GO:0034504

BP

protein localization to nucleus

A process in which a protein is transported to, or maintained in, a location within the nucleus.

TOR1A, XPO1, PLRG1, DNAJB6, CTDNEP1, COL1A1, LMNA, BMP4, CALR, SOX9, RPL11, MDM2, HHEX, ZBTB16, CNEP1R1, BANP, SYNE2, PIKFYVE

GO:0034505

BP

tooth mineralization

The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.

COL1A1

GO:0034508

BP

centromere complex assembly

The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere.

CENPV

GO:0034511

MF

U3 snoRNA binding

Interacting selectively and non-covalently with U3 small nucleolar RNA.

SNU13, TSR1, ISG20

GO:0034512

MF

box C/D snoRNA binding

Interacting selectively and non-covalently with box C/D small nucleolar RNA.

SNU13

GO:0034513

MF

box H/ACA snoRNA binding

Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.

DKC1, NOP10, GAR1

GO:0034515

CC

proteasome storage granule

A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.

PSMD2

GO:0034516

BP

response to vitamin B6

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

KYNU

GO:0034518

CC

RNA cap binding complex

Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.

NCBP1, NCBP3

GO:0034551

BP

mitochondrial respiratory chain complex III assembly

The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.

UQCRB, TTC19, UQCC3, UQCC2, UQCR10, BCS1L

GO:0034584

MF

piRNA binding

Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

PIWIL4

GO:0034587

BP

piRNA metabolic process

The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

PIWIL4, TDRD9

GO:0034589

BP

hydroxyproline transport

The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC1A4

GO:0034590

MF

L-hydroxyproline transmembrane transporter activity

Enables the transfer of L-hydroxyproline from one side of a membrane to the other.

SLC1A4

GO:0034594

MF

phosphatidylinositol trisphosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.

INPP5K

GO:0034595

MF

phosphatidylinositol phosphate 5-phosphatase activity

Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate.

SYNJ1, INPP5K

GO:0034596

MF

phosphatidylinositol phosphate 4-phosphatase activity

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.

SYNJ2, SYNJ1

GO:0034597

MF

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

INPP4B, INPP4A

GO:0034599

BP

cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

FOXO3, PRKRA, STAU1, PENK, GPX1, PARP1, HSPA1A, HSPA1B, G6PD, ATP2A2, NME2, MT3, PRDX2, SNCA, ETV5, NR4A2, SESN2, FOXO1, HDAC1, NFE2L1, PRKD1, ADNP2, SETX, CPEB2, SIRT2, PNPT1, TXN2, VIMP, PINK1, FANCD2, ATP13A2, SEPN1, PPARGC1A

GO:0034602

MF

oxoglutarate dehydrogenase (NAD+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.

OGDH

GO:0034604

MF

pyruvate dehydrogenase (NAD+) activity

Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.

PDHA1, DLD, DLAT, PDHB

GO:0034605

BP

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

TFEC, PDCD6, IL1A, EIF2S1, LYN, THBS1, HMOX1, HSPA1A, HSPA1B, TPR, HSPA6, CDKN1A, MKI67, IRAK1, ATXN3, HSF1, C11orf73, TRPV1, HDAC2, STAC, TRPV4, SLC52A3, ARPP21

GO:0034612

BP

response to tumor necrosis factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

ADAM10, MAP2K7, UBD, JAK2, CD14, SELE, PTGS2, CHI3L1, AFF3, IGBP1, ADAM9, RIPK1, CASP8, ADIPOQ, MAP4K3, CXCL16, YTHDC2, NUB1, TNFRSF11A

GO:0034613

BP

cellular protein localization

Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.

RAP2A, DMD, CTNNA1, WNT5A, ID4, CSNK1E, NLRP5, CDC42, ANK2, KCNA1, AMOT, LAMTOR1, NIPBL, AHI1, AJUBA, FRMD6, RRAGC, RRAGD, LATS2, ARMCX3, LAMTOR3, PRPF19, LAMTOR2

GO:0034614

BP

cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

FOS, TPM1, PDGFRA, MPV17, AKR1C3, ROMO1, PKD2, PTPRK, PPARGC1B

GO:0034616

BP

response to laminar fluid shear stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls.

SMAD7, SMAD6, ABCA1, TGFB1, ETS1, ADAM9

GO:0034617

MF

tetrahydrobiopterin binding

Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions.

TH, NOS3

GO:0034618

MF

arginine binding

Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid.

NOS3, RARS

GO:0034620

BP

cellular response to unfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

PARK2, RHBDD1, PACRG

GO:0034625

BP

fatty acid elongation, monounsaturated fatty acid

Elongation of a fatty acid chain into which one C-C double bond has been introduced.

