| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0034976 | BP | response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
BCL2L11, PARK2, ERN1, PPP1R15A, FLOT1, UBE4B, EIF2S1, P4HB, THBS1, CXCL8, EEF2, PDIA4, HSP90B1, ALOX15, ATP2A2, CEBPB, ATF4, PIK3R1, PDIA3, THBS4, DDIT3, UFM1, PPP2CB, EIF2B5, TARDBP, OS9, PDIA5, PDIA6, TMEM259, TXNDC11, DNAJC10, NRBF2, ERO1A, TRIB3, MAP3K5, ERP44, FAM129A, UBA5, TMX4, HYOU1 |
GO:0034979 | MF | NAD-dependent protein deacetylase activity | Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. |
SIRT2 |
GO:0034982 | BP | mitochondrial protein processing | The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. |
OMA1 |
GO:0034983 | BP | peptidyl-lysine deacetylation | The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. |
HDAC4, SIRT2, HDAC6, HDAC9 |
GO:0034986 | MF | iron chaperone activity | Assists in the delivery of iron ions to target proteins or compartments. |
FXN |
GO:0034987 | MF | immunoglobulin receptor binding | Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. |
IGLL5, FGR, CLEC4D |
GO:0034988 | MF | Fc-gamma receptor I complex binding | Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. |
FGR, FLNA |
GO:0034991 | CC | nuclear meiotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex. |
RAD21, SMC3 |
GO:0034993 | CC | LINC complex | A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains. |
SYNE2, SUN2 |
GO:0035004 | MF | phosphatidylinositol 3-kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. |
PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG |
GO:0035005 | MF | 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG |
GO:0035014 | MF | phosphatidylinositol 3-kinase regulator activity | Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. |
KLF4, PIK3R1 |
GO:0035019 | BP | somatic stem cell population maintenance | Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. |
POLR2D, KLF4, LDB2, LRP5, RAF1, FGF2, KIT, SKI, TDGF1, POLR2E, POLR2A, POLR2B, POLR2I, PBX1, STAT3, YAP1, ZFP36L2, SOX9, POLR2J, POLR2K, POLR2G, POLR2L, POU5F1, SOX4, KLF10, SMAD4, CUL4A, HES1, SMAD2, SFRP1, EPAS1, LIN28A, ELF5 |
GO:0035020 | BP | regulation of Rac protein signal transduction | Any process that modulates the frequency, rate or extent of Rac protein signal transduction. |
OGT, SSX2IP |
GO:0035021 | BP | negative regulation of Rac protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction. |
ARAP3, STMN3 |
GO:0035022 | BP | positive regulation of Rac protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. |
KRAS, CAMK2D, ALS2 |
GO:0035023 | BP | regulation of Rho protein signal transduction | Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
ARHGEF10, FLOT1, PLEKHG5, FARP2, RAF1, BCR, VAV1, ARHGDIA, ARHGDIB, SOS1, SOS2, ARHGEF5, ABR, TIAM1, MYO9B, ARHGEF7, ITSN1, ARHGEF16, DNMBP, FGD6, PREX2, NET1, FGD2, MCF2L2, ARHGEF28, ARHGEF39, ARHGEF2, ARHGEF26, FGD4, SPATA13, ALS2, PLEKHG2, ECT2, ARHGEF10L, ARHGEF4, ARHGEF3, ITSN2, VAV3, FARP1 |
GO:0035024 | BP | negative regulation of Rho protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. |
ARHGAP42, ITGB1, ITGA3, ADRA1A, BCL6, CUL3, KANK1, FLCN, ARAP3, KCTD13, DLC1 |
GO:0035025 | BP | positive regulation of Rho protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. |
COL3A1, APOA1, PDGFRB, F2R, F2RL1, RAC1, AKAP13, ADGRG1 |
GO:0035026 | BP | leading edge cell differentiation | The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet. |
JUN, DAB2 |
GO:0035032 | CC | phosphatidylinositol 3-kinase complex, class III | A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). |
PIK3C3, NRBF2, PIK3R4 |
GO:0035033 | MF | histone deacetylase regulator activity | Modulates the activity of histone deacetylase. |
MAPK8 |
GO:0035034 | MF | histone acetyltransferase regulator activity | Modulates the activity of histone acetyltransferase. |
PYGO2, EID1 |
GO:0035035 | MF | histone acetyltransferase binding | Interacting selectively and non-covalently with the enzyme histone acetyltransferase. |
