| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0045485 | MF | omega-6 fatty acid desaturase activity | Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. |
FADS1 |
GO:0045494 | BP | photoreceptor cell maintenance | Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. |
MAK, CROCC, DRAM2, BBS12, NPHP3, BBS1, BBS10, GPR98, BBS2, MKKS, SPATA7 |
GO:0045499 | MF | chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
SEMA3E, FLRT2, SEMA3D, APOA1, EFNA5, NRG1, SEMA3B, SEMA5A, SEMA3A, SEMA6D, SEMA3C, SEMA6A, SEMA4A, SEMA6B, FLRT3 |
GO:0045502 | MF | dynein binding | Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. |
RAB29, BCL2L11, NEFH, SNCA, CENPF, FMR1, DCTN1, BICD1, KATNB1, SMC3 |
GO:0045503 | MF | dynein light chain binding | Interacting selectively and non-covalently with a light chain of the dynein complex. |
DYNC1I1 |
GO:0045504 | MF | dynein heavy chain binding | Interacting selectively and non-covalently with a heavy chain of the dynein complex. |
DNALI1, DYNC2LI1 |
GO:0045505 | MF | dynein intermediate chain binding | Interacting selectively and non-covalently with an intermediate chain of the dynein complex. |
HTT, DNAAF5 |
GO:0045509 | MF | interleukin-27 receptor activity | Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL6ST |
GO:0045513 | MF | interleukin-27 binding | Interacting selectively and non-covalently with interleukin-27. |
IL12A |
GO:0045540 | BP | regulation of cholesterol biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. |
SEC14L2, APOB, DHCR7 |
GO:0045541 | BP | negative regulation of cholesterol biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. |
ERLIN2, APOE |
GO:0045542 | BP | positive regulation of cholesterol biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. |
SREBF1 |
GO:0045545 | MF | syndecan binding | Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. |
SDCBP, TNC, SEMA5A, HPSE |
GO:0045550 | MF | geranylgeranyl reductase activity | Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. |
AKR1C3 |
GO:0045556 | BP | positive regulation of TRAIL biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand. |
TNFRSF8 |
GO:0045569 | MF | TRAIL binding | Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. |
TNFRSF10C |
GO:0045576 | BP | mast cell activation | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
NDRG1 |
GO:0045577 | BP | regulation of B cell differentiation | Any process that modulates the frequency, rate or extent of B cell differentiation. |
ZFP36L2, ZFP36L1 |
GO:0045578 | BP | negative regulation of B cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. |
INHA, INHBA, ID2, SFRP1 |
GO:0045579 | BP | positive regulation of B cell differentiation | Any process that activates or increases the frequency, rate or extent of B cell differentiation. |
XBP1, CD27, SYK, MMP14, STAT5B, INPP5D, BAD |
GO:0045580 | BP | regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. |
SLC46A2, CYP26B1, PRELID1 |
GO:0045581 | BP | negative regulation of T cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. |
CD74 |
GO:0045582 | BP | positive regulation of T cell differentiation | Any process that activates or increases the frequency, rate or extent of T cell differentiation. |
CD74, RAG1, XBP1, IL12A, BAD |
GO:0045586 | BP | regulation of gamma-delta T cell differentiation | Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation. |
EGR3 |
GO:0045588 | BP | positive regulation of gamma-delta T cell differentiation | Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. |
SYK, STAT5B |
GO:0045589 | BP | regulation of regulatory T cell differentiation | Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. |
CD28, FANCD2 |
GO:0045590 | BP | negative regulation of regulatory T cell differentiation | Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. |
IRF1, TNFSF4 |
GO:0045591 | BP | positive regulation of regulatory T cell differentiation | Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. |
TGFB1, CD46, HLA-G |
GO:0045595 | BP | regulation of cell differentiation | Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. |
KLF4, SPRY2, FADS1, PTBP3, RAF1, FGFR1, APC, PPP2R1A, SIK1, RUNX3, RUNX2, SPOCK2, PLEKHB2, PLEKHB1, TCFL5, EID1 |
