GO:0043067

BP

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

CST3

GO:0043068

BP

positive regulation of programmed cell death

Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

TNF, NTRK1, CDKN1A, BNIP3, RIPK1, MARK4

GO:0043069

BP

negative regulation of programmed cell death

Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

ALB, KIT, PLCG2, NUP62, KANK2

GO:0043083

CC

synaptic cleft

The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.

PRSS12, COLQ

GO:0043084

BP

penile erection

The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.

ACVR2A

GO:0043085

BP

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

SH3PXD2B, AZIN1, OGT, CFLAR, PPP1R12B, PRKRA, IGF2, APOA2, APOC1, NPM1, PSAP, CXCL1, BCL2, IGFBP3, MT3, YWHAB, GTF2F1, TRIM23, NR4A2, PSEN1, PSEN2, MMP15, MMP16, ARF1, CAV1, STX4, NCF4, HSPB2, FXN, PITRM1, RICTOR, NOXA1, PHACTR4, APH1B, NSMAF, APH1A, MGST2, CIB1, SAE1, DBF4, GTF3C4, PLAA, MMP24

GO:0043086

BP

negative regulation of catalytic activity

Any process that stops or reduces the activity of an enzyme.

ACACB, PPP1R12A, HNRNPR, ENSA, PHACTR2, OAZ2, TIMP1, SCG5, ANXA2, ANXA5, ANXA4, ANXA3, RNH1, NQO1, PDC, PLN, SERPINB3, PPP1R2, NOTCH1, NES, OAZ1, ARPP19, SET, CLN3, FRY, CAND1, CCAR2, PPP1R14C, TMBIM1, PPP1R14A, PPP1R14B, FAF2, PPP1R10, ANP32E, TXNIP, PPME1, CABIN1

GO:0043087

BP

regulation of GTPase activity

Any process that modulates the rate of GTP hydrolysis by a GTPase.

ITGB1BP1, PLXNB2, ADAP1, VAV1, EPHA3, RDX, BCL6, PLXNA3, EFNA5, EPHA5, EPHA4, DYNLT1, OCRL, PTK2, ARHGEF5, RAB3GAP1, RALBP1, NTRK2, RICTOR, FGD6, SYDE1, FGD2, IQGAP3, BVES, TBC1D15, RAPGEF6, AJUBA, FGD4, MLST8, RAB3GAP2, STMN3, VAV3, PYCARD

GO:0043091

BP

L-arginine import

The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.

SLC11A1

GO:0043097

BP

pyrimidine nucleoside salvage

Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.

TK2, UPP2, TK1, TYMP, DCK, UPP1, UPRT, UCK2, UCK1, UCKL1

GO:0043101

BP

purine-containing compound salvage

Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.

PNP, ADA, APRT, DCK, GMPR, AMPD3, MTAP, DGUOK

GO:0043103

BP

hypoxanthine salvage

Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.

ADA

GO:0043111

BP

replication fork arrest

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork.

TIPIN

GO:0043112

BP

receptor metabolic process

The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

FUT8

GO:0043113

BP

receptor clustering

The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.

ITGB1BP1, ITGB2, FLNA, CDK5, DLG1, MAGI2, SYNGAP1

GO:0043114

BP

regulation of vascular permeability

Any process that modulates the extent to which blood vessels can be pervaded by fluid.

BCR, NPPB, HRH1, TEK, ABR

GO:0043116

BP

negative regulation of vascular permeability

Any process that reduces the extent to which blood vessels can be pervaded by fluid.

SLIT2, ADM, TJP1, PTPRJ, PDE3A, ANGPT1

GO:0043117

BP

positive regulation of vascular permeability

Any process that increases the extent to which blood vessels can be pervaded by fluid.

TGFB1, CXCR2, PDE3A, TRPV4

GO:0043120

MF

tumor necrosis factor binding

Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.

A2M

GO:0043121

MF

neurotrophin binding

Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.

