GO:0035803

BP

egg coat formation

Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.

ZP3

GO:0035810

BP

positive regulation of urine volume

Any process that increases the amount of urine excreted from the body over a unit of time.

EDN1, DRD2, NPPB, NPR3, BTC, OPRL1, HYAL2, HAS2, INPP5K

GO:0035811

BP

negative regulation of urine volume

Any process that decreases the amount of urine excreted from the body over a unit of time.

AVPR2

GO:0035813

BP

regulation of renal sodium excretion

Any process that modulates the amount of sodium excreted in urine over a unit of time.

AGT, AGTR1

GO:0035814

BP

negative regulation of renal sodium excretion

Any process that decreases the amount of sodium excreted in urine over a unit of time.

COMT, AVPR2, ADORA1, SPX

GO:0035815

BP

positive regulation of renal sodium excretion

Any process that increases the amount of sodium excreted in urine over a unit of time.

AGT, EDN1, DRD2, NPPB, AGTR2

GO:0035822

BP

gene conversion

A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor.

NUCKS1

GO:0035841

CC

new growing cell tip

A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.

GRM6

GO:0035844

BP

cloaca development

The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.

AHI1

GO:0035845

BP

photoreceptor cell outer segment organization

A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.

AHI1

GO:0035851

MF

Krueppel-associated box domain binding

Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.

TRIM28

GO:0035855

BP

megakaryocyte development

The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.

MEIS1, KIT, TAL1, PTPN11, EP300, ABI1, WASF2

GO:0035860

BP

glial cell-derived neurotrophic factor receptor signaling pathway

The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands.

SULF2, SULF1

GO:0035861

CC

site of double-strand break

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

NBN, RNF8, H2AFX, MRE11A, VCP, RAD51, ESCO2, RFWD3, SLF2, SMC5, RNF169, RAD50, SMC6, SLF1, SMARCAD1, RAD18, PRPF19

GO:0035863

BP

dITP catabolic process

The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.

NUDT16

GO:0035864

BP

response to potassium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.

GNRH1

GO:0035865

BP

cellular response to potassium ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.

CYP11B1, CYP11B2, HSF1, PPARGC1A

GO:0035867

CC

alphav-beta3 integrin-IGF-1-IGF1R complex

A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.

IGF1, ITGB3, ITGAV, IGF1R

GO:0035869

CC

ciliary transition zone

A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.

UNC119B, SEPT2, PCM1, TMEM107, C5orf30, CC2D2A, B9D1

GO:0035870

MF

dITP diphosphatase activity

Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.

NUDT16

GO:0035871

BP

protein K11-linked deubiquitination

A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.

TNFAIP3, OTUD7B, OTUB2, VCPIP1

GO:0035873

BP

lactate transmembrane transport

The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.

SLC16A7

GO:0035877

MF

death effector domain binding

Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).

NOL3, FADD, CASP8

GO:0035878

BP

nail development

The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.

ITGB4, ITGA6

GO:0035879

BP

plasma membrane lactate transport

The directed movement of lactate across a plasma membrane.

SLC16A6, SLC16A3, SLC16A7, SLC16A12

GO:0035880

BP

embryonic nail plate morphogenesis

The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.

FZD6

GO:0035886

BP

vascular smooth muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.

PITX2, EPC1

GO:0035897

BP

proteolysis in other organism

The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds.

MAP2K7, MAP2K2, MAP2K6, MAP2K1

GO:0035900

BP

response to isolation stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.

TH, NAPEPLD

GO:0035902

BP

response to immobilization stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.

FOS, TGFB1, CYP1A1, GPI, TH, GAL, PPARG, HNMT, NR0B1

GO:0035904

BP

aorta development

The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.

SMAD6, LOX, NDST1, AP2B1, LRP2, LOXL1, PKD2, LTBP1, TAB1, PRICKLE1, DCTN5, ADAMTS6, SUFU, PLXND1

GO:0035909

BP

aorta morphogenesis

The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.

TBX1, PDGFRB, JAG1, NPRL3, CHD7

GO:0035910

BP

ascending aorta morphogenesis

The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.

TGFB2, SOX4, HES1

GO:0035912

BP

dorsal aorta morphogenesis

The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.

BMPR1A, DLL4, HEY1

GO:0035914

BP

skeletal muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.

