GO:0042526

BP

positive regulation of tyrosine phosphorylation of Stat6 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.

PIBF1

GO:0042527

BP

negative regulation of tyrosine phosphorylation of Stat6 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.

PTPN2

GO:0042531

BP

positive regulation of tyrosine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

LYN, CCL5, HCLS1

GO:0042535

BP

positive regulation of tumor necrosis factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

TLR4, HSPB1, CYBB, THBS1, TNFRSF8, MAPKAPK2, TLR1

GO:0042536

BP

negative regulation of tumor necrosis factor biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

BCL3, IL10, LILRB1, GHSR, GHRL, ERRFI1

GO:0042538

BP

hyperosmotic salinity response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

TRPV4

GO:0042541

BP

hemoglobin biosynthetic process

The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

INHA, INHBA, HIF1A

GO:0042542

BP

response to hydrogen peroxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

KPNA4, LDHA, HP, ADA, COL1A1, CRYAB, JUN, GPX1, HMOX1, PDGFRB, BCL2, HSPD1, EEF2, FOSL1, AREG, SDC1, DUSP1, STAR, PPP2CB, HBB, HBA1, ADAM9, NR4A3, BAD, PDCD10, TXNIP, GLRX2, STK24

GO:0042551

BP

neuron maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.

KDM1A, CLN5, RB1, NR4A2, CDKN1C

GO:0042552

BP

myelination

The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

DHH, TSPAN2, TNFRSF21, TGFB1, ERBB2, EGR2, ZNF24, MAL, PMP22, EIF2B5, GPR126, SERINC5, QKI, JAM3, EIF2B4, MYO5A

GO:0042554

BP

superoxide anion generation

The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.

CYBB, EDN1, NCF2, NOX5, NOX4, DUOX1

GO:0042555

CC

MCM complex

A hexameric protein complex required for the initiation and regulation of DNA replication.

MCM3, MCM4, MCM5, MCM7, MCM2, MCM6, TONSL

GO:0042558

BP

pteridine-containing compound metabolic process

The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.

MTR

GO:0042562

MF

hormone binding

Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.

NPR3, NPR2, CALR, MTNR1A, AMHR2

GO:0042564

CC

NLS-dependent protein nuclear import complex

A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore.

MYBBP1A

GO:0042567

CC

insulin-like growth factor ternary complex

A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.

IGF1, IGFBP3, IGFBP5

GO:0042571

CC

immunoglobulin complex, circulating

An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.

IGLL5

GO:0042572

BP

retinol metabolic process

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.

DHRS3, ALDH1A2, ALDH1A1, RBP4, TTR, ADH7, AKR1C3, ALDH1A3, CYP1B1, RDH10, RDH13, RDH11, DGAT2, DHRS9, DHRS4

GO:0042573

BP

retinoic acid metabolic process

The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.

CYP26A1, ALDH1A2, ADH7, ALDH1A3, ALDH8A1, SCPEP1

GO:0042574

BP

retinal metabolic process

The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

ALDH1A2, AKR1C3, ALDH1A3, AKR1C1, CYP1B1, RDH10, RDH11, ALDH8A1

GO:0042577

MF

lipid phosphatase activity

Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.

PLPP1, PLPP3, PLPPR4, PLPPR2, INPP5K

GO:0042578

MF

phosphoric ester hydrolase activity

Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.

PGAP1

GO:0042581

CC

specific granule

Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

SNAP23, ANXA3, ANXA11, CLCN3, CRISP3, ADAM8, STX4, STX3, STXBP2, OLFM4

GO:0042582

CC

azurophil granule

Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.

SNAP23, STX7, MPO, HEXA, DEFA4, ANXA11, STX3, STXBP2

GO:0042583

CC

chromaffin granule

Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.

CLU

GO:0042584

CC

chromaffin granule membrane

The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.

SYT1, SRI

GO:0042585

CC

germinal vesicle

The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.

AURKA, MARCKS

GO:0042587

CC

glycogen granule

Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.

PPP1R3D, FASN, PCYT1A, PPP1CA, PPP1CB, PPP1R3B

GO:0042588

CC

zymogen granule

A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.

