GO:0042269

BP

regulation of natural killer cell mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.

LEP

GO:0042270

BP

protection from natural killer cell mediated cytotoxicity

The process of protecting a cell from natural killer cell mediated cytotoxicity.

HLA-E, SERPINB4, SERPINB9

GO:0042271

BP

susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.

PVR, CADM1

GO:0042272

CC

nuclear RNA export factor complex

A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.

ATXN1

GO:0042273

BP

ribosomal large subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

RPL35A, RPL7, RPL5, RPL14, RPL26, RPL11, RRS1, WDR74, MALSU1, EBNA1BP2, WDR12, SDAD1, NIP7, NOC2L

GO:0042274

BP

ribosomal small subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.

RPS17, RPS7, RPS16, RPS6, NOM1, EMG1

GO:0042275

BP

error-free postreplication DNA repair

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.

UBE2V2

GO:0042276

BP

error-prone translesion synthesis

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

REV3L, UBC, PCNA, RPA3, RFC4, RFC2, RFC5, RFC3, POLE2, RPS27A, UBA52, POLK, POLI

GO:0042277

MF

peptide binding

Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.

TPP1, GPR37, ANG, RPLP0, MME, CLTA, FURIN, IDE, PPIB, CALR, TPP2, AVPR2, OXTR, GNRHR, CSNK1D, THOP1, PGGT1B, NPEPPS, PPIA, TUBB3, ERAP2, AOPEP, TMEM158, PCSK5, NLN, ERAP1, LNPEP, LOC440434

GO:0042278

BP

purine nucleoside metabolic process

The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

MACROD2, MACROD1

GO:0042281

MF

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

ALG8, ALG6

GO:0042282

MF

hydroxymethylglutaryl-CoA reductase activity

Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.

HMGCR

GO:0042285

MF

xylosyltransferase activity

Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

LARGE

GO:0042287

MF

MHC protein binding

Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

MARCH1, CLEC7A

GO:0042288

MF

MHC class I protein binding

Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

TUBB, HLA-E, BCAP31, VCP, TUBB4B, LILRB1, CD244, PILRB, PILRA

GO:0042289

MF

MHC class II protein binding

Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

CD4, CD74, LAG3, KRT17, MARCH8

GO:0042296

MF

ISG15 transferase activity

Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.

UBE2E1, UBE2E2

GO:0042297

BP

vocal learning

A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.

FOXP2, HTT, NRXN1

GO:0042301

MF

phosphate ion binding

Interacting selectively and non-covalently with phosphate.

PNP, MTHFD2, ADSS, G6PC, RELA, ADSSL1

GO:0042304

BP

regulation of fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.

PRKAA2, EIF6, PDK4

GO:0042306

BP

regulation of protein import into nucleus

Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.

TGFB1, BMP4, NUP62, NUP58

GO:0042307

BP

positive regulation of protein import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.

IPO5, ZPR1, TGFB1, GLI3, TPR, JUP, NUTF2, PRKCD, HYAL2, ZIC1, MAPK14, ECT2

GO:0042308

BP

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

APOD, PKIA, ANGPT1, CHP1, PKIG

GO:0042310

BP

vasoconstriction

A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.

EDN1, EDN2, EDNRA, HTR7, HTR2B, CAV1, TRPM4

GO:0042311

BP

vasodilation

An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.

AGT, KNG1, APOE, GPX1, BBS2, MKKS

GO:0042312

BP

regulation of vasodilation

Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels.

ADRB2, ACE, NPPB, AGTR1

GO:0042313

BP

protein kinase C deactivation

Any process resulting in the inhibition or termination of the activity of protein kinase C.

EDN1

GO:0042321

BP

negative regulation of circadian sleep/wake cycle, sleep

Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.

DRD2

GO:0042322

BP

negative regulation of circadian sleep/wake cycle, REM sleep

Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.

GHRL

GO:0042323

BP

negative regulation of circadian sleep/wake cycle, non-REM sleep

Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.

ADA, ADORA1

GO:0042325

BP

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

SRPX2, CD24, MCM7, PSEN1, RICTOR, SIRT2, PPP1R14C, PPP1R14A, PPP1R14B, BARD1

GO:0042326

BP

negative regulation of phosphorylation

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

AHSG, INHA, INHBA, BMP4, CDKN1A, CDKN2B, CDKN2C, CDKN1B, CDKN1C, DYNLL1, GRB10, ANKLE2

GO:0042327

BP

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

SDCBP, EREG, FZD7, BCL10, EGFR, ANG, THBS1, AR, CCL5, MIF, AREG, ITGA6, ILK, ITSN1, KCTD20, PPARGC1B, GLMN, APLN

GO:0042328

MF

heparan sulfate N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.

EXT1, EXT2

GO:0042335

BP

cuticle development

The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.