GO:0045596 | BP | negative regulation of cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. |
HMGB3, TBX1, GDF11, KRAS, TGFB1, ITGB1, IAPP, SKIL, MAPK1, NR0B1, CDK6, SUZ12, ANP32B, HOPX, ELF5 |
GO:0045597 | BP | positive regulation of cell differentiation | Any process that activates or increases the frequency, rate or extent of cell differentiation. |
SOCS3, PAX4, JAK2, INS, JUN, AR, JUNB, JUND, CTGF, BTC, NF2, INSM1, ZNF268, RPS6KA1, PPP1R13L, SOX17, PA2G4 |
GO:0045598 | BP | regulation of fat cell differentiation | Any process that modulates the frequency, rate or extent of adipocyte differentiation. |
NR1D1, HES1, MEX3C, LGALS12, HDAC6 |
GO:0045599 | BP | negative regulation of fat cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. |
ARNTL, AXIN1, INSIG1, TGFB1, TNF, IL6, ENPP1, MMP11, RORA, DDIT3, WNT5A, ID4, ZFP36L2, JAG1, SMAD3, E2F1, FOXO1, CCDC85B, ADIPOQ, BBS12, SIRT2, ZFPM2, JDP2, TRIB2, TRIB3, GPER1 |
GO:0045600 | BP | positive regulation of fat cell differentiation | Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. |
SH3PXD2B, SNAI2, CREBL2, LRP5, BMP2, CREB1, CEBPB, XBP1, ZFP36, HTR2C, AKT1, PPARG, ID2, PPARD, ZBTB16, ZFP36L1, STK4, ADIRF, ASXL2, CARM1, SFRP1, TRPM4, RARRES2, CCDC3, WNT5B, NOCT, WIF1 |
GO:0045601 | BP | regulation of endothelial cell differentiation | Any process that modulates the frequency, rate or extent of endothelial cell differentiation. |
APOLD1 |
GO:0045602 | BP | negative regulation of endothelial cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. |
ID1, XDH |
GO:0045603 | BP | positive regulation of endothelial cell differentiation | Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. |
BMP4, BMP6, CTNNB1, NOTCH1, BTG1, ATOH8 |
GO:0045604 | BP | regulation of epidermal cell differentiation | Any process that modulates the frequency, rate or extent of epidermal cell differentiation. |
MAFG, MAFF |
GO:0045605 | BP | negative regulation of epidermal cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. |
EZH2 |
GO:0045606 | BP | positive regulation of epidermal cell differentiation | Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. |
BMP4, SFN, PTCH1, SFRP4 |
GO:0045607 | BP | regulation of auditory receptor cell differentiation | Any process that modulates the frequency, rate or extent of auditory hair cell differentiation. |
MYCN |
GO:0045608 | BP | negative regulation of auditory receptor cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation. |
NOTCH1, HES1 |
GO:0045616 | BP | regulation of keratinocyte differentiation | Any process that modulates the frequency, rate or extent of keratinocyte differentiation. |
ROCK2, ZFP36, ZFP36L1, AQP3, ERRFI1 |
GO:0045617 | BP | negative regulation of keratinocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. |
SRSF6 |
GO:0045618 | BP | positive regulation of keratinocyte differentiation | Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. |
CYP27B1, H2AFY, VDR, NME2, NOTCH1, H2AFY2, NCOA3 |
GO:0045619 | BP | regulation of lymphocyte differentiation | Any process that modulates the frequency, rate or extent of lymphocyte differentiation. |
FAS, NDFIP1 |
GO:0045624 | BP | positive regulation of T-helper cell differentiation | Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. |
SHB |
GO:0045626 | BP | negative regulation of T-helper 1 cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation. |
TNFSF4, IL4R, JAK3 |
GO:0045627 | BP | positive regulation of T-helper 1 cell differentiation | Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation. |
RIPK2, SOCS5, ANXA1 |
GO:0045629 | BP | negative regulation of T-helper 2 cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation. |
SOCS5, ANXA1, BCL6 |
GO:0045630 | BP | positive regulation of T-helper 2 cell differentiation | Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. |
IL6, TNFSF4, IL4R, IL18 |
GO:0045634 | BP | regulation of melanocyte differentiation | Any process that modulates the frequency, rate or extent of melanocyte differentiation. |
GNA11, GNAQ |
GO:0045636 | BP | positive regulation of melanocyte differentiation | Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. |
