GO:0043277

BP

apoptotic cell clearance

The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.

ITGAV, HMGB1, ALOX15, CD36, TGM2, TYRO3, MERTK, NR1H3, GAS6, PDIA6

GO:0043278

BP

response to morphine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.

ADA, PENK, GPI, DRD2, CNR1, FOSB, MDM2, RELA, PEA15

GO:0043279

BP

response to alkaloid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.

DHX15, UQCRC1, TMED10, SRSF9

GO:0043280

BP

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

DDX3X, CYR61, PDCD5, BCL2L11, PDCD6, ARL6IP5, BCL10, MYC, TNF, HMGB1, F2R, CTGF, PPM1F, TNFSF10, BCAP31, DAPK1, FOXL2, HSF1, PMAIP1, BAD, APOPT1, GPER1, MAP3K5, NDUFA13, PYCARD

GO:0043281

BP

regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.

NGF, NGFR, FAS

GO:0043292

CC

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

PPP1R12A, CST3, GJA1, DEK

GO:0043293

CC

apoptosome

A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.

CASP9

GO:0043295

MF

glutathione binding

Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.

PTGES, GSTP1, GSTM1, MGST1, GSTM3, GSTM2, GSTM4

GO:0043296

CC

apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.

CCDC85C, RHOA, TJP1, PKN2, FBF1, SHROOM3, FRMD6, NECTIN3

GO:0043297

BP

apical junction assembly

The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.

WDR1, CTNNA1, RHOA, PKN2, FBF1

GO:0043303

BP

mast cell degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.

PIK3CD, KIT, PIK3CG, CPLX2, NR4A3, S100A13

GO:0043304

BP

regulation of mast cell degranulation

Any process that modulates the frequency, rate, or extent of mast cell degranulation.

LYN, RAC2, STXBP2

GO:0043305

BP

negative regulation of mast cell degranulation

Any process that stops, prevents, or reduces the rate of mast cell degranulation.

HMOX1, RABGEF1

GO:0043306

BP

positive regulation of mast cell degranulation

Any process that activates or increases the frequency, rate or extent of mast cell degranulation.

FGR, IL4R, ADORA2B, SYK

GO:0043308

BP

eosinophil degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.

CCL3, VAMP7, VAMP2

GO:0043311

BP

positive regulation of eosinophil degranulation

Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.

F2RL1, STX4

GO:0043312

BP

neutrophil degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.

PPBP, ANXA3, VAMP7, STXBP2

GO:0043313

BP

regulation of neutrophil degranulation

Any process that modulates the frequency, rate, or extent of neutrophil degranulation.

SYK

GO:0043314

BP

negative regulation of neutrophil degranulation

Any process that stops, prevents, or reduces the rate of neutrophil degranulation.

BCR, ABR

GO:0043315

BP

positive regulation of neutrophil degranulation

Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.

PTAFR

GO:0043316

BP

cytotoxic T cell degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.

RAB27A

GO:0043320

BP

natural killer cell degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.

CORO1A, RAB27A, VAMP7

GO:0043323

BP

positive regulation of natural killer cell degranulation

Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.

LAMP1

GO:0043325

MF

phosphatidylinositol-3,4-bisphosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.

MYO1G, AKT1, COMMD1, ARAP3, MAPKAP1, ZFYVE1, ADAP2

GO:0043330

BP

response to exogenous dsRNA

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.

TLR3, RIPK2, IFNA1 , IFNA16, SLC3A2, MAPK3, MAPK1, RFTN1, RFTN2, IFNE, DHX36, IRAK3

GO:0043331

BP

response to dsRNA

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.

PMAIP1, PELI1

GO:0043335

BP

protein unfolding

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

HSP90AA1, ERP29

GO:0043337

MF

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.

CRLS1

GO:0043353

BP

enucleate erythrocyte differentiation

The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.

RB1, CEBPG, ID2, SP3

GO:0043366

BP

beta selection

The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.

SYK

GO:0043367

BP

CD4-positive, alpha-beta T cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.

SATB1

GO:0043371

BP

negative regulation of CD4-positive, alpha-beta T cell differentiation

Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.

HMGB1

GO:0043372

BP

positive regulation of CD4-positive, alpha-beta T cell differentiation

Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.

SASH3, TNFSF4, CD83

GO:0043374

BP

CD8-positive, alpha-beta T cell differentiation

The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.

IRF1, SATB1

GO:0043375

BP

CD8-positive, alpha-beta T cell lineage commitment

The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.

BCL2

GO:0043380

BP

regulation of memory T cell differentiation

Any process that modulates the frequency, rate, or extent of memory T cell differentiation.

BCL6

GO:0043382

BP

positive regulation of memory T cell differentiation

Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.

