GO:0044029

BP

hypomethylation of CpG island

An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.

PIK3CA

GO:0044030

BP

regulation of DNA methylation

Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

MBD3, PARP1, BRCA1, MPHOSPH8, MIS18A

GO:0044053

BP

translocation of peptides or proteins into host cell cytoplasm

The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm.

TCP1

GO:0044065

BP

regulation of respiratory system process

Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.

MTG1, FTO, MTG2

GO:0044070

BP

regulation of anion transport

Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

AHCYL1, CA2, STC1, RAB11B, LRRC8A, LRRC8C, TTYH1

GO:0044088

BP

regulation of vacuole organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.

MTM1

GO:0044089

BP

positive regulation of cellular component biogenesis

Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.

LDB2

GO:0044090

BP

positive regulation of vacuole organization

Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.

KIAA1324

GO:0044117

BP

growth of symbiont in host

The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.

PGLYRP2

GO:0044128

BP

positive regulation of growth of symbiont in host

Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.

OSBP

GO:0044130

BP

negative regulation of growth of symbiont in host

Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.

TNF, MPO, MBL2, CD36, IL10, TIRAP, SQSTM1

GO:0044154

BP

histone H3-K14 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.

MEAF6

GO:0044183

MF

protein binding involved in protein folding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.

CLGN, CD74, HSPA1A, HSPA1B, CALR, CCT6A, CCT3, CCT2, PDCL3

GO:0044194

CC

cytolytic granule

A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.

LAMP1, STXBP2, RNF19B

GO:0044205

BP

de novo' UMP biosynthetic process

The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.

UMPS, CAD, DHODH

GO:0044206

BP

UMP salvage

Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.

UPP2, UPP1, UCK2, UCK1, UCKL1

GO:0044207

CC

translation initiation ternary complex

A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).

EIF2S1

GO:0044208

BP

de novo' AMP biosynthetic process

The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).

ADSS, ADSL, ADSSL1

GO:0044209

BP

AMP salvage

The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis.

APRT

GO:0044210

BP

de novo' CTP biosynthetic process

The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.

CTPS1, CTPS2

GO:0044211

BP

CTP salvage

Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis.

UCK2, UCK1, UCKL1

GO:0044212

MF

transcription regulatory region DNA binding

Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

NR5A2, SMAD7, KLF4, SMAD6, KDM1A, CCNT1, TBL1X, ZNF217, H2AFY, NCOR1, FOS, TNF, TP53, JUN, AR, THRA, EGR2, XRCC5, HNRNPL, HIVEP1, JUND, TAL1, ATF3, ATF4, TFEB, WT1, NFKB1, NR1D1, HNF1A, SFPQ, NFYB, YY1, HMGB2, MZF1, HIVEP2, CTNNB1, PHB, DDIT3, SOX6, AHR, PPARG, SNCA, BRCA1, STAT3, ETV5, WNT5A, GATA4, NKX2-1, YAP1, SMARCA2, DLX5, HDAC4, SMAD3, ZNF200, HHEX, RELA, MEF2C, GABPA, PAX8, FOXC1, NR1H3, IKZF1, SMAD4, HDAC1, NFYC, ARID5B, RBBP5, ERBB4, TAF5, ARID4B, HIVEP3, CARM1, ZNF567, ZNF513, CTCFL, GABPB2, ZNF564, GLMP, PROX1, GATA6, CREB3L1, ZNF382, TCF12, CDC5L, CITED1, SALL3, TBL1XR1, IKZF4, DHX36, ZNF335, SOX17, TAF9B, ZNF532, TCF7L1, BRD7, TCF7L2, GRHL1, H2AFY2, RCOR3, ASH2L, TCF20, ZNF639, KLF15, HDAC5

GO:0044213

MF

intronic transcription regulatory region DNA binding

Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within.

NKX2-1

GO:0044214

CC

spanning component of plasma membrane

The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.

BMPR2, CDHR2

GO:0044216

CC

other organism cell

A cell of a secondary organism with which the first organism is interacting.

C4A, C4B

GO:0044224

CC

juxtaparanode region of axon

A region of an axon near a node of Ranvier that is between the paranode and internode regions.

DLG4, KCNA1, SIRT2, EPB41L3

GO:0044232

CC

organelle membrane contact site

A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.

ESYT2, ESYT1

GO:0044233

CC

ER-mitochondrion membrane contact site

A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.

ACSL4, CANX, RAB32, TOMM20, ZFYVE1

GO:0044236

BP

multicellular organism metabolic process

The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.

GHR

GO:0044241

BP

lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.

LIPH, LMF1, LIPG

GO:0044242

BP

cellular lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.

MT3, SIRT2

GO:0044245

BP

polysaccharide digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.

MGAM, LCT

GO:0044252

BP

negative regulation of multicellular organismal metabolic process

Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.

