GO:0043537

BP

negative regulation of blood vessel endothelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

ANGPT2, TGFB1, APOE, THBS1, FGF2, HMGB1, AGTR2, RGCC

GO:0043538

BP

regulation of actin phosphorylation

Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.

TWF1

GO:0043539

MF

protein serine/threonine kinase activator activity

Binds to and increases the activity of a protein serine/threonine kinase.

SPRY2, TGFB1, IGF2, MAP2K2, IQGAP1, CALM2, MAP2K1, STK4, ALS2, CAB39

GO:0043540

CC

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.

PFKFB1

GO:0043541

CC

UDP-N-acetylglucosamine transferase complex

A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.

EXT2

GO:0043542

BP

endothelial cell migration

The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

ITGB2, SCG2, S100P, DPP4, S100A2, NOS3, PRSS3, TGFBR1, PIK3CA, PRKX, CDH13, PTEN, RHOA, PTK2, CYP1B1, STARD13, PLXND1, LOXL2

GO:0043544

MF

lipoamide binding

Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.

DLD

GO:0043545

BP

molybdopterin cofactor metabolic process

The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

MOCOS

GO:0043546

MF

molybdopterin cofactor binding

Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

XDH, SUOX, AOX1, MARC1

GO:0043547

BP

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

TBC1D3D, TBC1D3E, DENND3, TBC1D3F, ARHGAP42, ARHGAP33, RGS12, EREG, AXIN1, RGS5, ASAP2, ARHGAP6, RASA4, RGS10, CYTH3, JAK2, ADAP1, RP2, BCAR3, FGF18, PLEKHG5, FARP2, FAM13A, SBF1, FGF19, ALDH1A1, EGFR, A2M, PDGFB, PDGFA, ERBB2, NTRK1, ICAM1, JUN, ITGB1, FYN, ADRB1, FGF2, PDGFRB, CCL3, KIT, BCR, FGFR1, CCL4, CCL2, CCL5, NCAM1, VAV1, CHN1, PDGFRA, ARF4, RCC1, RASA1, S1PR1, KITLG, FGF7, FGFR2, ERBB3, ITGA6, JAK1, CHM, CHML, GDI1, FGF9, BTC, IRS1, ACTN2, RGS2, HTR2B, ARHGAP25, RANBP1, RANGAP1, IQGAP1, LIMS1, RGS3, RGS4, RGS7, TSC2, GSK3B, GNAQ, GDI2, CAV2, RAP1GDS1, JAK3, ARHGDIA, ARHGDIB, AGFG1, S100A10, CALM2, RAP1A, GRB2, RAC1, RACK1, DLG4, CCL20, CCL8, SHC2, SPTBN1, IL5RA, OCRL, NRG1, TEK, PTK2, SOS1, SOS2, ARHGEF5, AKAP13, GRIN2A, RALGDS, ABR, NPRL3, ARHGAP5, EIF2B5, MYO9B, CAMK2D, RAPGEF1, ARHGEF7, GIT2, EIF2B1, RASA3, ARHGAP19, RAB3GAP1, ACAP2, RABEP1, RASA2, ERBB4, RALBP1, ANGPT1, RGN, TRIP10, ITSN1, EZH2, ARHGAP31, ARHGAP29, RALGPS1, DOCK11, FNBP1L, STXBP5, ARHGAP21, DEPDC1, ARFGEF3, DENND4C, DENND2C, IQSEC1, LAMTOR1, TBC1D3C, DENND5A, ARHGAP11A, DNMBP, DENND5B, FGD6, PREX2, KNDC1, RASGRP2, DENND4A, ARHGAP22, NET1, SRGAP1, ARHGAP30, FGD2, RALGPS2, MCF2L2, TBC1D3, TAGAP, ARHGEF28, ARHGAP24, ARHGAP18, SFRP1, ARHGEF39, TBC1D19, ARFGAP2, RGS22, DOCK8, FLCN, RIN3, DENND1A, RAPGEF6, FNIP1, FRS2, DEPDC1B, ARAP3, RIN2, ARAP2, RAPGEF4, STARD8, GBF1, ELMO1, DOCK2, RPGR, HPS1, ARHGEF2, DOCK10, ARHGEF26, DOCK6, FGD4, SPATA13, ANKRD27, ARAP1, AGAP4, SYNGAP1, ALS2, DLC1, RAB3IP, SNX18, FNBP1, HBEGF, PKP4, TBCD, NDEL1, RACGAP1, SPTBN4, SH3BGRL3, RAB3GAP2, DOCK5, PLEKHG2, ECT2, ARHGEF10L, RANGRF, ARFGAP3, ADAP2, PLCB1, HPS4, EIF2B3, ARHGEF4, ARHGEF3, FBXO8, FAM13B, PSD3, RGL1, ITSN2, HACD3, ARHGAP23, ARHGAP20, SIPA1L2, KL, LAMTOR3, EIF2B4, RABGEF1, ERRFI1, CDC42EP3, VAV3, ASAP1, ARHGAP26, AGAP1, VPS9D1, STXBP5L, DIS3, LAMTOR2, GIT1, STARD13, FARP1, IRS2, TRAPPC1, SNX9, F11R, ARFGEF2