ELOVL7, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0034626

BP

fatty acid elongation, polyunsaturated fatty acid

Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.

ELOVL7, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0034628

BP

de novo' NAD biosynthetic process from aspartate

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

NMNAT3

GO:0034629

BP

cellular protein complex localization

A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.

WASL, SMAD7, SNAPIN, EZR, DLG1, SEH1L

GO:0034632

MF

retinol transporter activity

Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.

RBP4

GO:0034633

BP

retinol transport

The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.

RBP4

GO:0034638

BP

phosphatidylcholine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

ENPP2, PNPLA8

GO:0034644

BP

cellular response to UV

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

TRIAP1, KDM1A, N4BP1, MYC, TP53, EIF2S1, PCNA, ATF4, YY1, PIK3R1, POLD1, CDC25A, PTGS2, CASP9, FMR1, BAX, EP300, NFATC4, PTPRK, RHBDD1, CREBBP, ERCC4, TP53INP1, AURKB, PBK, USP28, RHNO1, EIF2AK4, RUVBL2, NOC2L

GO:0034645

BP

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

PTH

GO:0034647

MF

histone demethylase activity (H3-trimethyl-K4 specific)

Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.

KDM5B

GO:0034648

MF

histone demethylase activity (H3-dimethyl-K4 specific)

Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.

KDM1A, KDM5B

GO:0034650

BP

cortisol metabolic process

The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.

CYP11A1

GO:0034651

BP

cortisol biosynthetic process

The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.

CYP11B1, CYP11B2

GO:0034653

BP

retinoic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A.

CYP26A1, CYP26B1

GO:0034656

BP

nucleobase-containing small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.

NUDT1, NUDT16, NUDT9, NUDT15, NUDT5

GO:0034657

CC

GID complex

A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p.

MAEA, RMND5B, RMND5A

GO:0034663

CC

endoplasmic reticulum chaperone complex

A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.

P4HB, HSPA5, HSP90B1, PPIB, PDIA6, DNAJC10, HYOU1

GO:0034665

CC

integrin alpha1-beta1 complex

An integrin complex that comprises one alpha1 subunit and one beta1 subunit.

ITGB1

GO:0034666

CC

integrin alpha2-beta1 complex

An integrin complex that comprises one alpha2 subunit and one beta1 subunit.

ITGB1, LYN, ITGA2

GO:0034667

CC

integrin alpha3-beta1 complex

An integrin complex that comprises one alpha3 subunit and one beta1 subunit.

ITGB1, ITGA3

GO:0034670

BP

chemotaxis to arachidonic acid

The directed movement of a motile cell or organism in response to the presence of arachidonic acid.

CREB1

GO:0034673

CC

inhibin-betaglycan-ActRII complex

A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B.

INHA, ACVR2A, TGFBR3

GO:0034676

CC

integrin alpha6-beta4 complex

An integrin complex that comprises one alpha6 subunit and one beta1 subunit.

ITGA6

GO:0034677

CC

integrin alpha7-beta1 complex

An integrin complex that comprises one alpha7 subunit and one beta1 subunit.

ITGB1

GO:0034678

CC

integrin alpha8-beta1 complex

An integrin complex that comprises one alpha8 subunit and one beta1 subunit.

ITGB1

GO:0034679

CC

integrin alpha9-beta1 complex

An integrin complex that comprises one alpha9 subunit and one beta1 subunit.

ITGA9

GO:0034680

CC

integrin alpha10-beta1 complex

An integrin complex that comprises one alpha10 subunit and one beta1 subunit.

ITGA10, ITGB1

GO:0034681

CC

integrin alpha11-beta1 complex

An integrin complex that comprises one alpha11 subunit and one beta1 subunit.

ITGB1, ITGA11

GO:0034683

CC

integrin alphav-beta3 complex

An integrin complex that comprises one alphav subunit and one beta3 subunit.

ITGB3, ITGAV

GO:0034684

CC

integrin alphav-beta5 complex

An integrin complex that comprises one alphav subunit and one beta5 subunit.

ITGAV, ITGB5

GO:0034686

CC

integrin alphav-beta8 complex

An integrin complex that comprises one alphav subunit and one beta8 subunit.

ITGAV, ITGB8

GO:0034687

CC

integrin alphaL-beta2 complex

An integrin complex that comprises one alphaL subunit and one beta2 subunit.

ITGB2

GO:0034695

BP

response to prostaglandin E

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.

GNRH1, TGFBR3

GO:0034696

BP

response to prostaglandin F

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus.

EDN1, YY1

GO:0034698

BP

response to gonadotropin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.

ICAM1, ITGA3

GO:0034699

BP

response to luteinizing hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.

