GO:0045732

BP

positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

AXIN1, PARK2, SEC22B, OAZ2, GJA1, TNFAIP3, APC, WNT5A, NSF, CDKN1B, SOX9, GSK3B, RAB7A, OAZ1, VCP, FOXO1, SNX1, CUL4B, MYLIP, SORL1, NEDD4L, BARD1, NDFIP1, SOX17, DACT1, PLK2, NDUFA13, GGA1, FZR1

GO:0045736

BP

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

HEXIM1, LATS1, TNFAIP3, NR2F2, APC, CDKN1A, CDKN1B, PLK1, HHEX, KAT2B, LATS2

GO:0045737

BP

positive regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that activates or increases the frequency, rate or extent of CDK activity.

CCNT1, CCNT2, PSMD10, PDGFB, CCND2, CCND3, CKS2, CDKN1B, CKS1B, PSRC1, PROX1, CCNL2, CDC6, CCNL1, MAPRE3

GO:0045739

BP

positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair.

EYA2, APBB1, RNF8, EYA4, EGFR, PCNA, H2AFX, BRCA1, BRCC3, CEBPG, TRIM28, UBE2V2, NPAS2

GO:0045740

BP

positive regulation of DNA replication

Any process that activates or increases the frequency, rate or extent of DNA replication.

EREG, EGFR, CST3, PDGFB, INS, PDGFA, IGF1, IL6, JUN, INSR, CDK1, NPM1, IGF1R, GLI2, PCNA, AREG, PDGFRA, ATF1, KITLG, CALR, DNA2, CDC42, RAC1, KCTD13, OBFC1, CACYBP, PDGFC

GO:0045741

BP

positive regulation of epidermal growth factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.

EREG, TGFA, ADORA1, ADAM17

GO:0045742

BP

positive regulation of epidermal growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

AGT, UBC, MMP9, AKT1, NUP62, RPS27A, UBA52, PLAUR, SOS1, AFAP1L2, ARAP1, GPER1, DOK1

GO:0045743

BP

positive regulation of fibroblast growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

CTNNB1, DSTYK, PRKD2

GO:0045744

BP

negative regulation of G-protein coupled receptor protein signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

CXCL8, CCL5, YWHAB, RGS2, RGS4, CRY1, RPH3AL

GO:0045745

BP

positive regulation of G-protein coupled receptor protein signaling pathway

Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

C3, DRD2, PHB, GPER1

GO:0045746

BP

negative regulation of Notch signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.

BCL6, NUMB, MMP14, DLK1, DLX2, PEAR1, RITA1, CHAC1, DLL4, HEY1

GO:0045747

BP

positive regulation of Notch signaling pathway

Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.

ITGB1BP1, KIT, STAT3, NOTCH1, ASCL1, TSPAN5, JAG1, ERH, HES1, AAK1, TSPAN14, PDCD10, SLC35C2, DLL4

GO:0045759

BP

negative regulation of action potential

Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

CNR1

GO:0045760

BP

positive regulation of action potential

Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

ADRA1A

GO:0045762

BP

positive regulation of adenylate cyclase activity

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.

TIMP2

GO:0045765

BP

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

TSPAN12, KRT1, ERBB2, IL6, FGF2, HMOX1, RNH1, ETS1, EFNA1, SP100, CTNNB1, ID1, LEP, EMP2, MAPK7, ENPP2, SFRP1, HTATIP2, TNFRSF12A, PLXND1

GO:0045766

BP

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

ANGPT2, GREM1, PDCD6, DDAH1, C3, IL1A, IL1B, LRG1, HSPB1, CYBB, ITGB2, SERPINE1, PRKCB, THBS1, FGF2, HMOX1, CTSH, CXCL8, RRAS, ANXA3, C6, HGF, ETS1, VEGFA, PRKCA, XBP1, C5AR1, CXCR2, NOS3, ADM, CHI3L1, CHRNA7, TGFBR2, BRCA1, WNT5A, GATA4, PGF, VEGFC, BTG1, RHOB, RUNX1, TEK, SEMA5A, PRKD1, TWIST1, PTGIS, HIF1A, CYP1B1, CCBE1, MTDH, VASH2, AGGF1, GATA6, MYDGF, PRKD2, PDCL3, HIPK2, SPHK1, ERAP1

GO:0045769

BP

negative regulation of asymmetric cell division

Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.