ZBTB7A, TP53, GLI3, PCNA, ETS1, CREB1, CEBPB, EGR1, MEF2A, MTF1, HIF1A, SIRT2, NR4A3, EPAS1, CITED2, FOXP3, EID1 |
GO:0035036 | BP | sperm-egg recognition | The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. |
SPAM1 |
GO:0035048 | BP | splicing factor protein import into nucleus | The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane. |
TNPO3 |
GO:0035050 | BP | embryonic heart tube development | The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. |
CTNNB1, GJA5, HHEX, FOXC1, SOX17, IFT122, NDRG4 |
GO:0035051 | BP | cardiocyte differentiation | The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. |
BMP2 |
GO:0035054 | BP | embryonic heart tube anterior/posterior pattern specification | The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. |
BMP2, GATA4 |
GO:0035058 | BP | nonmotile primary cilium assembly | The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. |
CSNK1D, PCM1, TMEM107, BBS7, BBS1, BBS10, PIBF1, CEP89, BBS2, CENPJ, MKKS, MKS1, CC2D2A, FAM179B |
GO:0035061 | CC | interchromatin granule | A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). |
SRSF2, TARDBP, SMC5, SMC6 |
GO:0035063 | BP | nuclear speck organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized. |
SRPK2 |
GO:0035064 | MF | methylated histone binding | Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
CHD1, CBX7, NCAPD3, CBX5, ATRX, MSH6, FMR1, SUZ12, RBBP5, ZMYND11, GLYR1, PHF19, KDM7A, NCAPG2, L3MBTL2, SGF29, UHRF1, MPHOSPH8, CHD8, ING3, LRWD1, CDYL, L3MBTL1, MTF2, LOXL2, SPIN1 |
GO:0035065 | BP | regulation of histone acetylation | Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
FLCN, PYGO2, EID1 |
GO:0035066 | BP | positive regulation of histone acetylation | Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
SNAI2, TADA2A, RPS6KA5, TGFB1, IL1B, MAPK3, BRCA1, TADA2B, FOXP3, BRD7, PPARGC1A, RUVBL2 |
GO:0035067 | BP | negative regulation of histone acetylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
SNCA, BRCA1, SET, TWIST1, FOXP3, NOC2L |
GO:0035068 | CC | micro-ribonucleoprotein complex | A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA. |
TNRC6A, AGO4, AGO2 |
GO:0035082 | BP | axoneme assembly | The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
TTLL1, RSPH4A, C6orf165, CFAP46, RSPH1, CC2D2A, FAM179B |
GO:0035087 | BP | siRNA loading onto RISC involved in RNA interference | The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference. |
AGO2, DICER1 |
GO:0035088 | BP | establishment or maintenance of apical/basal cell polarity | Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. |
CDC42 |
GO:0035089 | BP | establishment of apical/basal cell polarity | The specification and formation of the polarity of a cell along its apical/basal axis. |
PRKCI, FSCN1 |
GO:0035091 | MF | phosphatidylinositol binding | Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
ESYT2, HIP1, PIK3C2A, ARHGAP33, TULP3, SNX4, SNX16, PITPNA, FCHO2, MYO1E, PLD1, MTM1, SNX1, ITPR2, ITPR3, ITPR1, CCDC88A, HS1BP3, PXK, TRPV1, SNX29, SNX33, MITD1, ZCCHC14, SGK3, SH3YL1, PHF12, PASK, ZCCHC2, PLEKHA2, TULP4, SNX15, WDR35, PITPNC1, SNX12, SNX6, NISCH, SNX9, SNX5 |
GO:0035092 | BP | sperm chromatin condensation | The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. |
SRPK1 |
GO:0035093 | BP | spermatogenesis, exchange of chromosomal proteins | The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin. |
PSME4 |
GO:0035094 | BP | response to nicotine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
KCNK1, PENK, EDN1, HMOX1, BCL2, DRD2, CREB1, VCAM1, CNR1, CHRNA7, STAR, ATP1A2, ABAT, LYPD1, HDAC2, SLC7A11 |
GO:0035095 | BP | behavioral response to nicotine | Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. |
CHRNB1, CHRNA5, CHRNA7, PPARA |
GO:0035097 | CC | histone methyltransferase complex | A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. |
KDM6A, CBX5, RBBP5, KMT2C, PAGR1, ZNF335, ASH2L, HDAC9, KMT2B |
