| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0045956 | BP | positive regulation of calcium ion-dependent exocytosis | Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. |
CACNA1G, SYT1, STXBP1, ARF1, CDK5 |
GO:0045957 | BP | negative regulation of complement activation, alternative pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway. |
CR1 |
GO:0045959 | BP | negative regulation of complement activation, classical pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway. |
CR1 |
GO:0045963 | BP | negative regulation of dopamine metabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine. |
COMT, SNCA |
GO:0045964 | BP | positive regulation of dopamine metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. |
GPR37, MAOB, ABAT |
GO:0045976 | BP | negative regulation of mitotic cell cycle, embryonic | Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle. |
CTNNB1 |
GO:0045977 | BP | positive regulation of mitotic cell cycle, embryonic | Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle. |
HES1 |
GO:0045986 | BP | negative regulation of smooth muscle contraction | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. |
ADRB2, PTGS2 |
GO:0045987 | BP | positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
ADA, EDN1, ITGA2, CHRM3, EDN2, ADRA1D, F2R, ADRA1A, PTGS2, ADRA1B, NMU, NPY2R, CTTN, SPHK1 |
GO:0045988 | BP | negative regulation of striated muscle contraction | Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. |
ATP1A2 |
GO:0045994 | BP | positive regulation of translational initiation by iron | Any process involving iron that activates or increases the rate of translational initiation. |
TNF |
GO:0045995 | BP | regulation of embryonic development | Any process that modulates the frequency, rate or extent of embryonic development. |
INSR, CDK1, LAMA2, LAMA4, LAMA3, PHLDA2, NIPBL, SOX17, NOCT |
GO:0046005 | BP | positive regulation of circadian sleep/wake cycle, REM sleep | Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. |
GHRH |
GO:0046007 | BP | negative regulation of activated T cell proliferation | Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. |
PRNP, PRKAR1A, BTN2A2, FOXP3 |
GO:0046010 | BP | positive regulation of circadian sleep/wake cycle, non-REM sleep | Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. |
NPY2R, GHRL |
GO:0046022 | BP | positive regulation of transcription from RNA polymerase II promoter during mitosis | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis. |
ZNF268 |
GO:0046030 | MF | inositol trisphosphate phosphatase activity | Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. |
INPP5K |
GO:0046031 | BP | ADP metabolic process | The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. |
AMPD3, BAD |
GO:0046032 | BP | ADP catabolic process | The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate. |
NUDT9 |
GO:0046033 | BP | AMP metabolic process | The chemical reactions and pathways involving AMP, adenosine monophosphate. |
AK1, AK4, AK3 |
GO:0046034 | BP | ATP metabolic process | The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. |
AK1, ATP1B1, HSPA1A, HSPA1B, ATP6V1B2, AK4, NDUFS1, ATP1A2, VCP, AMPD3, GUK1, BAD, MYH4 |
GO:0046037 | BP | GMP metabolic process | The chemical reactions and pathways involving GMP, guanosine monophosphate. |
CASK, DLG4, MPP1, DLG1, GUK1, TJP2 |
GO:0046039 | BP | GTP metabolic process | The chemical reactions and pathways involving GTP, guanosine triphosphate. |
GNAI3, RHOQ, AK4, AMPD3, AK3 |
GO:0046040 | BP | IMP metabolic process | The chemical reactions and pathways involving IMP, inosine monophosphate. |
ADSS, ADSSL1 |
GO:0046041 | BP | ITP metabolic process | The chemical reactions and pathways involving ITP, inosine triphosphate. |
AK3 |
GO:0046051 | BP | UTP metabolic process | The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. |
AK3 |
GO:0046054 | BP | dGMP metabolic process | The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). |
GUK1 |
GO:0046058 | BP | cAMP metabolic process | The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). |
PTH, PTHLH |
GO:0046060 | BP | dATP metabolic process | The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). |
GUK1 |
GO:0046061 | BP | dATP catabolic process | The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). |
ADA, NUDT1, SAMHD1 |
GO:0046068 | BP | cGMP metabolic process | The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. |
PDE9A, RORA |
GO:0046069 | BP | cGMP catabolic process | The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate. |
PDE5A, PDE9A |
GO:0046070 | BP | dGTP metabolic process | The chemical reactions and pathways involving dGTP, guanosine triphosphate. |
