| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0042766 | BP | nucleosome mobilization | The movement of nucleosomes along a DNA fragment. |
ARID1A |
GO:0042769 | BP | DNA damage response, detection of DNA damage | The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. |
USP1, PARP1, UBC, PCNA, POLD1, DNAJA1, RPA3, RFC4, RFC2, RFC5, RFC3, HMGA2, RBX1, RPS27A, UBA52, UBE2B, SOX4, CUL4A, CUL4B, POLD3, MRPS26, POLD4, RAD18, DTL |
GO:0042770 | BP | signal transduction in response to DNA damage | A cascade of processes induced by the detection of DNA damage within a cell. |
GADD45A, CASP9, BID, GRB2, SMC1A, MAPK14 |
GO:0042771 | BP | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
NUPR1, TP53, BCL3, CDKN1A, MSH2, BRCA2, EP300, PMAIP1, IFI16, RPS27L, DYRK2, USP28, HIPK2, DDIT4, PYCARD |
GO:0042775 | BP | mitochondrial ATP synthesis coupled electron transport | The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. |
SNCA |
GO:0042776 | BP | mitochondrial ATP synthesis coupled proton transport | The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
ATP5H, ATP5L, COX5B, ATP5J, ATP5D, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5I, ATP5G2 |
GO:0042780 | BP | tRNA 3'-end processing | The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. |
PTCD1, TRNT1, ELAC2 |
GO:0042787 | BP | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. |
UBA6, WWP2, UBE2C, AURKA, SIAH2, BUB3, PARK2, BUB1B, UBR5, UBE4B, PTTG1, CDK1, FBXO45, UBC, CCNB1, CDC27, RNF144A, UBE2E1, PLK1, RBX1, RPS27A, UBA52, MDM2, CDC20, MAD2L1, OS9, CUL2, CUL3, CUL4A, CUL4B, TRIM25, HERC3, TCEB1, UBE3C, HERC4, UBR4, HECTD2, SPOPL, RNF19B, RNF111, RNF165, MAEA, RNF144B, RBBP6, HUWE1, SYVN1, C19orf68, CACUL1, SIAH1, KLHL7, KLHDC8A, HACE1, ABTB2, RNF128, MYLIP, RFFL, CUL5, ANAPC16, RMND5B, AURKB, ITCH, KLHL15, KLHL32, NEDD4L, BTBD9, UHRF1, RNF126, WWP1, ANAPC1, UBE2Z, RMND5A, SMURF2, RNF146, RNF19A, KBTBD4, KLHL28, RNF181, KLHL8, HECW2, RNF14, KLHL3, CDC23, ANAPC5, ANAPC4, FBXO10, AMFR, FZR1, ANAPC10, STUB1, RNF24, BTBD3, ARIH1 |
GO:0042788 | CC | polysomal ribosome | A ribosome bound to mRNA that forms part of a polysome. |
EEF2, NR0B1, RPL7A, FMR1, NUFIP2 |
GO:0042789 | BP | mRNA transcription from RNA polymerase II promoter | The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. |
ATF4, FLNA, C5AR1, LMO2, ARNT, DDIT3, SREBF1, POU5F1, HIF1A, SOX17 |
GO:0042791 | BP | 5S class rRNA transcription from RNA polymerase III type 1 promoter | The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter. |
GTF3C2, GTF3C4 |
GO:0042795 | BP | snRNA transcription from RNA polymerase II promoter | The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. |
ELL2, POLR2D, CCNT1, CCNT2, GTF2F2, POU2F1, POLR2E, POLR2A, POLR2B, GTF2F1, POLR2I, CDK7, POLR2J, GTF2A1, GTF2A2, POLR2K, POLR2G, POLR2L, GTF2B, NCBP1, TAF5, TAF11, SNAPC1, CPSF3L, ICE2, INTS3, INTS1, SNAPC3, NABP1, INTS4, RPRD1A, VWA9, NABP2, PHAX, INTS7, INTS10, INTS6 |
GO:0042796 | BP | snRNA transcription from RNA polymerase III promoter | The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. |
SNAPC1, ICE2 |
GO:0042797 | BP | tRNA transcription from RNA polymerase III promoter | The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. |