GO:0035098 | CC | ESC/E(Z) complex | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. |
H2AFY, TRIM37, RBBP4, SUZ12, EZH2, PHF19, HDAC2, EZH1, H2AFY2, MTF2 |
GO:0035101 | CC | FACT complex | An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. |
TONSL |
GO:0035102 | CC | PRC1 complex | A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. |
CBX7, RING1, PHC3 |
GO:0035105 | BP | sterol regulatory element binding protein import into nucleus | The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. |
LMNA |
GO:0035108 | BP | limb morphogenesis | The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. |
GLI3, PTCH1, ZNF141, PCSK5 |
GO:0035112 | BP | genitalia morphogenesis | The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. |
CTNNB1 |
GO:0035115 | BP | embryonic forelimb morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. |
SHOX2, ALDH1A2, RECK, CTNNB1, WNT3, CACNA1C, RUNX2, TWIST1, NIPBL, RDH10, OSR1, LNP, IFT122, ZNF358 |
GO:0035116 | BP | embryonic hindlimb morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. |
BMP4, CTNNB1, NOTCH1, AFF3, WNT3, GNAS, ZBTB16, TWIST1, GNAS, OSR1, PITX2, CHD7 |
GO:0035128 | BP | post-embryonic forelimb morphogenesis | The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism. |
ATRX |
GO:0035136 | BP | forelimb morphogenesis | The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. |
HOXD10, GDF5, ZBTB16, NIPBL, RNF165, SALL3 |
GO:0035137 | BP | hindlimb morphogenesis | The process in which the anatomical structures of the hindlimb are generated and organized. |
HOXD10, BMPR1A, GDF5, PTCH1, SALL3 |
GO:0035145 | CC | exon-exon junction complex | A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. |
SAP18, SRSF1, RNPS1, ALYREF, UHMK1, POLDIP3, UPF3A, PNN, UPF2, THRAP3, R3HCC1, RBM8A |
GO:0035148 | BP | tube formation | Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. |
ITGB1BP1, BCL2L11, VEGFA, NOTCH1, SDCCAG8, ATOH8 |
GO:0035162 | BP | embryonic hemopoiesis | The stages of blood cell formation that take place within the embryo. |
KIT, TAL1, KITLG, TGFBR2, PBX1, HIF1A, SH2B3 |
GO:0035166 | BP | post-embryonic hemopoiesis | The stages of blood cell formation that take place after completion of embryonic development. |
KLF4, ERCC1, MYO1E |
GO:0035173 | MF | histone kinase activity | Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
CDK1, CCNB1, CDK2, BAZ1B |
GO:0035174 | MF | histone serine kinase activity | Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. |
AURKA, PRKAA2, AURKB |
GO:0035175 | MF | histone kinase activity (H3-S10 specific) | Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. |
RPS6KA5, VRK1 |
GO:0035176 | BP | social behavior | Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. |
TBX1, BRINP1, KRAS, TH, OXTR, PTEN, DLG4, MAPK8IP2, EIF4EBP2, NLGN4X, DNAJC9, PTCHD1, MKKS, NRXN1 |
GO:0035189 | CC | Rb-E2F complex | A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. |
RB1, E2F1 |
GO:0035194 | BP | posttranscriptional gene silencing by RNA | Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. |
TNRC6A, TNRC6C, AGO4, AGO2, TNRC6B |
GO:0035195 | BP | gene silencing by miRNA | Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. |
CNOT1, EIF6, TNRC6A, AJUBA, TNRC6C, LIMD1, CNOT7, CNOT6 |
GO:0035196 | BP | production of miRNAs involved in gene silencing by miRNA | Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein. |
PRKRA, AGO4, AGO2, DICER1 |
GO:0035197 | MF | siRNA binding | Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
FMR1, AGO2, DICER1 |
GO:0035198 | MF | miRNA binding | Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
HNRNPA2B1, POU5F1, MEF2C, FMR1, PNPT1, RBM4, LIN28A, AGO4, AGO2 |
GO:0035226 | MF | glutamate-cysteine ligase catalytic subunit binding | Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase. |
GCLM |
GO:0035229 | BP | positive regulation of glutamate-cysteine ligase activity | Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. |
GCLM |