NTRK1, NTRK2

GO:0043122

BP

regulation of I-kappaB kinase/NF-kappaB signaling

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

TNF, IL1B, HSPB1, CAPN3, F2RL1, SQSTM1, ANGPT1, ZFAND6, OPTN, BTRC

GO:0043123

BP

positive regulation of I-kappaB kinase/NF-kappaB signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

GPR89A, TRIM38, TNFSF11, UBD, CFLAR, MAP3K7, RIPK2, TSPAN6, TRAF3IP2, PARK2, TRIM13, BRD4, PLEKHG5, BCL10, TNF, IL1A, S100B, PRKCB, FYN, LGALS1, HMOX1, GPR89B, UBC, CD36, GJA1, FLNA, TGM2, F2R, S100A4, CASP1, EEF1D, CTH, CTNNB1, LTBR, NUP62, HTR2B, TNFSF10, IRAK1, F2RL1, TIRAP, RHOA, RPS27A, UBA52, UBE2I, ATP2C1, RELA, REL, BST2, AKAP13, FADD, UBE2V1, BIRC3, RIPK1, TRIM25, CASP8, PRKD1, TRADD, ADIPOQ, WLS, CXXC5, MAVS, TMED4, MTDH, ZDHHC17, SLC44A2, TRIM22, C18orf32, SLC20A1, SECTM1, TFG, MIB2, PELI1, AJUBA, S100A13, LITAF, NDFIP1, TRIM62, PINK1, TRIM8, ECT2, PELI2, NEK6, TNFRSF19, NDFIP2, PLK2, GPRC5B, VAPA, TBK1, GOLT1B

GO:0043124

BP

negative regulation of I-kappaB kinase/NF-kappaB signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

PER1, PPM1B, ESR1, GSTP1, TNFAIP3, RORA, IL1RL1, TLE1, RIPK1, CASP8, ZMYND11, ADIPOQ, OTUD7B, TANK, OPTN, CARD19, NR1H4, ASH1L, PYCARD

GO:0043125

MF

ErbB-3 class receptor binding

Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.

ERBB2, PIK3R1, CDK5, NRG1

GO:0043128

BP

positive regulation of 1-phosphatidylinositol 4-kinase activity

Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase.

CD81

GO:0043129

BP

surfactant homeostasis

Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.

CTSH, VEGFA, EPAS1

GO:0043130

MF

ubiquitin binding

Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

UBAP1L, BUB3, PARK2, UBXN7, UBR5, BCL10, HSPB1, UCHL1, TOP2A, IDE, UCHL3, TNFAIP3, CKS2, NUP62, UBE2A, TERF1, CKS1B, CXCR4, RAE1, SMAD3, SQSTM1, NBR1, CRY1, RHBDD2, FAAP20, TP53INP2, SIRT2, KIF18A, DYRK2, USP13, FAF2, OTUB2, MVB12A, OTUB1, MARK4, RNF216, USP25, FAF1, NSFL1C, FAN1

GO:0043132

BP

NAD transport

The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH.

SLC25A17

GO:0043134

BP

regulation of hindgut contraction

Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.

GHSR

GO:0043137

BP

DNA replication, removal of RNA primer

Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.

RNASEH2A, FEN1, DNA2

GO:0043138

MF

3'-5' DNA helicase activity

Catalysis of the unwinding of the DNA helix in the direction 3' to 5'.

GINS1, FBXO18, GINS4, GINS2

GO:0043139

MF

5'-3' DNA helicase activity

Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.

ERCC2, DNA2, PEO1

GO:0043140

MF

ATP-dependent 3'-5' DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.

RECQL4, RECQL, BLM, ASCC3

GO:0043141

MF

ATP-dependent 5'-3' DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.

PIF1, RUVBL2, RUVBL1

GO:0043142

MF

single-stranded DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction.

POLQ, RFC4, RFC2, RFC5, RFC3, DNA2, RAD51, CHTF18, DSCC1, RAD18

GO:0043149

BP

stress fiber assembly

The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.

ITGB5, RHOA, CUL3, ZYX, KCTD13, SORBS1

GO:0043152

BP

induction of bacterial agglutination

Any process in which infecting bacteria are clumped together by a host organism.

FGA, FGB, SPON2, DMBT1

GO:0043153

BP

entrainment of circadian clock by photoperiod

The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).