DUOX2, DUOX1

GO:0042340

BP

keratan sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.

HEXA, GNS, OGN, GALNS, LUM, FMOD, OMD

GO:0042345

BP

regulation of NF-kappaB import into nucleus

Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

NOL3, BCL3, PRDX1

GO:0042346

BP

positive regulation of NF-kappaB import into nucleus

Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

TLR4, TLR3, GREM1, TLR2, TNF, IL1B, PTGS2, RHOA, IL18R1, IL18, SPHK1

GO:0042347

BP

negative regulation of NF-kappaB import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

PPM1B, LITAF, C1QTNF3, CYLD

GO:0042351

BP

de novo' GDP-L-fucose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).

GMDS

GO:0042355

BP

L-fucose catabolic process

The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).

FUT1, FUT4, FUT2, FUT8

GO:0042359

BP

vitamin D metabolic process

The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

CYP27B1, GC, CYP1A1, CYP11A1, CYP3A4, LRP2, CYP2R1

GO:0042369

BP

vitamin D catabolic process

The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).

CYP27B1

GO:0042373

BP

vitamin K metabolic process

The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.

CBR1, VKORC1

GO:0042379

MF

chemokine receptor binding

Interacting selectively and non-covalently with any chemokine receptor.

CCL5, CXCL12

GO:0042382

CC

paraspeckles

Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.

NUDT21, SFPQ, HNRNPM, NONO, PSPC1

GO:0042383

CC

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

FXYD1, FLOT1, PDE9A, ANXA1, ATP1B1, ITGB1, KRT8, ANXA2, KRT19, LAMP1, DMD, COL6A1, COL6A2, COL6A3, DES, VCAM1, BGN, SLC2A5, LAMA2, BSG, ANK2, PPP3CA, AHNAK, ANK3, DLG1, SNTA1, SNTB1, DAG1, FLNC, SSPN, SLMAP, RYR3, SGCB, BVES, SGCD, RYR2, SGCZ, CIB1, SYNC, FKRP, POPDC2, MYOT, PEMT, SLC27A6, DTNA

GO:0042384

BP

cilium assembly

The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

BBIP1, EXOC5, ABLIM1, ABCC4, ABLIM3, PCNT, SNAP29, FLNA, RFX2, ACTR2, ATP6V0D1, OCRL, SEPT2, PCM1, FAM161A, FNBP1L, TMEM107, BBS7, AHI1, BBS1, TTC8, POC1B, DYNC2LI1, DNAH5, FBF1, IFT81, RPGR, CLUAP1, TCTN2, IFT74, FOPNL, NEK1, CEP89, BBS2, CCDC113, IFT122, TMEM138, MKKS, IFT46, MKS1, CELSR3, EHD3, CC2D2A, WDR35, ATXN10, RAB23, INTU, CDC14A, B9D1, SSX2IP, KIF3A, CEP83, ATP6V1D

GO:0042391

BP

regulation of membrane potential

Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

WWP2, CACNA1G, DLD, CHRNB1, CNGA1, ACTN2, CHRNA7, GLRB, SLC1A6, SLC26A2, KCNA1, KCNMA1, KCNH2, DLG1, KCNJ11, ASIC2, PXK, SLC26A11, BVES, NEDD4L, SLC26A1, RIMS4, POPDC3, RANGRF, RIMS2

GO:0042392

MF

sphingosine-1-phosphate phosphatase activity

Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.

PLPP1, PLPP3, SGPP2

GO:0042393

MF

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

APBB1, CHD2, SMARCA5, JAK2, TBL1X, RNF8, TNKS, PRKCB, PTMA, NPM1, CTSL, CD1D, RAG1, H2AFX, RCC1, CKS2, DEK, SNCA, ANP32A, ATRX, MCM2, SMARCA2, CKS1B, HIST1H4A, HIST1H3D, H3F3A, SET, RBBP4, CHAF1B, SART3, NCAPD2, ZMYND11, PKN1, SPTY2D1, ATAD2, SUPT6H, HJURP, CTCFL, ANP32B, L3MBTL2, TONSL, PRMT6, IPO9, UHRF2, PHF12, RSF1, UHRF1, PYGO2, ANP32E, TBL1XR1, CHD8, BRD7, ASF1B, NAP1L2, ASF1A, NOC2L, L3MBTL1

GO:0042403

BP

thyroid hormone metabolic process

The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.

DIO2

GO:0042405

CC

nuclear inclusion body

An intranuclear focus at which aggregated proteins have been sequestered.

NBN, TPR, NUP153, RANBP2, ATXN3, ATXN1, PABPN1, SLF1, RAD18, NXF1, STUB1

GO:0042406

CC

extrinsic component of endoplasmic reticulum membrane

The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

TOR1A

GO:0042407

BP

cristae formation

The assembly of cristae, the inwards folds of the inner mitochondrial membrane.