ASPM

GO:0045773

BP

positive regulation of axon extension

Any process that activates or increases the frequency, rate or extent of axon extension.

SEMA7A, FN1, MAPT, MAP1B, GSK3B, RAB11A, NRG1, ILK, GOLGA4, TWF2, RUFY3, NDEL1, TNFRSF12A, MACF1, TRPV2

GO:0045776

BP

negative regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is decreased.

DRD2, CNR1, PTAFR, NOS3, ADORA1, GJA5, OPRL1, VEGFC, ABAT, PPARA, ADIPOQ, SCPEP1, MKKS, APLN

GO:0045777

BP

positive regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is increased.

AGT, CNR1, ADORA1, OXTR, ID2, ADIPOQ, CARTPT, OR51E2, F11R

GO:0045778

BP

positive regulation of ossification

Any process that activates or increases the frequency, rate or extent of bone formation.

BMP2, BMP4, WNT5A, TGFB2, ZBTB16, BMPR2, TOB2, NIPBL

GO:0045779

BP

negative regulation of bone resorption

Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.

TNFRSF11B, IL6, IAPP, TNFAIP3, CSK, CARTPT, UBASH3B, INPP5D

GO:0045780

BP

positive regulation of bone resorption

Any process that activates or increases the frequency, rate or extent of bone resorption.

TNFSF11, EGFR, CA2, FSHB, TFRC, SPP1, MC4R, SYK, ADAM8, PPARGC1B

GO:0045785

BP

positive regulation of cell adhesion

Any process that activates or increases the frequency, rate or extent of cell adhesion.

RHOD, CYTH3, TNF, ERBB2, ITGAV, TPM1, SAA1, CCL5, VEGFA, PRKCA, ITGA2, TGM2, IL12A, MIP, CXCL12, ADAM8, C1QBP, STX4, PTPRJ, STX3, ANGPT1, FLCN, DUSP26, PRKD2, EPB41L4B, VAV3, ADGRG1

GO:0045786

BP

negative regulation of cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.

NUPR1, BRINP1, GMNN, TGFB1, INHA, INHBA, BMP2, BMP4, HPGD, NR4A1, PTGS2, PLA2G16, RHOB, CDK6, CDK5, ZBTB17, TP53BP2, RUNX3, PTPRK, RPS6KA2, PDCD4, LILRB1, TSPYL2

GO:0045787

BP

positive regulation of cell cycle

Any process that activates or increases the rate or extent of progression through the cell cycle.

BCL2L11, LRP6, FGFR1, CDK4, FOSL1, FGFR2, CALR, CDKN1B, ASCL1, PGGT1B, TGFB2, RPS15A, SRPK2, C6orf89, NR4A3, PROX1, CITED2, CCPG1

GO:0045792

BP

negative regulation of cell size

Any process that reduces cell size.

AKT1, RDX, PTEN, DEPTOR

GO:0045793

BP

positive regulation of cell size

Any process that increases cell size.

KDM1A, EDN1, HSP90AA1, HSP90AB1, CDK4, PRR16, RB1CC1

GO:0045794

BP

negative regulation of cell volume

Any process that decreases cell volume.

CLCN3, KCNMA1, ANO6

GO:0045795

BP

positive regulation of cell volume

Any process that increases cell volume.

SLC12A2

GO:0045796

BP

negative regulation of intestinal cholesterol absorption

Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.

ABCG8

GO:0045799

BP

positive regulation of chromatin assembly or disassembly

Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly.

TAL1

GO:0045806

BP

negative regulation of endocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.

LGALS3, MTMR2, PRKD1, LILRB1, SNX33, PACSIN1

GO:0045807

BP

positive regulation of endocytosis

Any process that activates or increases the frequency, rate or extent of endocytosis.

