GO:0045116

BP

protein neddylation

Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.

UBE2M, RBX1, NAE1, NEDD8, DCUN1D4, DCUN1D1

GO:0045120

CC

pronucleus

The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.

AURKA, HNRNPL, CENPF, HSF1, EZH2

GO:0045121

CC

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

MYO1C, SDCBP, SYNJ2, NPC1, PLSCR1, CFLAR, DAPK3, TLR2, JAK2, FLOT1, ERLIN2, ABCA1, BCL10, EGFR, PGK1, KRAS, TNF, CD4, PRNP, GNAI2, APP, ICAM1, ITGB1, FYN, LDHB, CTSD, ANXA2, LYN, CD55, CD14, PTPRC, GNAI3, CD48, FURIN, HSPD1, DMD, TDGF1, EEF2, SLC2A4, PECAM1, SELE, CD36, RHOQ, GJA1, HK1, ATP2B1, TNFRSF1B, RAB5A, MAL, S1PR1, CNR1, CD24, FAS, STOM, DPP4, PPP2R1B, PRKAR2B, SDC4, GPC1, BSG, TGFBR1, TGFBR2, CSK, IQGAP1, PSEN1, SERPINH1, PPT1, CAV2, EPHB1, EMP2, S100A10, RAP2B, GNAI1, CXADR, OLR1, ADAM17, ANK2, TEK, CAV1, AHNAK, BST2, CNTN1, HYAL2, DLG1, MALL, FADD, CBLB, CLN3, BIRC3, GPM6B, RIPK1, DAG1, RFTN1, CASP8, ANGPT1, TLR1, TRADD, RFTN2, LAMTOR1, RGMB, PTRF, RTN4RL1, SULF1, UNC5B, ITLN1, TNR, INPP5D, GHSR, MAL2, EFHD2, MYADM, ARID3A, SORBS1, SMURF2, PAG1, GPRC5B, HPSE, PIKFYVE, ADGRG1

GO:0045123

BP

cellular extravasation

The migration of a leukocyte from the blood vessels into the surrounding tissue.

ITGB2

GO:0045124

BP

regulation of bone resorption

Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).

BGLAP, ITGB3, CSF1R, S1PR1, PDK4

GO:0045128

BP

negative regulation of reciprocal meiotic recombination

Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.

MSH2

GO:0045132

BP

meiotic chromosome segregation

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.

SMC2, SGOL1, WAPL, SMC4

GO:0045134

MF

uridine-diphosphatase activity

Catalysis of the reaction: UDP + H2O = UMP + phosphate.

ENTPD6

GO:0045136

BP

development of secondary sexual characteristics

The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.

B4GALT1, BAX

GO:0045141

BP

meiotic telomere clustering

The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.

MLH1, TERF1, UBE2B

GO:0045143

BP

homologous chromosome segregation

The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.

PTTG1, PLK1, ESPL1

GO:0045145

MF

single-stranded DNA 5'-3' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.

EXO1

GO:0045155

MF

electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity

Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex.

CYC1, CYCS

GO:0045159

MF

myosin II binding

Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.

TRIOBP

GO:0045160

CC

myosin I complex

A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.

MYO1C

GO:0045162

BP

clustering of voltage-gated sodium channels

The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.

GLDN, NRCAM, SPTBN4

GO:0045163

BP

clustering of voltage-gated potassium channels

The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.

KCNIP2

GO:0045165

BP

cell fate commitment

The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

SOX12, SPRY2, WNT2, BMP2, TAL1, GAP43, FGFR2, PPARG, WNT5A, GATA4, GAS1, WNT3, SOX8, ERBB4, SMAD2, GATA6, WNT2B, WNT5B, TRPS1, WNT6

GO:0045171

CC

intercellular bridge

A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.

CDC7, RAB11FIP3, TDP2, ESRRA, BCL3, XPA, PRKCI, PIK3CB, TIRAP, KIF23, UNC119, CEP55, CDCA8, TEX14, KMT2E, PPP1R13L, AURKB, EAF1, C9orf72, C12orf66, SNRNP25, PCIF1, SRA1, FAN1

GO:0045174

MF

glutathione dehydrogenase (ascorbate) activity

Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.

GSTO1, GSTO2

GO:0045176

BP

apical protein localization

Any process in which a protein is transported to, or maintained in, apical regions of the cell.