GNAI3, SRGN, HSPD1

GO:0042589

CC

zymogen granule membrane

The lipid bilayer surrounding a zymogen granule.

RAB27B, SCAMP1, TMED10, VAMP2, STX3, TMED2, STXBP2, DMBT1

GO:0042592

BP

homeostatic process

Any biological process involved in the maintenance of an internal steady state.

NR5A2, ANG, MPV17, SMAD1, CREBBP

GO:0042593

BP

glucose homeostasis

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

POMC, INS, RBP4, IL6, INSR, GPI, NGFR, NMB, SLC2A4, CYP11B1, PTPN2, HNF1A, CNR1, IGFBP5, AKT1, SSTR5, ADRA1B, PCK1, IRS1, G6PC, PPARG, STAT3, LEP, LEPR, MTNR1B, DHPS, PRKAA2, SESN3, RPS6, PTPN11, SOX4, PTCH1, STK11, ADIPOQ, CRY1, PDK4, HIF1A, ADIPOR2, ERO1B, BAD, ADIPOR1, NR1H4, INPP5K, ASPSCR1, TRPV4, TCF7L2, GPRC5B, MBD5, RPH3AL, STXBP5L

GO:0042594

BP

response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

GNPAT, ULK1, GCG, PFKFB1, ZFP36, CAD, ADSL, SSTR1, ADM, DDIT3, HMGCL, PPARG, OXCT1, DHODH, FSTL1, PDK4, AACS, ADSSL1, TBC1D5, PPARGC1A

GO:0042596

BP

fear response

The response of an organism to a perceived external threat.

ADRB1

GO:0042599

CC

lamellar body

A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.

SFTPC

GO:0042602

MF

riboflavin reductase (NADPH) activity

Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.

BLVRB

GO:0042605

MF

peptide antigen binding

Interacting selectively and non-covalently with an antigen peptide.

HLA-B, HLA-DRA, HLA-DQA1, HLA-DQB1, HLA-E, HLA-DPA1, HLA-A, HLA-F, HLA-DRB3, SLC7A9, SLC7A5, DHCR24, HLA-DRB5, CD209, SLC7A8

GO:0042608

MF

T cell receptor binding

Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.

FYN, DOCK2

GO:0042609

MF

CD4 receptor binding

Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.

PLSCR1, FYN, PLSCR4

GO:0042610

MF

CD8 receptor binding

Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.

FYN

GO:0042612

CC

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

HLA-B, HLA-E, HLA-G, HLA-A, HLA-F, B2M, MR1

GO:0042613

CC

MHC class II protein complex

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, HLA-DRB4, HLA-DOB, HLA-DPA1, HLA-DMB, HLA-DRB3, HLA-DRB5

GO:0042622

CC

photoreceptor outer segment membrane

The membrane surrounding the outer segment of a vertebrate photoreceptor.

DHRS3, OPN1SW, CNGA1, GNB1, NAPEPLD, PHLPP2

GO:0042623

MF

ATPase activity, coupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.

VPS4B, HSPA1A, HSPA1B, HSPA6, NSF, CCT8, MYO1E

GO:0042624

MF

ATPase activity, uncoupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction.

ATP6V1F

GO:0042625

MF

ATPase coupled ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate.

ATP6V0E1, ATP6V1F

GO:0042626

MF

ATPase activity, coupled to transmembrane movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.

ABCD4, ABCA8, ABCA1, ABCD3, ABCC1, ABCA6, ABCA5, ABCG8, ABCB10, ATP6V1D

GO:0042627

CC

chylomicron

A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.

APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, APOBR, APOA5, LSR

GO:0042628

BP

mating plug formation

The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.

SERPINE2

GO:0042629

CC

mast cell granule

Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.

SNAP23, PIK3CD, ANXA1, LYN, SRGN, KIT, AKR1B1, CXCR2, PIK3CG, CPLX2, NR4A3, S100A13

GO:0042631

BP

cellular response to water deprivation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.