FLOT1, CD14, SNCA, WNT5A, ARF1, DAB2, CBLL1, MIB1, NEDD4L, TFR2

GO:0045814

BP

negative regulation of gene expression, epigenetic

Any epigenetic process that stops, prevents or reduces the rate of gene expression.

H2AFY, DNMT1, HIST1H4A, HIST1H3D, H3F3A, RBBP4, SUZ12, EZH2, PHF19, EPC1, H2AFY2, DNMT3B, MTF2

GO:0045815

BP

positive regulation of gene expression, epigenetic

Any epigenetic process that activates or increases the rate of gene expression.

MYO1C, POLR1C, CD3EAP, SMARCA5, H2AFY, POLR1A, POLR2E, DEK, POLR2K, ACTB, HIST1H4A, POLR2L, HIST1H3D, H3F3A, EP300, TAF1C, TAF1A, TAF1B, KAT2B, WBP2, MYBBP1A, POLR1E, TAF1D, ZNRD1, BAZ1B, POLR1D

GO:0045818

BP

negative regulation of glycogen catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.

INS

GO:0045820

BP

negative regulation of glycolytic process

Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.

FBP1, STAT3, HDAC4, PPARA, DDIT4, PPARGC1A

GO:0045821

BP

positive regulation of glycolytic process

Any process that activates or increases the frequency, rate or extent of glycolysis.

INS, IGF1, INSR, ARNT, PRKAA2, HIF1A

GO:0045822

BP

negative regulation of heart contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.

JAK2, ATP2A2, ATP1A2, PDE4D

GO:0045823

BP

positive regulation of heart contraction

Any process that activates or increases the frequency, rate or extent of heart contraction.

TGFB2

GO:0045824

BP

negative regulation of innate immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.

TRAFD1, DRD2, TNFAIP3, TYRO3, NMI, IFI16, IRAK3

GO:0045830

BP

positive regulation of isotype switching

Any process that activates or increases the frequency, rate or extent of isotype switching.

TFRC, UNG, MSH6, EXOSC6, EXOSC3

GO:0045833

BP

negative regulation of lipid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.

IL1B, APOC1, APOC3

GO:0045835

BP

negative regulation of meiotic nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.

PRKAR1A, LIF, RPS6KA2, FBXO5

GO:0045836

BP

positive regulation of meiotic nuclear division

Any process that activates or increases the frequency, rate or extent of meiosis.

WNT5A, SIRT2

GO:0045837

BP

negative regulation of membrane potential

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

IL6, BNIP3

GO:0045838

BP

positive regulation of membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

GLRX, ANK3

GO:0045839

BP

negative regulation of mitotic nuclear division

Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.

CHEK1, NME6, BMP4, AURKAIP1

GO:0045840

BP

positive regulation of mitotic nuclear division

Any process that activates or increases the frequency, rate or extent of mitosis.

EREG, AURKA, LRP5, PDGFB, TGFA, INS, IGF2, IL1A, IL1B, IGF1, EDN1, INSR, PDGFRB, CD28, BTC, PHIP, NUSAP1, RGCC, SH2B1

GO:0045842

BP

positive regulation of mitotic metaphase/anaphase transition

Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

RB1, CUL3, ESPL1, DLGAP5

GO:0045843

BP

negative regulation of striated muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.

SOX15, BMP4, SIRT2, LUC7L

GO:0045844

BP

positive regulation of striated muscle tissue development

Any process that activates or increases the frequency, rate or extent of striated muscle development.

GJA1, MKL2

GO:0045859

BP

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IKBKAP, FGR, CDK4, RAC2, CDC42, TRPT1, SMG8, TTN, GCN1, ELP4, TSPYL2, ECT2, ELP3, KIDINS220, FAF1

GO:0045860

BP

positive regulation of protein kinase activity

Any process that activates or increases the frequency, rate or extent of protein kinase activity.