GTF3C2, GTF3C4 |
GO:0042799 | MF | histone methyltransferase activity (H4-K20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
WHSC1, KMT5B, KMT5C, KMT5A |
GO:0042800 | MF | histone methyltransferase activity (H3-K4 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
RBBP5, KMT2E, KMT2C, ASH1L, ASH2L, KMT2B |
GO:0042802 | MF | identical protein binding | Interacting selectively and non-covalently with an identical protein or proteins. |
PLK4, SDCBP, CLDN4, AXIN1, MID1, KDM6A, CLDN3, SSNA1, BNIP3L, PARK2, SRPX2, VPS4B, PRKRA, USP2, BRI3, CLDN1, LDHA, GOT2, EGFR, SERPINA1, CST3, LDLR, GCG, INS, TNF, COL1A1, CRYAB, APOA1, APOE, TTR, ALB, FTL, ESR1, VTN, ALDOA, PRNP, CD74, S100B, VWF, ERBB2, TP53, HSPB1, APP, ITGB3, JUN, LDHB, HSP90AA1, HNRNPC, THBS1, COL1A2, INHBA, VIM, FBP1, ANXA4, CCL3, CD28, IAPP, FGFR1, G6PD, PCNA, CCL4, ALAD, LCP1, DRD2, ACPP, NME1, NQO1, VEGFA, PFKFB1, DES, PFKL, NFKB1, NPR2, GSTM3, SYT1, PAICS, FBLN1, PTPRG, AHCY, MPST, PTX3, S100A4, PLN, DPP4, CAD, MAPK1, S100A2, EPHB2, GBP1, ACTN2, TRIM23, SNCA, RBMX, CSK, EPS15, FHIT, NUP153, SEPHS1, CPT1A, DAPK1, CTSC, ATXN3, ATXN1, BCAT1, EPHA4, ALDH18A1, VCP, CASP6, SNX16, PTEN, ACTB, PSME3, LYZ, STXBP1, B2M, GRB2, DYNLT1, GPSM2, SORD, PLIN5, CAV1, RELA, TLE1, ZBTB16, FMR1, PRDX1, BAX, KCNH2, BNIP3, TARDBP, FADD, SMAD4, SQSTM1, RIPK1, PKD2, TP53BP2, PAFAH1B3, PCM1, TRIP10, TRIP13, MAPRE1, SMAD1, ADIPOQ, CLPP, UGP2, KLHL12, CDC42BPA, ATL3, DESI1, RGMB, JMJD6, CBLL1, SETX, SDK1, CCDC91, ADIPOR2, HOOK3, ZDHHC17, PHYKPL, PLEKHH2, SCUBE1, KLHL7, AMOTL1, SFRP1, HJURP, MNS1, TRPV1, ATL2, PPP1R13L, KCTD13, TTN, TOPBP1, TFG, RYR2, ADIPOR1, DACT3, OPTN, YIPF6, HOOK2, EDC3, UHRF1, CCT7, CORO1B, SDF4, NIF3L1, CHMP4B, DCTPP1, C10orf88, SMURF2, ROBO2, TRIM39, RAD18, MTPAP, THAP1, NDE1, ATXN10, NUFIP1, PYCARD, PRPF19, MAPRE3, MAPK8IP1, RUVBL2, SH3GLB1, L3MBTL1, USP15, TNPO3, FHOD1, SNCAIP |
GO:0042803 | MF | protein homodimerization activity | Interacting selectively and non-covalently with an identical protein to form a homodimer. |
E2F8, ACOT7, SDCBP, PDXK, BHLHE40, KCNK3, ADAM10, AXIN1, GSTA4, SLC22A1, GRM6, MID1, TOX3, FOXP2, IRAK2, MAP3K13, DAPK3, RIPK2, TBX1, ACTN4, GSTZ1, NUDT21, BNIP3L, RAB11FIP3, PDCD6, VPS4B, ERN1, BANF1, PRKRA, LRP6, IDH1, STC2, RNF8, SLIT2, TRIM37, VAPB, PEX11B, GOT2, PDGFB, TGFB1, CD4, CRYAB, APOE, APOA2, AMBP, TFRC, ANG, HMGCR, ANXA1, PDGFA, S100B, VWF, NTRK1, TYMS, JUN, S100A6, NPM1, CSF1R, ADRB2, HSP90AA1, ANXA6, ASNS, IL6R, SNRPC, LGALS1, QDPR, GSTM1, INHBB, HMOX1, BCL2, MGST1, KIT, GHR, FGFR1, TOP2A, G6PD, PRPS2, ODC1, TPR, ACTN1, CCL5, ENO3, ADRB3, DRD2, TYR, IDE, JUP, PVR, HPGD, VEGFA, TCF4, RAG1, TCF3, PDGFRA, PRLR, NPR3, CEBPB, HLA-G, RPL7, ATF3, SRM, NFKB1, GSTM3, FLNA, AGXT, FGFR2, ERBB3, ENPP1, XPA, CBLN1, SP100, NR2F2, TARS, STOM, PON1, MAOB, DPP4, DCK, GSTM2, ABCD3, MZF1, IMPA1, TKT, ERP29, CLIP1, CORO1A, S100A11, SHMT1, RDX, PTGS2, CBS, MYH9, ACTN2, CHKA, HMGCL, CHRNA7, CPOX, BMPR1A, IL6ST, ID1, CD200, NBL1, ECE1, MSH2, NR4A2, NAMPT, CBX5, ALDH1A3, XDH, SLC11A1, FASN, CENPF, PCYT1A, HARS2, CEBPD, PGF, VEGFB, TSC2, ASCL1, FXR1, IRAK1, CAV2, HSD17B4, PSMD7, CLCN3, NR0B1, GTF2A2, HRSP12, CEBPG, MVD, TERF1, GYS2, CDH13, TPD52, OXCT1, CTBP2, TIRAP, PRPS1, S100A10, TGFB2, RACK1, PAFAH1B2, ABAT, CBX1, SMAD3, NDP, HMGCS1, PLOD1, GSTM4, HHEX, RELA, ACVR1, ZBTB16, FMR1, BAX, MCL1, SMAGP, BST2, KCNH2, DPYD, BNIP3, STK4, CALCOCO2, PRDX4, MAD2L1, SMAD4, SQSTM1, CAMK2D, PKD2, TDG, SNX1, MTMR1, MTMR2, CUL3, GALE, HES1, MEF2D, EEA1, NECTIN1, PPP2R4, QPRT, RABEP1, ERBB4, NR0B2, TWIST1, ELAVL1, SMAD2, SMAD1, ADIPOQ, USF2, EXT1, NTRK2, KYNU, PTPRO, AOC3, TPD52L1, LRRFIP1, CCDC88A, NADK2, ANO6, MLK4, OLFML2A, TENM4, JMJD6, SLC27A1, MTHFD1L, OLFM4, RBPMS2, RAB11FIP2, EMSY, SLC51A, SPATA24, CARM1, CEP57, CCDC103, SLC30A8, KLHL7, SUPV3L1, NLGN4X, ADSSL1, CISD2, COMMD1, FAM73A, ZBTB38, SUMF1, UXS1, LILRB1, GABPB2, SPPL3, SPPL2A, HM13, SCARB1, PDCD6IP, MITD1, NR4A3, BCL2L2, RBPMS, NUDT16, S100A16, DGAT2, ALS2, KIF20B, TCF12, P2RX4, S100A13, MAP3K5, MGLL, BARD1, ARID3A, CITED1, TREX2, SYT11, PDCD10, JAM3, CADM1, TRIM8, FOXP3, TRIM9, MFF, DNTTIP1, SDCBP2, IKZF4, MUC13, CHMP4B, GLIPR2, GREM2, ECT2, GRPEL1, CACYBP, APOBEC3G, GOPC, PLCB1, HEYL, ANO2, HPS4, NECTIN3, PRDM6, PDGFC, PRTFDC1, ABCB10, FGFR1OP2, MTPAP, CLN6, FLRT3, ZBTB4, TENM3, GRHPR, PLEKHB1, MLX, GNPTG, NUDT5, ACSL6, BLOC1S6, FZD4, PYCARD, BOK, STUB1, SNX6, TIMELESS, CRYL1, SH3GLB1, SNX9, IRAK3, CPQ |
GO:0042805 | MF | actinin binding | Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. |
NFKB1, RELA, PKD2, TTN, PDLIM5, TRPC6 |
GO:0042809 | MF | vitamin D receptor binding | Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. |
MED14, TOB2, TAF11, MED12, MED30, MED4, MED17, THRAP3, MED16 |
GO:0042813 | MF | Wnt-activated receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
FZD6, FZD7, LRP5, LRP6, SFRP5, SFRP4, SFRP1, FZD8, FZD4 |
GO:0042816 | BP | vitamin B6 metabolic process | The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. |
PDXK, AOX1 |
GO:0042823 | BP | pyridoxal phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. |
PDXK |
GO:0042824 | CC | MHC class I peptide loading complex | A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. |
CALR |
GO:0042826 | MF | histone deacetylase binding | Interacting selectively and non-covalently with the enzyme histone deacetylase. |
HDAC3, ZNHIT1, KLF4, TCF21, NUDT21, PARK2, NCOR1, GMNN, HSP90AA1, HSP90AB1, PARP1, HSPA1A, HSPA1B, GLI3, TOP2A, TAL1, CEBPB, XBP1, SFPQ, YY1, HOXA10, YWHAB, PHB, CBX5, MAPK8, NRIP1, KPNA2, HDAC4, YWHAE, RAC1, INSM1, MEF2A, RELA, MEF2C, RBBP4, CDC20, HDAC1, HNRNPD, HES1, MEF2D, ANKRD1, PKN1, PKN2, CRY1, HIF1A, BRMS1L, NIPBL, SIRT2, KAT2B, RAD9A, FOXP3, DHX36, SUDS3, DACT1, DNMT3B, HDAC6, DDX20, HDAC9, SMG5, HDAC5, NCOR2 |
GO:0042827 | CC | platelet dense granule | Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. |
HPS4 |
GO:0042832 | BP | defense response to protozoan | Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism. |
IL6, BCL3, IL10, IL4R, IL12A, SLC11A1, LYST, CLEC7A |
GO:0042834 | MF | peptidoglycan binding | Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. |
TLR2, PGLYRP2 |
GO:0042851 | BP | L-alanine metabolic process | The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. |
GPT2 |