ZEB2, BCL2, KITLG, ADAMTS20, ADAMTS9 |
GO:0045637 | BP | regulation of myeloid cell differentiation | Any process that modulates the frequency, rate or extent of myeloid cell differentiation. |
FAS, PURB, CSF3R |
GO:0045638 | BP | negative regulation of myeloid cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. |
MEIS1, CDK6, ZBTB16, RBM15 |
GO:0045639 | BP | positive regulation of myeloid cell differentiation | Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. |
LEP, JAG1 |
GO:0045645 | BP | positive regulation of eosinophil differentiation | Any process that activates or increases the frequency, rate or extent of eosinophil differentiation. |
TRIB1 |
GO:0045646 | BP | regulation of erythrocyte differentiation | Any process that modulates the frequency, rate or extent of erythrocyte differentiation. |
LYN, CDK6 |
GO:0045647 | BP | negative regulation of erythrocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. |
ZFP36, STAT5B, ZFP36L1, KLF13, MAFB |
GO:0045648 | BP | positive regulation of erythrocyte differentiation | Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. |
FOXO3, KDM1A, ISG15, INHBA, ETS1, TAL1, HMGB2, ACVR2A, ARNT, ACVR1B, STAT5B, ID2, MAPK14, HIF1A, INPP5D, PRMT1 |
GO:0045650 | BP | negative regulation of macrophage differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. |
INHA, INHBA, PTPN2, ADIPOQ |
GO:0045651 | BP | positive regulation of macrophage differentiation | Any process that activates or increases the frequency, rate or extent of macrophage differentiation. |
PF4, RB1, HCLS1, LIF, PRKCA, ID2, FADD, RIPK1, CASP8, IL34, TRIB1 |
GO:0045652 | BP | regulation of megakaryocyte differentiation | Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. |
EIF6, MEF2C, L3MBTL1 |
GO:0045653 | BP | negative regulation of megakaryocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. |
PF4, HIST1H4A, GABPA, CIB1, PRMT1 |
GO:0045654 | BP | positive regulation of megakaryocyte differentiation | Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. |
KDM1A, HMGB2 |
GO:0045655 | BP | regulation of monocyte differentiation | Any process that modulates the frequency, rate or extent of monocyte differentiation. |
FOXP1 |
GO:0045656 | BP | negative regulation of monocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. |
MYC, APCS, CDK6, INPP5D |
GO:0045657 | BP | positive regulation of monocyte differentiation | Any process that activates or increases the frequency, rate or extent of monocyte differentiation. |
JUN, ZFP36L1, IL34 |
GO:0045659 | BP | negative regulation of neutrophil differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation. |
INPP5D, TRIB1 |
GO:0045661 | BP | regulation of myoblast differentiation | Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
CAPN3, ZFP36L1 |
GO:0045662 | BP | negative regulation of myoblast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
MSTN, CXCL14, TGFB1, TNF, BMP4, DDIT3, NOTCH1, SOX9, SOX8, ID3, PPARD, IL18, MBNL3 |
GO:0045663 | BP | positive regulation of myoblast differentiation | Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
IGFBP3, BTG1, MEF2C, ILK, MAPK14, MAP3K5, PLCB1 |
GO:0045664 | BP | regulation of neuron differentiation | Any process that modulates the frequency, rate or extent of neuron differentiation. |
BIN1, NGF, YWHAH, ZFHX3, NREP, CASZ1, NLGN1 |
GO:0045665 | BP | negative regulation of neuron differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. |
MEIS1, HOXA2, FOXO3, APP, EIF4E, GLI3, CALR, PBX1, ID4, ASCL1, IRX3, JAG1, ID2, DIXDC1, MIB1, CNTN4, ASPM, CTDSP1, HMG20A, EIF4ENIF1, EIF2AK4, PRPF19 |
GO:0045666 | BP | positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
SPAG9, BRINP1, DAB1, GLI2, FGFR1, BMP2, BMP4, TCF4, TCF3, TIMP2, ADRA2B, BMP6, ZEB1, ETV5, BCL6, NBL1, GDF5, ASCL1, RHOA, IRX3, MEF2C, MMD, NCOA1, DUOXA1, KCTD11, CYB5D2, NRCAM, TCF12, TLE6, ECT2, LIN28A, HEYL, GPRC5B, HMG20B, IMPACT, DNMT3B, NAP1L2, MAPK8IP3, TRPC6 |
GO:0045667 | BP | regulation of osteoblast differentiation | Any process that modulates the frequency, rate or extent of osteoblast differentiation. |
SNAI2, ESRRA, PRKACA, DDX5, FGFR2, PTK2 |
GO:0045668 | BP | negative regulation of osteoblast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. |
