GO:0001994

BP

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.

ADRA1D, ADRA1A, ADRA1B

GO:0001996

BP

positive regulation of heart rate by epinephrine-norepinephrine

The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.

ADRB1, ADRA1A

GO:0001997

BP

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.

ADRB1, ADRA1A

GO:0002001

BP

renin secretion into blood stream

The regulated release of renin into the blood stream by juxtoglomerular cells.

PCSK5

GO:0002003

BP

angiotensin maturation

The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.

AGT, MME, ACE, CTSZ

GO:0002005

BP

angiotensin catabolic process in blood

The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood.

ACE

GO:0002009

BP

morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

CA2, KRT16, SERPINB5, FRAS1, TIMELESS

GO:0002011

BP

morphogenesis of an epithelial sheet

The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.

JAG1, DAG1, MPP5, LIN7C

GO:0002016

BP

regulation of blood volume by renin-angiotensin

The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.

AGT

GO:0002017

BP

regulation of blood volume by renal aldosterone

The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.

CYP11B2, HSD11B2

GO:0002018

BP

renin-angiotensin regulation of aldosterone production

The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.

AGT, AGTR1, AGTR2

GO:0002019

BP

regulation of renal output by angiotensin

The process in which angiotensin directly modulates the rate of urine output by the kidney.

AGT, ACE

GO:0002020

MF

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

CHL1, CFLAR, FLOT1, BCL10, SERPINC1, SERPINA1, A2M, TIMP1, CST3, CSTA, LDLR, INS, TNF, FN1, CSTB, VWF, TP53, ITGB3, SERPINE1, SERPINA5, ITGB1, ITGAV, ANXA2, CST2, FURIN, UBC, BCL2, KIT, CD28, HSPD1, SELL, IL1R1, TIMP2, TNFAIP3, ITGA3, DPP4, SERPINB3, SRI, TIMP3, SERPINB4, COMP, SERPINB9, INSL3, BRCA2, POLG, CRADD, FADD, OS9, ADRM1, NFRKB, CCBE1, ADAMTSL4, LONP2, TTN, RFFL, PANX1, PEO1, PINK1, SERPINB13, PYCARD

GO:0002021

BP

response to dietary excess

The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.

APOE, LEP, TBL1XR1, PPARGC1A

GO:0002024

BP

diet induced thermogenesis

The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.

ADRB2, ADRB1, ADRB3, MC4R, BMP8A, TRPV1, OMA1, TRPV4, CLIC5

GO:0002025

BP

vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.

ADRB2, ADRB1, ADRB3

GO:0002026

BP

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

GAA, MYL4, ATP2A2, PLN, ADM, ATP1A2, CAMK2D, APLN

GO:0002027

BP

regulation of heart rate

Any process that modulates the frequency or rate of heart contraction.

AGT, DMD, DRD2, PRKACA, CALM2, MDM2, ANK2, PDE4D, SNTA1, SEMA3A, BVES, RYR2, EPAS1, POPDC2, RANGRF

GO:0002028

BP

regulation of sodium ion transport

Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

PER1, TGFB1, ADRB2, DRD2, NOS3, SIK1, YWHAH, DMPK, NKAIN1, NKAIN2, P2RX4, SPTBN4, WNK1

GO:0002031

BP

G-protein coupled receptor internalization

The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle.

DRD2, ADM, HTR2B, GTF2H2

GO:0002032

BP

desensitization of G-protein coupled receptor protein signaling pathway by arrestin

The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.

ADRB2

GO:0002033

BP

vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

The process that increases the size of a blood vessel via the renin-angiotensin system.

AGTR2

GO:0002034

BP

regulation of blood vessel size by renin-angiotensin

The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.

AGT, AGTR1

GO:0002035

BP

brain renin-angiotensin system

The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.

AGTR2, RPS6KA2

GO:0002036

BP

regulation of L-glutamate transport

Any process that modulates the frequency, rate or extent of L-glutamate transport.

SEPT2

GO:0002037

BP

negative regulation of L-glutamate transport

Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport.

ARL6IP5

GO:0002038

BP

positive regulation of L-glutamate transport

Any process that activates or increases the frequency, rate or extent of L-glutamate transport.

ARL6IP1

GO:0002039

MF

p53 binding

Interacting selectively and non-covalently with one of the p53 family of proteins.

TRIAP1, NUAK1, KDM1A, BRD4, TP53, HSPD1, EEF2, MUC1, HTT, GSK3B, SMARCA4, PTTG1IP, BLM, PSME3, CDK5, MDM2, EP300, TP53BP2, ANKRD1, STK11, ZNF385B, ZMAT1, RFWD3, BANP, SETD7, RFFL, CREBBP, EHMT2, TP53RK, TEP1, DUSP26, BCL2L12, CHD8, BRD7, KMT5A, CDKN2AIP

GO:0002040

BP

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

E2F8, NRP1, SEMA3E, THBS1, FLT4, NOTCH1, PGF, CDH13, CDC42, TEK, ANGPT1, JMJD6, CCBE1, RSPO3, ESM1, PARVA, LOXL2

GO:0002041

BP

intussusceptive angiogenesis

The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.

