GO:0032943

BP

mononuclear cell proliferation

The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.

TGFB1, ACE

GO:0032945

BP

negative regulation of mononuclear cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.

LILRB1

GO:0032946

BP

positive regulation of mononuclear cell proliferation

Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.

IL12A

GO:0032947

MF

protein complex scaffold

Functions to provide a physical support for the assembly of a multiprotein complex.

CNOT1, AXIN1, CAPN3, CAV2, EIF3B, RACK1, CAV1, AKAP13, DLG1, AKAP6, SEPT2, ITSN1, WWC2, LAMTOR1, WWC1, RB1CC1, SMARCD1, MAGI1, PKP2, LAMTOR3, WWC3, LAMTOR2

GO:0032956

BP

regulation of actin cytoskeleton organization

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

ROCK2, PDGFA, PDGFRB, RHOQ, PAM, EPHA3, CORO1A, EFNA5, EPHA5, RHOA, TGFB2, PRKCD, BST2, ARHGEF5, ILK, GPM6B, DIXDC1, FSCN1, CCDC88A, TWF2, RICTOR, ARHGAP18, DLC1, MLST8, SH3BGRL3

GO:0032957

BP

inositol trisphosphate metabolic process

The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.

ITPK1

GO:0032958

BP

inositol phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

FGF2, PPIP5K1

GO:0032959

BP

inositol trisphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.

PLCG2, PTAFR

GO:0032962

BP

positive regulation of inositol trisphosphate biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.

LHCGR, HRH1, GPER1

GO:0032963

BP

collagen metabolic process

The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

TNXB, ID1, HIF1A, TNS2, P3H2

GO:0032964

BP

collagen biosynthetic process

The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

COL1A1, COL5A1, SERPINH1, TRAM2

GO:0032966

BP

negative regulation of collagen biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.

IL6, PPARG, RAP1A, PPARD, CYGB, ERRFI1

GO:0032967

BP

positive regulation of collagen biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.

F2, TGFB1, PDGFRB, BMP4, CCL2, ITGA2, F2R, CTGF, HDAC2, RGCC

GO:0032968

BP

positive regulation of transcription elongation from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

BRD4, GTF2F2, GTF2F1, TCEB1, SUPT6H, RTF1

GO:0032970

BP

regulation of actin filament-based process

Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.

FRMD6

GO:0032976

BP

release of matrix enzymes from mitochondria

The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.

BAX

GO:0032981

BP

mitochondrial respiratory chain complex I assembly

The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.

NDUFS8, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, NDUFV3, NDUFA5, NDUFAF6, NDUFAF5, NDUFA11, NDUFAF2, NUBPL, NDUFAF3, TIMM21, TIMMDC1, NDUFB11, NDUFAF4, NDUFA13, BCS1L

GO:0032982

CC

myosin filament

A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.

MYH11, ACTG2, MYBPC1, MYH2, MYH4

GO:0032991

CC

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

CRTAP, PPIB

GO:0032993

CC

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

SOX12, JUP, JUND, NFYB, KDM5A, CTNNB1, DDIT3, HMGA2, HHEX, NFYC, CHD4, SUZ12, TCF7L2

GO:0032994

CC

protein-lipid complex

A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.

PEX3

GO:0032996

CC

Bcl3-Bcl10 complex

A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.

BCL3

GO:0033003

BP

regulation of mast cell activation

Any process that modulates the frequency, rate, or extent of mast cell activation.

PLSCR1, LYN

GO:0033004

BP

negative regulation of mast cell activation

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.

CNR1

GO:0033010

CC

paranodal junction

A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.

AKR1B1, SIRT2, JAM3

GO:0033017

CC

sarcoplasmic reticulum membrane

The lipid bilayer surrounding the sarcoplasmic reticulum.

ATP2A2, PLN, SRI, DMPK, ASPH, CAMK2D, ITPR2, RYR3, CHERP, SYNE2, RYR2, JSRP1, TMEM38B

GO:0033018

CC

sarcoplasmic reticulum lumen

The volume enclosed by the membranes of the sarcoplasmic reticulum.

CALU, CALR

GO:0033025

BP

regulation of mast cell apoptotic process

Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.

ADAM17

GO:0033026

BP

negative regulation of mast cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.

KITLG

GO:0033030

BP

negative regulation of neutrophil apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.

CXCR2

GO:0033031

BP

positive regulation of neutrophil apoptotic process

Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.

ANXA1

GO:0033032

BP

regulation of myeloid cell apoptotic process

Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.

THRA, PTEN

GO:0033033

BP

negative regulation of myeloid cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.

APOH, BCL2, MIF, MAEA

GO:0033034

BP

positive regulation of myeloid cell apoptotic process

Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.

ADIPOQ

GO:0033037

BP

polysaccharide localization

Any process in which a polysaccharide is transported to, or maintained in, a specific location.

CHST11

GO:0033043

BP

regulation of organelle organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.

SEC22B, CAMSAP2, CAMSAP3

GO:0033044

BP

regulation of chromosome organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.