DGUOK |
GO:0046078 | BP | dUMP metabolic process | The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). |
TYMS |
GO:0046081 | BP | dUTP catabolic process | The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. |
DUT |
GO:0046084 | BP | adenine biosynthetic process | The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. |
PAICS |
GO:0046085 | BP | adenosine metabolic process | The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. |
ACPP, PTGDR |
GO:0046086 | BP | adenosine biosynthetic process | The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. |
NT5E |
GO:0046092 | BP | deoxycytidine metabolic process | The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. |
TK2 |
GO:0046098 | BP | guanine metabolic process | The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. |
KDM1A |
GO:0046101 | BP | hypoxanthine biosynthetic process | The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. |
PRPS1 |
GO:0046103 | BP | inosine biosynthetic process | The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. |
ADA |
GO:0046104 | BP | thymidine metabolic process | The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. |
TK2, TK1 |
GO:0046108 | BP | uridine metabolic process | The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. |
UPP2 |
GO:0046111 | BP | xanthine biosynthetic process | The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. |
ADA |
GO:0046121 | BP | deoxyribonucleoside catabolic process | The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). |
DERA |
GO:0046122 | BP | purine deoxyribonucleoside metabolic process | The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). |
DGUOK |
GO:0046130 | BP | purine ribonucleoside catabolic process | The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. |
ENPP4 |
GO:0046134 | BP | pyrimidine nucleoside biosynthetic process | The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). |
TYMS, UMPS, CAD, DCTD, DUT, DHODH |
GO:0046135 | BP | pyrimidine nucleoside catabolic process | The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). |
UPP2, TYMP, NT5E, DPYD, UPP1, NT5C |
GO:0046166 | BP | glyceraldehyde-3-phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. |
TKT, TPI1 |
GO:0046167 | BP | glycerol-3-phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol. |
GK |
GO:0046177 | BP | D-gluconate catabolic process | The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. |
IDNK |
GO:0046185 | BP | aldehyde catabolic process | The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. |
GPI |
GO:0046204 | BP | nor-spermidine metabolic process | The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. |
SAT1, SAT2 |
GO:0046208 | BP | spermine catabolic process | The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. |
SAT1, SAT2 |
GO:0046209 | BP | nitric oxide metabolic process | The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. |
TLR2 |
GO:0046219 | BP | indolalkylamine biosynthetic process | The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. |
TPH2 |
GO:0046226 | BP | coumarin catabolic process | The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. |
CYP2A6 |
GO:0046316 | MF | gluconokinase activity | Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). |
IDNK |
GO:0046320 | BP | regulation of fatty acid oxidation | Any process that modulates the frequency, rate or extent of fatty acid oxidation. |
FABP3, PDK4 |
GO:0046321 | BP | positive regulation of fatty acid oxidation | Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. |
PPARG, PPARA, NR4A3, PPARGC1A |
GO:0046322 | BP | negative regulation of fatty acid oxidation | Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. |
ACADVL, DGAT2 |
GO:0046323 | BP | glucose import | The directed movement of the hexose monosaccharide glucose into a cell or organelle. |
SLC2A10, SLC2A4, HNF1A, SESN2, RAB4B, SLC2A6 |
GO:0046324 | BP | regulation of glucose import | Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
ASPSCR1 |
GO:0046325 | BP | negative regulation of glucose import | Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
TNF, ENPP1, LEP, GRB10, PEA15, VIMP, LMBRD1 |
GO:0046326 | BP | positive regulation of glucose import | Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
CREBL2, FGF19, PTH, INS, IGF1, INSR, RHOQ, PIK3R1, AKT1, AKT2, IRS1, PRKCI, SLC1A2, ARPP19, RAP1A, ADIPOQ, MAPK14, ADIPOR2, ITLN1, SORBS1, CAPN10, IRS2 |
GO:0046327 | BP | glycerol biosynthetic process from pyruvate | The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate. |
PCK1 |