NUPR1, FOS, RB1, EGR2, EEF2, EGR1, ATF3, FOXN2, NOTCH1, EMD, SOX8, BTG2, MEF2C, MEF2D, ANKRD1, HLF, HIVEP3, ZNF689, HEYL, HMG20B, MAFF, PLAGL1

GO:0035921

BP

desmosome disassembly

The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

SNAI2

GO:0035922

BP

foramen ovale closure

The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow.

GJA5

GO:0035924

BP

cellular response to vascular endothelial growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.

ITGB1BP1, NRP1, ERN1, HSPB1, MT1G, VEGFA, VCAM1, NR4A1, AKT1, FLT4, NOTCH1, MAPKAPK2, GAS1, EGR3, PRKD1, MAPK14, PRKD2, DLL4

GO:0035925

MF

mRNA 3'-UTR AU-rich region binding

Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.

ZFP36, ZFP36L2, ZFP36L1, CPSF1, HNRNPD, ELAVL1, CPEB2, CPEB3, KHSRP

GO:0035926

BP

chemokine (C-C motif) ligand 2 secretion

The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell.

F2RL1, FOXP1

GO:0035927

BP

RNA import into mitochondrion

The directed movement of RNA from the cytoplasm into a mitochondrion.

PNPT1

GO:0035928

BP

rRNA import into mitochondrion

The directed movement of rRNA, ribosomal ribonucleic acid, from the cytoplasm into a mitochondrion.

PNPT1

GO:0035932

BP

aldosterone secretion

The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.

AGTR2

GO:0035939

MF

microsatellite binding

Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.

HEYL, HEY1

GO:0035945

BP

mitochondrial ncRNA surveillance

The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.

SUPV3L1

GO:0035946

BP

mitochondrial mRNA surveillance

The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.

SUPV3L1

GO:0035947

BP

regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter.

NR1D1, FOXO1

GO:0035948

BP

positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.

GCG, KAT2B

GO:0035963

BP

cellular response to interleukin-13

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.

ALOX15, SHPK

GO:0035964

BP

COPI-coated vesicle budding

The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle.

TMED10

GO:0035965

BP

cardiolipin acyl-chain remodeling

Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.

PLA2G4A, HADHB, LCLAT1

GO:0035967

BP

cellular response to topologically incorrect protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.

HDAC6

GO:0035970

BP

peptidyl-threonine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.

PPM1G, PPM1B, DUSP1, PPM1F, DUSP5, DUSP18, PPM1E, PDP1

GO:0035971

BP

peptidyl-histidine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine.

PHPT1

GO:0035976

CC

transcription factor AP-1 complex

A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.

DDIT3

GO:0035978

BP

histone H2A-S139 phosphorylation

The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone.

HMGA2

GO:0035984

BP

cellular response to trichostatin A

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.

MEF2C, EZH2

GO:0035985

CC

senescence-associated heterochromatin focus

A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.

HMGA1, HMGA2

GO:0035986

BP

senescence-associated heterochromatin focus assembly

The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.

HMGA1, HMGA2

GO:0035987

BP

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

HSBP1, FN1, VTN, ITGB2, ITGAV, LAMB1, MMP2, INHBA, COL4A2, ITGA5, COL11A1, COL6A1, MMP9, ITGB5, MMP8, MMP14, MMP15, HMGA2, LAMA3, COL12A1

GO:0035988

BP

chondrocyte proliferation

The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.

CTGF, MMP14, MMP16, STC1, HMGA2

GO:0035989

BP

tendon development

The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.

COL11A1, COL5A1

GO:0035990

BP

tendon cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.

BMP4

GO:0035993

BP

deltoid tuberosity development

The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.

BMP4, PITX2

GO:0035994

BP

response to muscle stretch

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.

FOS, RAF1, EDN1, JUN, GPI, DMD, NFKB1, RELA, ANKRD1, MAPK14, RYR2

GO:0035995

BP

detection of muscle stretch

The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.

TTN

GO:0035999

BP

tetrahydrofolate interconversion

The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

TYMS, MTHFD1, SHMT1, MTHFR, MTHFS, MTHFD1L, MTHFD2L

GO:0036002

MF

pre-mRNA binding

Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.