LETM1, UQCC3, APOOL, OMA1, APOO, SAMM50

GO:0042412

BP

taurine biosynthetic process

The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.

CDO1, CSAD

GO:0042415

BP

norepinephrine metabolic process

The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.

PARK2, AKR1B1, EPAS1

GO:0042416

BP

dopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

GPR37, TH, SNCA, NR4A2, AGTR2, TGFB2

GO:0042417

BP

dopamine metabolic process

The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

PARK2, DRD2, GRIN2A, SNCAIP

GO:0042418

BP

epinephrine biosynthetic process

The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.

TH, PNMT

GO:0042420

BP

dopamine catabolic process

The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.

MAOA, COMT, MAOB

GO:0042421

BP

norepinephrine biosynthetic process

The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.

TH, INSM1

GO:0042423

BP

catecholamine biosynthetic process

The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.

TH, PNMT

GO:0042426

BP

choline catabolic process

The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.

ALDH7A1, SLC44A1, DMGDH, SARDH

GO:0042427

BP

serotonin biosynthetic process

The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

TPH2

GO:0042428

BP

serotonin metabolic process

The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

SRD5A1, GRIN2A, BTBD9

GO:0042438

BP

melanin biosynthetic process

The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.

TYR, DDT, PMEL, TRPC1, CITED1, SLC45A2, MYO5A

GO:0042445

BP

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

LEP, ALDH9A1, PTPN11

GO:0042446

BP

hormone biosynthetic process

The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

CYP17A1, FDX1, HFE, DIO2, DUOX2, DUOX1

GO:0042447

BP

hormone catabolic process

The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

ACE, IDE, ECE1

GO:0042448

BP

progesterone metabolic process

The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.

CYP17A1, SRD5A1, AKR1C3, STAT5B, AKR1C2, AKR1C1, DHRS9

GO:0042462

BP

eye photoreceptor cell development

Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.

TH, VEGFA, PRKCI, CRB1, RDH13

GO:0042470

CC

melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

RAB27B, SDCBP, TPP1, RAB29, CALU, SEC22B, FLOT1, ATP6V1G2, TFRC, ITGB3, ITGB1, P4HB, CTSD, ANXA2, CTSB, HSP90AA1, ANXA6, SLC3A2, HSP90AB1, CNP, HSPA5, SLC2A1, LAMP1, PDIA4, HSP90B1, TYR, RAB5A, ATP6V1B2, PPIB, AHCY, STOM, CANX, ERP29, PDIA3, YWHAB, BSG, MYH11, SERPINF1, CAPG, PMEL, SLC1A4, FASN, TMED10, MMP14, ANXA11, RAB5C, RAB9A, RAB27A, ATP1B3, NAP1L1, RAB2A, RAB5B, YWHAE, RAB1A, RAC1, YWHAZ, PRDX1, STX3, RAB32, GANAB, GPNMB, PDIA6, SLC1A5, MYRIP, PDCD6IP, GGH, ATP6V0A1, ANKRD27, SYTL2, HPS4, MYO5A, TRPV2

GO:0042471

BP

ear morphogenesis

The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

TBX1, NIPBL

GO:0042472

BP

inner ear morphogenesis

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.

SOBP, INSIG1, TBX1, SPRY2, FZD6, BCR, FGFR1, COL11A1, FGFR2, EPHB2, FGF9, ALDH1A3, DLX5, PAX8, ABR, ZIC1, CHD7, MAFB

GO:0042473

BP

outer ear morphogenesis

The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.

TBX1, PRKRA, FGFR1, MAPK3, MAPK1, HOXA1, TWIST1

GO:0042474

BP

middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).

INSIG1, HOXA2, TBX1, PRKRA, EDN1, FGFR1, NAGLU, RPL38, TSHZ1, OSR1

GO:0042475

BP

odontogenesis of dentin-containing tooth

The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.

TBX1, BCL2L11, LRP6, CA2, NFIC, GLI2, GLI3, BMP2, BMP4, TNC, CTNNA1, CTNNB1, NF2, ADM, BSG, BMPR1A, DLX2, BAX, FOXC1, HDAC1, ACVR2B, RUNX2, ANKRD11, SOSTDC1, HDAC2, PITX2, WNT6

GO:0042476

BP

odontogenesis

The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.

BGLAP, LAMB1, COL1A2, INHBA, BMP4, ZNF22, SDC1, PAM, FGFR2, TGFB2, ID3, TWIST1, OSR1, AQP3, PITX2, MYO5A

GO:0042482

BP

positive regulation of odontogenesis

Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.