GO:0043548

MF

phosphatidylinositol 3-kinase binding

Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.

IRS4, JAK2, DAB1, INSR, FYN, IGF1R, PDGFRB, PIK3R1, CORO1A, IRS1, CALM2, TYRO3, IRS2

GO:0043549

BP

regulation of kinase activity

Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

LDB2, EMP2, NLRC5

GO:0043550

BP

regulation of lipid kinase activity

Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.

RB1, RBL1, NRBF2

GO:0043551

BP

regulation of phosphatidylinositol 3-kinase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.

KLF4, PIK3R1, CCKBR

GO:0043552

BP

positive regulation of phosphatidylinositol 3-kinase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

PDGFB, TGFB1, LYN, FGF2, PDGFRB, FGR, KIT, PDGFRA, IRS1, CDC42, RAC1, TEK, PTK2, PIK3R4, VAV3

GO:0043553

BP

negative regulation of phosphatidylinositol 3-kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

WASH1

GO:0043555

BP

regulation of translation in response to stress

Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

RPS6KA1

GO:0043559

MF

insulin binding

Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.

INSR, IGF1R, HSPD1, IDE, PIK3R1

GO:0043560

MF

insulin receptor substrate binding

Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.

JAK2, INSR, IGF1R, PIK3R1, PIK3CA, PIK3CB, GRB2, PRKCD, PTPN11

GO:0043564

CC

Ku70:Ku80 complex

Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.

XRCC5

GO:0043565

MF

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

ARNTL, FOXN3, NR5A2, ZNF213, FOXP2, MAFG, ZSCAN9, HOXA3, TBX1, FOXO3, SNAI2, CREBL2, EDF1, SHOX2, MAF, ZNF205, WHSC1, TP53, CENPB, HOXC4, GLI2, BCL2, NR2F1, VDR, ESRRA, POU2F1, ETS1, HIVEP1, RAG1, ZNF24, ZKSCAN1, ATF7, EGR1, ATF4, WT1, NR4A1, NR2F2, NFYB, ARNT, HOXD10, HOXA6, HIVEP2, FOXN2, RORA, SOX6, PPARG, PBX2, BCL6, GATA4, NOTCH1, HOXA1, MEOX1, LHX2, ERF, NR0B1, CEBPG, FOXG1, HDAC4, MTPN, IRX3, SMAD3, FOXO4, ZNF200, E2F1, POU5F1, MEF2A, CREB5, HHEX, POU3F1, PPARD, EMX2, PPARA, FOXM1, FOXO1, TFCP2, FOXC1, NR1H3, TRIM28, SMAD4, CUX1, HES1, TSN, USF2, SNAPC1, HIF1A, ZSCAN26, ZSCAN23, HIVEP3, ZNF449, CXXC5, ZBTB33, ZSCAN30, CREBRF, FOXP4, ZNF397, CTCFL, GATAD1, CSRNP3, HDAC2, CREB3L1, ZNF274, ZSCAN31, NR1H4, CSRNP1, CDC5L, MEIS3, HNRNPAB, EPAS1, MYBBP1A, SALL3, FOXP3, CSRNP2, IKZF4, FOXP1, SOX17, ZNF532, TCF7L1, TCF7L2, THAP1, SLTM, GRHL1, ZBTB4, RERE, PPARGC1A, MAFF, FOXJ3, ZNF148, KLF2, CHCHD2, CAMTA1