GO:0042853 | BP | L-alanine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. |
AGXT, GPT2 |
GO:0042866 | BP | pyruvate biosynthetic process | The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. |
AGXT |
GO:0042903 | MF | tubulin deacetylase activity | Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. |
SIRT2, HDAC6 |
GO:0042904 | BP | 9-cis-retinoic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. |
ALDH1A2, CYP1A1, DHRS9, ALDH8A1 |
GO:0042908 | BP | xenobiotic transport | The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
ABCA8, SLC2A1 |
GO:0042910 | MF | xenobiotic transporter activity | Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells. |
SLC2A1 |
GO:0042921 | BP | glucocorticoid receptor signaling pathway | Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor. |
ARID1A, NR3C1, CALR, YWHAH |
GO:0042922 | MF | neuromedin U receptor binding | Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor. |
NMU |
GO:0042923 | MF | neuropeptide binding | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). |
SSTR1, MC4R, SSTR5, OPRL1, ADCYAP1R1, NPBWR1 |
GO:0042930 | BP | enterobactin transport | The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
ASIC3 |
GO:0042931 | MF | enterobactin transporter activity | Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells. |
ASIC3 |
GO:0042953 | BP | lipoprotein transport | The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
UNC119B, APOB, PRKCB, CD36, PPARG, LRP2, UNC119, ZDHHC17 |
GO:0042954 | MF | lipoprotein transporter activity | Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells. |
LRP2 |
GO:0042974 | MF | retinoic acid receptor binding | Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. |
CNOT1, ACTN4, HMGA1, CTBP2, LRIF1 |
GO:0042975 | MF | peroxisome proliferator activated receptor binding | Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. |
HMGA1, MDM2, NFATC4, NR0B2, ASXL2, PPARGC1A |
GO:0042977 | BP | activation of JAK2 kinase activity | The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it. |
JAK2, GHR, PRLR |
GO:0042978 | MF | ornithine decarboxylase activator activity | Upregulation of the activity of the enzyme ornithine decarboxylase. |
AZIN1, PRLR |
GO:0042981 | BP | regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
HAX1, HIP1, TNFRSF11B, NME4, MSTN, TNFRSF10C, BIRC5, DAPK3, ACTN4, TRIAP1, BNIP3L, GDF9, JAK2, MITF, LRP5, TNFRSF21, RSL1D1, GDF11, BMP10, BMP15, TGFB1, ESR1, RAF1, TP53, INHA, FYN, CTSB, NGFR, LGALS1, INHBB, BMP3, ACTN1, BMP1, TPT1, NME1, IGFBP3, EGR1, TNFRSF1B, BCL3, BMP6, CHM, FAS, CALR, DUSP1, CASP1, PRDX2, BMP8B, PHB, ACTN2, BRCA1, ANP32A, BCL6, GDF5, SOX9, CASP4, RBM25, DAPK1, RABGGTB, GAS1, VCP, INHBC, CASP6, BID, CRADD, CDK5, PAX8, BAX, SKP2, BIRC3, NAE1, TP53BP2, PMAIP1, DIP2A, HS1BP3, CARD16, SARM1, RASSF6, BMP8A, RASSF3, TMEM219, SERBP1, ZNF420, DLG5, FRS2, RASSF5, NDRG1, CREBBP, TNFRSF25, TP53INP1, SGK3, PERP, GDF15, AIFM2, ANP32E, CARD10, BEX2, SRA1, RTN4, LCMT1, FBXO10, PRELID1, TNFRSF11A |
GO:0042982 | BP | amyloid precursor protein metabolic process | The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. |
DLG1, LDLRAP1 |