TGFB1, EDN1, BMP2

GO:0042487

BP

regulation of odontogenesis of dentin-containing tooth

Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.

BMP2, BMP4, RUNX2

GO:0042489

BP

negative regulation of odontogenesis of dentin-containing tooth

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.

TNFRSF11B

GO:0042490

BP

mechanoreceptor differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.

NTRK1, NTRK2

GO:0042491

BP

auditory receptor cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell.

JAG1

GO:0042493

BP

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

TNFRSF11B, ACACB, KCNK3, XPO1, PFAS, NPC1, GNPAT, ABCC4, PAX4, DAB1, BCAR3, SRP72, NDUFA10, ABCA1, CBX7, LDHA, PNP, ADA, ASS1, CST3, FOS, MYC, TGFB1, PTH, COL1A1, APOA1, APOA2, BGLAP, AMH, ANXA1, NTRK1, CYP1A1, TYMS, CYBB, APOD, CYP2E1, IL6, ICAM1, JUN, FABP3, FYN, CDK1, LPL, HSP90AA1, LYN, THBS1, INHBA, LGALS1, BCL2, MGST1, HSPD1, TOP1, CDK4, XRCC5, ALAD, ENO3, DRD2, CCNB1, FOSL1, TIMP2, CREB1, JUNB, ITGA2, JUND, CTPS1, IGFBP2, SRD5A1, PAM, MDK, COMT, IL10, GAL, ITGA3, HMGB2, AK4, MAOB, CALR, ABCD3, LOX, HTR2C, PTPRM, TSPO, OXTR, SRD5A2, ACSL1, ABCC1, MCM7, CTNNB1, ADRA1A, PTGS2, SREBF1, SRP14, TGFBR2, PPARG, SNCA, CDKN1A, COL18A1, NNMT, STAT3, ADCYAP1R1, HTR2B, MTHFR, SLC1A3, SLC1A2, GATA4, CDKN1B, UQCRFS1, GCLM, CENPF, STAR, PGF, VEGFB, VEGFC, CPT1A, MAP2K6, FOSB, TERF1, PMS1, OXCT1, HDAC4, PTEN, SRP54, B2M, DAD1, TGFB2, UBE2B, ACTC1, ADAM17, HSD11B2, ABAT, GNAS, SORD, MDM2, HMGCS1, XPC, DHODH, GNA12, RELA, EMX2, RAD51, TJP1, GRIN2A, NFATC2, HDAC1, PTCH1, BLMH, PDE3A, KCNJ11, DPYSL2, DUSP6, HADH, GNAS, AACS, SFRP1, RAD54L, HDAC2, GGH, GATA6, BAD, CPB2, PLIN2, TXN2, SEMA3C, ABCG8, TXNIP, WFDC1, DNMT3B, PPARGC1A, PEMT, VAV3, MYO6, RPH3AL, HDAC5

GO:0042495

BP

detection of triacyl bacterial lipopeptide

The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.

TLR2, TLR1

GO:0042496

BP

detection of diacyl bacterial lipopeptide

The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.

TLR2

GO:0042497

MF

triacyl lipopeptide binding

Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.

TLR2

GO:0042500

MF

aspartic endopeptidase activity, intramembrane cleaving

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.

SPPL3, SPPL2A, HM13

GO:0042503

BP

tyrosine phosphorylation of Stat3 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein.

JAK2, LIF

GO:0042506

BP

tyrosine phosphorylation of Stat5 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein.

JAK2

GO:0042508

BP

tyrosine phosphorylation of Stat1 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein.

JAK2

GO:0042511

BP

positive regulation of tyrosine phosphorylation of Stat1 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.

KIT, LIF, IL6ST

GO:0042512

BP

negative regulation of tyrosine phosphorylation of Stat1 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.

SOCS3, SOCS1, PTPN2

GO:0042517

BP

positive regulation of tyrosine phosphorylation of Stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

SOCS3, JAK2, GH1, IL6, CSF1R, IL6R, KIT, GHR, LIF, IL6ST, STAT3, LEP, HSF1, HDAC1, IL18, HES1, CTF1, HDAC2, CLCF1

GO:0042518

BP

negative regulation of tyrosine phosphorylation of Stat3 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

SOCS3, SOCS1, PPP2R1A, NF2

GO:0042520

BP

positive regulation of tyrosine phosphorylation of Stat4 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.

IL12A

GO:0042521

BP

negative regulation of tyrosine phosphorylation of Stat4 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.

PIBF1

GO:0042523

BP

positive regulation of tyrosine phosphorylation of Stat5 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.

JAK2, GH1, IGF1, FYN, KIT, GHR, ERBB4

GO:0042524

BP

negative regulation of tyrosine phosphorylation of Stat5 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.

PTPN2, NF2, CAV1