GO:0043566

MF

structure-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.

ERCC1, TDG, ERCC4

GO:0043567

BP

regulation of insulin-like growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.

IGFBP1, IGFBP3, IGFBP2, IGFBP4, IGFBP6

GO:0043568

BP

positive regulation of insulin-like growth factor receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.

GH1, GHRH, IGF1, AR, IGFBP3, IGFBP4, IGFBP5, PHIP, GHSR

GO:0043569

BP

negative regulation of insulin-like growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.

CILP, BMP2, IGFBP5

GO:0043570

BP

maintenance of DNA repeat elements

Any process involved in sustaining the fidelity and copy number of DNA repeat elements.

MSH3, MSH2, TCF7L2

GO:0043576

BP

regulation of respiratory gaseous exchange

Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.

NR4A2, PASK, APLN

GO:0043583

BP

ear development

The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

BCL2L11, BCL2, ECE1, DDR1, TCF15, SHROOM2, RDH10

GO:0043584

BP

nose development

The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).

RDH10, CHD7

GO:0043585

BP

nose morphogenesis

The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).

GLI3, SKI

GO:0043586

BP

tongue development

The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.

EGFR, GLI3, BNC2

GO:0043587

BP

tongue morphogenesis

The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.

TBX1, KRT13, CYP26B1

GO:0043588

BP

skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

COL3A1, PDGFA, COL5A2, JUP, ITGB4, COL5A1, ITGA6, COL5A3, ITGA3, KRT9, PKD1, TCF15, DHCR24, SLC27A4, FRAS1, WDR48, ARRDC3, ABCB6, SUFU

GO:0043589

BP

skin morphogenesis

The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

COL1A1, COL1A2, ITGA2, PSEN1, ERRFI1

GO:0043596

CC

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

SMARCA5, PCNA, ZMIZ2, TONSL, SMARCAD1, BAZ1B

GO:0043603

BP

cellular amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.

CYP2C9

GO:0043614

CC

multi-eIF complex

A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.

EIF2S1, EIF3A

GO:0043615

BP

astrocyte cell migration

The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.

CCL3, CCL2, MMP14, APCDD1

GO:0043616

BP

keratinocyte proliferation

The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.

IRF6, EREG, CDH13, PPARD, PTCH1, FERMT1

GO:0043618

BP

regulation of transcription from RNA polymerase II promoter in response to stress

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

MUC1

GO:0043619

BP

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

HMOX1, ARNT, HIF1A, EPAS1

GO:0043620

BP

regulation of DNA-templated transcription in response to stress

Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

DDIT3, RPS6KA1, BCLAF1

GO:0043621

MF

protein self-association

Interacting selectively and non-covalently with a domain within the same polypeptide.

BCL10, TP53, SLC2A1, CCL5, AGXT, TNFAIP3, ACVR2A, ABCD3, MDH2, ID1, CTSC, ATXN1, VAMP2, ADAM8, S100A7A, PCSK9, SVIP, TTN, RYR2, TMEM43, FOXP1, ZNF639

GO:0043622

BP

cortical microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.

EZR, DLG1, TRPV4

GO:0043623

BP

cellular protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell.

AXIN1, FGA, FGB, FGG, DMD, CCL5, ATF1, NLRP5, PDE4DIP

GO:0043625

CC

delta DNA polymerase complex

A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.

