| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0036094 | MF | small molecule binding | Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule. |
AMBP, PAEP, PTGDS, LCN2 |
GO:0036109 | BP | alpha-linolenic acid metabolic process | The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
ACOT8, FADS1, FADS2, SCP2, ACSL1, HSD17B4, ACOX1, ELOVL1, ELOVL5 |
GO:0036111 | BP | very long-chain fatty-acyl-CoA metabolic process | The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
HSD17B4 |
GO:0036112 | BP | medium-chain fatty-acyl-CoA metabolic process | The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. |
HSD17B4 |
GO:0036114 | BP | medium-chain fatty-acyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. |
ACOT7 |
GO:0036116 | BP | long-chain fatty-acyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
ACOT7 |
GO:0036120 | BP | cellular response to platelet-derived growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. |
FYN, PDGFRB, CCL2, CREB1, CCNA2, RDX, IQGAP1, HAS2, CORO1B, PDGFD, ERRFI1 |
GO:0036122 | MF | BMP binding | Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family. |
GREM1, NBL1, GDF5, BMPR2, GREM2 |
GO:0036123 | BP | histone H3-K9 dimethylation | The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone. |
SUV39H2 |
GO:0036124 | BP | histone H3-K9 trimethylation | The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone. |
ARID4B, SUV39H2 |
GO:0036126 | CC | sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
DRD2, ATP2B4, MNS1, RPGR, AK8, SLIRP, IQCG, RNF38, DNAH1 |
GO:0036130 | MF | prostaglandin H2 endoperoxidase reductase activity | Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). |
AKR1C3 |
GO:0036131 | MF | prostaglandin D2 11-ketoreductase activity | Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+. |
AKR1C3 |
GO:0036132 | MF | 13-prostaglandin reductase activity | Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. |
PTGR1 |
GO:0036143 | MF | kringle domain binding | Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. |
CLEC3B |
GO:0036145 | BP | dendritic cell homeostasis | The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
GPR183 |
GO:0036148 | BP | phosphatidylglycerol acyl-chain remodeling | Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. |
PLA2G2A, PLA2G5, PLA2G4A, LPGAT1, PLA2G12A, CRLS1 |
GO:0036149 | BP | phosphatidylinositol acyl-chain remodeling | Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. |
PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, MBOAT7, PLA2G12A, PLA2G4C |
GO:0036150 | BP | phosphatidylserine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. |
PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, PLA2G12A |
GO:0036151 | BP | phosphatidylcholine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. |
DBI, PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, MBOAT2, LPCAT2, PLA2G12A, PNPLA8, PLA2G4C |
GO:0036152 | BP | phosphatidylethanolamine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. |
PLA2G2A, PLA2G5, PLA2G4A, PLA2G16, LPCAT3, MBOAT2, PLA2G12A, PNPLA8, PLA2G4C |
GO:0036153 | BP | triglyceride acyl-chain remodeling | Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains. |
PNPLA3 |
GO:0036155 | BP | acylglycerol acyl-chain remodeling | Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains. |
PNPLA2, DGAT2, MGLL, PNPLA3 |
GO:0036156 | CC | inner dynein arm | Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. |
DNAH1 |
GO:0036157 | CC | outer dynein arm | Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. |
DNAH5, DNAI1 |
GO:0036158 | BP | outer dynein arm assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. |
ARMC4, DNAAF5, CCDC103, DNAH5, DNAI1 |
GO:0036159 | BP | inner dynein arm assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. |
CCDC42B, DNAAF5, CCDC103, DNAH1, TEKT2 |
GO:0036164 | BP | cell-abiotic substrate adhesion | The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules. |
ID1 |
GO:0036179 | BP | osteoclast maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. |
FAM20C |
GO:0036195 | CC | muscle cell projection membrane | The portion of the plasma membrane surrounding a muscle cell projection. |
ARPC2, PLEKHO1 |
GO:0036211 | BP | protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
PARP1 |
GO:0036219 | MF | GTP diphosphatase activity | Catalysis of the reaction: GTP + H2O = GMP + diphosphate. |
NUDT1 |
GO:0036228 | BP | protein targeting to nuclear inner membrane | The process of targeting a protein to, and inserting it into, the nuclear inner membrane; usually uses signals contained within the protein. |
NUP155 |