ARF4, MAL, RDX, SHROOM2, DLG5, SHROOM3, GOPC

GO:0045177

CC

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

CHL1, DAB1, AQP8, PLAT, CA2, LDLR, APP, MGST1, EZR, VCAM1, ATP6V1C1, C5AR1, TUBG1, CTNNB1, NF2, SLC11A2, NUMB, CLCN5, VAMP7, EMP2, CDC42, GPSM2, ACVR1, TJP1, IFIT5, ITPR3, HFE, HOMER1, DYNC2LI1, PARD6B, EPB41L4B, PARD6A, MYO6

GO:0045178

CC

basal part of cell

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.

TF, EDN1, ITGA2, SLC11A2, HFE, DOCK7, HOMER3

GO:0045179

CC

apical cortex

The region that lies just beneath the plasma membrane on the apical edge of a cell.

GM2A, NLRP5, HAMP, MYO5B

GO:0045180

CC

basal cortex

The region that lies just beneath the plasma membrane on the basal edge of a cell.

PKD2, PHLDB2, PHLDB1

GO:0045182

MF

translation regulator activity

Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

IGF2BP3, RPS9, RPS14, IGF2BP2

GO:0045184

BP

establishment of protein localization

The directed movement of a protein to a specific location.

CHMP2A, RAP2A, ITGA2, FLNA, RDX, LIMS1, PLK1, IST1, VCP, DLG4, MDM2, ANK3, KPNB1, KIF14, CEP55, PHLDB2, NLGN1, WBP2, VIMP, SMYD3, CRIPT, CORO1C

GO:0045186

BP

zonula adherens assembly

Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

DLG5

GO:0045187

BP

regulation of circadian sleep/wake cycle, sleep

Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.

PTGDS

GO:0045188

BP

regulation of circadian sleep/wake cycle, non-REM sleep

Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.

IL6

GO:0045190

BP

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

NBN, RNF8, ERCC1, CD40LG, MLH1, MSH2, MSH6, EXOSC6, EXOSC3, EXO1

GO:0045191

BP

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

IL10, SUPT6H

GO:0045197

BP

establishment or maintenance of epithelial cell apical/basal polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.

ARF4, PRKCI, DLG4, DLG1, ILK, DLG5

GO:0045198

BP

establishment of epithelial cell apical/basal polarity

The specification and formation of the apicobasal polarity of an epithelial cell.

WNT5A, TCF15, PTK7

GO:0045199

BP

maintenance of epithelial cell apical/basal polarity

The maintenance of the apicobasal polarity of an epithelial cell.

WDR1, LHX2, PDZD11, LIN7B, LIN7C

GO:0045200

BP

establishment of neuroblast polarity

The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.

FGF13, DOCK7

GO:0045202

CC

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

KCNK1, APBB1, RGS12, ARPC2, FLRT2, LRP6, UNC5C, SNAPIN, EGFR, APP, PFN1, CHRM2, MME, ITGA5, C4A, C4B, CHRNB1, DMD, CCL2, CDH2, CHRM3, CALB2, MPST, HTR2B, MTHFR, VAMP7, VAMP2, DLG4, MDM2, FMR1, KCNA1, STX4, SNTB2, SNTB1, SEPT2, ITSN1, VAMP3, CPEB4, SDK2, PDZD11, SARM1, CBLN3, NSMF, DNMBP, SHISA6, CYFIP1, RASGRP2, SDK1, CPEB2, MAGI2, ERC1, NLGN4X, SPG20, NLGN1, TMEM57, ENAH, CPEB3, MYRIP, GPR98, SLC9A6, SYN2, NRCAM, APBB2, CYFIP2, OLFM1, PRRT1, SH3GL2, PACSIN1, CADM1, NRN1, CBLN4, NDE1, DACT1, SAMD4A, MAPK8IP1, DLGAP4, DTNA, PCLO

GO:0045203

CC

integral component of cell outer membrane

The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

FAM73A

GO:0045204

BP

MAPK export from nucleus

The directed movement of a MAP kinase from the nucleus to the cytoplasm.

DUSP16

GO:0045209

BP

MAPK phosphatase export from nucleus, leptomycin B sensitive

Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm.

DUSP16

GO:0045210

BP

FasL biosynthetic process

The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines.

PHLDA1

GO:0045211

CC

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

APBB1, DLGAP1, MUSK, LZTS3, GABBR2, CLSTN1, CHRM2, FBXO45, CHRNB1, BCR, DMD, CHRM3, COMT, CBLN1, F2R, CHRNA5, ADORA1, GABRA5, CHRNA7, NSG1, GRIA4, GLRB, EPHA4, PTEN, NCS1, DLG4, ARF1, CDK5, ANK2, FMR1, GRIN2A, ANK3, DLG1, PICALM, DAG1, SSPN, GRM3, NTRK2, COL13A1, NSMF, ARC, CAMK2N1, LRRTM4, HOMER1, ABI1, NLGN4X, NLGN1, MINK1, ATAD1, TRPV1, CACNG8, KCTD12, PDLIM5, SIGMAR1, CLSTN2, LIN7B, MAGEE1, GOPC, NECTIN3, GPHN, HOMER3, LIN7C, PSD3, GABBR1, IGSF9B, LZTS1

GO:0045213

BP

neurotransmitter receptor metabolic process

The chemical reactions and pathways involving neurotransmitter receptors.

