| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0035563 | BP | positive regulation of chromatin binding | Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
KDM1A, CTBP2, PYGO2, EBF2 |
GO:0035566 | BP | regulation of metanephros size | Any process that modulates the size of a metanephric kidney. |
AGTR2 |
GO:0035567 | BP | non-canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. |
FZD6, WNT5A, SFRP5, SFRP4, FZD8 |
GO:0035574 | BP | histone H4-K20 demethylation | The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone. |
KDM7A |
GO:0035575 | MF | histone demethylase activity (H4-K20 specific) | Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein. |
KDM7A |
GO:0035577 | CC | azurophil granule membrane | The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
VAMP7 |
GO:0035581 | BP | sequestering of extracellular ligand from receptor | The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor. |
CD46 |
GO:0035582 | BP | sequestering of BMP in extracellular matrix | Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. |
FBN1, NBL1 |
GO:0035583 | BP | sequestering of TGFbeta in extracellular matrix | Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. |
FBN1, FBN2, LTBP1 |
GO:0035584 | BP | calcium-mediated signaling using intracellular calcium source | A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. |
PRKACA, VCAM1, PTGFR, BCAP31, CCL20, NTRK2, RYR2 |
GO:0035585 | BP | calcium-mediated signaling using extracellular calcium source | A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response. |
CACNA1C |
GO:0035589 | BP | G-protein coupled purinergic nucleotide receptor signaling pathway | The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. |
PTAFR, P2RY14, P2RY8, GPR34 |
GO:0035590 | BP | purinergic nucleotide receptor signaling pathway | The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. |
ANO6, P2RX4 |
GO:0035591 | MF | signaling adaptor activity | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
RACK1, LDLRAP1, HOMER1, AFAP1L2, SH2B1, SH2B3 |
GO:0035598 | MF | N6-threonylcarbomyladenosine methylthiotransferase activity | Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). |
CDKAL1 |
GO:0035600 | BP | tRNA methylthiolation | The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule. |
CDKAL1 |
GO:0035602 | BP | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. |
FGFR2 |
GO:0035603 | BP | fibroblast growth factor receptor signaling pathway involved in hemopoiesis | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis. |
FGFR2 |
GO:0035604 | BP | fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. |
FGFR2 |
GO:0035605 | MF | peptidyl-cysteine S-nitrosylase activity | Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. |
GAPDH |
GO:0035606 | BP | peptidyl-cysteine S-trans-nitrosylation | Transfer of a nitric oxide (NO) group from one cysteine residue to another. |
GAPDH, S100A9 |
GO:0035607 | BP | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development | The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state. |
FGFR1, FGFR2 |
GO:0035609 | BP | C-terminal protein deglutamylation | The removal of a C-terminal, gene-encoded glutamate residue from a protein. |
AGBL1, AGTPBP1 |
GO:0035610 | BP | protein side chain deglutamylation | The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation. |
AGBL1, AGTPBP1 |
GO:0035612 | MF | AP-2 adaptor complex binding | Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
AAK1, LDLRAP1, TBC1D5 |
GO:0035613 | MF | RNA stem-loop binding | Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
DDX3X, EPRS, FMR1, CPEB3, DAZAP1 |
GO:0035614 | MF | snRNA stem-loop binding | Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. |
SNRPA |
GO:0035615 | MF | clathrin adaptor activity | The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way. |
AP2A2, AP2S1, AP2B1, DAB2, PICALM, LDLRAP1, AP2M1 |
GO:0035616 | BP | histone H2B conserved C-terminal lysine deubiquitination | A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. |
USP15 |
GO:0035622 | BP | intrahepatic bile duct development | The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). |
SOX9 |
GO:0035623 | BP | renal glucose absorption | A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. |
HNF1A |
GO:0035624 | BP | receptor transactivation | The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer. |
NCOA3 |
GO:0035625 | BP | epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | The process in which an epidermal growth factor-activated receptor is activated via signaling events from a G-protein coupled receptor. This is an example of cross-talk between the EGF and GPCR signaling pathways. |
ADRA2B, ADAM17 |