CD46, TNFSF4, IL12RB1

GO:0043388

BP

positive regulation of DNA binding

Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

PARK2, JAK2, EDF1, IGF1, HMGB1, TXN, SKI, MMP9, NME1, ITGA2, ERCC2, HMGB2, CEBPG, CALM2, PLAUR, TRIM28, HES1, SIRT2, PITX2, HIPK2

GO:0043390

BP

aflatoxin B1 metabolic process

The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi.

CYP2W1

GO:0043392

BP

negative regulation of DNA binding

Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

KDM1A, JAK2, JUN, HMOX1, SP100, NEK2, HMGA2, E2F1, ID2, IFI16, HABP4, HDAC2, ZNF462, RSF1, MDFI

GO:0043393

BP

regulation of protein binding

Any process that modulates the frequency, rate or extent of protein binding.

SNAPIN, APP, PRKACA, TGFBR1, PSEN1, PLK1, HDAC4, TGFBR3, CAMK1, ANGPT1, LDLRAP1, SMARCD3, HOPX, HDAC5

GO:0043394

MF

proteoglycan binding

Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

SLIT2, CTSL, CTSB, THBS1, NID1, COL5A1, CTSS, COL5A3, CTSK, FCN2

GO:0043395

MF

heparan sulfate proteoglycan binding

Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.

GPC4, CFH, FST, GPC1, COMP, SEMA5A, GPC2, HPSE, GPC6

GO:0043397

BP

regulation of corticotropin-releasing hormone secretion

Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.

HTR2C

GO:0043398

MF

HLH domain binding

Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.

UBE2I, PKD2

GO:0043400

BP

cortisol secretion

The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland.

GHRL

GO:0043401

BP

steroid hormone mediated signaling pathway

A series of molecular signals mediated by a steroid hormone binding to a receptor.

NR5A2, PGRMC2, PGR, NR2F1, THRA, VDR, ESRRA, BMP4, NR1D1, NR4A1, NR2F2, RXRB, RORA, PPARG, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, NR0B2, PAQR8, NR4A3, NR1H4, GPER1, OR51E2, PAQR5

GO:0043402

BP

glucocorticoid mediated signaling pathway

A series of molecular signals mediated by the detection of a glucocorticoid hormone.

NR3C1

GO:0043403

BP

skeletal muscle tissue regeneration

The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.

IFRD1, MSTN, CFLAR, SOX15, LARGE, GPX1, ENO3, GJA1, MTPN, EYS

GO:0043405

BP

regulation of MAP kinase activity

Any process that modulates the frequency, rate or extent of MAP kinase activity.

TRIB2, TRIB3, TRIB1, CDK12

GO:0043406

BP

positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

TNFSF11, PDE5A, FGF18, EGFR, KRAS, PDGFB, TGFB1, GH1, TNF, PDGFA, ERBB2, EDN1, FGF2, PDGFRB, FGFR1, MIF, VEGFA, KITLG, CD24, CSK, HTR2B, IQGAP1, PIK3CG, PSEN1, IRAK1, ILK, EZH2, TPD52L1, NEK10, AJUBA, PDCD10, PDGFD, NOX4, PDGFC

GO:0043407

BP

negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

SPRY2, SPRY1, IL1B, APOE, HMGCR, LYN, GSTP1, UCHL1, BMP4, DUSP1, NUP62, RGS2, PRKCD, HYAL2, PTPRJ, MAPK7, STK38, ADIPOQ, DUSP7, SORL1, INPP5K, IRAK3

GO:0043408

BP

regulation of MAPK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

MSTN, GDF9, GDF11, BMP10, BMP15, INHA, INHBA, INHBB, BMP3, BMP1, BMP6, CD24, BMP8B, ID1, GDF5, INHBC, GRB2, BMP8A, ULK4, SYNGAP1, GDF15

GO:0043409

BP

negative regulation of MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.

PSMD10, GSTP1, DUSP1, NF2, DUSP3, CAV1, DAG1, RNF149, ASH1L

GO:0043410

BP

positive regulation of MAPK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

TNFRSF11B, GPR37, TBX1, SORBS3, PDGFB, INS, IGF2, PDGFA, IGF1, IL6, INSR, ADRB2, PSAP, NGFR, HMGB1, AR, KIT, FGFR1, BMP2, ADRB3, LIF, TIMP2, IGFBP3, CDH2, TNFRSF1B, IL11, FGFR2, IGFBP4, F2R, FAS, CD27, FGF9, CTNNB1, ADRA1A, ADRA1B, FLT4, LEP, CAV2, CDK10, KISS1, NTRK2, LAMTOR1, WWC1, DUSP19, TNFRSF25, MYDGF, GPER1, C1QTNF1, PELI2, NENF

GO:0043415

BP

positive regulation of skeletal muscle tissue regeneration

Any process that activates or increase the rate of skeletal muscle regeneration.

