| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0035284 | BP | brain segmentation | Division of the brain into a series of semi-repetitive parts or segments. |
HOXA2, EGR2, MAFB |
GO:0035295 | BP | tube development | The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. |
ITGB3, GLI2 |
GO:0035303 | BP | regulation of dephosphorylation | Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. |
SMG5 |
GO:0035304 | BP | regulation of protein dephosphorylation | Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein. |
PPP1R14C, PPP1R14A, PPP1R14B |
GO:0035305 | BP | negative regulation of dephosphorylation | Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. |
IQGAP1, INPP5K |
GO:0035306 | BP | positive regulation of dephosphorylation | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. |
IGBP1 |
GO:0035307 | BP | positive regulation of protein dephosphorylation | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. |
TGFB1, ADORA1, CALM2, PRKCD, PPP2R5A, PPP2R4, PPP1R7, CDCA2, NSMF, ANKLE2, CNEP1R1, SPPL3, SYMPK, DLC1, PINK1 |
GO:0035308 | BP | negative regulation of protein dephosphorylation | Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein. |
PPP1R15A, YWHAB, IGBP1, PPP2R4 |
GO:0035312 | MF | 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. |
DCLRE1C, EXO1 |
GO:0035313 | BP | wound healing, spreading of epidermal cells | The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. |
ITGA5, COL5A1, ADAM17, AJUBA, HBEGF |
GO:0035315 | BP | hair cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a hair cell. |
ERCC2, CTNNB1, PITX2 |
GO:0035325 | MF | Toll-like receptor binding | Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. |
TLR2, TOLLIP |
GO:0035326 | MF | enhancer binding | Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. |
TCF3, ARNT, AHR, SOX9, SMAD3, HNRNPU, SMAD2, TCF12 |
GO:0035327 | CC | transcriptionally active chromatin | The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. |
PSIP1, ESR1, HIST1H1C, ICE2, EXOSC4, EXOSC3, AFF4 |
GO:0035329 | BP | hippo signaling | The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. |
LATS1, YWHAB, YAP1, YWHAE, TJP1, STK4, TEAD4, TEAD2, AMOT, WWC1, AMOTL1, TEAD3, MOB1A, LATS2, TJP2 |
GO:0035330 | BP | regulation of hippo signaling | Any process that modulates the frequency, rate or extent of hippo signaling. |
NF2, NEK8, WWC1 |
GO:0035331 | BP | negative regulation of hippo signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. |
WWC2, WWC1, AJUBA, LIMD1, WWC3 |
GO:0035335 | BP | peptidyl-tyrosine dephosphorylation | The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. |
PTPDC1, EYA2, CDC14B, DUSP11, EYA4, PTPRC, PTPRF, PTPN2, PTPRB, PTPRD, PTPRG, DUSP1, PTPRM, PTPN4, CDC25A, CDC25B, CDC25C, PTPN9, DUSP3, TPTE, PTEN, DUSP2, PTPN11, PTPRJ, PTP4A2, DUSP8, MTM1, MTMR1, MTMR2, PTPRK, CDKN3, DUSP5, PTPN21, PTPRO, DUSP6, DUSP7, TIMM50, SSH2, DUSP18, SSH3, UBASH3B, DUSP19, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP16, DUSP21, DUSP22, MTMR4, DUSP13, CDC14A, PTPN22, DUSP10 |
GO:0035336 | BP | long-chain fatty-acyl-CoA metabolic process | The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
FAR2, DGAT2 |
GO:0035338 | BP | long-chain fatty-acyl-CoA biosynthetic process | The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
ELOVL7, HACD1, ACOT7, SCD, ACOT8, ACSL4, ACSL1, FASN, PPT1, SLC25A1, HSD17B12, THEM4, HACD2, SCD5, ACOT4, ELOVL1, ELOVL4, ELOVL6, ACOT13, ELOVL5, ACSL6, PPT2, ACOT9 |
GO:0035339 | CC | SPOTS complex | A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. |
ORMDL2 |
GO:0035349 | BP | coenzyme A transmembrane transport | The process in which coenzyme A is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
SLC25A17 |
GO:0035350 | BP | FAD transmembrane transport | The process in which flavin-adenine dinucleotide (FAD) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
SLC25A17 |
