GO:0034197

BP

triglyceride transport

The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

APOH, CD36, VAMP7

GO:0034198

BP

cellular response to amino acid starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.

DAPL1, EIF2S1, ATF3, ATF4, CDKN1A, DAP, UCP2, NPRL3, RNF152, GCN1, SEH1L, RRAGC, EIF2AK4, IMPACT, SH3GLB1

GO:0034199

BP

activation of protein kinase A activity

Any process that initiates the activity of the inactive enzyme protein kinase A.

ADCY3, ADCY9, PRKAR1A, PRKAR2A, PRKACA, PRKAR2B, ADCY7

GO:0034201

BP

response to oleic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.

ACSL1, AACS, BAD

GO:0034205

BP

beta-amyloid formation

The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP).

PSEN1

GO:0034212

MF

peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.

EP300, CREBBP

GO:0034213

BP

quinolinate catabolic process

The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.

QPRT

GO:0034214

BP

protein hexamerization

The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.

MAT2A, VCP, PANX2, PANX1, PEO1, SPAST

GO:0034219

BP

carbohydrate transmembrane transport

The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

SLC35E1

GO:0034220

BP

ion transmembrane transport

A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

FXYD1, KCNK3, ATP6V0E1, ATP8B1, ATP6V1G1, BEST1, AQP8, ATP6V1G2, RAF1, ATP1B1, S100A6, ANXA6, UBC, ATP2A2, GJA1, ATP2B1, ATP6V1B2, ATP6V1C1, ATP2B4, MIP, GABRA5, GJC1, CHRNA7, SCNN1A, AQP2, GRIA4, GLRB, ATP1A2, SCNN1G, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, ATP12A, ATP1B3, FXYD4, ATP6V0D1, NCALD, CALM2, RPS27A, UBA52, DLG4, ATP2C1, ASPH, DLG1, TCIRG1, CLCA4, RYR3, ASIC2, ATP6V1F, CHRFAM7A, ANO6, ATP13A5, PDZD11, FAM26F, SFXN4, OSTM1, ATP6V1C2, TPCN2, AQP3, RYR2, ATP6V0A1, SGK3, NEDD4L, P2RX4, TSC22D3, SFXN3, WWP1, TTYH1, SFXN1, CALHM2, ATP13A2, ANO2, ASIC3, ATP6V1H, ATP11B, ATP6V1D

GO:0034224

BP

cellular response to zinc ion starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions.

SLC39A4

GO:0034235

MF

GPI anchor binding

Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.

PIGK, PIGU

GO:0034236

MF

protein kinase A catalytic subunit binding

Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.

PRKAR1A, PRKAR2A, EZR, PRKAR2B, CSK, SOX9, GSK3B, PKIA, RYR2

GO:0034237

MF

protein kinase A regulatory subunit binding

Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.

EZR, PRKACA, AKAP6, AKAP1, RYR2, ACBD3, AKAP7, ARFGEF2

GO:0034241

BP

positive regulation of macrophage fusion

Any process that activates or increases the frequency, rate or extent of macrophage fusion.

ADAM9

GO:0034243

BP

regulation of transcription elongation from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

ZMYND11

GO:0034244

BP

negative regulation of transcription elongation from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

AXIN1, RNF8, EZH2

GO:0034255

BP

regulation of urea metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea.

NR1H4

GO:0034260

BP

negative regulation of GTPase activity

Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.

IPO5, RASA4, SPRY2, SPRY1, PDE6D, SLIT2, RDX, IQGAP1, TNK2, GPS2, IQGAP2, TMED2, RGN, AMOT, CPEB2, FICD, MKKS, CDC42SE1, SH3BP4, F11R

GO:0034263

BP

autophagy in response to ER overload

The process in which cells digest parts of their own cytoplasm in response to the accumulation of misfolded proteins in the endoplasmic reticulum.

ATG10

GO:0034271

CC

phosphatidylinositol 3-kinase complex, class III, type I

A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.

PIK3R4

GO:0034272

CC

phosphatidylinositol 3-kinase complex, class III, type II

A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.

PIK3R4

GO:0034274

CC

Atg12-Atg5-Atg16 complex

A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.

ATG12

GO:0034314

BP

Arp2/3 complex-mediated actin nucleation

The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.

WASH1, ARPC2, ARPC3, ARPC4, ACTR3, ACTR2, IQGAP2, JMY

GO:0034315

BP

regulation of Arp2/3 complex-mediated actin nucleation

Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.

ARFIP1, ARF1, CORO1B

GO:0034316

BP

negative regulation of Arp2/3 complex-mediated actin nucleation

Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.

CORO1B

GO:0034329

BP

cell junction assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.