TGFBR2, PPARD, HOPX

GO:0043418

BP

homocysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.

CBS, BLMH

GO:0043420

BP

anthranilate metabolic process

The chemical reactions and pathways involving anthranilate (2-aminobenzoate).

KMO, KYNU

GO:0043422

MF

protein kinase B binding

Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.

BCL10, SRSF1, SRSF5, PDE3B, CCDC88A, BAD, PINK1

GO:0043425

MF

bHLH transcription factor binding

Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.

BHLHE40, TCF21, TCF4, TCF3, LMO2, SOX9, ASCL1, SMAD3, RUNX2, TWIST1, USF2, TCF12, IKZF4

GO:0043426

MF

MRF binding

Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.

BHLHE40, KDM1A, CREBBP, TSC22D3

GO:0043433

BP

negative regulation of sequence-specific DNA binding transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

WWP2, BHLHE40, SMAD7, KDM1A, FZD6, PEX14, ESR1, PRNP, RB1, HMOX1, FLNA, SP100, TNFSF4, DDIT3, ID1, NR0B1, CEBPG, HDAC4, ID2, ID3, PTCH1, GAS6, NR0B2, TWIST1, EZH2, SFRP5, SFRP4, SIGIRR, HDAC2, PROX1, TRIB1, PHB2, FOXP3, TCF7L2, RLIM, SUFU, BTRC

GO:0043434

BP

response to peptide hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

EREG, LRP5, LRP6, STC2, TIMP1, COL1A1, ANXA1, TH, SPARC, AREG, ATP2A2, GJA1, JUND, CTGF, OXTR, SRD5A2, IRS1, BSG, CDKN1B, CXCL12, BTG1, GNAI1, BTG2, TEK, HHEX, EIF2B5, DAG1, EIF2B1, TRPV1, EIF2B3, EIF2B4

GO:0043456

BP

regulation of pentose-phosphate shunt

Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.

BPGM, PGAM1

GO:0043457

BP

regulation of cellular respiration

Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.

PIK3CA, PNPT1, SLC25A23, CISD1

GO:0043462

BP

regulation of ATPase activity

Any process that modulates the rate of ATP hydrolysis by an ATPase.

TPM2

GO:0043473

BP

pigmentation

The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.

SNAI2, TH, KIT, DRD2, ARCN1, BLOC1S3, HPS3, LYST, CITED1

GO:0043482

BP

cellular pigment accumulation

The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus.

SHROOM2, SHROOM3

GO:0043484

BP

regulation of RNA splicing

Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

PQBP1, HNRNPH1, CLK2, AFF2, AHNAK, FASTK, ZNF326, MBNL2, AGGF1, RBM38, ESRP2, CLK4, MBNL1, MBNL3, CDK12

GO:0043486

BP

histone exchange

The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.

ZNHIT1, RNF8, PTMA, NASP, SPTY2D1, ANP32B, ANP32E

GO:0043487

BP

regulation of RNA stability

Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.

NLRP5, SMG5

GO:0043488

BP

regulation of mRNA stability

Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.

PSMD11, PSMD12, XPO1, PSMD3, PSMD10, TNFSF13, PARN, HSPB1, UBC, HSPA1A, HSPA1B, PRKCA, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, ZFP36, PSMB8, PSMB9, PSMB4, PSMB5, AKT1, YWHAB, PSMC2, ANP32A, PSMB10, PSMC4, ZFP36L2, MAPKAPK2, PSMB3, PSMD7, PCBP4, PSME3, PSMC1, PSMC6, RPS27A, UBA52, YWHAZ, SET, PRKCD, RNASEL, EXOSC9, FMR1, ZFP36L1, PSMD2, EXOSC2, HNRNPD, PUM1, PSME4, EXOSC7, ELAVL1, SAMD4B, EXOSC6, ZC3H14, DCP2, XRN1, SERBP1, PUM2, KHSRP, EXOSC8, RBM24, EXOSC4, EXOSC3, SAMD4A, DIS3, CARHSP1, YTHDF2

GO:0043490

BP

malate-aspartate shuttle

The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.

SLC25A12, SLC25A13

GO:0043491

BP

protein kinase B signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.

TGFB1, TNF, IL1B, IGF1, CCL3, CCL2, CCL5, MT3, AKT1, PIK3CA, SOX9, TSC2, SESN2, PTEN, TYRO3, ZFP36L1, MERTK, ILK, GAS6, THEM4, SETX, SIRT2

GO:0043492

MF

ATPase activity, coupled to movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance.

ASNA1, RALBP1

GO:0043495

MF

protein anchor

Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane.