GO:0035354 | CC | Toll-like receptor 1-Toll-like receptor 2 protein complex | A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). |
TLR2, TLR1 |
GO:0035356 | BP | cellular triglyceride homeostasis | Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment. |
XBP1, DGAT2, NR1H4, C1QTNF3 |
GO:0035357 | BP | peroxisome proliferator activated receptor signaling pathway | The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. |
ACTN4, PPARG |
GO:0035358 | BP | regulation of peroxisome proliferator activated receptor signaling pathway | Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. |
ALOX15 |
GO:0035359 | BP | negative regulation of peroxisome proliferator activated receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. |
PLIN5, TWIST1 |
GO:0035360 | BP | positive regulation of peroxisome proliferator activated receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. |
LEP, PTGIS, ASXL2, CITED2 |
GO:0035363 | CC | histone locus body | A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body. |
ICE2 |
GO:0035368 | MF | selenocysteine insertion sequence binding | Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. |
SECISBP2L, SECISBP2 |
GO:0035370 | CC | UBC13-UEV1A complex | A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A). |
UBE2V1 |
GO:0035371 | CC | microtubule plus-end | The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. |
CLIP1, DST, CKAP5, MAPRE2, MAPRE1, KIF18B, SPAG5, KIF2C, SLAIN2, CLIP2, MAPRE3, KNSTRN, MYO5A |
GO:0035372 | BP | protein localization to microtubule | A process in which a protein is transported to, or maintained at, a microtubule. |
MID1, GSK3B, MAPRE1, CHAMP1, KIF20B, CRIPT |
GO:0035373 | MF | chondroitin sulfate proteoglycan binding | Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. |
PTPRF, SEMA5A |
GO:0035374 | MF | chondroitin sulfate binding | Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). |
DPYSL3 |
GO:0035375 | MF | zymogen binding | Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. |
DMBT1 |
GO:0035385 | BP | Roundabout signaling pathway | A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
SLIT2, RHOA, MYO9B, ROBO3, ROBO2 |
GO:0035397 | BP | helper T cell enhancement of adaptive immune response | Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell. |
CD4 |
GO:0035401 | MF | histone kinase activity (H3-Y41 specific) | The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. |
JAK2 |
GO:0035402 | MF | histone kinase activity (H3-T11 specific) | Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3. |
CHEK1, PKN1 |
GO:0035403 | MF | histone kinase activity (H3-T6 specific) | Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3. |
PRKCB, PRKCA |
GO:0035404 | BP | histone-serine phosphorylation | The modification of histones by addition of a phosphate group to a serine residue. |
AURKA, PRKAA2 |
GO:0035407 | BP | histone H3-T11 phosphorylation | The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone. |
CHEK1, PKN1 |
GO:0035408 | BP | histone H3-T6 phosphorylation | The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone. |
PRKCB, PRKCA |
GO:0035409 | BP | histone H3-Y41 phosphorylation | The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. |
JAK2 |
GO:0035410 | MF | dihydrotestosterone 17-beta-dehydrogenase activity | Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. |
AKR1C3 |
GO:0035411 | BP | catenin import into nucleus | The directed movement of a catenin protein from the cytoplasm into the nucleus. |
AGT, CTNNB1 |
GO:0035412 | BP | regulation of catenin import into nucleus | Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. |
AXIN1, FZD7, GNAQ, DACT1 |
GO:0035413 | BP | positive regulation of catenin import into nucleus | Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. |
UBR5, EGFR, SMAD3, BAMBI, SEMA5A, KANK1, SULF2, DACT1 |
GO:0035414 | BP | negative regulation of catenin import into nucleus | Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. |