BHLHE40, PER1, USP2, TP53, PPP1CC, SIK1, PPP1CA, PPP1CB, ID2, MTA1, CRY1, RBM4B, RBM4

GO:0043154

BP

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.

DDX3X, SIAH2, KLF4, TRIAP1, DNAJB6, NGF, CRYAB, RAF1, IL6, GPI, GPX1, THBS1, NGFR, HGF, VEGFA, RAG1, CD44, MT3, CD27, AKT1, SFN, SNCA, SERPINB9, YWHAE, IGBP1, XIAP, MDM2, MAP2K5, GAS6, ARL6IP1, DHCR24, RPS6KA1, MICAL1, FNIP1, LAMP3

GO:0043159

CC

acrosomal matrix

A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.

DLD

GO:0043161

BP

proteasome-mediated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

PSMD11, PSMD12, WWP2, ARNTL, TRIM38, UBE2C, AXIN1, PSMD3, SIAH2, BUB3, PARK2, BUB1B, TRIM13, TBL1X, PSMD10, UBE4B, TP53, CDK1, UCHL1, FBXO45, UBC, PSMC3, PSMB1, APC, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, CTNNB1, DDIT3, PSMC2, PSMB10, PSMC4, CSNK1A1, CDC34, UBE2A, PSMB3, GSK3B, PSMD7, UBE2E1, ATXN3, RAD23A, RAD23B, VCP, UBE2D3, PSME3, PSMC1, UBE2H, PSMC6, PPP2CB, RBX1, RPS27A, UBA52, UBE2B, SKP1, CDC20, PSMD2, MAD2L1, MTA1, PPP2R5C, CUL3, CUL4A, PSME4, KIF14, SPOPL, RNF111, RNF165, MAEA, C19orf68, SIAH1, SIRT2, ABTB2, KCTD13, RFFL, FBXW5, UBE2W, ANAPC16, RMND5B, NEDD4L, BTBD9, RNF126, TBL1XR1, TRIM9, USP44, RNF38, WWP1, ANAPC1, KCTD10, RMND5A, RLIM, KBTBD4, RNF216, GTSE1, RNF181, KLHL42, CDC23, ANAPC5, ANAPC4, ANAPC10, STUB1, FAF1, NSFL1C, RNF24, RNF6, BTRC, BTBD3

GO:0043162

BP

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

UBAP1L, VPS4B, VPS37A, MVB12A, NDFIP1, RNF126, HDAC6

GO:0043169

MF

cation binding

Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.

PARN, GBE1

GO:0043171

BP

peptide catabolic process

The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.

TPP1, ACE, NPEPPS, ERAP2, AOPEP, ERAP1, LNPEP, CPQ, LOC440434

GO:0043175

MF

RNA polymerase core enzyme binding

Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.

SCAF8

GO:0043177

MF

organic acid binding

Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage.

HMGCS1

GO:0043179

BP

rhythmic excitation

Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.

EDN1

GO:0043181

BP

vacuolar sequestering

The process of transporting a substance into, and confining within, a vacuole.

GAA

GO:0043183

MF

vascular endothelial growth factor receptor 1 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1.

VEGFA

GO:0043184

MF

vascular endothelial growth factor receptor 2 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.

GREM1, ITGB3, ITGA5, VEGFA, PDCL3

GO:0043185

MF

vascular endothelial growth factor receptor 3 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3.

VEGFC

GO:0043186

CC

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

PIWIL4, TDRD9, CARHSP1

GO:0043190

CC

ATP-binding cassette (ABC) transporter complex

A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.

ABCD4, ABCG8, ABCB6, ABCF2

GO:0043194

CC

axon initial segment

Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.

BIN1, CCK, ANK3, CAMK2D, NRCAM, SPTBN4

GO:0043195

CC

terminal bouton

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

AP3D1, SYNJ1, STX6, GHRH, APP, CCK, TH, SYN1, RAB5A, SYT1, CALB2, CAD, ADORA1, SNCA, NMU, RAB7A, POLG, PRSS12, STXBP1, AP1S1, SLC18A2, ILK, DPYSL2, NTRK2, AAK1, CPLX2, SV2A, AP2M1, P2RX4

GO:0043196

CC

varicosity

Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.