PDCD6, MYH9, NUP153, AKAP6, CIB1

GO:0043496

BP

regulation of protein homodimerization activity

Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.

BCL2, NRG1, BAX

GO:0043497

BP

regulation of protein heterodimerization activity

Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.

BCL2, CDC42, NRG1, BAX

GO:0043504

BP

mitochondrial DNA repair

The process of restoring mitochondrial DNA after damage.

PARP1, DNA2, MGME1

GO:0043507

BP

positive regulation of JUN kinase activity

Any process that activates or increases the frequency, rate or extent of JUN kinase activity.

MAP3K7, TNF, EDN1, EPHA4, ARHGEF5, TIAM1, FGD2, DUSP19, MAP3K5, TAOK3, FZD8, FZD4, TNFRSF11A, MAP3K4

GO:0043508

BP

negative regulation of JUN kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.

GSTP1, SERPINB3, DNAJA1, PDCD4, SFRP1, ZNF675, DUSP19, MAPK8IP1, PTPN22, DUSP10

GO:0043509

CC

activin A complex

A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).

INHBA

GO:0043512

CC

inhibin A complex

Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.

INHA, INHBA

GO:0043513

CC

inhibin B complex

Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit.

INHA

GO:0043514

CC

interleukin-12 complex

A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.

IL12A

GO:0043515

MF

kinetochore binding

Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.

CENPE, SPDL1, CENPH

GO:0043516

BP

regulation of DNA damage response, signal transduction by p53 class mediator

Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

KMT5A

GO:0043517

BP

positive regulation of DNA damage response, signal transduction by p53 class mediator

Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

EEF1E1, DDX5, PMAIP1, ANKRD1, SPRED1

GO:0043518

BP

negative regulation of DNA damage response, signal transduction by p53 class mediator

Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

SNAI2, KDM1A, PSMD10, CD74, MIF, CD44, PTTG1IP, MDM2, TWIST1

GO:0043519

BP

regulation of myosin II filament organization

Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.

DAPK3

GO:0043522

MF

leucine zipper domain binding

Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.

DAPK3, ATF4, DDIT3, ERC1, PAWR, CDC5L, AATF

GO:0043523

BP

regulation of neuron apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.

NPM1, GPX1, G6PD, MEF2C, NAE1, KIF14, NSMF, PCSK9, SIGMAR1, TRIM2, EGLN3

GO:0043524

BP

negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

CHL1, NRP1, TOX3, PARK2, JAK2, STAMBP, KRAS, NGF, APOE, SOD2, NTRK1, JUN, FYN, GPI, HSP90AB1, HMOX1, BCL2, HSPD1, CCL2, CEBPB, RASA1, C5AR1, MDK, ERBB3, BDNF, F2R, MT3, CORO1A, GABRA5, SNCA, PRKCI, PIK3CA, GDF5, MSH2, NR4A2, GCLC, GCLM, NES, STAR, PSEN1, PPT1, STXBP1, ADAM8, BTG2, SET, MEF2C, TYRO3, BAX, CLN3, ILK, HDAC1, ALKBH1, KIF14, ANGPT1, ITSN1, UBE2V2, NTRK2, CPEB4, UNC5B, OXR1, NDNF, NR4A3, VSTM2L, SYNGAP1, CITED1, PINK1, HIPK2, NRBP2, CLCF1, PPARGC1A

GO:0043525

BP

positive regulation of neuron apoptotic process

Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.

BCL2L11, FOXO3, PAK3, AIFM1, TP53, JUN, CCL3, NQO1, NQO2, ATF4, CTNNB1, DDIT3, CDC34, ASCL1, CASP9, HDAC4, CDC42, UBE2M, TGFB2, SRPK2, CDK5, BAX, PMAIP1, PCSK9

GO:0043531

MF

ADP binding

Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.

ERN1, CYB5R3, ATP5D, MYH9, MSH2, GCLC, GLUD2, MSH6, PRKAG1, VCP, PRPS1, MYO9B, CHORDC1, MYO6

GO:0043532

MF

angiostatin binding

Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.

AMOT

GO:0043533

MF

inositol 1,3,4,5 tetrakisphosphate binding

Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate.

ADAP1, ITPR3, ADAP2

GO:0043534

BP

blood vessel endothelial cell migration

The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.

APOA1, GPX1, MYH9, ID1, EMP2, AMOT, SCARB1

GO:0043535

BP

regulation of blood vessel endothelial cell migration

Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

EFNA1, SH3BGRL3

GO:0043536

BP

positive regulation of blood vessel endothelial cell migration

Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

PDGFB, TGFB1, HSPB1, THBS1, FGF2, VEGFA, PRKCA, AKT1, STAT5A, VEGFC, PRKD1, ANGPT1, AMOTL1, PRKD2