SNAI2, EMD, SFRP5, DACT3 |
GO:0035418 | BP | protein localization to synapse | Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
DLG4, CDK5, ASIC2, NLGN1, PCLO |
GO:0035419 | BP | activation of MAPK activity involved in innate immune response | Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. |
ADAM8 |
GO:0035425 | BP | autocrine signaling | Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. |
SERPINB3, HILPDA |
GO:0035426 | BP | extracellular matrix-cell signaling | Any process that mediates the transfer of information between the extracellular matrix and a cell. |
LRP5, NDP, FZD4 |
GO:0035434 | BP | copper ion transmembrane transport | The directed movement of copper cation across a membrane. |
ATOX1, SLC31A1, SLC31A2, SLC11A2 |
GO:0035435 | BP | phosphate ion transmembrane transport | The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore. |
SLC37A4, SLC25A3, SLC20A2, SLC20A1, ANKH, ADAMTS8 |
GO:0035437 | BP | maintenance of protein localization in endoplasmic reticulum | Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. |
HSPA5 |
GO:0035441 | BP | cell migration involved in vasculogenesis | The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. |
PDGFRB |
GO:0035455 | BP | response to interferon-alpha | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. |
IFITM1, IFNAR2, IFITM3, BST2, LAMP3 |
GO:0035456 | BP | response to interferon-beta | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. |
PLSCR1, IFITM1, IFNAR2, IFITM3, BST2, XAF1 |
GO:0035457 | BP | cellular response to interferon-alpha | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. |
TPR, IFNAR1, STAR, GAS6 |
GO:0035458 | BP | cellular response to interferon-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. |
TLR3, IRF1, CDC34, PNPT1, TRIM6, NDUFA13 |
GO:0035459 | BP | cargo loading into vesicle | The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle. |
TMED10, PICALM, TMED2 |
GO:0035461 | BP | vitamin transmembrane transport | The process in which a vitamin is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
ABCC1, SCARB1, SLC23A2 |
GO:0035469 | BP | determination of pancreatic left/right asymmetry | Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. |
NPHP3 |
GO:0035470 | BP | positive regulation of vascular wound healing | Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. |
XBP1 |
GO:0035472 | MF | choriogonadotropin hormone receptor activity | Combining with the choriogonadotropin hormone to initiate a change in cell activity. |
LHCGR |
GO:0035473 | MF | lipase binding | Interacting selectively and non-covalently with any lipase. |
APOB, LRPAP1, PLIN5, APOA5, FAF2 |
GO:0035491 | BP | positive regulation of leukotriene production involved in inflammatory response | Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. |
SERPINE1 |
GO:0035493 | BP | SNARE complex assembly | The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. |
VAMP4, VAMP7, STX4, VAMP3 |
GO:0035494 | BP | SNARE complex disassembly | The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. |
NAPB |
GO:0035497 | MF | cAMP response element binding | Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. |
JUN, CREB1, ATF6, HMGA2, CREB3L1, TCF12 |
GO:0035500 | MF | MH2 domain binding | Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. |
HMGA2 |
GO:0035501 | MF | MH1 domain binding | Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. |
HMGA2 |
GO:0035502 | BP | metanephric part of ureteric bud development | The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros. |
PKD2 |
GO:0035505 | BP | positive regulation of myosin light chain kinase activity | Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity. |
IL1B |
GO:0035507 | BP | regulation of myosin-light-chain-phosphatase activity | Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. |
PPP1R12A, NUAK1 |