GO:0046328 | BP | regulation of JNK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
MAP4K4, IGF1R, RAP2A, EPHB1, F2RL1, MAPK8IP2, ULK4, MAPK8IP3, MAPK8IP1 |
GO:0046329 | BP | negative regulation of JNK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
HDAC3, PER1, PARK2, NCOR1, AMBP, AKT1, DUSP3, F2RL1, GPS2, ZMYND11, ZNF675, DUSP19, MARVELD3, ITCH, PINK1, TAOK3, DACT1 |
GO:0046330 | BP | positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
TLR4, SDCBP, AXIN1, TLR3, RIPK2, FZD7, GADD45B, GADD45G, FGF19, IL1A, IL1B, HMGB1, GADD45A, CD27, CTGF, FLT4, LTBR, F2RL1, TIRAP, CDC42, RIPK1, TPD52L1, MINK1, RB1CC1, DUSP19, MAP3K5, TAOK3, HIPK2, TRPV4, PLCB1, DUSP22, TNFRSF19, TAOK2, PYCARD |
GO:0046331 | BP | lateral inhibition | Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells. |
HES1 |
GO:0046332 | MF | SMAD binding | Interacting selectively and non-covalently with a SMAD signaling protein. |
AXIN1, COL3A1, COL5A2, COL1A2, BMP2, SKI, SKIL, FLNA, YY1, CTNNB1, BMPR1A, ACVR1B, TGFBR1, TGFBR2, HMGA2, DAB2, PURA, MEF2A, TGFBR3, ACVR1, SMAD2, RNF111, MAGI2, EID2, PURB, TCF12, HIPK2, SMURF2, STUB1, USP15 |
GO:0046338 | BP | phosphatidylethanolamine catabolic process | The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
PNPLA8 |
GO:0046339 | BP | diacylglycerol metabolic process | The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. |
DGKZ, PGS1, DGKK, GPAT4, DGAT2 |
GO:0046340 | BP | diacylglycerol catabolic process | The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. |
APOA2, LIPE |
GO:0046356 | BP | acetyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. |
NUDT7 |
GO:0046360 | BP | 2-oxobutyrate biosynthetic process | The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. |
THNSL2 |
GO:0046368 | BP | GDP-L-fucose metabolic process | The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. |
FUT8 |
GO:0046370 | BP | fructose biosynthetic process | The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose. |
AKR1B1, SORD |
GO:0046386 | BP | deoxyribose phosphate catabolic process | The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. |
PGM2, DERA |
GO:0046390 | BP | ribose phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. |
G6PD |
GO:0046395 | BP | carboxylic acid catabolic process | The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. |
PON1 |
GO:0046398 | BP | UDP-glucuronate metabolic process | The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. |
CSGALNACT1 |
GO:0046415 | BP | urate metabolic process | The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. |
G6PC, LRRC16A, SLC16A9 |
GO:0046425 | BP | regulation of JAK-STAT cascade | Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. |
PIGU |
GO:0046426 | BP | negative regulation of JAK-STAT cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. |
SOCS2, SOCS3, SOCS6, LEPROT, SOCS1, FLRT2, SOCS5, DAB1, DCN, BGN, NF2, CAV1, PODN, RTN4RL1, LRRTM4, ADIPOR1, LRRC19, FLRT3, FLRT1 |
GO:0046427 | BP | positive regulation of JAK-STAT cascade | Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. |
PRL, GH1, IL6, KIT, CCL5, AKR1B1, IL10, F2R, LEP, NOTCH1, HES1, CYP1B1, CRLF3, ADIPOR1 |
GO:0046434 | BP | organophosphate catabolic process | The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. |
PON1 |
GO:0046449 | BP | creatinine metabolic process | The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. |
MME, GHR, STAT5A, STAT5B |
GO:0046452 | BP | dihydrofolate metabolic process | The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate. |
DHFR |
GO:0046456 | BP | icosanoid biosynthetic process | The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. |
FADS1, PLA2G4A |
GO:0046459 | BP | short-chain fatty acid metabolic process | The chemical reactions and pathways involving fatty acids with a chain length of less than C6. |
ACOT4 |
GO:0046464 | BP | acylglycerol catabolic process | The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. |
ABHD12, MGLL, ABHD6 |
GO:0046466 | BP | membrane lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. |
CYP1B1 |
GO:0046469 | BP | platelet activating factor metabolic process | The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. |
PLA2G7 |
GO:0046470 | BP | phosphatidylcholine metabolic process | The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. |
PON1, GPLD1, APOA5 |
GO:0046473 | BP | phosphatidic acid metabolic process | The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
PLA2G2A |
GO:0046474 | BP | glycerophospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
AJUBA |
GO:0046475 | BP | glycerophospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
ABHD12, SMPD4, GDE1, PLA2G4C |