GO:0042984 | BP | regulation of amyloid precursor protein biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
NECAB3 |
GO:0042985 | BP | negative regulation of amyloid precursor protein biosynthetic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
ITM2A, AATF, ITM2B |
GO:0042986 | BP | positive regulation of amyloid precursor protein biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. |
SOAT1, PAWR |
GO:0042987 | BP | amyloid precursor protein catabolic process | The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. |
PSEN1, PSEN2, CLN3, DHCR24, APH1A |
GO:0042988 | MF | X11-like protein binding | Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein. |
CLSTN1 |
GO:0042989 | BP | sequestering of actin monomers | The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. |
TMSB15A, TMSB4X, TMSB10, TWF1, TWF2 |
GO:0042990 | BP | regulation of transcription factor import into nucleus | Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. |
AGTR2 |
GO:0042991 | BP | transcription factor import into nucleus | The directed movement of a transcription factor from the cytoplasm to the nucleus. |
SYK, IPO9 |
GO:0042992 | BP | negative regulation of transcription factor import into nucleus | Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. |
CD36, RAB23, SUFU |
GO:0042993 | BP | positive regulation of transcription factor import into nucleus | Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. |
HDAC3, HCLS1, FLNA, PIK3R1, SMAD3, TRIM28, MAVS |
GO:0042994 | BP | cytoplasmic sequestering of transcription factor | The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. |
THRA, SRI, MXI1, PKD1, PKD2, TONSL, MDFI, NFKBIL1, SUFU |
GO:0042995 | CC | cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
SH3PXD2B, ANGPT2, TLR2, LPXN, WDR1, CLSTN1, SPP1, ACTN1, EZR, MDK, RRM1, CAD, GJA5, AGFG1, ARPC4, PTEN, ACTR2, GTF2I, FMR1, ARHGEF5, TRIP10, SCN9A, KIZ, RHOU, CFAP52, ARHGAP24, CFAP36, MEGF10, MAGI1, RTN4, CDC42SE2, BIN2 |
GO:0042997 | BP | negative regulation of Golgi to plasma membrane protein transport | Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. |
LYPLA1, CSK |
GO:0042998 | BP | positive regulation of Golgi to plasma membrane protein transport | Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. |
RACK1, CNST |
GO:0043000 | BP | Golgi to plasma membrane CFTR protein transport | The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. |
KRT18 |
GO:0043001 | BP | Golgi to plasma membrane protein transport | The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. |
NSF, VAMP7, VAMP2, SPTBN1, ANK3, GOLGA4, RAB31, VAMP3, BBS1, OPTN, BBS2, RAB34, BLZF1, MACF1 |
GO:0043004 | BP | cytoplasmic sequestering of CFTR protein | The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. |
GOPC |
GO:0043005 | CC | neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