CYR61, EREG, DAB1, GCG, TNF, CD4, RPLP1, PTPRC, ZP3, CDC25B, SDC4, CDKN1A, IQGAP1, PRKAG1, RAP1A, VLDLR, CDK5, CENPE, PTK2, GAS6, MMD, CACUL1, DUSP19, ALS2, SNX9

GO:0045861

BP

negative regulation of proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

F2, PLAT, CST3, CSTA, KNG1, INS, CSTB, SERPINE2, IDE, SERPINB3, AKT1, NR1H2, CDK5, CLN3, DNAJC1, HDAC6

GO:0045862

BP

positive regulation of proteolysis

Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

OGT, CAPN3, PLK1, IST1, ASPH, FADD, CASP8, HDAC2, BAD, CYFIP2, PERP, AURKAIP1, CLN6, BTRC

GO:0045869

BP

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.

HMGA2, TRIM28, INPP5K, APOBEC3G

GO:0045870

BP

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that activates or increases the frequency, rate or extent of retroviral genome replication.

TOP2A

GO:0045875

BP

negative regulation of sister chromatid cohesion

Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.

ESPL1, WAPL

GO:0045876

BP

positive regulation of sister chromatid cohesion

Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.

SFPQ

GO:0045879

BP

negative regulation of smoothened signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.

TULP3, RB1, SERPINE2, GLI3, PTCH1, RUNX2, KCTD11, HHIP, SALL3, IFT122, SUFU, BTRC

GO:0045880

BP

positive regulation of smoothened signaling pathway

Any process that activates or increases the frequency, rate or extent of smoothened signaling.

SHOX2, FGF9, CTNNA1, EVC, CHSY1, SFRP1, DCDC2, INTU

GO:0045892

BP

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

WWP2, ARNTL, FOXN3, BHLHE40, EREG, BTAF1, HDAC3, BIRC5, FOXP2, PER1, RBFOX2, CBFA2T2, KLF4, ATP8B1, KDM1A, GREM1, RAMP3, DNAJB6, ZNF253, ZNF217, PEX14, GMNN, RPS6KA5, HEXIM1, ZBTB7A, PDGFB, TGFB1, TNF, TP53, JUN, RB1, ENO1, GLI3, THRA, IRF1, VDR, BMP2, BMP4, XRCC5, POU2F1, FABP4, GCFC2, ZNF12, ZNF24, HMGA1, CEBPB, WT1, NR1D1, BCL3, CAPN3, ZP3, SFPQ, TNFSF4, NR2F2, MT3, HMGB2, CALR, YWHAB, CTNNB1, PHB, DDIT3, ZNF93, AHR, PPARG, ZEB1, BRCA1, ID1, BCL6, WNT5A, ELK3, NKX2-1, CBX5, CDKN1B, NOTCH1, ID4, LIMS1, SOX9, GCLC, CENPF, PPM1F, CEBPD, CDKN1C, ASCL1, DAP, SMARCA2, SMARCA4, NR0B1, HMGA2, ATXN1, NR1H2, FOXG1, HDAC4, CTBP2, SOX8, FOXL2, UBE2I, ELF3, CBX1, FOXK1, ZBED6, DAB2, CDK5, PURA, MDM2, E2F1, SET, NRG1, ID2, SP3, ID3, HHEX, CREM, PPARD, RELA, TLE1, ZNF91, ZBTB16, RING1, KHDRBS1, FOXM1, AES, FOXO1, ILF3, STRN3, KLF10, CBX3, TRIM28, IKZF1, SMAD4, HDAC1, C1D, RUNX2, GAS6, HES1, ARID5B, NR1D2, NONO, PTPRK, TWIST1, SMAD2, CCDC85B, ADIPOQ, EZH2, CRY1, IFI16, ZNF423, LRRFIP1, GON4L, PDCD4, DEPDC1, ZNF658, NIPBL, ZNF280D, ATF7IP, KCTD1, BEND5, ZBTB33, ZNF280B, PPARGC1B, GATAD2A, TMPRSS6, MINA, NOSTRIN, SIRT2, YAF2, CCAR2, SFRP1, NKAP, EID2, ZBTB38, SMARCC2, ZFPM2, PSPC1, KAT6B, HDAC2, PROX1, KAT6A, GATA6, PBXIP1, HIC2, PRMT6, PRICKLE1, PHF12, TRIB3, ATOH8, RSF1, SPEN, SETDB2, PFDN5, MPHOSPH8, PHB2, MDFI, CITED1, CITED2, MYBBP1A, INPP5K, LGR4, FOXP3, TRIM6, ZNF350, WWP1, EPC1, IKZF4, FOXP1, SUV39H2, ZNF552, SUDS3, SMURF2, PATZ1, CHD8, BRD7, PLCB1, HEYL, TCF7L2, KMT5A, PRDM6, RLIM, BCLAF1, RBAK, ZNF224, NDUFA13, ZBTB4, HDAC6, DKK3, KDM5B, LIMD1, MLX, DACH1, ZNF639, HDAC9, ZHX1, YEATS2, SNX6, TIMELESS, TRIM33, PA2G4, HDAC5, ZNF148, RASD1, BTRC, TSC22D4, L3MBTL1, LOXL2, HES2, HEY1, ZNF706, EID1