CYR61

GO:0002042

BP

cell migration involved in sprouting angiogenesis

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

NRP1, GREM1, SLIT2, ITGB1, FGF2, TDGF1, VEGFA, NR4A1, EFNB2, EPHB4, GPLD1, EGR3

GO:0002043

BP

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.

ITGB1BP1, BMP4, SEMA5A, BMPER

GO:0002051

BP

osteoblast fate commitment

The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.

RUNX2, SMAD1, SMAD5

GO:0002052

BP

positive regulation of neuroblast proliferation

Any process that activates or increases the rate of neuroblast proliferation.

GLI3, DRD2, VEGFA, CTNNB1, NOTCH1, VEGFC, HIF1A, SMARCD3, ASPM, ZNF335

GO:0002053

BP

positive regulation of mesenchymal cell proliferation

The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.

FOXP2, TBX1, SHOX2, LRP5, MYC, PDGFA, MYCN, WNT2, FGFR1, VEGFA, FGFR2, FGF9, CTNNB1, BMPR1A, TGFBR2, WNT5A, SOX9, IRS2

GO:0002055

MF

adenine binding

Interacting selectively and non-covalently with adenine, a purine base.

APRT

GO:0002060

MF

purine nucleobase binding

Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.

PNP

GO:0002062

BP

chondrocyte differentiation

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.

NFIB, TGFB1, GLI2, FGFR1, BMP2, BMP4, FGF9, BMPR1A, GDF5, HMGA2, GPLD1, RUNX1, MEF2C, RUNX3, RUNX2, MEF2D, TGFBI, MAPK14, OSR1, SNX19, WNT2B, WNT5B

GO:0002063

BP

chondrocyte development

The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.

SHOX2, FGF18, COL11A1, BMPR2, RUNX2, CHSY1, SULF2, SULF1, CHST11

GO:0002064

BP

epithelial cell development

The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

ESR1, B4GALT1, ADAMTSL4, SHROOM3

GO:0002070

BP

epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

GJA1

GO:0002071

BP

glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.

GPAT4

GO:0002072

BP

optic cup morphogenesis involved in camera-type eye development

The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.

ALDH1A3

GO:0002074

BP

extraocular skeletal muscle development

The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

FOXL2, PITX2

GO:0002076

BP

osteoblast development

The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.

HOXA2, LRP5, BGLAP, GLI2, PTHLH, JUND, HDAC4, SMAD3, RUNX2, LIMD1

GO:0002079

CC

inner acrosomal membrane

The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.

CD46, TRIP11

GO:0002080

CC

acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.

SERPINA5, BSG, CAV2, CAV1, PLA1A

GO:0002081

CC

outer acrosomal membrane

The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.

ZP3, TRIP11

GO:0002082

BP

regulation of oxidative phosphorylation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

UQCC2, SLC25A23, PINK1

GO:0002083

MF

4-hydroxybenzoate decaprenyltransferase activity

Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.

COQ2

GO:0002084

BP

protein depalmitoylation

The removal of palymitoyl groups from a lipoprotein.

LYPLA1, LYPLA2, PPT1

GO:0002086

BP

diaphragm contraction

A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.

GAA

GO:0002087

BP

regulation of respiratory gaseous exchange by neurological system process

A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.

GLS, ADORA1, ATP1A2, NLGN1

GO:0002088

BP

lens development in camera-type eye

The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

CRYAB, WNT2, CDK4, GJA1, MIP, TGFBR1, TGFBR2, WNT5A, DLG1, NHS, PROX1, WNT2B, PYGO2

GO:0002089

BP

lens morphogenesis in camera-type eye

The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

MEIS1, BCAR3, SKI, CTNNB1, SHROOM2, NECTIN1, NECTIN3

GO:0002090

BP

regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.

FLOT1, DKK1, ARF1, SH3GL2

GO:0002091

BP

negative regulation of receptor internalization

Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.

SDCBP, ANXA2, DLG4, MTMR2

GO:0002092

BP

positive regulation of receptor internalization

Any process that activates or increases the frequency, rate or extent of receptor internalization.

GREM1, DRD2, VEGFA, SELE, PLCG2, SYK, SYNJ2BP, FMR1, ANGPT1, SFRP4, MAGI2, AHI1, PCSK9, ATAD1, TBC1D5

GO:0002093

BP

auditory receptor cell morphogenesis

Any process that alters the size or shape of an auditory receptor cell.

RAC1

GO:0002098

BP

tRNA wobble uridine modification

The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

IKBKAP, GTPBP3, ELP3

GO:0002102

CC

podosome

An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.

SH3PXD2B, LPXN, WDR1, LCP1, VCAM1, TPM4, ADAM8, ARHGEF5, CTTN, FSCN1, RHOU, PALLD, BIN2

GO:0002113

MF

interleukin-33 binding

Interacting selectively and non-covalently with interleukin-33.