TNFRSF1B

GO:0043197

CC

dendritic spine

A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including thin, stubby, mushroom, and branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.

APBB1, RGS10, CTNND1, CRYAB, APP, ITGB1, DRD2, ARF4, NR1D1, COMT, ITPKA, LAMA2, MT3, CANX, ADORA1, PRKAR2B, ACTN2, PPP1CC, MAP1B, ATP1A2, FXR1, EPHA4, PTEN, PPP1CA, DLG4, MYL7, FMR1, STX4, TIAM1, MTMR2, CTTN, GRM3, FRMPD4, CNN3, ASIC2, PTPRO, ARC, NLGN1, ALS2, P2RX4, SYT11, STRN4, CRIPT, ASAP1, LZTS1, FARP1, ARFGEF2

GO:0043198

CC

dendritic shaft

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

APP, FLNA, PRKAR2B, NSF, PSEN1, GSK3B, ILK, NLGN1, ARHGEF2, SYNGAP1, GPER1, CRIPT, LZTS1

GO:0043200

BP

response to amino acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

IL6, EDN1, ICAM1, LYN, ASNS, GSTP1, CCL2, ALAD, CTGF, MTHFR, SLC1A2, CDKN1B, GLRB, RELA, CDO1, BAD, RRAGC, PEMT

GO:0043201

BP

response to leucine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.

PIK3C3, PPARGC1A

GO:0043202

CC

lysosomal lumen

The volume enclosed within the lysosomal membrane.

RNASET2, MAN2B1, NCAN, TPP1, GYG2, SDC3, GPC4, CSPG5, GC, FUCA1, CD74, HEXA, CTSD, DCN, PSAP, CTSL, HSP90AA1, PDGFRB, GAA, LAMP2, VCAN, ARSA, GNS, ARSB, GM2A, SDC1, OGN, BGN, CTSS, SDC4, GALNS, SDC2, GPC1, PPT1, SGSH, LUM, NAGLU, GALC, HSPG2, FMOD, ASAH1, CSPG4, GPC2, BCAN, NEU1, OMD, ATP13A2, CTSF, PPT2, HPSE, MAN2B2, GPC6

GO:0043203

CC

axon hillock

Portion of the neuronal cell soma from which the axon originates.

AURKA, CCK, SERPINF1, NDEL1, SPTBN4, TPX2

GO:0043204

CC

perikaryon

The portion of the cell soma (cell body) that excludes the nucleus.

KCNK1, ZPR1, PDE9A, GOT2, ASS1, GNRH1, PENK, CRYAB, BGLAP, CCK, TH, ENO2, TOP1, CCL2, DRD2, PAM, MAPK1, FUS, EPHA4, PPP1CA, RACK1, CDK5, FMR1, KCNA1, KLHL24, NSMF, RUFY3, SIRT2, OLFM1, NGB, HDAC6

GO:0043205

CC

fibril

Extracellular matrix material consisting of polysaccharides and protein.

SNCA, SLC1A3, MUC5AC

GO:0043206

BP

extracellular fibril organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins.

CST3, COL3A1, COL5A1, SNCA, MUC5AC, MFAP5, ILK

GO:0043208

MF

glycosphingolipid binding

Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.

LYN, SELL

GO:0043209

CC

myelin sheath

An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

PHGDH, TSPAN2, WDR1, SLC25A12, TPPP, MYO1D, NDUFA10, GOT2, CA2, CRYAB, PMP2, ALB, TUBB4A, ERBB2, ATP1B1, SLC25A5, GPI, LDHB, HSP90AA1, PDHA1, ENO2, DLD, UCHL1, BCL2, DLAT, HSPD1, HSPA5, RALA, NEFH, SLC25A4, CKB, MIF, PKM, EZR, SYN1, TCP1, SRD5A1, NDUFV2, COX5A, ATP6V1B2, NME2, UQCRC2, CANX, NDUFS1, TKT, PDIA3, SDHA, GDI1, UQCRC1, STIP1, PHB, RDX, ATP5C1, DLST, MDH1, MDH2, VDAC2, NSF, UQCRFS1, CCT3, GDI2, ATP1A2, VCP, PLP1, ACTB, SNAP25, CDC42, STXBP1, RAP1A, GNB1, GNB2, RPS27A, ACTG1, TUBA1B, TUBB4B, CCT2, PITPNA, SLC25A3, EEF1A2, PRDX1, CNTN1, ITPR3, KCNJ11, SEPT2, DPYSL2, FSCN1, TUBA1A, SERINC5, SIRT2, CA13, PDCD6IP, NDRG1, CNRIP1, ACO2, PACSIN1, PLCB1, EHD3, SUCLA2