GO:0035630 | BP | bone mineralization involved in bone maturation | The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state. |
IGF1, BMP2, LEP, ANO6 |
GO:0035633 | BP | maintenance of blood-brain barrier | Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. |
PTGS2 |
GO:0035634 | BP | response to stilbenoid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. |
CD36 |
GO:0035640 | BP | exploration behavior | The specific behavior of an organism in response to a novel environment or stimulus. |
CHL1, ITGA3, AGTR2, ABAT |
GO:0035641 | BP | locomotory exploration behavior | The specific movement from place to place of an organism in response to a novel environment. |
PENK, DPP4, DLG4, LSAMP, TNR |
GO:0035642 | MF | histone methyltransferase activity (H3-R17 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3. |
CARM1 |
GO:0035644 | BP | phosphoanandamide dephosphorylation | The process of removing one or more phosphate groups from a phosphorylated anandamide. |
PTPN22 |
GO:0035646 | BP | endosome to melanosome transport | The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle. |
AP3D1, RAB32, BLOC1S3, ANKRD27, BLOC1S6 |
GO:0035650 | MF | AP-1 adaptor complex binding | Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
RAB32 |
GO:0035651 | MF | AP-3 adaptor complex binding | Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
RAB32 |
GO:0035655 | BP | interleukin-18-mediated signaling pathway | A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PDGFB, AKT1, IL18R1, IL18 |
GO:0035662 | MF | Toll-like receptor 4 binding | Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
S100A8, S100A9, TIRAP |
GO:0035663 | MF | Toll-like receptor 2 binding | Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. |
TIRAP, TLR1 |
GO:0035665 | BP | TIRAP-dependent toll-like receptor 4 signaling pathway | Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. |
TIRAP |
GO:0035666 | BP | TRIF-dependent toll-like receptor signaling pathway | Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. |
TLR4, TLR3, CD14, UBC, UBE2D3, RPS27A, UBA52, FADD, BIRC3, RIPK1, CASP8, TANK, TBK1 |
GO:0035672 | BP | oligopeptide transmembrane transport | The directed movement of an oligopeptide across a membrane by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. |
CDH17 |
GO:0035674 | BP | tricarboxylic acid transmembrane transport | The process in which tricarboxylic acids are transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
SLC25A1 |
GO:0035684 | BP | helper T cell extravasation | The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells. |
CCL2 |
GO:0035686 | CC | sperm fibrous sheath | A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. |
GSTM3, SPA17 |
GO:0035690 | BP | cellular response to drug | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
PPP1R12A, TLR3, EGFR, MYC, IL1B, TFRC, MT2A, PRNP, TP53, EDN1, TH, HSP90AB1, QDPR, FBP1, RAP2A, UMPS, CCL4, CCL2, NME1, MT3, CAD, PPM1F, PRKAA2, RAP1A, GPLD1, PPAT, MEF2C, PPP3CA, KCNH2, EIF2B5, GAS6, ANKRD1, ADIPOQ, ADSSL1, RNF149, PPM1E, PPP1R14A, RBM22 |
GO:0035691 | BP | macrophage migration inhibitory factor signaling pathway | A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
CD74 |
GO:0035692 | CC | macrophage migration inhibitory factor receptor complex | A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. |
CD74, CD44 |
GO:0035693 | CC | NOS2-CD74 complex | A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases. |
CD74 |
GO:0035694 | BP | mitochondrial protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. |
BNIP3L, BNIP3, SPATA18, YME1L1 |
GO:0035695 | BP | mitophagy by induced vacuole formation | The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes. |
SPATA18 |
GO:0035701 | BP | hematopoietic stem cell migration | The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. |
KIT, GPLD1 |
GO:0035709 | BP | memory T cell activation | The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
TNFSF4 |
GO:0035711 | BP | T-helper 1 cell activation | The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
HMGB1, CEBPB |
GO:0035712 | BP | T-helper 2 cell activation | The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
TNFSF4 |
GO:0035713 | BP | response to nitrogen dioxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. |
TNFSF4 |
GO:0035714 | BP | cellular response to nitrogen dioxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. |
TNFSF4 |
GO:0035718 | MF | macrophage migration inhibitory factor binding | Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor. |
CD74 |
GO:0035720 | BP | intraciliary anterograde transport | The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. |
IFT122 |