IL1RL1

GO:0002114

MF

interleukin-33 receptor activity

Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL1RL1, IL1RAP

GO:0002115

BP

store-operated calcium entry

A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

ORAI2, ORAI3, STIM2

GO:0002116

CC

semaphorin receptor complex

A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

NRP1, PLXNB2, NRP2, PLXNC1, PLXNA2, PLXNA3, PLXNA1, PLXND1

GO:0002118

BP

aggressive behavior

A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.

PENK

GO:0002133

CC

polycystin complex

A stable heterodimeric complex composed of polycystin-1 and polycystin-2.

PKD1, PKD2

GO:0002134

MF

UTP binding

Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.

HSP90AA1, HSP90AB1, MTPAP

GO:0002135

MF

CTP binding

Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate.

HSP90AA1, HSP90AB1

GO:0002138

BP

retinoic acid biosynthetic process

The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

ALDH1A2, RBP1, ALDH1A3, RDH10, DHRS9

GO:0002143

BP

tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

TRMU

GO:0002149

BP

hypochlorous acid biosynthetic process

The chemical reactions and pathways resulting in the formation of hypochlorous acid.

MPO

GO:0002151

MF

G-quadruplex RNA binding

Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.

FXR1, AFF2, FMR1, DHX36, LIN28A

GO:0002153

MF

steroid receptor RNA activator RNA binding

Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.

THRA

GO:0002155

BP

regulation of thyroid hormone mediated signaling pathway

Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.

THRA, NCOA1

GO:0002158

BP

osteoclast proliferation

The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.

TNFSF11, NPR3

GO:0002159

BP

desmosome assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

JUP, PRKCA, PKP2, PKP3

GO:0002161

MF

aminoacyl-tRNA editing activity

The hydrolysis of an incorrectly aminoacylated tRNA.

LARS2, DTD2

GO:0002162

MF

dystroglycan binding

Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).

MAP2, DMD, DAG1, AGR3

GO:0002169

CC

3-methylcrotonyl-CoA carboxylase complex, mitochondrial

A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.

MCCC1, MCCC2

GO:0002175

BP

protein localization to paranode region of axon

A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.

EPB41L3

GO:0002177

CC

manchette

A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.

IQCG

GO:0002178

CC

palmitoyltransferase complex

A protein complex with palmitoyltransferase activity.

ZDHHC9

GO:0002181

BP

cytoplasmic translation

The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

EIF3J, RPLP1, RPLP2, RPLP0, RPL35A, RPL7, EIF4B, RPL22, RPL29, RPL26, RPL15, RPL31, RPL36A, RPL22L1, RPL36

GO:0002184

BP

cytoplasmic translational termination

The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.

GSPT1

GO:0002188

BP

translation reinitiation

A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

EIF3A

GO:0002189

CC

ribose phosphate diphosphokinase complex

A protein complex having ribose phosphate diphosphokinase activity.

PRPS1

GO:0002190

BP

cap-independent translational initiation

The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.

RBM4

GO:0002192

BP

IRES-dependent translational initiation

The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.

DENR, EIF4EBP1, RBM4

GO:0002193

CC

MAML1-RBP-Jkappa- ICN1 complex

A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.

NOTCH1

GO:0002194

BP

hepatocyte cell migration

The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.

PROX1

GO:0002199

CC

zona pellucida receptor complex

A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.

TCP1, CCT3, CCT8, CCT2, CCT7

GO:0002215

BP

defense response to nematode

A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

PRG2, TNFSF4

GO:0002218

BP

activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

HMGB1, IFI16, MAVS, PYCARD

GO:0002221

BP

pattern recognition receptor signaling pathway

Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.

PGLYRP2, CLEC7A, DMBT1

GO:0002223

BP

stimulatory C-type lectin receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.

PSMD11, PSMD12, PSMD3, MAP3K7, RPS6KA5, PSMD10, PAK3, BCL10, NRAS, KRAS, RAF1, FYN, LYN, UBC, PLCG2, PRKACA, PSMC3, NFKB1, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMC2, PSMB10, SYK, PSMC4, PSMB3, PSMD7, PSME3, PSMC1, PSMC6, RPS27A, UBA52, SKP1, RELB, RELA, PRKCD, EP300, PAK2, PSMD2, UBE2V1, PSME4, TAB1, TAB3, CLEC4D, CREBBP, CLEC7A, CD209, BTRC

GO:0002224

BP

toll-like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

TLR4, TLR3, IRAK2, BCL10, CTSL, CTSB, HSP90B1, CTSS, CTSK, MAPKAPK2, IRAK1, TLR1, CNPY3

GO:0002227

BP

innate immune response in mucosa

Any process of the innate immune response that takes place in the mucosal tissues.

HIST1H2BK, HIST1H2BC, HIST2H2BE, BPIFB1

GO:0002230

BP

positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.

TRAF3IP2, IL12RB1, MAVS, LILRB1, TRIM6, APOBEC3G, EIF2AK4, PYCARD

GO:0002236

BP

detection of misfolded protein

The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.

HSPD1