GO:0043217

BP

myelin maintenance

The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.

CXCR4, EPB41L3

GO:0043218

CC

compact myelin

The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.

PMP22

GO:0043219

CC

lateral loop

Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.

STX4, DLG1, SIRT2, MPP5

GO:0043220

CC

Schmidt-Lanterman incisure

Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.

ANXA2, AKR1B1, MAG, PRKCI, PTEN, SIRT2, MPP5, JAM3

GO:0043224

CC

nuclear SCF ubiquitin ligase complex

A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

RBX1

GO:0043225

MF

ATPase-coupled anion transmembrane transporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in).

ABCC4, ABCC5, CFTR, ABCC1, ABCC10

GO:0043231

CC

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

CNOT1, AGPS, HIP1, ARNTL, IPO5, CHD2, ADAM10, CHEK1, MGST3, XPO1, BTAF1, SCAMP1, SCAMP2, STX7, P4HA2, SIAH2, AQP9, SLC25A17, FADS1, RAD1, DIAPH2, RAB11FIP3, PEX14, VPS26A, ECI2, DAB1, STAM2, URI1, SEC31A, GDF11, PPP1R3D, CYB5A, AMBP, TFRC, APOB, S100B, GAPDH, CYP1A1, APP, UGT2B4, INSR, CTSB, IGF1R, COL4A2, CYP3A4, STS, CLTA, G6PD, CYP2C9, VCAN, P4HA1, POU2F1, LIG1, ATP2B1, CYP3A5, ATP6V1B2, CNR1, FGFR2, SCP2, PTGS1, ME2, ATP2B4, PTAFR, MCM3, CTSS, PSMA4, PON1, ABCD3, GRN, CTGF, TSPO, ALDH1B1, FOXN2, STX2, CTNNA1, GTF2F1, IRS1, PSMC2, NUP62, PPARG, DDOST, ELK3, EPS15, RANGAP1, ARCN1, PRRC2A, ATP1A2, RAB5C, RAB7A, NOVA1, SMARCA2, ALDH3A2, HSD17B4, PLXNA3, VAMP7, AGFG1, MSH6, ATXN1, ATP12A, VCP, SEC13, POLE2, AP1S2, PEX3, AP3S2, AP1S1, NCS1, AP2B1, VAMP2, YBX1, OLR1, GPLD1, SARNP, DAB2, RUNX1, SLC7A5, COL4A3, MEF2C, CHAF1A, CALCOCO2, IFIT5, MTA1, SLC14A1, GOLGA4, TRA2A, SNX1, PTCH1, VEZF1, CTTN, GRB14, MEF2D, ZNF638, ACOX1, NECTIN1, RABEP1, TMED2, PCBP1, TAF5, TAF1C, TAF1A, TRIP10, NSDHL, VAMP3, USF2, ZFHX3, SNAPC1, CYP1B1, TBRG1, ATP13A5, KLHL12, ZNF326, ACBD5, FAM72A, LAMTOR1, FAM72D, SFXN4, AGTRAP, AFTPH, PARM1, UGT2A3, DRAM2, RAB11FIP1, RAB11FIP2, ZFYVE16, WAPL, ARHGAP30, RABEPK, CASZ1, ALYREF, SLC26A11, OSTM1, GPBP1, FAM72B, PPP1R3B, TDRP, DCP2, ZDHHC17, SLF2, KMT2E, RDH10, ABCA6, CA13, EIF1AD, HSD17B11, LSM14A, TNRC6A, PHC3, VPS37A, NUP35, GPRC5A, DBF4B, MFSD8, SPATA18, SPPL3, SPPL2A, ABHD5, SCARB1, MITD1, ABCA5, SLC9A6, GOLGA1, ATP6V0A1, KISS1R, PMEPA1, CLUAP1, MVB12A, ERO1A, SENP5, EAF1, SEC16B, EXOC2, PLIN4, SNX18, ERGIC2, CCNL2, ACOX2, NEU1, PLIN2, BARD1, LITAF, MGST2, MYBBP1A, DHRS4, TIPIN, CLEC7A, POLDIP3, ASPSCR1, TRIM8, EIF5A2, UBA5, UPF3A, OBFC1, ATP13A3, PHAX, DDX31, RRAGC, TMEM165, NEK6, ANLN, ACSS2, EIF4ENIF1, SNX15, GLRX2, TMEM106B, TDP1, NDFIP2, MTPAP, THAP1, AURKAIP1, SYBU, ZDHHC7, GPRC5B, GRHL1, DTL, GLTSCR2, KANSL3, DNMT3B, VPS29, CTSZ, POLK, AASS, VTI1B, KCNG1, GGA1, CROT, ZMIZ1, PLAGL1, PPT2, POLI, TRIM33, HPSE, RNF6, RUVBL1, ITM2B, GSTK1, CCDC53, TNPO3, XRCC6BP1