AQP2

GO:0042632

BP

cholesterol homeostasis

Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.

NR5A2, NPC1, LRP5, ABCA1, LDLR, APOA1, APOE, APOA2, APOC3, APOB, FABP3, LPL, FABP4, XBP1, CD24, G6PC, SOAT1, NR1H2, NPC2, CAV1, AKR1C1, MALL, NR1H3, IL18, ACSM3, TMEM97, LDLRAP1, LAMTOR1, APOA5, PCSK9, SCARB1, MYLIP, DGAT2, ABCG8, LIPG

GO:0042633

BP

hair cycle

The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.

KRT16, PTGS2, PPP1R13L

GO:0042634

BP

regulation of hair cycle

Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.

ARNTL, PER1, NIPBL, FA2H

GO:0042637

BP

catagen

The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.

TGFB2

GO:0042641

CC

actomyosin

Any complex of actin, myosin, and accessory proteins.

MYH9, HDAC4, DBN1, CDC42BPA, KAT2B, MYO5A, CDC42BPB

GO:0042643

CC

actomyosin, actin portion

The actin part of any complex of actin, myosin, and accessory proteins.

ACTC1

GO:0042645

CC

mitochondrial nucleoid

The region of a mitochondrion to which the DNA is confined.

KIAA0391, CLPX, SLC25A5, DBT, MPG, LRPPRC, VDAC2, ACADVL, DNA2, POLG, HADHB, TFAM, SSBP1, GRSF1, DHX30, SUPV3L1, TEFM, PEO1, MTERF1, ELAC2, UQCC2, DDX28, ATAD3A, POLDIP2

GO:0042658

MF

MHC class II protein binding, via antigen binding groove

Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules.

CD74

GO:0042659

BP

regulation of cell fate specification

Any process that mediates the adoption of a specific fate by a cell.

LMO4

GO:0042660

BP

positive regulation of cell fate specification

Any process that activates or enables a cell to adopt a specific fate.

FGF2

GO:0042662

BP

negative regulation of mesodermal cell fate specification

Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.

DKK1, SOX17

GO:0042663

BP

regulation of endodermal cell fate specification

Any process that mediates the specification of a cell into an endoderm cell.

DKK1, DUSP6

GO:0042666

BP

negative regulation of ectodermal cell fate specification

Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.

FZD7

GO:0042668

BP

auditory receptor cell fate determination

The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.

HES1

GO:0042692

BP

muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.

BIN1, RORA, HIRA, H3F3A, ANKRD1, SMARCD3, GLMN, QKI, ASF1A

GO:0042693

BP

muscle cell fate commitment

The process in which the cellular identity of muscle cells is acquired and determined.

TBX1

GO:0042698

BP

ovulation cycle

The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.

EGFR, SERPINF1, TYRO3

GO:0042699

BP

follicle-stimulating hormone signaling pathway

The series of molecular signals mediated by follicle-stimulating hormone.

FSHB, FSHR

GO:0042700

BP

luteinizing hormone signaling pathway

The series of molecular signals mediated by luteinizing hormone.

EREG, LHCGR

GO:0042701

BP

progesterone secretion

The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.

INHBA, FZD4

GO:0042703

BP

menstruation

The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.

FOXL2

GO:0042704

BP

uterine wall breakdown

The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels.

TGFB2

GO:0042711

BP

maternal behavior

Female behaviors associated with the care and rearing of offspring.

OXTR, GNAQ, PTEN, CREBRF

GO:0042713

BP

sperm ejaculation

The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.

ACVR2A, OXTR

GO:0042719

CC

mitochondrial intermembrane space protein transporter complex

Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.

TIMM10B

GO:0042723

BP

thiamine-containing compound metabolic process

The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.

SLC19A2, TPK1

GO:0042730

BP

fibrinolysis

A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.

F2, PLG, PLAU, PLAT, FGA, FGB, FGG, KRT1, SERPINE1, SERPING1, ANXA2, PLAUR, TMPRSS6, CPB2

GO:0042731

MF

PH domain binding

Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

EPHA4, INPP5A

GO:0042732

BP

D-xylose metabolic process

The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

DCXR

GO:0042733

BP

embryonic digit morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.