GO:0045893

BP

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

APBB1, ARNTL, FOXN3, NR5A2, ARID1A, MSTN, IRF6, AXIN1, TOX3, TGFB1I1, TBX1, KLF4, FOXO3, MED14, SMARCA5, CREBL2, EDF1, TBL1X, MITF, FZD7, LRP5, SUPT3H, TADA3, LRP6, KLF7, SEC14L2, BMP10, YEATS4, NFATC1, BMP15, BCL10, AGT, FOS, MYC, PDGFB, TGFB1, TNF, IL1B, COL1A1, ESR1, MYCN, TP53, IGF1, IL6, JUN, INSR, RB1, NPM1, INHBA, FGF2, GLI2, GLI3, MYBL1, AR, IRF1, EGR2, BMP2, BMP4, ETS1, ETS2, TCF4, TCF3, CREB1, HMGA1, IFNAR1, TAL1, ERCC2, EGR1, ATF4, ELK1, WT1, NFKB1, CCNA2, NR1D1, BCL3, CAPN3, HNF1A, MDK, ZP3, FGF7, IL10, SP100, NR2F2, CDK2, F2R, NFYB, MT3, HMGB2, ARNT, SMARCA1, MAPK1, KDM5A, OTX2, FOXN2, CKS2, CTNNB1, PHB, RORA, DDIT3, AHR, MAP2K2, TGFBR1, NUP62, PPARG, BRCA1, STAT3, WNT5A, GATA4, NKX2-1, NOTCH1, SOX9, NRIP1, PSEN1, CDKN1C, AGTR2, LHX2, CDK7, SMARCA2, SMARCA4, BRCA2, IRAK1, NEK4, MRPL12, HMGA2, BLM, NR1H2, DLX5, HDAC4, SOX8, FOXL2, CKS1B, ELF3, SMAD3, FOXK1, DAB2, TFAM, NDP, E2F1, RUNX1, ID2, SP3, MAP2K1, CREB5, POU3F1, PPARD, RELA, ACVR1, YWHAH, ZBTB16, MEF2C, PAX8, SOX4, PPARA, FOXM1, FOXO1, ILF2, ILF3, FOXC1, MLLT11, ZBTB17, NR1H3, BAMBI, TRIM28, UBE2V1, ILK, NFATC2, SMAD4, PICALM, HDAC1, PTCH1, RUNX3, NCOA4, RUNX2, HNRNPD, NPAT, NFE2L1, NR1D2, ERBB4, NCOA1, SMAD2, ZFHX3, ZIC1, HIF1A, ZNF423, HIVEP3, RGMB, PSRC1, ATAD2, SMARCD3, ATF7IP, KDM7A, RNF111, GPBP1, CRLF3, TP53INP2, YAF2, KMT2E, SFRP1, AFAP1L2, BANP, CTCFL, SMARCC2, SETD7, CHURC1, NAT14, PHIP, ARNTL2, KAT6B, ESR2, HDAC2, PROX1, CREBBP, KAT6A, TAF15, SMARCC1, MED12, TP53INP1, MED30, ATOH8, RSF1, KLF6, SMAD5, HNRNPAB, NPAS2, CITED1, CITED2, SOST, INPP5K, WAC, NUP85, LGR4, NAA15, TBL1XR1, FOXP3, NIF3L1, EPC1, HIPK2, SMARCAD1, SOX17, ZNF287, GPBP1L1, CHD8, ENY2, BRD7, MED4, PLCB1, MED17, RRN3, EHF, PPARGC1A, RNF14, FZD4, USP22, MAPRE3, RNF6, BTRC, MYRF, THRAP3, MED16, NFE2L3, KLF2, WNT6, NCOA3