GO:0043234

CC

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

APBB1, KRIT1, SMAD7, RIPK2, PRPF3, SMAD6, ACTN4, TRIAP1, KDM1A, MITF, PEX14, ERLIN2, SNX4, GDF11, MBD3, BCL10, PEX11B, ACTL6A, GOT2, MYC, RBP4, TTR, ALB, ANXA1, NR3C1, NTRK1, TP53, SERPINA5, KLK3, TUBB, HSP90AA1, HNRNPC, PARP1, AR, PRKAR1A, HSPD1, CLU, BCR, TOP2A, DMD, COL6A1, COL6A2, SKI, SKIL, CFTR, PDGFRA, ATP2A2, NPPB, SDC1, BCL3, CAPN3, HNF1A, SCP2, ATP2B4, HMGB2, MAPK3, CAD, CANX, MAPK1, CORO1A, GDI1, AKT1, STIP1, OTX2, CTNNB1, PTGS2, MYH9, PPP1CC, SREBF1, BRCA1, CDKN1A, DDOST, FEN1, PRKCI, HTT, SYK, IQGAP1, LIMS1, SOX9, NASP, CDK8, PPM1F, RGS4, PSEN2, SMARCA4, BRCA2, CAV2, NEK2, POLG, HIRA, MLLT10, SNU13, PEX3, NLRP5, ACTB, STXBP1, DCAF7, RAB11A, ACTA2, HIST1H4A, GNB2, HIST1H3D, CXADR, H3F3A, HSF1, MDM2, SPTBN1, SET, ID2, FKBP4, CAV1, PTPN11, MEF2C, RBBP4, STRN3, STK4, CHAF1A, CHAF1B, MAPK8IP2, UBE2V1, ILK, IKZF1, SNTA1, SNTB2, BIRC3, EIF4EBP1, HDAC1, SNX1, ACVR2B, SNTB1, CKAP5, ARHGEF7, RFTN1, LTBP1, CHD4, RAB3GAP1, PCM1, NR0B2, TAB1, SMAD1, PKN1, PKN2, DPYSL2, CDCA8, PTRF, CNST, RNF111, RNF165, PXK, MAGI2, SLC51A, WWC1, MPP5, CISD2, INADL, SMARCC2, PARD3, IPO4, PPM1E, RYR2, HDAC2, TANK, SMARCC1, ARHGEF2, PRKCDBP, DNAJC19, ALS2, PANX1, USP28, PHB2, SMAD5, SOST, AIF1L, CCM2, NAT9, SSBP3, PARD6B, FOXP3, CCDC113, RAB3GAP2, TLE6, PLEKHA2, CHD8, GOPC, PARD6A, SPATS2L, ASF1B, TES, NUFIP1, AMFR, MYH2, NRXN1, KIDINS220, MYO5B, HIGD1A, PRELID1, ASF1A, EXOG, SSX2IP, SUGT1, PAM16, DTNA, WIPI2, N6AMT1