POLD1, POLD3, POLD4

GO:0043626

CC

PCNA complex

A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.

PCNA

GO:0043627

BP

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

TNFRSF11B, MSTN, CYP27B1, DHH, SMAD6, LDHA, CA2, APOA1, APOA2, BGLAP, ESR1, HSP90AA1, KRT19, HMOX1, PDGFRB, GLI3, HSPD1, ARSB, IGFBP2, SRD5A1, GSTM3, GAL, DTYMK, IL4R, CD24, MAPK1, CTNNA1, TGFBR2, PPARG, BRCA1, STAR, MMP14, TEK, CAV1, EP300, TRIM25, RBBP5, TPH2, CRIPAK, GATA6, CITED4, CITED1, CITED2, ASH2L, GHRL

GO:0043631

BP

RNA polyadenylation

The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.

PAPOLA, PAPD4, PNPT1, PAPOLG

GO:0043647

BP

inositol phosphate metabolic process

The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

INPP4B, SYNJ1, NUDT3, PLCG2, ITPKA, IMPA1, INPP1, PLCD1, PTEN, CALM2, OCRL, ITPK1, INPP5A, PPIP5K1, NUDT10, INPP5D, NUDT11, INPP4A, ISYNA1, PLCB1, IP6K2, MINPP1

GO:0043648

BP

dicarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).

ACOT4, GRHPR

GO:0043649

BP

dicarboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.

ACOT8, ACOT4

GO:0043651

BP

linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

FADS1, FADS2, GSTA1, GSTP1, GSTM2, ACSL1, ELOVL1, PNPLA8, ELOVL5

GO:0043652

BP

engulfment of apoptotic cell

The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.

THBS1, RAC1

GO:0043653

BP

mitochondrial fragmentation involved in apoptotic process

The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.

BAX, BNIP3, ERBB4, CCAR2, MFF

GO:0043654

BP

recognition of apoptotic cell

The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.

FCN2, PEAR1, JMJD6, SCARB1, MEGF10

GO:0043657

CC

host cell

A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.

DYNLT1

GO:0043666

BP

regulation of phosphoprotein phosphatase activity

Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.

DRD2, HSP90B1, PPP1R2, PPP2R4, PPP6R1

GO:0043679

CC

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

HNRNPR, RGS10, SRSF10, GNRH1, PENK, CHRM2, CCL2, DRD2, ITGA2, ELK1, CHRM3, RAB5A, SRI, NTS, EPHA4, ATP6V0D1, FMR1, KCNA1, SEPT6, SLC9A6, GPER1, PACSIN1, FLRT3

GO:0043686

BP

co-translational protein modification

The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome.

STT3A, STT3B

GO:0043687

BP

post-translational protein modification

The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.

ICMT, STS, ARSA, ARSB, STT3A, ARSD, ARSK, MINA, SUMF1, STT3B, RHBDD1

GO:0043691

BP

reverse cholesterol transport

The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.

ABCA1, APOA1, APOE, APOA2, APOC3, CLU, APOA5, SCARB1, ABCA5, LIPG

GO:0043697

BP

cell dedifferentiation

The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.

CDK6

GO:0043734

MF

DNA-N1-methyladenine dioxygenase activity

Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.

FTO

GO:0043754

MF

dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity

Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.

DBT

GO:0043783

MF

oxidoreductase activity, oxidizing metal ions with flavin as acceptor

Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor.

ETFDH

GO:0043795

MF

glyceraldehyde oxidoreductase activity

Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor.

AKR1B1

GO:0043812

MF

phosphatidylinositol-4-phosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate.

SYNJ1

GO:0043813

MF

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.

SYNJ2, SYNJ1, PIKFYVE

GO:0043849

MF

Ras palmitoyltransferase activity

Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins.

ZDHHC9

GO:0043890

MF

N-acetylgalactosamine-6-sulfatase activity

Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.

GALNS

GO:0043914

MF

NADPH:sulfur oxidoreductase activity

Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+.