GO:0035234 | BP | ectopic germ cell programmed cell death | Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. |
IL1A, IL1B, KIT, KITLG, PRKDC, BAX |
GO:0035235 | BP | ionotropic glutamate receptor signaling pathway | A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. |
APP, GRIA4, GRIN2A, CLN3, CPEB4 |
GO:0035239 | BP | tube morphogenesis | The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. |
GATA6 |
GO:0035240 | MF | dopamine binding | Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. |
TH, DRD2 |
GO:0035241 | MF | protein-arginine omega-N monomethyltransferase activity | Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. |
PRMT6 |
GO:0035242 | MF | protein-arginine omega-N asymmetric methyltransferase activity | Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. |
PRMT3, CARM1, PRMT6, PRMT1 |
GO:0035249 | BP | synaptic transmission, glutamatergic | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
PARK2, SLC1A4, CDK5, ALS2 |
GO:0035250 | MF | UDP-galactosyltransferase activity | Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. |
B4GALT1 |
GO:0035252 | MF | UDP-xylosyltransferase activity | Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. |
LARGE, XXYLT1 |
GO:0035253 | CC | ciliary rootlet | A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. |
KIF5C, APP, PSEN1, RAB28, CROCC, KLC3 |
GO:0035255 | MF | ionotropic glutamate receptor binding | Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
FLOT1, DRD2, CANX, FUS, DLG4, GNAS, DLG1, GNAS, NETO2 |
GO:0035256 | MF | G-protein coupled glutamate receptor binding | Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor). |
HOMER1, HOMER3 |
GO:0035257 | MF | nuclear hormone receptor binding | Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell. |
ACTN4, NCOR1, TACC2, CTNNB1, BUD31, NRIP1, EP300, NCOA2, NCOA1, CRY1, HIF1A, SMARCD3, NCOA7, TCF7L2, NCOA3 |
GO:0035258 | MF | steroid hormone receptor binding | Interacting selectively and non-covalently with a steroid hormone receptor. |
NR0B1 |
GO:0035259 | MF | glucocorticoid receptor binding | Interacting selectively and non-covalently with a glucocorticoid receptor. |
ETS2, CEBPB, STAT3, NR4A2, NRIP1, STAT5B, FKBP4, YWHAH, NR4A3 |
GO:0035261 | BP | external genitalia morphogenesis | The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. |
LRP6, NIPBL |
GO:0035264 | BP | multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
KDM6A, NDUFS6, ERCC1, AR, ERCC2, FGFR2, XPA, G6PC, SLC1A2, GPD2, ATRX, CDKN1C, CDC42, H3F3A, GNAS, APBA1, HHEX, PTPN11, ZFP36L1, SOS1, PDE4D, ARID5B, TMED2, STIL, GNAS, TNS2, PLAG1, ANKRD11, GIGYF2, RBBP6, WDR48, PPP1R13L, CCM2, TBL1XR1, TNKS2, RC3H2, DUOX2, DHCR7, HEG1, KLF2 |
GO:0035265 | BP | organ growth | The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. |
BCL2, FGFR2, ADRA1A, PTPN11, ACVR2B, SMAD2, NLGN4X |
GO:0035267 | CC | NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
YEATS4, ACTL6A, ACTB, MORF4L2, EPC1, MEAF6, ING3, MORF4L1, RUVBL2, RUVBL1, TRRAP |
GO:0035268 | BP | protein mannosylation | The addition of a mannose residue to a protein acceptor molecule. |
DPM3 |
GO:0035269 | BP | protein O-linked mannosylation | The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. |
B4GAT1, LARGE, POMGNT2, SDF2, FKRP, DPM3, POMT1 |
GO:0035276 | MF | ethanol binding | Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH. |
ADH7 |
GO:0035278 | BP | miRNA mediated inhibition of translation | The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs |
ZFP36, STAT3, EIF6, TNRC6A, RBM4, TNRC6C, AGO4, AGO2, TNRC6B |
GO:0035279 | BP | mRNA cleavage involved in gene silencing by miRNA | The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. |
AGO2 |
GO:0035280 | BP | miRNA loading onto RISC involved in gene silencing by miRNA | The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC). |
AGO4, AGO2, DICER1 |
GO:0035282 | BP | segmentation | The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. |
ACD |