GO:0045898

BP

regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

ATF7IP

GO:0045899

BP

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

CREB1, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, CAND1

GO:0045900

BP

negative regulation of translational elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

SRP9

GO:0045901

BP

positive regulation of translational elongation

Any process that activates or increases the frequency, rate or extent of translational elongation.

EIF5A, EIF5A2

GO:0045903

BP

positive regulation of translational fidelity

Any process that increases the ability of the translational apparatus to interpret the genetic code.

RPS9

GO:0045905

BP

positive regulation of translational termination

Any process that activates or increases the frequency, rate or extent of translational termination.

EIF5A, EIF5A2

GO:0045906

BP

negative regulation of vasoconstriction

Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.

ADM, LEP, BMPR2, APLN

GO:0045907

BP

positive regulation of vasoconstriction

Any process that activates or increases the frequency, rate or extent of vasoconstriction.

EGFR, FGA, FGB, FGG, ICAM1, GJA1, ADRA1D, PTAFR, F2R, AVPR2, OXTR, AKT1, ADRA1A, PTGS2, HRH1, ADRA1B, GJA5, CAV1, TRPM4

GO:0045908

BP

negative regulation of vasodilation

Any process that stops, prevents, or reduces the frequency, rate or extent of vasodilation.

INS, CRP, HMGCR, ADORA1

GO:0045909

BP

positive regulation of vasodilation

Any process that activates or increases the frequency, rate or extent of vasodilation.

EGFR, AGT, INS, HMOX1, GJA1, PTAFR, PTPRM, NOS3, ADM, GJA5, AGTR2, F2RL1, PPARD, PTGDR, GPER1, SCPEP1, APLN

GO:0045910

BP

negative regulation of DNA recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

MSH3, MSH2, MSH6, BLM

GO:0045916

BP

negative regulation of complement activation

Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.

CD55

GO:0045917

BP

positive regulation of complement activation

Any process that activates or increases the frequency, rate or extent of complement activation.

PHB

GO:0045918

BP

negative regulation of cytolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.

PF4, BAD

GO:0045919

BP

positive regulation of cytolysis

Any process that activates or increases the frequency, rate or extent of cytolysis.

GPLD1, LILRB1

GO:0045920

BP

negative regulation of exocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.

ANXA1, SNCA, STXBP6

GO:0045921

BP

positive regulation of exocytosis

Any process that activates or increases the frequency, rate or extent of exocytosis.

RAB27B, FGA, FGB, FGG, CFTR, RAB5A, RAB9A, RAB27A, NCS1, STXBP5, EXPH5, RAB2B, SYTL4

GO:0045922

BP

negative regulation of fatty acid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

INS

GO:0045923

BP

positive regulation of fatty acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

ADIPOQ, GHSR

GO:0045925

BP

positive regulation of female receptivity

Any process that activates or increases the receptiveness of a female to male advances.

THRA, NCOA1

GO:0045926

BP

negative regulation of growth

Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.

MT2A, MT1E, MT1F, MT1G, IGFBP5, MT1H, MT1X, HIF1A, MT1M, PNPT1

GO:0045927

BP

positive regulation of growth

Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.

ZPR1, PPM1F

GO:0045930

BP

negative regulation of mitotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

BRINP1, EGFR, TGFB1, TIMP2, IL10, CDKN1B, GAS1, SMAD3, FOXC1, DLG1, MAD2L1, HECA, TRIM35

GO:0045931

BP

positive regulation of mitotic cell cycle

Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.