ARRDC3

GO:0044255

BP

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

HDAC3, TBL1X, SIN3B, NCOR1, ECI2, NUDT7, GPD2, NR1H2, PPARA, NCOA2, NCOA1, CHD9, SMARCD3, PNPLA5, CARM1, CREBBP, HELZ2, TBL1XR1, HAO2, FAM135A, NCOR2

GO:0044257

BP

cellular protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

DENND3, SIAH2, PARK2, APOB, PPT1, RIPK1, RAB12

GO:0044259

BP

multicellular organismal macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.

AKR1C3

GO:0044262

BP

cellular carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

TKFC, IDNK

GO:0044265

BP

cellular macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.

CLN6

GO:0044267

BP

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.

SIAH2, PARK2, F2, PLG, CST3, PRL, INS, IGF2, APOA1, FGA, APCS, TTR, MMP1, IGF1, APP, KLK3, MMP2, IGFBP1, CTSH, FURIN, UBC, SAA1, IAPP, SFTPC, IGFBP3, IGFBP2, IGFBP4, IGFBP6, IGFBP5, ADORA2B, SNCA, LYZ, B2M, HIST1H4A, RPS27A, UBA52, HIST1H3D, H3F3A, HSPG2, MFGE8, PAPPA, TGFBI, GIGYF2, SIAH1, GATA6, LMCD1, CCDC59, DMBT1, ZDHHC2, GGA2, GGA1, ITM2B, SNCAIP

GO:0044275

BP

cellular carbohydrate catabolic process

The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

ENOSF1

GO:0044281

BP

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.

FDX1, FXN, FDX1L

GO:0044291

CC

cell-cell contact zone

Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.

FLOT1, RAP2B, AHNAK, TIAM1, FLCN, PKP4, JAM3, PCDH9

GO:0044294

CC

dendritic growth cone

The migrating motile tip of a growing nerve cell dendrite.

COBL, PTCH1, MAPK8IP1

GO:0044295

CC

axonal growth cone

The migrating motile tip of a growing nerve cell axon.

COBL, EPHA4, FKBP4, TIAM1, PTCH1, PARD3, OLFM1, FLRT3, MAPK8IP1, TRPV2

GO:0044297

CC

cell body

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

TLR2, STAU1, GNAI2, TUBB, MAPT, EZR, GNB3, TCP1, COMT, NF2, RPL28, CCT3, GNAQ, CCT8, ACTA2, RPS6, GNB1, GNB2, ACTG2, ACTC1, CXADR, CCT2, NRG1, FADD, DPYSL3, CASP8, RDH10, PACRG, CCT7, SYT11, PINK1, GABARAPL1, CACYBP, MAPK8IP1, LZTS1, TRPV2

GO:0044299

CC

C-fiber

The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.

CCL2

GO:0044300

CC

cerebellar mossy fiber

An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as mossy appearance in Golgi stained preparations.

NFIB, DLG4

GO:0044302

CC

dentate gyrus mossy fiber

Distinctive, unmyelinated axons produced by granule cells.

MAPK8IP1

GO:0044304

CC

main axon

The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites.

APBB1, APP, TIAM1

GO:0044306

CC

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

SCRG1, MME, UCHL1, DMD, VAMP2, DLG4, TMEM57, FLRT1

GO:0044308

CC

axonal spine

A spine that originates from the axon, usually from the initial segment.

EEA1, SLC9A6

GO:0044309

CC

neuron spine

A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.

DLG4

GO:0044314

BP

protein K27-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.

PARK2, UBE2S, UBE2T, RNF6, UBE2D4

GO:0044319

BP

wound healing, spreading of cells

The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.

CYR61, TOR1A, FLNA, RHOA, DDR1, PDCD10, TMEFF2

GO:0044320

BP

cellular response to leptin stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.

FGB, INHBB, CCNA2, STAT3, LEP, PID1, NR4A3

GO:0044321

BP

response to leptin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].

EDN1, NR1D1, STAT3, LEPR, STAR

GO:0044322

CC

endoplasmic reticulum quality control compartment

A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.

OS9, SYVN1, RHBDD1, EDEM1, EDEM3, DERL2, UGGT1, SEL1L, MAN1B1

GO:0044323

MF

retinoic acid-responsive element binding

Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind.

NR2F1

GO:0044324

BP

regulation of transcription involved in anterior/posterior axis specification

Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis.

DDIT3

GO:0044325

MF

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

FXYD1, ACTN4, PRNP, FYN, HSP90AA1, LYN, HSP90AB1, TRAPPC2, ACTN1, PRKCSH, TSPO, SRI, CDH5, CTNNB1, ACTN2, HTT, S100A10, FGF12, CALM2, YWHAE, PKD1, ANK2, ID2, CAV1, YWHAH, FMR1, PDE4D, ANK3, DLG1, AKAP6, SNTA1, CAMK2D, PKD2, FHL1, KCNJ11, GRINA, HOMER1, CHERP, KCNE4, RYR2, FGF13, AP2M1, NEDD4L, PANX1, CIB1, PKP2, RIMS4, GOPC, RANGRF, PHPT1, KCNIP2, PYCARD, RIMS2, TCAF1

GO:0044326

CC

dendritic spine neck

Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.