NRG1

GO:0045214

BP

sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

WDR1, LDB3, BMP10, ITGB1, KRT8, KRT19, TPM1, PRKAR1A, CAPN3, ACTN2, ACTG1, ANKRD1, TTN

GO:0045216

BP

cell-cell junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.

CLDN1, TGFB1, NF2, PRKCI, TGFB2, RAC1, CXADR, SMAD3, OCLN, NLGN4X, MARVELD3, CCM2

GO:0045217

BP

cell-cell junction maintenance

The maintenance of junctions between cells.

CSF1R, PARD6A

GO:0045218

BP

zonula adherens maintenance

Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.

CAMSAP3

GO:0045221

BP

negative regulation of FasL biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.

JAK3

GO:0045225

BP

negative regulation of CD4 biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.

ACOT8

GO:0045226

BP

extracellular polysaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.

HAS2

GO:0045236

MF

CXCR chemokine receptor binding

Interacting selectively and non-covalently with a chemokine receptor in the CXCR family.

PPBP, CXCL1, CXCL2, CXCL5, CXCL12, CXCL6, ITCH

GO:0045239

CC

tricarboxylic acid cycle enzyme complex

Any of the heteromeric enzymes that act in the TCA cycle.

FH

GO:0045252

CC

oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).

DLD, DLST, OGDH

GO:0045254

CC

pyruvate dehydrogenase complex

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

PDHA1, DLD, DLAT, PDHB

GO:0045273

CC

respiratory chain complex II

A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.

SDHB, SDHC

GO:0045277

CC

respiratory chain complex IV

A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).

COX7B, COX7B2

GO:0045292

BP

mRNA cis splicing, via spliceosome

The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.

NCBP1, RBM22

GO:0045294

MF

alpha-catenin binding

Interacting selectively and non-covalently with the alpha subunit of the catenin complex.

JUP, CDH2, CTNNB1, NUMB, AJUBA, PKP2, PKP3

GO:0045295

MF

gamma-catenin binding

Interacting selectively and non-covalently with the gamma subunit of the catenin complex.

CDH2, APC, CTNNA1, PTPRJ, PTPRK, TCF7L2

GO:0045296

MF

cadherin binding

Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.

CTNND1, JUP, CD46, PTPRM, CTNNA1, CTNNB1, PSEN1, CDH13, ANK3, OLFM4, NDRG1, P2RX4, CTNNAL1, MMP24

GO:0045298

CC

tubulin complex

A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.

MAPT, TPT1, BICD1

GO:0045309

MF

protein phosphorylated amino acid binding

Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.

BTRC

GO:0045321

BP

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

EDN1, TOLLIP

GO:0045322

MF

unmethylated CpG binding

Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters.

DNMT3B

GO:0045323

CC

interleukin-1 receptor complex

A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.

IRAK1, TRIP6, TOLLIP

GO:0045324

BP

late endosome to vacuole transport

The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.

PIK3R4

GO:0045329

BP

carnitine biosynthetic process

The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.

SHMT1, ALDH9A1

GO:0045332

BP

phospholipid translocation

The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.

ATP8B1, ATP9A, ABCA1, ATP8B4, TMEM30A, ATP11B

GO:0045333

BP

cellular respiration

The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

NDUFS4, NDUFS1, CYCS, NFATC4, NDUFAF2, NR4A3, TBRG4, PPARGC1A, SLC25A13

GO:0045334

CC

clathrin-coated endocytic vesicle

A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.

SFTPC, MYO1E, LMBRD1, MYO6

GO:0045335

CC

phagocytic vesicle

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

STX6, ABCA1, ITGAV, CD36, ITGB5, CORO1A, ANXA11, RAB7A, RAB9A, CLCN3, VAMP7, RAB11A, RAB31, RAB32, RAB11B, RAB8B, SYT11, RAB34, RAB22A, RAB23

GO:0045337

BP

farnesyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.

FDPS

GO:0045338

BP

farnesyl diphosphate metabolic process

The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.

FDFT1

GO:0045342

BP

MHC class II biosynthetic process

The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.

SLC11A1

GO:0045345

BP

positive regulation of MHC class I biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.