HOXA2, LRP5, TNF, SKI, AREG, IGFBP5, ID1, NOTCH1, HDAC4, SMAD3, CDK6, ID2, ID3, PTCH1, NBR1, TWIST1, SFRP1, TRPM4, HDAC7, CITED1, LIMD1, NOCT, SUFU |
GO:0045669 | BP | positive regulation of osteoblast differentiation | Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. |
CLIC1, CYR61, IGF1, IL6, IL6R, GLI3, BMP2, BMP4, IFITM1, HGF, GJA1, JUND, CEBPB, BMP6, ACVR2A, CTNNB1, FBN2, BMPR1A, IL6ST, ID4, CEBPD, JAG1, GNAS, ACVR1, MEF2C, ILK, ACVR2B, BMPR2, RUNX2, PRKD1, SMAD1, GNAS, CD276, FAM20C, CTHRC1, SMAD5, PDLIM7 |
GO:0045670 | BP | regulation of osteoclast differentiation | Any process that modulates the frequency, rate or extent of osteoclast differentiation. |
MITF, FSHB, BGLAP, ESRRA, CEBPB, FSHR, FAM213A |
GO:0045671 | BP | negative regulation of osteoclast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. |
TLR4, TLR3, CCL3, PIK3R1, CTNNB1, FBN1, TOB2, CARTPT, SFRP1, LRRC17, TMEM178A, ZNF675, UBASH3B, INPP5D, MAFB |
GO:0045672 | BP | positive regulation of osteoclast differentiation | Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. |
TNFSF11, CA2, FOS, TNF, CREB1, GNAS, KLF10, GNAS, PPARGC1B |
GO:0045682 | BP | regulation of epidermis development | Any process that modulates the frequency, rate or extent of epidermis development. |
NME2 |
GO:0045684 | BP | positive regulation of epidermis development | Any process that activates or increases the frequency, rate or extent of epidermis development. |
PPARD |
GO:0045686 | BP | negative regulation of glial cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. |
LIN28A |
GO:0045703 | MF | ketoreductase activity | Catalysis of the reduction of a ketone group to form the corresponding alcohol. |
AKR1C3 |
GO:0045713 | BP | low-density lipoprotein particle receptor biosynthetic process | The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells. |
PPARG |
GO:0045714 | BP | regulation of low-density lipoprotein particle receptor biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors. |
FURIN |
GO:0045715 | BP | negative regulation of low-density lipoprotein particle receptor biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors. |
ITGB3, ITGAV, ADIPOQ |
GO:0045716 | BP | positive regulation of low-density lipoprotein particle receptor biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors. |
CNPY2 |
GO:0045717 | BP | negative regulation of fatty acid biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. |
INSIG1, ERLIN2, APOC1, APOC3, BRCA1, ACADVL, TRIB3 |
GO:0045719 | BP | negative regulation of glycogen biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. |
ENPP1, GSK3B, PASK, VIMP, INPP5K |
GO:0045720 | BP | negative regulation of integrin biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. |
AR, TMEFF2 |
GO:0045721 | BP | negative regulation of gluconeogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. |
INS, IL6, MST1, LEPR, CLK2, SIK1, ADIPOQ, SERPINA12, C1QTNF3 |
GO:0045722 | BP | positive regulation of gluconeogenesis | Any process that activates or increases the frequency, rate or extent of gluconeogenesis. |
PTPN2, ARPP19, PPARA, FOXO1, DGAT2, PPARGC1A |
GO:0045723 | BP | positive regulation of fatty acid biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. |
APOA1, NR1H2, NR1H3, RGN, APOA5, MID1IP1 |
GO:0045724 | BP | positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
HTT, CEP120, MNS1 |
GO:0045725 | BP | positive regulation of glycogen biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. |
PTH, INS, IGF2, IGF1, INSR, AKT1, AKT2, IRS1, EPM2AIP1, DYRK2, SORBS1, IRS2 |
GO:0045726 | BP | positive regulation of integrin biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. |
AR, TGFB2 |
GO:0045727 | BP | positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. |
DDX3X, ERBB2, IL6, NPM1, THBS1, CD28, CDK4, EEF2, ITGA2, BCL3, PTAFR, MAPK3, MAPK1, EIF6, RBM3, KRT17, FMR1, SOX4, CIRBP, HNRNPD, ELAVL1, PRR16, LARP1, RPS27L, GUF1, CPEB3, PASK, PINK1, POLDIP3, FAM129A, PAIP1, UPF3A, LIN28A, SAMD4A |
GO:0045730 | BP | respiratory burst | A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
CYBB, CD55, PGAM1, NCF2, CD24, SLC11A1 |