SNAP23, ARPC2, FLRT2, SIAH2, ACTN4, PARK2, KIF5C, KIF1B, DAB1, GABBR2, MYO1D, UNC5C, FOS, GPI, TH, PFN1, HSP90AA1, NGFR, VIM, NMB, QDPR, PTPRF, MAP2, FOSL1, STMN1, ATF4, PAM, SYT1, CALB2, AHCY, ATP2B4, MPST, FAS, S100A4, CD27, SLC6A1, SSTR1, GDI1, NF2, SSTR5, PTGS2, OPRL1, RGS2, ADCYAP1R1, SLC1A3, IQGAP1, NPBWR1, CSNK1D, STAR, HNMT, VAMP7, HNRNPA3, CDH13, PTEN, RAC3, SNAP25, CDC42, RAP1A, VAMP2, CXADR, ABAT, ARF1, CDK16, ANK2, APBA1, FMR1, GRIN2A, ANK3, FADD, STX3, CLN3, HDAC1, ARHGEF7, CASP8, KISS1, NPY5R, NCOA1, ITSN1, VAMP3, PTPRO, CPEB4, SLC4A8, TENM4, KLC3, NSMF, SV2A, SV2B, CYFIP1, RASGRP2, CPEB2, TPH2, CPEB3, CYGB, ANKS1A, NRCAM, GHSR, FGF13, RAB39B, CYFIP2, PDLIM5, MARK4, PACRG, DOCK7, ANKRD27, CIB1, INPP5K, CADM1, LIN7B, CACYBP, ATP13A2, LIN7C, STMN3, TENM3, MYO5A, LSM4 |
GO:0043006 | BP | activation of phospholipase A2 activity by calcium-mediated signaling | A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal. |
EGFR |
GO:0043008 | MF | ATP-dependent protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP. |
PRNP, PLK2, SAE1 |
GO:0043009 | BP | chordate embryonic development | The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. |
FGFR1, BRCA1, CENPU |
GO:0043010 | BP | camera-type eye development | The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. |
FOXP2, CYP1A1, SKI, WT1, FBN1, FBN2, GPD2, CDKN1C, EFEMP1, FOXC1, MAB21L1, SHROOM2, CACNA1C, RAB3GAP1, RCN1, PITX2, CC2D2A, B9D1 |
GO:0043011 | BP | myeloid dendritic cell differentiation | The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. |
UBD, TGFB1, LTBR, TGFBR2, PSEN1, RELB |
GO:0043012 | BP | regulation of fusion of sperm to egg plasma membrane | Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane. |
NOX5 |
GO:0043014 | MF | alpha-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. |
WASH1, OFD1, SNCA, NCALD, FAM110C, HSPH1, ARL8A, PACRG, NDEL1, RACGAP1, TRPV4, ARL8B, PPARGC1A, HDAC6, SPAST |
GO:0043015 | MF | gamma-tubulin binding | Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. |
OFD1, RAD51D, LYN, NME1, BRCA2, MZT1, DIXDC1, CEP57, PIFO, NDRG1, TUBGCP3, MARK4, FEZ1, RACGAP1 |
GO:0043020 | CC | NADPH oxidase complex | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
CYBB, NCF2, NCF4, NOXA1, NOX4 |
GO:0043021 | MF | ribonucleoprotein complex binding | Interacting selectively and non-covalently with any complex of RNA and protein. |
PPIH, PQBP1, CD2BP2, SRP54, PPP1CA, HNRNPU, RNASEL, BOP1, EZH2, TIMM50, UHMK1, PRPF31, SECISBP2L, ITCH, SECISBP2, WDR12, SMG5 |
GO:0043022 | MF | ribosome binding | Interacting selectively and non-covalently with any part of a ribosome. |
LETM1, EIF2S1, RPSA, HSPA5, EEF2, EIF6, SEC61A1, EIF5A, FMR1, ICT1, CPEB4, LETM2, LETMD1, RICTOR, CPEB2, GUF1, CPEB3, GCN1, NAA15, YTHDF1, EIF5A2, MTIF3, C12orf65, SEC61A2, IMPACT, EIF3K, SBDS |
GO:0043023 | MF | ribosomal large subunit binding | Interacting selectively and non-covalently with any part of the larger ribosomal subunit. |
NPM1, EIF6, CPEB2, MALSU1 |
GO:0043024 | MF | ribosomal small subunit binding | Interacting selectively and non-covalently with any part of the small ribosomal subunit. |
DDX3X, NPM1, NME1, EIF4B, ABCE1, DHX29, CPEB2, PTCD3, MTIF3 |
GO:0043025 | CC | neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