GO:0043235

CC

receptor complex

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

NRP1, MUSK, GPR37, RAMP1, RAMP3, LRP5, LRP6, TM7SF2, EGFR, LDLR, ERBB2, NTRK1, APP, ITGB3, ITGB2, ITGB1, INSR, ADRB2, IGF1R, GHR, FGFR1, VDR, ADRB3, ITGB4, ITGB5, ERBB3, PTPRB, IL4R, ITGA3, KLRC1, ACVR2A, FLT4, ACVR1B, TGFBR1, TGFBR2, ADCYAP1R1, LIFR, NOTCH1, MTNR1A, LEPR, TRPC1, OLR1, SMAD3, VLDLR, LRP2, ROR1, TGFBR3, NOTCH2, DDR1, NR1H3, RIPK1, ACVR2B, ITPR2, ITPR3, ERBB4, TRADD, NTRK2, NT5DC3, ITLN1, GPR98, LOXL4, GPR63, ABCG8, GPRC5C, GPR160, TAOK2

GO:0043236

MF

laminin binding

Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.

ITGB1, THBS1, RPSA, LGALS1, NID1, ITGA2, LGALS3, ITGA6, CTSS, ITGA3, GPC1, BCAM, ADAM9, ITGA9, TINAGL1, PLEKHA2

GO:0043237

MF

laminin-1 binding

Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.

SLIT2, NID1, DAG1, NTN4

GO:0043240

CC

Fanconi anaemia nuclear complex

A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.

STRA13, FANCG, FAAP100, FAAP20, FANCM, APITD1, FANCB, FANCE

GO:0043241

BP

protein complex disassembly

The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.

DDIT4, HDAC6

GO:0043242

BP

negative regulation of protein complex disassembly

Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.

TNF, HDAC6, IRAK3

GO:0043243

BP

positive regulation of protein complex disassembly

Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.

TNF, BNIP3

GO:0043244

BP

regulation of protein complex disassembly

Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.

IRAK3

GO:0043248

BP

proteasome assembly

The aggregation, arrangement and bonding together of a mature, active proteasome complex.

PSMD11, PSMG1, SHFM1, ADRM1, PSMG4, POMP

GO:0043249

BP

erythrocyte maturation

A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.

PTBP3, G6PD, TAL1, ERCC2, MAEA, L3MBTL3, KLF2

GO:0043252

BP

sodium-independent organic anion transport

The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLCO2B1, ALB, SLCO4C1, SLCO6A1, SLCO2A1, SLCO3A1

GO:0043254

BP

regulation of protein complex assembly

Any process that modulates the frequency, rate or extent of protein complex assembly.

LATS1, HSP90AA1, INSM1, PTPN11, HJURP, BBS10, NCLN, PINK1

GO:0043257

CC

laminin-8 complex

A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.

LAMB1

GO:0043259

CC

laminin-10 complex

A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.

LAMB1, LAMC1

GO:0043260

CC

laminin-11 complex

A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.

LAMC1

GO:0043262

MF

adenosine-diphosphatase activity

Catalysis of the reaction: ADP + H2O = AMP + phosphate.

NUDT9

GO:0043265

CC

ectoplasm

Granule free cytoplasm, lying immediately below the plasma membrane.

GYS2

GO:0043266

BP

regulation of potassium ion transport

Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

DRD2, ANK3

GO:0043267

BP

negative regulation of potassium ion transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ATF4, NOS3, ACTN2

GO:0043268

BP

positive regulation of potassium ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ADORA1, ACTN2, ANK2, DLG1, FHL1

GO:0043270

BP

positive regulation of ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

LEP

GO:0043271

BP

negative regulation of ion transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

CNR1, PXK, BEST3

GO:0043273

MF

CTPase activity

Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction.

DDX3X

GO:0043274

MF

phospholipase binding

Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.

PARK2, SELE, LMNB1, SNCA, CALM2, PTPN11

GO:0043276

BP

anoikis

Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.

E2F1, STK11