FLNA, LIMS1, ACTB, ACTG1, ILK, FLNC, FBLIM1, VMP1

GO:0034332

BP

adherens junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

CTNND1, ANG, JUP, PVR, DSP, CDH2, CDH5, CTNNA1, CSK, NUMB, CDH6, CDH11, CDH12, CDH13, CDH15, CDC42, CDH17, NECTIN1, RAB8B, CADM1, NECTIN3

GO:0034333

BP

adherens junction assembly

The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

SMAD7, PIP5K1C, JUP, CTNNB1, TBCD

GO:0034334

BP

adherens junction maintenance

The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

RASSF8, PKP2

GO:0034340

BP

response to type I interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

ISG15, SP100

GO:0034341

BP

response to interferon-gamma

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.

UBD, CYP27B1, IFITM1, SP100, SNCA, SLC11A1, SEC61A1, IFITM3, BST2, CALCOCO2, KYNU, SLC30A8, CITED1, CXCL16, NUB1

GO:0034346

BP

positive regulation of type III interferon production

Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.

TLR3

GO:0034349

BP

glial cell apoptotic process

Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.

RB1, CASP9, BID

GO:0034351

BP

negative regulation of glial cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.

CCL2, PRKCA, PRKCI, PRKCD

GO:0034353

MF

RNA pyrophosphohydrolase activity

Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end.

DXO

GO:0034354

BP

de novo' NAD biosynthetic process from tryptophan

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

KMO, KYNU

GO:0034356

BP

NAD biosynthesis via nicotinamide riboside salvage pathway

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.

PNP

GO:0034359

CC

mature chylomicron

A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph.

APOB

GO:0034360

CC

chylomicron remnant

A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver.

APOB

GO:0034361

CC

very-low-density lipoprotein particle

A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.

APOA1, APOE, APOA2, APOC1, APOC3, APOH, APOB, LPL, VLDLR, APOBR, APOA5, LSR, VIMP, APOO, PCYOX1

GO:0034362

CC

low-density lipoprotein particle

A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.

LDLR, APOE, APOB, APOBR, PLA2G7, LSR, SORL1, VIMP, APOO

GO:0034363

CC

intermediate-density lipoprotein particle

A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).

APOE, APOC3, APOB

GO:0034364

CC

high-density lipoprotein particle

A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.

ABCA1, APOA1, APOE, APOA2, APOC1, APOH, SAA1, SAA2, PON1, HDLBP, APOA5, APOO

GO:0034365

CC

discoidal high-density lipoprotein particle

A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).

APOA1

GO:0034366

CC

spherical high-density lipoprotein particle

A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

APOA1, APOA2, APOC3, CLU, PON1

GO:0034369

BP

plasma lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

APOC1

GO:0034370

BP

triglyceride-rich lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle.

APOA2, APOA5

GO:0034371

BP

chylomicron remodeling

The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid.

LPL

GO:0034372

BP

very-low-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.

APOE, LPL

GO:0034374

BP

low-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.

AGT, APOE, APOA2, APOB, MPO, PLA2G2A, AGTR1, PLA2G7

GO:0034375

BP

high-density lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.

APOA1, APOE, APOA2, APOC1, APOC3, SCARB1, ABCA5, LIPG

GO:0034379

BP

very-low-density lipoprotein particle assembly

The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.

APOC1, APOC3, APOB, SOAT1, ARF1

GO:0034380

BP

high-density lipoprotein particle assembly

The aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.

ABCA1, APOA1, APOE, APOA2, APOA5

GO:0034381

BP

plasma lipoprotein particle clearance

The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

CD36

GO:0034382

BP

chylomicron remnant clearance

The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.

APOE, APOC1, APOC3, LMF1

GO:0034383

BP

low-density lipoprotein particle clearance

The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

LDLR, APOB, HMOX1, CD36, ADIPOQ, SCARB1, DGAT2

GO:0034384

BP

high-density lipoprotein particle clearance

The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

APOA1, APOE, APOA2, SCARB1

GO:0034388

CC

Pwp2p-containing subcomplex of 90S preribosome

A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.

TBL3, WDR3, UTP18

GO:0034389

BP

lipid particle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.

PPIA, PLIN5, PPID, RAB3GAP1, SPG20, PNPLA2, FAF2

GO:0034392

BP

negative regulation of smooth muscle cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.

LRP6, APOH, IGF1, EDN1

GO:0034393

BP

positive regulation of smooth muscle cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.

IL12A, PDCD4, APOPT1

GO:0034394

BP

protein localization to cell surface

A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.