GO:0035721 | BP | intraciliary retrograde transport | The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. |
IFT43, IFT122, WDR35 |
GO:0035722 | BP | interleukin-12-mediated signaling pathway | A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
JAK2, IL12RB1, PLCB1 |
GO:0035723 | BP | interleukin-15-mediated signaling pathway | A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PLCB1 |
GO:0035725 | BP | sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
KCNK1, SLC3A2, SCNN1A, SLC6A8, TRAPPC10, SCNN1G, SLC20A2, PKD2, SHROOM2, SCN9A, ASIC2, ANO6, TRPM4, SLC20A1, SLC5A5, SLC24A3, SLC23A2, ASIC3, SLC4A4 |
GO:0035726 | BP | common myeloid progenitor cell proliferation | The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. |
GSTP1, NR4A3 |
GO:0035727 | MF | lysophosphatidic acid binding | Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors. |
GAP43 |
GO:0035729 | BP | cellular response to hepatocyte growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. |
NRP1, IL6, TDGF1, HGF, CREB1, IL10, GCLC, GCLM, GSK3B, RELA, SIRT2 |
GO:0035730 | MF | S-nitrosoglutathione binding | Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems. |
GSTP1 |
GO:0035731 | MF | dinitrosyl-iron complex binding | Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO. |
GSTP1 |
GO:0035732 | BP | nitric oxide storage | The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins. |
GSTP1 |
GO:0035733 | BP | hepatic stellate cell activation | A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. |
GCLM |
GO:0035735 | BP | intraciliary transport involved in cilium morphogenesis | The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium morphogenesis. |
PCM1, IFT81, IFT74, IFT122, SSX2IP |
GO:0035743 | BP | CD4-positive, alpha-beta T cell cytokine production | Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell. |
CD55 |
GO:0035747 | BP | natural killer cell chemotaxis | The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
PIK3CD, PIK3CG |
GO:0035748 | CC | myelin sheath abaxonal region | The region of the myelin sheath furthest from the axon. |
ITGB1, CNP, DLG1, EXOC4 |
GO:0035749 | CC | myelin sheath adaxonal region | The region of the myelin sheath nearest to the axon. |
ANXA2, CNP, MAG, PTEN, STX4, MPP5 |
GO:0035750 | BP | protein localization to myelin sheath abaxonal region | Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon. |
MPP5 |
GO:0035751 | BP | regulation of lysosomal lumen pH | Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. |
TMEM165 |
GO:0035752 | BP | lysosomal lumen pH elevation | Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. |
CLN3 |
GO:0035754 | BP | B cell chemotaxis | The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
PIK3CD, CH25H, GAS6, HSD3B7 |
GO:0035767 | BP | endothelial cell chemotaxis | The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
NRP1, PLEKHG5, VEGFA, NR4A1, EGR3, CORO1B |
GO:0035770 | CC | ribonucleoprotein granule | A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. |
HNRNPL, FXR1, HNRNPA3, GRSF1, DHX30, UHMK1, DDX28 |
GO:0035771 | BP | interleukin-4-mediated signaling pathway | A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IL4R, JAK3 |
GO:0035773 | BP | insulin secretion involved in cellular response to glucose stimulus | The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. |
RAF1, RAB11B, RAB11FIP2 |
GO:0035774 | BP | positive regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
GCG, CFTR, SRI, OXCT1, GPLD1, STX4, HIF1A, TRPM4, BAD, NR1H4, PHPT1, GPR27 |
GO:0035783 | BP | CD4-positive, alpha-beta T cell costimulation | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation. |
TNFSF4 |
GO:0035789 | BP | metanephric mesenchymal cell migration | The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros. |
PDGFRB |
GO:0035790 | BP | platelet-derived growth factor receptor-alpha signaling pathway | A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PDGFRA |
GO:0035791 | BP | platelet-derived growth factor receptor-beta signaling pathway | A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PDGFRB |
GO:0035793 | BP | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway | Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands. |
PDGFB, PDGFA, PDGFRB |
GO:0035794 | BP | positive regulation of mitochondrial membrane permeability | Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. |
HEBP2 |
GO:0035799 | BP | ureter maturation | A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. |
ALDH1A2 |
GO:0035800 | MF | deubiquitinase activator activity | Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. |
VCP, TANK |
GO:0035802 | BP | adrenal cortex formation | The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate). |
WT1, CITED2 |