GO:0036250 | BP | peroxisome transport along microtubule | The directed movement of a peroxisome along a microtubule, mediated by motor proteins. |
PEX14 |
GO:0036257 | BP | multivesicular body organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
RAB27A |
GO:0036258 | BP | multivesicular body assembly | The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
VPS37C, CHMP2A, VPS4B, STAM2, IST1, RAB11A, VPS37A, PDCD6IP, STAM, MVB12A, CHMP4B, VTA1 |
GO:0036289 | BP | peptidyl-serine autophosphorylation | The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. |
ERN1, MAP2K2, RIPK1, PINK1 |
GO:0036292 | BP | DNA rewinding | The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA. |
ANXA1 |
GO:0036294 | BP | cellular response to decreased oxygen levels | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. |
CPEB4 |
GO:0036297 | BP | interstrand cross-link repair | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
STRA13, FANCG, RAD51D, RNF8, USP1, ERCC1, UBC, RPA3, RPS27A, UBA52, FAAP100, FAAP20, FANCM, APITD1, FANCB, ATRIP, ERCC4, EME1, RAD51AP1, DCLRE1C, FANCD2, NUCKS1, FANCE, UBE2T, FANCI, FAN1 |
GO:0036302 | BP | atrioventricular canal development | The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. |
PTPN11, SMAD4, HAS2, CHD7 |
GO:0036303 | BP | lymph vessel morphogenesis | The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. |
VEGFA, PKD1 |
GO:0036304 | BP | umbilical cord morphogenesis | The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. |
HEY1 |
GO:0036309 | BP | protein localization to M-band | Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere. |
ANK2 |
GO:0036310 | MF | annealing helicase activity | Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA). |
RECQL4, ANXA1, SMARCA1, RECQL, BLM, RAD54L |
GO:0036312 | MF | phosphatidylinositol 3-kinase regulatory subunit binding | Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. |
XBP1, PIK3R1, FBXL2 |
GO:0036315 | BP | cellular response to sterol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. |
RORA |
GO:0036317 | MF | tyrosyl-RNA phosphodiesterase activity | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
TDP2 |
GO:0036324 | BP | vascular endothelial growth factor receptor-2 signaling pathway | Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PDCD6 |
GO:0036333 | BP | hepatocyte homeostasis | Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. |
EZH2 |
GO:0036335 | BP | intestinal stem cell homeostasis | Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. |
LGR4 |
GO:0036336 | BP | dendritic cell migration | The movement of a dendritic cell within or between different tissues and organs of the body. |
CDC42, EPS8, DOCK8 |
GO:0036342 | BP | post-anal tail morphogenesis | The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. |
WNT5A, TCF15, TMED2, MED12, CHST11 |
GO:0036343 | BP | psychomotor behavior | The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. |
DPP4 |
GO:0036344 | BP | platelet morphogenesis | Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. |
ACTN1 |
GO:0036353 | BP | histone H2A-K119 monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. |
TRIM37 |
GO:0036363 | BP | transforming growth factor beta activation | The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms. |
LTBP3 |
GO:0036371 | BP | protein localization to T-tubule | A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. |
ANK2 |
GO:0036374 | MF | glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
GGT7 |
GO:0036376 | BP | sodium ion export from cell | The directed movement of sodium ions out of a cell. |
ATP1B1, ATP1A2, ATP12A, ATP1B3 |
GO:0036378 | BP | calcitriol biosynthetic process from calciol | Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. |
CYP27B1, CYP3A4, CYP2R1 |
GO:0036396 | CC | MIS complex | An mRNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and WTAP. |
WTAP, METTL14 |
GO:0036398 | CC | TCR signalosome | A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. |
STK11 |
GO:0036399 | BP | TCR signalosome assembly | The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome. |
STK11 |
GO:0036402 | MF | proteasome-activating ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
PSMC3, PSMC2, PSMC4, PSMC1, PSMC6 |
GO:0036404 | BP | conversion of ds siRNA to ss siRNA | The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA). |
DICER1 |
GO:0036413 | BP | histone H3-R26 citrullination | The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3. |
PADI4 |
GO:0036414 | BP | histone citrullination | The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein. |
PADI4 |
GO:0036435 | MF | K48-linked polyubiquitin binding | Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers. |
VCP, UFD1L |
