GO:0046968

BP

peptide antigen transport

The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

CD209

GO:0046970

MF

NAD-dependent histone deacetylase activity (H4-K16 specific)

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.

SIRT2

GO:0046972

MF

histone acetyltransferase activity (H4-K16 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.

OGT, PHF20, KANSL3

GO:0046974

MF

histone methyltransferase activity (H3-K9 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.

EHMT2, SETDB2, SUV39H2

GO:0046975

MF

histone methyltransferase activity (H3-K36 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.

ASH1L

GO:0046976

MF

histone methyltransferase activity (H3-K27 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein.

EZH2, EHMT2

GO:0046978

MF

TAP1 binding

Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein.

HLA-F

GO:0046979

MF

TAP2 binding

Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein.

HLA-F

GO:0046982

MF

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

SUPT5H, MEIS1, SDCBP, BHLHE40, KCNK3, MID1, FOXP2, MAFG, IRAK2, BNIP3L, SOX15, TLR2, HIST1H2BK, H2AFY, SUPT3H, FLOT1, VAPB, SMC2, EGFR, FOS, PDGFB, TGFB1, APOA2, RBP4, TTR, RAF1, PDGFA, ERBB2, TP53, CYBB, ITGB2, INHA, JUN, ITGB1, NPM1, HEXA, P4HB, INHBA, ADRB1, POLA1, H2AFZ, HIST1H2AG, BCL2, HSPD1, ITGAM, TOP2A, BMP2, ENO3, HGF, DRD2, TYR, VEGFA, TCF4, TCF3, H2AFX, ITGA2, TAL1, CEBPB, XBP1, ATF1, ATF3, ATF4, ATF6, NFKB1, HIST1H2AD, ERBB3, BMP6, NR4A1, NFYB, ITGA3, ARNT, PIK3R1, IL12A, PPP2R1A, ADORA1, AGTR1, SRI, HIST1H2BB, ADRA1A, ADRA1B, DDIT3, SOX6, AHR, PBX1, NR4A2, NOTCH1, SOX9, GCLC, GCLM, CENPA, CEBPD, PGF, VEGFB, FXR1, IRAK1, CAV2, CLCN3, GTF2A1, GTF2A2, CEBPG, LIMK2, TPD52, SOX8, JAM2, TIRAP, HIST1H2BD, TGFB2, YWHAE, HIST1H4A, HIST1H2BC, PAFAH1B2, HIST1H3D, SIM1, SMAD3, H3F3A, DR1, MEF2A, CAV1, PPARD, RELA, YWHAH, MEF2C, TYRO3, GABPA, FMR1, SOX4, BAX, MCL1, SOS1, SOS2, PPP3CA, BNIP3, SMAD4, NAE1, SNX1, CUL3, NFYC, POLA2, SIM2, SMC1A, MEF2D, DRAP1, PAFAH1B3, NECTIN1, PPP2R4, TLR1, TAF11, TWIST1, SMAD2, SMAD1, USF2, EXT1, TAF12, HIF1A, HIST2H2BE, AOC3, TPD52L1, RALGAPA2, CENPW, PDSS1, HIST2H2AA3, RALGAPA1, TENM4, H2AFV, HIST3H2A, SLC51A, ADIPOR2, RALGAPB, PDSS2, SCUBE1, MICU2, APITD1, ABTB2, FAM73A, GABPB2, JDP2, BCL2L2, BAD, EXT2, HIST1H2AC, HIST1H2BH, ADIPOR1, PANX1, TCF12, BARD1, EPAS1, H2AFJ, KATNB1, JAM3, SDCBP2, ABCG8, RAB3GAP2, IKZF4, SOX17, RRAGC, TAF9B, HMG20A, HEYL, ANO2, RRAGD, NECTIN3, POLE4, POLE3, CHRAC1, SMC4, TXLNG, VAPA, H2AFY2, HMG20B, TENM3, CLCF1, SAE1, MLX, ZHX1, FZD4, BOK, SNX6, TIMELESS, SMC3, SNX5, IRAK3

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

AHRR, ARNTL, TFEC, POLR1C, TCF21, ZNF862, MITF, PDCD6, AIFM1, ZBED1, MYC, MYCN, ERBB2, DBI, AR, TFEB, HNF1A, STX2, ACTN2, AHR, SREBF1, STAT3, ID4, MXI1, STAT5B, POLR2J, PEX3, ZBED6, E2F1, ID2, ID3, MXD1, PPP3CA, SREBF2, TCF15, STK4, E2F2, MXD4, NCF4, TAF5, NCOA2, NCOA1, MGA, NLGN1, ATP6V1C2, BHLHE22, NUP210, ARNTL2, HPS1, HES6, ATOH8, MNT, NPAS2, POLR2J2, HES4, HPS4, TCFL5, HPSE, BTRC, HIF3A, POLR1D, HES2, HEY1, NCOA3

GO:0046985

BP

positive regulation of hemoglobin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

KLF4, PRMT1

GO:0047006

MF

17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.

HSD17B2, AKR1C1

GO:0047012

MF

sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one.

NSDHL

GO:0047015

MF

3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity

Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA.

HSD17B10

GO:0047016

MF

cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity

Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one.

HSD3B7

GO:0047017

MF

prostaglandin-F synthase activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

AKR1C3

GO:0047020

MF

15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.

AKR1C3

GO:0047021

MF

15-hydroxyprostaglandin dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH.

CBR1

GO:0047023

MF

androsterone dehydrogenase activity

Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione.

AKR1C3

GO:0047035

MF

testosterone dehydrogenase (NAD+) activity

Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

HSD17B6, HSD17B1, HSD17B2, AKR1C3, DHRS9

GO:0047042

MF

androsterone dehydrogenase (B-specific) activity

Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.

AKR1C1

GO:0047045

MF

testosterone 17-beta-dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.

AKR1C3

GO:0047057

MF

vitamin-K-epoxide reductase (warfarin-sensitive) activity

Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.

VKORC1

GO:0047066

MF

phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.

GPX4

GO:0047086

MF

ketosteroid monooxygenase activity

Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate.

AKR1C3, AKR1C2, AKR1C1

GO:0047105

MF

4-trimethylammoniobutyraldehyde dehydrogenase activity

Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.

ALDH1L1, ALDH9A1, ALDH1L2, ALDH16A1

GO:0047115

MF

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol.

AKR1C3, AKR1C2, AKR1C1

GO:0047117

MF

enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+.

FASN

GO:0047130

MF

saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH.

AASS

GO:0047131

MF

saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.

AASS

GO:0047144

MF

2-acylglycerol-3-phosphate O-acyltransferase activity

Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA.

LPCAT3, MBOAT2, LPCAT2, LPGAT1, MBOAT7, CRLS1

GO:0047179

MF

platelet-activating factor acetyltransferase activity

Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.

PAFAH1B2, PAFAH1B3

GO:0047184

MF

1-acylglycerophosphocholine O-acyltransferase activity

Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.

LPCAT3, LPCAT2

GO:0047192

MF

1-alkylglycerophosphocholine O-acetyltransferase activity

Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA.

LPCAT2

GO:0047237

MF

glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP.

CSGALNACT1

GO:0047238

MF

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP.

CHSY3, CHSY1, CSGALNACT1