FLNA, FGF7, CTNNB1, EMP2, ANK2, PTPRK, ANGPT1, MRAP, PIGK, MRAP2

GO:0034395

BP

regulation of transcription from RNA polymerase II promoter in response to iron

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus.

HMOX1, SLC40A1

GO:0034399

CC

nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.

IPO5, TNPO2, RANBP6, MAPT, TPR, ATF7, ATF4, NUP153, NUP107, KPNB1, NUP93, IPO4, AHCTF1, NUP205, EBNA1BP2

GO:0034402

BP

recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript.

POLR2D

GO:0034405

BP

response to fluid shear stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.

PDGFRB, GJA1, NOS3, AKT1, PKD1, P2RX4, CITED2

GO:0034417

MF

bisphosphoglycerate 3-phosphatase activity

Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.

MINPP1

GO:0034418

BP

urate biosynthetic process

The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine.

PNP, PRPS1

GO:0034421

BP

post-translational protein acetylation

The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome.

ESCO2, DSCC1

GO:0034427

BP

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.

EXOSC9, EXOSC2, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3

GO:0034431

MF

bis(5'-adenosyl)-hexaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.

NUDT3, NUDT10, NUDT11

GO:0034432

MF

bis(5'-adenosyl)-pentaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.

NUDT3, NUDT10, NUDT11

GO:0034435

BP

cholesterol esterification

A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

SOAT1

GO:0034436

BP

glycoprotein transport

The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

VLDLR, GUK1

GO:0034437

MF

glycoprotein transporter activity

Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells.

VLDLR

GO:0034440

BP

lipid oxidation

The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

PLA2G7

GO:0034441

BP

plasma lipoprotein particle oxidation

The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group, occurring in the blood plasma.

PLA2G7

GO:0034446

BP

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

FZD7, FN1, ITGB3, ITGAV, LAMB1, LAMC1, EFNA1, RAB1A, RAC1, TEK, TYRO3, MERTK, ILK, KIF14, VAMP3, BVES, AKIP1, PARVA, FZD4

GO:0034447

BP

very-low-density lipoprotein particle clearance

The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

APOE, APOC1, VLDLR

GO:0034448

CC

EGO complex

A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Meh1p, and Slm4p.

RRAGC, RRAGD

GO:0034450

MF

ubiquitin-ubiquitin ligase activity

Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

UBR5, UBE4B, RBX1, PPIL2, PELI1, PELI2, AMFR, PRPF19, STUB1

GO:0034451

CC

centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.

OFD1, FLOT1, PCNT, KRT18, PCM1, CCDC14, SDCCAG8, HOOK3, PIBF1, FOPNL, SPAG5, CCDC113, EXOC7, SSX2IP

GO:0034452

MF

dynactin binding

Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity.

HTT, BICD1, SNX6, SNX5

GO:0034453

BP

microtubule anchoring

Any process in which a microtubule is maintained in a specific location in a cell.

PEX14, DAG1, PCM1, CEP57, FOPNL, CAMSAP3

GO:0034454

BP

microtubule anchoring at centrosome

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.

PCM1, HOOK3, NIN

GO:0034455

CC

t-UTP complex

A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

UTP4, NOL11

GO:0034456

CC

UTP-C complex

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.

RRP7A

GO:0034458

MF

3'-5' RNA helicase activity

Catalysis of the unwinding of an RNA helix in the direction 3' to 5'.

SUPV3L1

GO:0034463

BP

90S preribosome assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions.

RPL38

GO:0034464

CC

BBSome

A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.

BBIP1, BBS7, BBS1, TTC8, BBS2

GO:0034465

BP

response to carbon monoxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus.

IL10, KCNMA1

GO:0034473

BP

U1 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U1 snRNA molecule.

EXOSC9, EXOSC7, EXOSC8

GO:0034475

BP

U4 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U4 snRNA molecule.

EXOSC9, EXOSC2, EXOSC7, EXOSC6, EXOSC8, EXOSC4, EXOSC3

GO:0034476

BP

U5 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U5 snRNA molecule.

EXOSC9, EXOSC7, EXOSC8

GO:0034485

MF

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate.

INPP5D, INPP5K

GO:0034497

BP

protein localization to pre-autophagosomal structure

Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS).

MFN2, WIPI1, PIK3C3, WDR45, WIPI2

GO:0034498

BP

early endosome to Golgi transport

The directed movement of substances from early endosomes to the Golgi.

TRAPPC10, SNX1, EHD3

GO:0034501

BP

protein localization to kinetochore

Any process in which a protein is transported to, or maintained at, the kinetochore.

BUB1B, CDK1, CASC5, SPDL1, AURKB, CHAMP1

GO:0034502

BP

protein localization to chromosome

Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.

TEX15