USP2, APP, CDK1, EIF4E, ASNS, CCNB1, PRKCA, TAL1, CDC25B, DUSP3, BRCA2, STAT5B, MDM2, PTPN11, EIF4EBP1, SHB, PKN2, SPHK1, USP22, POLDIP2

GO:0045932

BP

negative regulation of muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.

TNNT1

GO:0045943

BP

positive regulation of transcription from RNA polymerase I promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter.

PPP1R15A, ERBB2, UBTF, ATF4

GO:0045944

BP

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

E2F8, MED19, HAX1, TLR4, APBB1, SUPT5H, WWP2, ARNTL, MEIS1, NR5A2, DDX3X, CYR61, NFIB, ITGB1BP1, TNFSF11, BACH1, CASK, PPP1R12A, SMAD7, PLSCR1, OGT, SOX12, HDAC3, TLR3, MAFG, PER1, RIPK2, HOXA2, TBX1, CBFA2T2, KLF4, FOXO3, LDB2, TCF21, TRIAP1, RAD21, MED14, SOX15, PARK2, ZEB2, KDM1A, CCNT1, GREM1, CCNT2, TLR2, BRD4, SHOX2, TBL1X, MITF, LRP5, MAF, LRP6, RPS6KA5, MED6, NFAT5, ABLIM3, TNKS, NFATC1, IL33, EGFR, FOS, MYC, TGFB1, POMC, CGA, FSHB, PTH, TNF, IL1A, IL1B, PF4, ESR1, RAF1, NR3C1, MYCN, TP53, IGF1, APP, SERPINE1, IL6, EDN1, JUN, RB1, PGR, ADRB2, DCN, PFN1, INHBA, MET, NFIC, FGF2, HOXB5, HMGB1, WNT2, PARP1, H2AFZ, UBC, GLI2, GLI3, MYBL1, MYBL2, AR, NR2F1, CD28, THRA, IRF1, EGR2, TOP2A, VDR, ESRRA, BMP2, BMP4, SKI, HGF, HCLS1, DRD2, ETS1, LIF, ETS2, FOSL1, FOSL2, VEGFA, TCF4, TCF3, CREB1, EPCAM, RHOQ, HMGA1, JUNB, JUND, TAL1, CEBPB, DDX5, XBP1, ERCC2, ARF4, EGR1, ATF1, ATF3, ATF4, ELK1, TFEB, WT1, NFKB1, BCL3, IL11, HNF1A, S1PR1, FGFR2, BMP6, IL10, NME2, GAL, NR4A1, ITGA6, YY1, LMO2, HMGB2, ACVR2A, MAPK3, ARNT, PIK3R1, HOXD10, MZF1, RXRB, RBL1, HOXA10, AKT1, OTX2, GTF2H1, CTNNB1, RORA, DDIT3, SOX6, AHR, BMPR1A, ACVR1B, SREBF1, PPARG, ZEB1, RBMX, BRCA1, PBX1, PBX2, STAT3, ETV5, WNT5A, ELK3, CDKN2B, NR4A2, NAMPT, GATA4, NKX2-1, ATRX, NOTCH1, YAP1, ID4, SOX9, NRIP1, SLC11A1, CDK8, CEBPD, GSK3B, MEOX1, LHX2, ETV1, ASCL1, CDK7, SMARCA2, SMARCA4, STAT5B, LUM, GTF2A2, HMGA2, FOSB, CEBPG, SUB1, NR1H2, F2RL1, MLLT10, CDH13, HDAC4, CTBP2, SOX8, FOXL2, CD81, SUMO2, LMO4, RPS27A, UBA52, YBX1, IGBP1, JAG1, PRKDC, ELF3, SMAD3, PKD1, FOXO4, TFAM, HSF1, E2F1, RUNX1, RELB, POU5F1, MEF2A, NRG1, SP3, HHEX, POU3F1, CREM, CEBPZ, RELA, ACVR1, REL, RNASEL, EXOSC9, MEF2C, GABPA, PAX8, SOX4, DLX2, PPARA, FOXM1, PPP3CA, EP300, SREBF2, FOXO1, HYAL2, FOXC1, NR1H3, TARDBP, FADD, MAP2K5, MAPK7, TRIM28, IKZF1, NFATC2, SMAD4, SQSTM1, MED21, RIPK1, HDAC1, PKD2, BMPR2, CBFB, NFYC, CAMK1, IL18, TFDP1, HES1, NFE2L1, LPIN1, MEF2D, MTF1, NFATC4, MORF4L2, PRKD1, PPP2R5B, ANKRD1, PCBP1, RPS6KA1, TEAD2, NCOA2, TWIST1, NCOA1, SMAD2, SMAD1, ADIRF, USF2, ZIC1, HLF, MAPK14, HIF1A, IFI16, ARID4B, DCAF6, PLAG1, JADE1, NIPBL, ATAD2, SLC30A9, CRTC3, RNF111, ASXL2, PID1, SETX, MAVS, AKNA, PCGF5, NLRC5, PPARGC1B, TMPRSS6, CRLF3, SIRT2, MAML2, AHI1, ZNF567, ZBTB38, NFATC2IP, GLIS3, ZMIZ2, FLCN, LILRB1, NCOA7, CTCFL, GABPB2, OSR1, ZNF564, ZFPM2, GLMP, CKAP2, PHIP, ARNTL2, KAT6B, CSRNP3, RTF1, NR4A3, HSPH1, HDAC2, PROX1, CREBBP, EZH1, KAT2B, DDX17, GATA6, SMARCC1, ARHGEF2, MED12, MYDGF, WBP2, ZBED3, ABHD14B, MAML3, ZNF462, IFT74, NR1H4, CITED4, CSRNP1, CCNL2, ZNF382, UHRF1, TCF12, GPER1, TEAD3, MEIS3, PITX2, NPAS2, EPAS1, ARID3A, CITED1, CITED2, PAGR1, SSBP3, HELZ2, TBL1XR1, PRKD2, FOXP3, PEG3, ZNF350, CSRNP2, NUCKS1, EPC1, IKZF4, DHX36, HIPK2, FZD8, RGCC, SOX17, SMYD3, EBF2, BCL2L12, PATZ1, BEX1, TAF9B, CHD8, SLC40A1, HEYL, TCF7L2, ASH1L, MED17, AATF, EHF, GRHL1, CHD7, RERE, PPARGC1A, ASH2L, TCF20, ARMCX3, TBK1, TRPS1, NUFIP1, ZNF639, KLF15, CNOT7, MOSPD1, CCNL1, AGO2, ELF5, CCPG1, MKL2, ZMIZ1, MAFF, MYO6, PLAGL1, TFR2, HDAC5, ZNF148, RUVBL2, HIF3A, THRAP3, KLF13, MTF2, PAXBP1, HEY1, MAFB, KLF2, FHOD1, CHCHD2, NCOA3, CAMTA1

GO:0045945

BP

positive regulation of transcription from RNA polymerase III promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter.

ERBB2, AR, ICE2, CHD8

GO:0045947

BP

negative regulation of translational initiation

Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.

TPR, FMR1, EIF4EBP1, EIF4EBP2, PAIP2, RBM4, EIF2AK4, EIF2B4, AGO2

GO:0045948

BP

positive regulation of translational initiation

Any process that activates or increases the frequency, rate or extent of translational initiation.

DDX3X, POLR2D, CDC123, CCL5, POLR2G, KHDRBS1, EIF2B5, UHMK1, YTHDF1

GO:0045950

BP

negative regulation of mitotic recombination

Any process that inhibits or decreases the rate of DNA recombination during mitosis.

MLH1

GO:0045953

BP

negative regulation of natural killer cell mediated cytotoxicity

Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.

MICA, LILRB1

GO:0045954

BP

positive regulation of natural killer cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.

LAMP1, PVR, VAV1, LAG3, IL12A, STAT5B, CADM1

GO:0045955

BP

negative regulation of calcium ion-dependent exocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.

NOTCH1, TRIM9