TGFBR3

GO:0034702

CC

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

LRRC8A

GO:0034704

CC

calcium channel complex

An ion channel complex through which calcium ions pass.

PRKACA, CALM2, PDE4D, AKAP6, CAMK2D, PPP2R4, RYR3, MICU2, RYR2

GO:0034705

CC

potassium channel complex

An ion channel complex through which potassium ions pass.

KCNK1

GO:0034706

CC

sodium channel complex

An ion channel complex through which sodium ions pass.

SCNN1A, SCNN1G

GO:0034707

CC

chloride channel complex

An ion channel complex through which chloride ions pass.

FXYD1, CLIC1, BEST1, CLIC3, CFTR, GABRA5, CLCNKA, CLCNKB, ANO6, BEST3, CLIC6, TTYH1, ANO2, CLIC5

GO:0034709

CC

methylosome

A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.

SNRPB, SNRPF, SNRPD1, SNRPD2, SNRPD3, ERH, PRMT1

GO:0034711

MF

inhibin binding

Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers.

INHA, INHBA, ACVR2A, ACVR1B

GO:0034713

MF

type I transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type I transforming growth factor beta receptor.

SMAD7, SMAD6, TGFB1, TGFBR2, SMAD2

GO:0034714

MF

type III transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type III transforming growth factor beta receptor.

TGFB1, TGFB2

GO:0034715

CC

pICln-Sm protein complex

A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.

SNRPF, SNRPD1, SNRPD2, SNRPD3

GO:0034719

CC

SMN-Sm protein complex

A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.

SNRPB, GEMIN4, SNRPF, SNRPD1, SNRPD2, SNRPD3, GEMIN5, GEMIN6, GEMIN8, DDX20

GO:0034720

BP

histone H3-K4 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.

KDM1A, KDM5A, KDM5B

GO:0034721

BP

histone H3-K4 demethylation, trimethyl-H3-K4-specific

The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone.

KDM5B

GO:0034722

MF

gamma-glutamyl-peptidase activity

Catalysis of the cleavage of a gamma-linked glutamate bond.

GGH

GO:0034736

MF

cholesterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.

SOAT1

GO:0034750

CC

Scrib-APC-beta-catenin complex

A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.

CTNNB1

GO:0034751

CC

aryl hydrocarbon receptor complex

A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.

AIP

GO:0034752

CC

cytosolic aryl hydrocarbon receptor complex

An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP.

AHR

GO:0034753

CC

nuclear aryl hydrocarbon receptor complex

An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).

AHR

GO:0034755

BP

iron ion transmembrane transport

A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TTYH1, SLC40A1

GO:0034763

BP

negative regulation of transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

CTTNBP2NL

GO:0034765

BP

regulation of ion transmembrane transport

Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

GPR89A, CLIC1, WWP2, CACNA1G, CLIC3, CYBB, GPR89B, KCNA1, KCNMA1, KCNC3, KCNJ12, SCN9A, CACNA1E, ASIC2, TPCN2, KCNG3, KCNV2, KCNE4, TMEM37, CLIC6, NEDD4L, KCNK17, CACNG6, KCNK12, CLIC5, KCNK6

GO:0034767

BP

positive regulation of ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

ANO6

GO:0034769

BP

basement membrane disassembly

The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.

CTSS

GO:0034770

BP

histone H4-K20 methylation

The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone.

WHSC1, KMT5A

GO:0034773

BP

histone H4-K20 trimethylation

The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone.

PWP1, KMT5B, ARID4B, KMT5C

GO:0034774

CC

secretory granule lumen

The volume enclosed by the membrane of a secretory granule.

POMC, GCG, INS, APOA1, TF, PCSK1, GHRL

GO:0034776

BP

response to histamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

DRD2

GO:0034875

MF

caffeine oxidase activity

Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O.

CYP3A4, CYP2C9

GO:0034959

BP

endothelin maturation

The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin.

ECE1

GO:0034968

BP

histone lysine methylation

The modification of a histone by addition of one or more methyl groups to a lysine residue.

PRDM2, SETD6, SETD7, EHMT2, WHSC1L1, SMYD3, PRDM6

GO:0034969

BP

histone arginine methylation

The modification of a histone by addition of a methyl group to an arginine residue.

PRMT3

GO:0034970

BP

histone H3-R2 methylation

The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone.

CARM1, PRMT6

GO:0034971

BP

histone H3-R17 methylation

The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone.

CARM1, NR1H4

GO:0034975

BP

protein folding in endoplasmic reticulum

A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).

HSPA5, HSP90B1, CALR, CANX, PDIA3, ERO1B, DNAJC10, EMC1, ERO1A, EMC3