GO:0036438 | BP | maintenance of lens transparency | A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. |
MUC5AC, FOXC1, GCNT2, CHMP4B |
GO:0036444 | BP | calcium ion transmembrane import into mitochondrion | A process in which a calcium ion (Ca2+) is transported from one side of a membrane to the other into the mitochondrion by means of some agent such as a transporter or pore. |
MICU2, MCUR1, SLC25A23 |
GO:0036449 | CC | microtubule minus-end | The end of a microtubule that does not preferentially grow (polymerize). |
FAM175B, ASPM, NIN |
GO:0036457 | CC | keratohyalin granule | A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope. |
CELA2A |
GO:0036458 | MF | hepatocyte growth factor binding | Interacting selectively and non-covalently with a hepatocyte growth factor. |
SRPX2 |
GO:0036459 | MF | thiol-dependent ubiquitinyl hydrolase activity | Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. |
USP53, USP54, ALG13 |
GO:0036461 | MF | BLOC-2 complex binding | Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. |
RAB32 |
GO:0036462 | BP | TRAIL-activated apoptotic signaling pathway | An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface. |
FADD, CASP8 |
GO:0036464 | CC | cytoplasmic ribonucleoprotein granule | A ribonucleoprotein granule located in the cytoplasm. |
DYNC1I1, ROCK2, STAU1, RPLP0, TUBB, MAPT, RPL28, IQGAP1, ACTB, CDC42, RPS6, RAC1, HNRNPU, FMR1, TUBA1A |
GO:0036465 | BP | synaptic vesicle recycling | The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. |
RAB5A |
GO:0036477 | CC | somatodendritic compartment | The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. |
RAB5A, STX4 |
GO:0036481 | BP | intrinsic apoptotic signaling pathway in response to hydrogen peroxide | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). |
PDCD10 |
GO:0036486 | BP | ventral trunk neural crest cell migration | The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. |
NRP1, SEMA3A |
GO:0036487 | MF | nitric-oxide synthase inhibitor activity | Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase. |
ATP2B4 |
GO:0036488 | CC | CHOP-C/EBP complex | A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. |
CEBPB, DDIT3 |
GO:0036492 | BP | eiF2alpha phosphorylation in response to endoplasmic reticulum stress | The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. |
EIF2AK4 |
GO:0036494 | BP | positive regulation of translation initiation in response to endoplasmic reticulum stress | Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress. |
DNAJC3 |
GO:0036496 | BP | regulation of translational initiation by eIF2 alpha dephosphorylation | Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha. |
PPP1R15A, PPP1CA |
GO:0036498 | BP | IRE1-mediated unfolded protein response | A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. |
CTDSP2, GOSR2, TPP1, ASNA1, KDELR3, ERN1, SEC31A, LMNA, SULT1A3, HSPA5, XBP1, SSR1, ACADVL, HDGF, SEC61G, ATP6V0D1, SEC61A1, GFPT1, ZBTB17, DNAJC3, DCTN1, PDIA5, CUL7, PDIA6, PPP2R5B, WIPI1, SYVN1, EDEM1, MYDGF, SEC62, TSPYL2, SEC61A2, FKBP14, DNAJB9, SEC63, TLN1, HYOU1, SRPRB |
GO:0036499 | BP | PERK-mediated unfolded protein response | A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. |
EIF2S1, ASNS, IGFBP1, CXCL8, HSPA5, CCL2, ATF3, ATF4, DDIT3 |
GO:0036500 | BP | ATF6-mediated unfolded protein response | A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. |
HSPA5, HSP90B1, XBP1, ATF6, CALR, DDIT3 |
GO:0036501 | CC | UFD1-NPL4 complex | A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. |
UFD1L |
GO:0036502 | CC | Derlin-1-VIMP complex | A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. |
VIMP |
GO:0036503 | BP | ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
PARK2, VCP, TRIM25, SYVN1, RHBDD1, SEL1L, AMFR, STUB1 |
GO:0036505 | MF | prosaposin receptor activity | Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D). |
GPR37 |
GO:0036508 | BP | protein alpha-1,2-demannosylation | The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. |
MAN1B1 |
GO:0036509 | BP | trimming of terminal mannose on B branch | The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. |
MAN1B1 |
GO:0036510 | BP | trimming of terminal mannose on C branch | The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. |
EDEM1 |
GO:0036513 | CC | Derlin-1 retrotranslocation complex | A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. |
VCP, SYVN1, SVIP, HM13, VIMP, SEL1L, AMFR |
GO:0036514 | BP | dopaminergic neuron axon guidance | The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues. |
CELSR3 |
GO:0036515 | BP | serotonergic neuron axon guidance | The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues. |
CELSR3 |