APBB1, AGRP, ENC1, NRP1, PMM2, SLC31A1, SIAH2, RGS10, BRINP1, ACSL4, COBL, ZPR1, SRSF10, DAB1, LRP6, MYO1D, STAU1, ADA, CST3, TGFB1, PENK, APOE, ANG, APOB, S100B, TUBB4A, NTRK1, CYBB, APOD, CYP17A1, INHA, HSP90AA1, CHRM2, UCHL1, C4A, PTPRF, IAPP, LAMP1, ANXA3, NQO1, TIMP2, CPE, SRD5A1, ELK1, TNFRSF1B, RAB5A, FLNA, GAL, RRM1, CAD, CANX, EPHB2, ADORA1, SRD5A2, PRKAR2B, BMPR1A, IL6ST, SLC1A3, SLC1A4, CSNK1E, STAR, PSEN1, PSEN2, GSK3B, ASCL1, PPT1, AGFG1, EPHA5, RAC3, CDC42, TGFB2, RACK1, GTF2I, CDK5, PURA, DHODH, FKBP4, EEF1A2, SOS1, KCNA1, TIAM1, STRN3, MAPK8IP2, ILK, PICALM, TUBB3, CAMK2D, ALCAM, BMPR2, ARHGEF7, ITPR3, KCNJ11, PTPRK, CNN3, KISS1, ASIC2, DPYSL2, FBXO31, CPLX2, KNDC1, CAMK2N1, TRPV1, DNER, TRPM4, DENND1A, PARD3, CYGB, ARHGEF2, ALS2, P2RX4, TXN2, OLFM1, CIB1, KATNB1, SPTBN4, PHAX, ATP13A2, GLRX2, ELOVL5, CRIPT, ATXN10, PPARGC1A, VTI1B, PTBP2, ADAM21, AMFR, NRXN1, PYCARD, IGSF9B, MYO5A, RBM8A, SNCAIP |
GO:0043027 | MF | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
NOL3, MT3, CD27, SNCA, SERPINB9, XIAP, BIRC3, GAS6, RPS6KA1 |
GO:0043028 | MF | cysteine-type endopeptidase regulator activity involved in apoptotic process | Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
FOXL2 |
GO:0043029 | BP | T cell homeostasis | The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
BCL2L11, CCNB2, TGFB1, BCL2, RAG1, CORO1A, STAT5B, JAK3, FADD, PMAIP1, SLC46A2, FOXP3, RC3H2 |
GO:0043030 | BP | regulation of macrophage activation | Any process that modulates the frequency or rate of macrophage activation. |
CD74, MIF, RORA, SNCA, SLC7A2, SHPK |
GO:0043031 | BP | negative regulation of macrophage activation | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. |
CD200, NR1H3 |
GO:0043032 | BP | positive regulation of macrophage activation | Any process that stimulates, induces or increases the rate of macrophage activation. |
IL33, THBS1, HSPD1, IL10, IL4R, WNT5A, IL1RL1 |
GO:0043033 | CC | isoamylase complex | A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. |
AGL |
GO:0043034 | CC | costamere | Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. |
KRT8, KRT19, DMD, SDC4, FXR1, ANK2, AHNAK, ANK3, ILK, DAG1, FLNC, HOMER1 |
GO:0043041 | BP | amino acid activation for nonribosomal peptide biosynthetic process | Activation of an amino acid for incorporation into a peptide by a nonribosomal process. |
AASDH |
GO:0043043 | BP | peptide biosynthetic process | The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. |
FURIN, DMD, PCSK1, PCSK5, MRPS26 |
GO:0043044 | BP | ATP-dependent chromatin remodeling | Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. |
ARID1A, SMARCA5, MBD3, ACTL6A, HNRNPC, SMARCA1, SMARCA4, ACTB, RBBP4, HDAC1, CHD4, SMARCC2, HDAC2, SMARCC1, SMARCAD1, CHD8 |
GO:0043045 | BP | DNA methylation involved in embryo development | The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression. |
TRIM28 |
GO:0043046 | BP | DNA methylation involved in gamete generation | The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. |
PIWIL4, TDRD9, CTCFL |
GO:0043047 | MF | single-stranded telomeric DNA binding | Interacting selectively and non-covalently with single-stranded telomere-associated DNA. |
HNRNPA2B1, RAD50, OBFC1, POT1 |
GO:0043049 | BP | otic placode formation | The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. |
PROX1 |
GO:0043060 | BP | meiotic metaphase I plate congression | The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I. |