MICAL2

GO:0043916

MF

DNA-7-methylguanine glycosylase activity

Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.

MPG

GO:0043922

BP

negative regulation by host of viral transcription

Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.

JUN, CCL3, CCL4, CCL5, HMGA2, TARDBP, HDAC1, INPP5K, ZNF639

GO:0043923

BP

positive regulation by host of viral transcription

Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

CHD1, CCNT1, JUN, SMARCA4, EP300, TAF11, NUCKS1, ZNF639

GO:0043924

MF

suramin binding

Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.

RYR2

GO:0043928

BP

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.

LSM3, LSM6, EXOSC9, EXOSC2, EXOSC7, EXOSC6, DCP2, EXOSC8, EDC3, EXOSC4, EXOSC3, CNOT7, LSM7, CNOT6, DIS3, LSM2, LSM5, LSM4

GO:0043931

BP

ossification involved in bone maturation

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.

RHOA

GO:0043932

BP

ossification involved in bone remodeling

The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.

TGFB1, CTHRC1

GO:0043947

BP

positive regulation by host of symbiont catalytic activity

Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

SUGT1

GO:0043949

BP

regulation of cAMP-mediated signaling

Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

GNAI1, RASD2

GO:0043950

BP

positive regulation of cAMP-mediated signaling

Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

PF4, ADRB1, LHCGR

GO:0043951

BP

negative regulation of cAMP-mediated signaling

Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

RGS2, CDC34, UBE2B, PDE3B, CRTC3

GO:0043966

BP

histone H3 acetylation

The modification of histone H3 by the addition of an acetyl group.

PER1, MAP3K7, TADA2A, SUPT3H, TADA3, SUPT7L, BRCA2, DR1, TAF10, JADE1, KAT6B, JADE3, KAT6A, KAT2B, TADA1, ELP4, SGF29, CSRP2BP, ELP3, TAF9B, POLE4, POLE3, YEATS2

GO:0043967

BP

histone H4 acetylation

The modification of histone H4 by the addition of an acetyl group.

APBB1, PER1, TADA3, YEATS4, ACTL6A, BRCA2, EP300, MORF4L2, NCOA1, ELP4, NAA50, EPC1, NAA60, ELP3, ING3, MORF4L1, USP22, RUVBL2, RUVBL1, TRRAP

GO:0043968

BP

histone H2A acetylation

The modification of histone H2A by the addition of an acetyl group.

YEATS4, ACTL6A, MORF4L2, EPC1, MEAF6, ING3, MORF4L1, RUVBL2, RUVBL1, TRRAP

GO:0043969

BP

histone H2B acetylation

The modification of histone H2B by the addition of an acetyl group.

EP300

GO:0043970

BP

histone H3-K9 acetylation

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.

KAT2B

GO:0043981

BP

histone H4-K5 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.

OGT, JADE1, JADE3, PHF20, MEAF6, KANSL3

GO:0043982

BP

histone H4-K8 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.

OGT, JADE1, JADE3, PHF20, MEAF6, KANSL3

GO:0043983

BP

histone H4-K12 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.

JADE1, JADE3, MEAF6

GO:0043984

BP

histone H4-K16 acetylation

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.

OGT, MSL1, PHF20, KANSL3

GO:0043985

BP

histone H4-R3 methylation

The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone.

PRMT6, PRMT1

GO:0043987

BP

histone H3-S10 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.

RPS6KA5, VRK1

GO:0043988

BP

histone H3-S28 phosphorylation

The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.

RPS6KA5, AURKB

GO:0043990

BP

histone H2A-S1 phosphorylation

The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.

RPS6KA5

GO:0043995

MF

histone acetyltransferase activity (H4-K5 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).

OGT, PHF20, KANSL3

GO:0043996

MF

histone acetyltransferase activity (H4-K8 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8).

OGT, PHF20, KANSL3

GO:0044020

MF

histone methyltransferase activity (H4-R3 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.

PRMT6, PRMT1

GO:0044027

BP

hypermethylation of CpG island

An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.

GSK3B