LRP5, TULP3, MYCN, GLI2, GLI3, BMP4, GJA1, CTNNB1, BMPR1A, WNT5A, ECE1, GNAQ, GNA12, ZBTB16, SMAD4, HDAC1, TWIST1, TMEM107, OSR1, LMBR1, HDAC2, CREBBP, LNP, IFT122, CHST11, MKS1, ZAK, INTU, B9D1

GO:0042734

CC

presynaptic membrane

A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

APBB1, GRM8, CASK, GRM6, FBXO45, FOSL1, SYT1, ADORA1, SNAP25, FMR1, KCNA1, GRIN2A, STX3, PICALM, GRM3, NECTIN1, ERC1, ZDHHC17, DENND1A, KCTD12, GPER1, GABBR1, NRXN1, RIMS2, SNCAIP

GO:0042737

BP

drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.

CYP3A4, CYP2D6, CYP2C9, CYP3A5, FMO4

GO:0042738

BP

exogenous drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.

CYP3A4, CYP2A6, CYP2C9, CYP2B6, NUDT15

GO:0042742

BP

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

IGLL5, TLR4, TLR3, COCH, HP, PPBP, S100A8, ISG15, MPO, S100A9, MBL2, ANXA3, PRG2, CEBPB, BCL3, IL10, CFP, SYK, SLC11A1, ROMO1, RAB1A, CCL20, CXCL6, HAMP, TMF1, PRKCD, TLR1, MICA, GBP6, MAVS, IFNE, DEFB104A, STAB2, CLEC4D, NR1H4, LYST, STAB1, ADAMTS5

GO:0042743

BP

hydrogen peroxide metabolic process

The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.

EGFR, DUOXA1, DUOXA2

GO:0042744

BP

hydrogen peroxide catabolic process

The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).

MPO, GPX1, GPX3, PRDX6, PRDX2, HBB, HBA1, PRDX1, DUOX2, DUOX1

GO:0042745

BP

circadian sleep/wake cycle

The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.

TH, AHCY

GO:0042747

BP

circadian sleep/wake cycle, REM sleep

A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.

CST3, SRD5A1, STAR

GO:0042748

BP

circadian sleep/wake cycle, non-REM sleep

All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions.

BTBD9

GO:0042752

BP

regulation of circadian rhythm

Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

PER1, ROCK2, TOP2A, CREB1, NR1D1, SFPQ, PPP1CC, PPARG, MAPK8, MAPK9, CSNK1D, CSNK1E, PRKAA2, PPP1CA, PPP1CB, PRKDC, ID2, CREM, PPARA, KLF10, NR1H3, HNRNPD, NR1D2, NONO, EZH2, CRY1, CCAR2, PSPC1, PROX1, OPN3, PPARGC1A, NOCT, TIMELESS, BTRC

GO:0042753

BP

positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.

ARNTL, RORA, NKX2-1, ARNTL2, BTRC, THRAP3

GO:0042754

BP

negative regulation of circadian rhythm

Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.

SFPQ, CRY1, SUV39H2

GO:0042755

BP

eating behavior

The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.

AGRP, CCK, TH, UCHL1, IAPP, ADRB3, TRH, OXTR, STAT3, OPRL1, LEP, NMU, CPT1A, TCF15, NPY5R, BBS12

GO:0042756

BP

drinking behavior

The specific behavior of an organism relating to the intake of liquids, especially water.

APLN

GO:0042758

BP

long-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22.

LIPE

GO:0042759

BP

long-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.

SCD, PLP1, SCD5, QKI, ELOVL6, MYO5A

GO:0042760

BP

very long-chain fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.

SLC27A2, ABCD3, ACADVL, SLC27A4

GO:0042761

BP

very long-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

ELOVL7, HACD4, HACD2, ELOVL1, ELOVL4, ELOVL6, ELOVL5, HACD3

GO:0042765

CC

GPI-anchor transamidase complex

An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.

PIGK, PIGT, PIGU