MLH1 |
GO:0043062 | BP | extracellular structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. |
TGFBR1 |
GO:0043063 | BP | intercellular bridge organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another. |
TEX14 |
GO:0043065 | BP | positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
USP27X, APBB1, DFFA, SAP18, BIN1, DDX3X, PDCD5, UBD, TLR3, DAPK3, EEF1E1, RIPK2, BCL2L11, FOXO3, BNIP3L, NUPR1, GADD45B, ARL6IP5, ALDH1A2, SLIT2, PLEKHG5, UNC5C, GADD45G, AIFM1, LATS1, LDHA, KNG1, TGFB1, NGF, TNF, S100B, TP53, IL6, ITGB1, NGFR, HMGB1, HMOX1, PDGFRB, UBC, HSPD1, TOP2A, IGF2R, CDK4, BMP2, BMP4, FOSL1, VAV1, CREB1, IGFBP3, ATF4, ATF6, CNR1, TGM2, GAL, ITGA6, GADD45A, APC, FAS, DUSP1, TNFRSF8, TSPO, DNAJA1, AKT1, CTNNB1, ADM, PTGS2, SNCA, BCL6, MNDA, MAPK8, NOTCH1, ALDH1A3, PSEN1, PSEN2, TNFSF10, MAP2K6, RBM5, HMGA2, BID, FOXL2, RHOB, RPS6, RPS27A, UBA52, RAC1, RACK1, PRKDC, GPLD1, DHODH, ID3, ZBTB16, EEF1A2, SOX4, C1QBP, BAX, SOS1, SOS2, PPID, FOXO1, KCNMA1, AKAP13, GRIN2A, ABR, BNIP3, TIAM1, MLLT11, STK4, EIF2B5, FADD, ITGB3BP, SQSTM1, RIPK1, PMAIP1, ARHGEF7, ZNF268, MELK, PPP2R4, RNPS1, ERBB4, ANKRD1, RPS6KA2, TRADD, NCOA1, ITSN1, PDCD2, CYP1B1, DUSP6, ANO6, ARHGEF16, SFRP4, SHQ1, ADAMTSL4, NET1, FGD2, CAMK1D, SIAH1, CCAR2, SFRP1, JMY, TRPV1, FLCN, LILRB1, APH1B, CSRNP3, NSMAF, INPP5D, APBB2, BAD, ARHGEF2, FAM162A, APH1A, MOAP1, PAWR, FGD4, GPER1, MAP3K5, BARD1, AIFM2, CDK19, TXNIP, SUDS3, PLEKHG2, ECT2, TNFRSF12A, NOX4, ARHGEF4, ARHGEF3, LATS2, ING3, BCLAF1, ZAK, IP6K2, DDX20, OSGIN1, VAV3, PNMA3, PNMA2, PYCARD, BOK, FAF1, TRIM35 |
GO:0043066 | BP | negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
HAX1, DDX3X, CYR61, SOCS2, SOCS3, AURKA, MDM4, HDAC3, BIRC5, CFLAR, SIAH2, PAX4, RIPK2, SMAD6, SPRY2, TRIAP1, BNIP3L, GREM1, FCMR, NOL3, PSMD10, MAP4K4, DDAH2, EGFR, TIMP1, MYC, NGF, GNRH1, GCG, CRYAB, ALB, RAF1, ANXA1, PRNP, CD74, TP53, HSPB1, IGF1, MPO, IL6, KRT18, CDK1, NPM1, CSF1R, THBS1, IGF1R, NGFR, ASNS, ANXA5, GSTP1, ANXA4, PDGFRB, CTSH, UBC, GLI2, GLI3, BCL2, HSPD1, HSPA5, BMP4, UNG, TDGF1, TPT1, MIF, HSP90B1, MMP9, NQO1, VEGFA, CD44, EPCAM, PRLR, XBP1, ARF4, SON, WT1, NFKB1, BCL3, CAPN3, FLNA, IL10, NME2, CFL1, FAS, MT3, CD27, PIK3R1, DUSP1, LTK, CD40LG, CCND2, PPIF, ADORA1, DNAJA1, AKT1, PRDX2, GRK5, BTC, FLT4, NUP62, SNCA, CDKN1A, IL6ST, STAT3, ID1, LEP, WNT5A, HTR2B, PRKCI, PTGFR, MAPK8, CDKN1B, IER3, SOX9, GCLC, COMP, PSEN1, PSEN2, GSK3B, MRE11A, SERPINB9, ASCL1, PPT1, IRAK1, STAT5B, ARHGDIA, HMGA2, PLK1, PRKAA2, UCP2, SOX8, ADAMTS20, PTEN, RPS3A, DAD1, RPS6, RPS27A, UBA52, YWHAZ, UBE2B, ACTC1, PRKDC, TMF1, SMAD3, DAB2, XIAP, TEK, PPARD, PLAUR, RELA, NOTCH2, GLO1, PTK2, EGR3, MCL1, FOXO1, BNIP3, PAK2, DNAJC3, MAD2L1, CLN3, BIRC3, SQSTM1, HDAC1, GAS6, PDE3A, ZNF268, ARL6IP1, KIF14, ERBB4, ANGPT1, DHCR24, RPS6KA1, STIL, RGN, TWIST1, NPY5R, ASIC2, FXN, PDCD4, ZFAND6, SETX, MTDH, TAX1BP1, ANKLE2, CAMK1D, SUPV3L1, AHI1, SFRP1, OSR1, RHBDD1, PHIP, HDAC2, BCL2L2, KIFAP3, APBB2, GATA6, MYDGF, ITCH, NR1H4, FAM129B, PHB2, BARD1, CIB1, CITED2, PDCD10, HTATIP2, NAA15, WNK3, TAF9B, AGO4, SLC40A1, CHST11, ATAD3A, AATF, SPHK1, PLK2, FMN2, GHRL, PA2G4, HIGD1A, PRELID1 |