SRI

GO:0044327

CC

dendritic spine head

Distal part of the dendritic spine, that carries the post-synaptic density.

FUS, GPER1

GO:0044328

BP

canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration.

PLPP3

GO:0044329

BP

canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion.

PLPP3

GO:0044330

BP

canonical Wnt signaling pathway involved in positive regulation of wound healing

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing.

PLPP3

GO:0044331

BP

cell-cell adhesion mediated by cadherin

The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.

CDH2, CDHR2, MMP24

GO:0044332

BP

Wnt signaling pathway involved in dorsal/ventral axis specification

The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis.

LRP5, LRP6

GO:0044334

BP

canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.

CTNNB1, TCF7L2

GO:0044335

BP

canonical Wnt signaling pathway involved in neural crest cell differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation.

LRP6

GO:0044336

BP

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.

CTNNB1

GO:0044337

BP

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process.

GSK3B

GO:0044338

BP

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.

WNT3

GO:0044339

BP

canonical Wnt signaling pathway involved in osteoblast differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation.

WNT3

GO:0044340

BP

canonical Wnt signaling pathway involved in regulation of cell proliferation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation.

LRP6

GO:0044341

BP

sodium-dependent phosphate transport

The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.

SLC20A2, SLC20A1

GO:0044342

BP

type B pancreatic cell proliferation

The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.

IGFBP3, IGFBP4, IGFBP5, BAD

GO:0044344

BP

cellular response to fibroblast growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.

ITGB1BP1, TBX1, SNAI2, COL1A1, CXCL8, TDGF1, CCL2, CCL5, CD44, NR4A1, ZFP36, SNCA, ZFP36L2, GCLC, GCLM, STAR, EGR3, ZFP36L1, HYAL2, POSTN, DSTYK, SETX, SFRP1, CDC5L, DLL4, KDM5B

GO:0044345

BP

stromal-epithelial cell signaling involved in prostate gland development

The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development.

SFRP1

GO:0044346

BP

fibroblast apoptotic process

Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.

MYC, CUL3

GO:0044351

BP

macropinocytosis

An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.

MAPKAPK2, LRRC16A, SNX33, DOCK2, PYCARD

GO:0044354

CC

macropinosome

A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.

ANXA2, CLIP1, MMP14, LRRC16A, ANKFY1

GO:0044375

BP

regulation of peroxisome size

Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.

PEX11B

GO:0044377

MF

RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

CEBPG

GO:0044378

MF

non-sequence-specific DNA binding, bending

The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

HMGB2

GO:0044380

BP

protein localization to cytoskeleton

A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.

FAM83H

GO:0044387

BP

negative regulation of protein kinase activity by regulation of protein phosphorylation

The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.

NPM1, PPM1F, ADARB1, DUSP26, CORO1C, DUSP10

GO:0044389

MF

ubiquitin-like protein ligase binding

Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.

CEBPB, XBP1, VCP, USP13

GO:0044393

CC

microspike

A dynamic, actin-rich projection extending from the surface of a migrating animal cell.

EZR, FSCN1

GO:0044406

BP

adhesion of symbiont to host

The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.

ICAM1, SCARB1

GO:0044458

BP

motile cilium assembly

The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function.

BBOF1, CC2D2A

GO:0044524

BP

protein sulfhydration

The modification of a protein amino acid by the addition of sulfur.

CTH

GO:0044530

CC

supraspliceosomal complex

Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing.

RBMX

GO:0044539

BP

long-chain fatty acid import

The directed movement of long-chain fatty acids into a cell or organelle. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

SLC27A2, FABP3, CD36, ACSL1, SLC27A4, SPX

GO:0044540

MF

L-cystine L-cysteine-lyase (deaminating)

Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.

CTH

GO:0044548

MF

S100 protein binding

Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.

KCNK3, S100B, S100A6, ANXA2, EZR, ATP2A2, S100A11, IQGAP1, ANXA11, AHNAK

GO:0044550

BP

secondary metabolite biosynthetic process

The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.

KMO, CYP11A1, CYP11B1, CYP11B2

GO:0044565

BP

dendritic cell proliferation

The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.

AZI2, TBK1

GO:0044594

MF

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.

HSD17B4

GO:0044595

MF

decaprenyldihydroxybenzoate methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate.

COQ3

GO:0044596

MF

3-demethylubiquinone-10 3-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-10 = S-adenosyl-L-homocysteine + ubiquinone-10.

COQ3