GO:0035508 | BP | positive regulation of myosin-light-chain-phosphatase activity | Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity. |
PPP1R12A |
GO:0035509 | BP | negative regulation of myosin-light-chain-phosphatase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity. |
ROCK2, TNF |
GO:0035511 | BP | oxidative DNA demethylation | Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
TDG |
GO:0035515 | MF | oxidative RNA demethylase activity | Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
ALKBH5, FTO |
GO:0035516 | MF | oxidative DNA demethylase activity | Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
FTO |
GO:0035517 | CC | PR-DUB complex | A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. |
BAP1 |
GO:0035518 | BP | histone H2A monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group. |
TRIM37, SKP1, RING1, CUL4B |
GO:0035519 | BP | protein K29-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation. |
PARK2, UBE2S, ITCH, UBE2T, UBE2D4 |
GO:0035520 | BP | monoubiquitinated protein deubiquitination | The removal of the ubiquitin group from a monoubiquitinated protein. |
USP1, ATXN3, BAP1, USP15 |
GO:0035522 | BP | monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
BAP1 |
GO:0035523 | BP | protein K29-linked deubiquitination | A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein. |
ZRANB1 |
GO:0035524 | BP | proline transmembrane transport | The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. |
SLC1A4, SLC36A1 |
GO:0035526 | BP | retrograde transport, plasma membrane to Golgi | The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. |
RAB29, USP6NL |
GO:0035529 | MF | NADH pyrophosphatase activity | Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. |
ENPP3, ENPP1 |
GO:0035539 | MF | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
NUDT1, NUDT15 |
GO:0035542 | BP | regulation of SNARE complex assembly | Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. |
STXBP1, STXBP6 |
GO:0035544 | BP | negative regulation of SNARE complex assembly | Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. |
ANKRD27, TRIM9 |
GO:0035548 | BP | negative regulation of interferon-beta secretion | Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion. |
LILRB1 |
GO:0035552 | BP | oxidative single-stranded DNA demethylation | Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
FTO |
GO:0035553 | BP | oxidative single-stranded RNA demethylation | Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. |
ALKBH5, FTO |
GO:0035556 | BP | intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
ASB14, SDCBP, DDX3X, ITGB1BP1, MAST4, DCLK1, FYB, MAPK13, DAPK3, TRAF3IP2, TYROBP, SH3BP5, NUAK1, JAK2, RPS6KA5, STK17B, NFATC1, MAP4K4, HSPB1, GNAI2, PRKCB, FYN, CXCL1, HMOX1, CXCL8, PRKAR1A, BCR, SCG2, PRKAR2A, PRKCSH, HCLS1, CHN1, STMN1, PRKCA, NPR2, RASA1, ZP3, JAK1, IGFBP5, DUSP1, CTGF, PRKAR2B, AKT1, AKT2, ADRA1A, ADRA1B, TGFBR1, ANP32A, PRKCI, CRKL, PSEN1, RGS7, PSEN2, GSK3B, AGTR2, PLCD1, JAK3, DAPK1, PRKAA2, SIK1, RAC3, YWHAE, RAC1, SRPK2, NRG1, GUCY2D, TGFBR3, PRKCQ, ARHGEF5, AKAP13, AKAP6, STK4, SMAD4, SQSTM1, PPP1R1A, DGKZ, ARHGEF7, MELK, PLCL1, PRKD1, STK38, RPS6KA2, RPS6KA1, SMAD2, PKN2, MAPK14, RALGPS1, DGKK, DEPDC1, CDC42BPA, TNS2, MAST2, SPSB3, CSPG4, DNMBP, DEF8, SH3BP5L, NET1, ZBTB33, STK32C, DGKH, TMPRSS6, MAP4K3, ARHGEF28, MINK1, PDZD8, NEK11, INADL, DEPTOR, DLG5, GSG2, DEPDC1B, BLNK, RASSF5, CORO2A, INPP5D, APBB2, ARHGEF2, SGK3, MASTL, ASB16, SRPK1, STAC, MKNK1, PINK1, WNK3, PRKD2, TOLLIP, RACGAP1, SIK2, SDCBP2, WNK1, ASB8, ECT2, MKNK2, CD209, TREM1, PLCB1, ARHGEF4, SH2B1, TULP4, LATS2, NRBP2, PAG1, SPHK1, ZAK, WSB2, PLEK2, FMN2, MARK1, NLK, PRKAG3, DCDC2, AKAP11, TNIK, TLK1, PLA2G4C, PLCL2, SH2B3, AKT3, STK38L, PIKFYVE, CARHSP1, CAB39, MAP4K5, ASB3, CDC42BPB, ARFGEF2, MAP3K4 |
GO:0035562 | BP | negative regulation of chromatin binding | Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
BTAF1, PPP3CA, TDG, NFATC4, WAPL, FBXO18 |