DDX5, PTBP1, TRA2B, SRSF2, SRSF6, RBM22, PTBP2

GO:0036003

BP

positive regulation of transcription from RNA polymerase II promoter in response to stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

MUC1, ATF4, MAPK7, GCN1, KLF2

GO:0036004

MF

GAF domain binding

Interacting selectively and non-covalently with the GAF domain of a protein.

AIP

GO:0036006

BP

cellular response to macrophage colony-stimulating factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.

CSF1R, CCL2

GO:0036010

BP

protein localization to endosome

A process in which a protein is transported to, or maintained in, a location within an endosome.

ACAP2, TOLLIP, TMEM30A

GO:0036016

BP

cellular response to interleukin-3

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.

MT2A, GSK3B

GO:0036017

BP

response to erythropoietin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis.

HAMP

GO:0036018

BP

cellular response to erythropoietin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.

MT2A, MT1X

GO:0036020

CC

endolysosome membrane

The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.

TLR3, AP2A2, CLTA, AP2S1, AP2B1, AP2M1

GO:0036021

CC

endolysosome lumen

The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.

CTSL, CTSB, CTSS, CTSK

GO:0036023

BP

embryonic skeletal limb joint morphogenesis

The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.

CTNNB1, OSR1

GO:0036024

CC

protein C inhibitor-TMPRSS7 complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.

SERPINA5

GO:0036025

CC

protein C inhibitor-TMPRSS11E complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.

SERPINA5

GO:0036026

CC

protein C inhibitor-PLAT complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.

SERPINA5

GO:0036027

CC

protein C inhibitor-PLAU complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.

SERPINA5

GO:0036028

CC

protein C inhibitor-thrombin complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.

SERPINA5

GO:0036029

CC

protein C inhibitor-KLK3 complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.

SERPINA5

GO:0036030

CC

protein C inhibitor-plasma kallikrein complex

A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.

SERPINA5

GO:0036033

MF

mediator complex binding

Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

SMC1A, NIPBL, SMC3

GO:0036035

BP

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

ANXA2, FOXP1

GO:0036037

BP

CD8-positive, alpha-beta T cell activation

The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

HLA-E

GO:0036038

CC

MKS complex

A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.

AHI1, TCTN2, MKS1, CC2D2A, B9D1

GO:0036041

MF

long-chain fatty acid binding

Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

FABP3, HRSP12

GO:0036042

MF

long-chain fatty acyl-CoA binding

Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

ACOT7, DBI, SCP2

GO:0036057

CC

slit diaphragm

A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.

IQGAP1, MAGI2, TRPC6, F11R

GO:0036060

BP

slit diaphragm assembly

The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.

PTPRO

GO:0036064

CC

ciliary basal body

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.

SSNA1, C21orf2, OFD1, RP2, EZR, TUBG1, AKT1, CENPF, RAB28, EVC, PKD2, PCM1, FAM161A, CFAP126, JADE1, BBS7, AHI1, POC1A, BBOF1, BBS1, TTC8, POC1B, PIFO, DYNC2LI1, IFT81, RPGR, KIFAP3, WDR34, MARK4, CEP19, FOPNL, BBS2, IFT122, CENPJ, CYLD, IFT46, MKS1, SPATA7, WDR35, WRAP73, INTU, B9D1, SSX2IP, DAAM1, FAM179B

GO:0036065

BP

fucosylation

The covalent attachment of a fucosyl group to an acceptor molecule.

FUT1, FUT4, FUT2

GO:0036066

BP

protein O-linked fucosylation

The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.

THBS1, CFP, ADAMTSL4, SPON1, SLC35C2, ADAMTS7, ADAMTS5

GO:0036071

BP

N-glycan fucosylation

The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.

FUT8

GO:0036089

BP

cleavage furrow formation

Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.

RHOA, SNX33, AURKB, SNX18, SNX9

GO:0036091

BP

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

ATF4, MT3, SESN2

GO:0036092

BP

phosphatidylinositol-3-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.

PIK3CD, PIK3C2A, SYNJ2, INPP4B, SYNJ1, FGF18, FGF19, FGF2, FGFR1, FGF7, FGFR2, PIK3R1, FGF9, IRS1, PIK3CA, PIK3CB, PIK3CG, GRB2, PTPN11, GAB1, PIK3C3, FRS2, INPP4A, PIK3R4, KL, PIKFYVE, IRS2