NLRC5, HSPH1

GO:0045347

BP

negative regulation of MHC class II biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.

PF4, IL10, MARCH8, HDAC2

GO:0045348

BP

positive regulation of MHC class II biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.

TLR4, XBP1, IL10

GO:0045351

BP

type I interferon biosynthetic process

The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

IFNAR1

GO:0045352

MF

interleukin-1 Type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.

IL1RN

GO:0045353

MF

interleukin-1 Type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.

IL1RN

GO:0045355

BP

negative regulation of interferon-alpha biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

IL10, NMI

GO:0045356

BP

positive regulation of interferon-alpha biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

TLR3

GO:0045358

BP

negative regulation of interferon-beta biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.

NMI

GO:0045359

BP

positive regulation of interferon-beta biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.

TLR4, TLR3, TBK1

GO:0045401

BP

positive regulation of interleukin-3 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.

SYK

GO:0045408

BP

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

CEBPB

GO:0045409

BP

negative regulation of interleukin-6 biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

INPP5D, GHSR, GHRL

GO:0045410

BP

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

EREG, IL1B, PTAFR, TIRAP, TLR1

GO:0045415

BP

negative regulation of interleukin-8 biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.

KLF4, BCL3, MAP2K5

GO:0045416

BP

positive regulation of interleukin-8 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.

TLR4, BCL10, TNF, APOA2

GO:0045425

BP

positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.

SYK

GO:0045429

BP

positive regulation of nitric oxide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

TLR4, KLF4, TLR5, JAK2, DDAH1, DDAH2, EGFR, ASS1, AGT, INS, TNF, IL1B, ITGB2, IL6, EDN1, ICAM1, INSR, HSP90AA1, HSP90AB1, CLU, PTX3, AKT1, PTGS2, AGTR2, HBB, SMAD3, PKD2, TRPV1, P2RX4, KLF2

GO:0045444

BP

fat cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.

TMEM120B, SOCS1, KLF4, SMAD6, GPX1, INHBB, EGR2, IL11, NR4A1, PSMB8, AKT2, GRK5, SREBF1, NR4A2, ID4, CEBPD, GSK3B, HMGA2, SOX8, RNASEL, EP300, FOXO1, ARID5B, STEAP4, NIPBL, BBS7, LRRC8C, NR4A3, SDF4, OSBPL11, BBS2, C1QTNF3, TMEM120A, OSBPL8, WNT5B, RETN, MKKS, PLCB1, TCF7L2, ERAP1, FBXO9

GO:0045445

BP

myoblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.

HMGCR, IGF1, RB1, LGALS1, DTYMK, JAG1, MBNL1

GO:0045446

BP

endothelial cell differentiation

The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

EDF1, HOXB5, S1PR1, JAG1, SCUBE1, BMPER

GO:0045453

BP

bone resorption

The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.

TPP1, TNFSF11, PTH, ADRB2, RAC2, CTNNB1, CTSK, RAB7A, RAC1, ZNF675, NOX4

GO:0045454

BP

cell redox homeostasis

Any process that maintains the redox environment of a cell or compartment within a cell.

KRIT1, AIFM1, GSR, CYBB, IL6, GPX1, P4HB, DLD, TXN, PDIA4, NCF2, NOS3, PRDX6, PDIA3, PRDX2, DDIT3, GLRX, GCLC, SLC11A1, PRDX1, PRDX4, PDIA5, NCF4, PDIA6, TXNRD1, TXNDC11, QSOX2, ERO1B, DNAJC10, NHLRC2, ERO1A, TXNDC15, TXN2, VIMP, ERP44, TMX4, SH3BGRL3, GLRX2, DNAJC16

GO:0045471

BP

response to ethanol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.

MSTN, GOT2, GNRH1, PENK, PTH, RBP4, BGLAP, HMGCR, NTRK1, TYMS, S100A8, CYP2E1, ICAM1, FYN, CDK1, TH, CA3, CD14, GSTP1, SPARC, G6PD, CCL2, EEF2, ALAD, SLC2A4, NQO1, VCAM1, TRH, CNR1, EEF1B2, TNC, CD27, MAOB, ADH7, STAT3, LEP, ADCYAP1R1, STAR, OXCT1, PTEN, RPL10A, ACTC1, ABAT, HAMP, TJP1, GRIN2A, EIF4EBP1, CASP8, ADIPOQ, CDO1, AACS, SETD7, GGH, BAD, SDF4, PEMT

GO:0045472

BP

response to ether

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.

TH, MDM2

GO:0045475

BP

locomotor rhythm

The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.

USP2, NAGLU, PTEN, ID2, MTA1, NCOA2