CENPV

GO:0033058

BP

directional locomotion

Self-propelled movement of a cell or organism from one location to another along an axis.

GRIN2A, ARPIN

GO:0033059

BP

cellular pigmentation

The deposition or aggregation of coloring matter in a cell.

POMC

GO:0033063

CC

Rad51B-Rad51C-Rad51D-XRCC2 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.

RAD51C, RAD51D

GO:0033065

CC

Rad51C-XRCC3 complex

A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.

RAD51C

GO:0033076

BP

isoquinoline alkaloid metabolic process

The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.

TH, CYP2D6

GO:0033077

BP

T cell differentiation in thymus

The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.

FZD7, GLI3, BCL2, RAG1, CTNNB1, ZFP36L2, STAT5B, B2M, RPS6, PRKDC, ADAM17, CDK6, ZFP36L1, FADD, JMJD6, NKAP, FZD8, MAFB

GO:0033081

BP

regulation of T cell differentiation in thymus

Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.

CLPTM1, ZEB1, SOS1

GO:0033085

BP

negative regulation of T cell differentiation in thymus

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.

BMP4

GO:0033087

BP

negative regulation of immature T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation.

GNRH1

GO:0033088

BP

negative regulation of immature T cell proliferation in thymus

Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus.

KIAA0922, ERBB2, BMP4

GO:0033089

BP

positive regulation of T cell differentiation in thymus

Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.

VNN1, ADA, GLI2, IL7R, ADAM8, EGR3

GO:0033091

BP

positive regulation of immature T cell proliferation

Any process that activates or increases the frequency, rate or extent of immature T cell proliferation.

RIPK2

GO:0033092

BP

positive regulation of immature T cell proliferation in thymus

Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.

FOXP3

GO:0033093

CC

Weibel-Palade body

A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.

VWF, EDN1, ECE1, RAB27A

GO:0033108

BP

mitochondrial respiratory chain complex assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.

TFAM, SAMM50

GO:0033116

CC

endoplasmic reticulum-Golgi intermediate compartment membrane

The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.

GOSR2, SURF4, SEC22B, F8, SERPINA1, TGFA, INS, CD55, F5, FOLR1, AREG, KDELR1, CSNK1D, TMED10, BCAP31, CTSC, RAB2A, GOLGA2, TMED2, MCFD2, SPPL3, PIEZO1, ERGIC1, VMP1, ERGIC2, ASPSCR1, RAB1B, SLC35C2, CTSZ, LAMP5, ERGIC3, TMED5, TMED3

GO:0033119

BP

negative regulation of RNA splicing

Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.

PTBP3, PTBP1, RPS13, RPS26, PTBP2

GO:0033120

BP

positive regulation of RNA splicing

Any process that activates or increases the frequency, rate or extent of RNA splicing.

ZPR1, ERN1, POLR2A, PIK3R1, SRSF1, SRSF5, SETX, RBM22

GO:0033128

BP

negative regulation of histone phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.

H2AFY, UBE2B, TWIST1

GO:0033129

BP

positive regulation of histone phosphorylation

Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.

RPS6KA5, IL1B, CCNB1, MAPK3, FMR1

GO:0033130

MF

acetylcholine receptor binding

Interacting selectively and non-covalently with an acetylcholine receptor.

JAK2, DLG4, LYPD1, NRXN1

GO:0033132

BP

negative regulation of glucokinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.

PARK2, RANBP2, MIDN, COX11

GO:0033133

BP

positive regulation of glucokinase activity

Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.

PFKFB2, PFKFB1, BAD

GO:0033135

BP

regulation of peptidyl-serine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.

PLCL1, RICTOR, SPTBN4, PLCL2

GO:0033136

BP

serine phosphorylation of STAT3 protein

The process of introducing a phosphate group to a serine residue of the STAT3 protein.

CDK5, NLK

GO:0033137

BP

negative regulation of peptidyl-serine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.

SMAD7, DKK1, DMD, HGF, PPM1F, RACK1, CAV1, BAX, PDE4D, CNKSR3, INPP5K, DDIT4

GO:0033138

BP

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

HAX1, AXIN1, RIPK2, SPRY2, CREBL2, PPP1R15A, BCAR3, LATS1, TGFB1, GCG, TNF, RAF1, IL6, BCL2, TXN, MIF, HCLS1, LIF, VEGFA, CD44, IL11, ATP2B4, AKT1, SNCA, WNT5A, PIK3CA, GSK3B, CDC42, CAV1, STK4, CAMK1, GAS6, PRKD1, ANGPT1, NTRK2, FNIP1, DOCK7, PDCD10, PINK1, PRKD2, TRIM6, SMYD3, FNIP2, TBK1

GO:0033141

BP

positive regulation of peptidyl-serine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

IFNA1 , IFNA16, LIF, IFNE

GO:0033142

MF

progesterone receptor binding

Interacting selectively and non-covalently with a progesterone receptor.

NCOA1

GO:0033144

BP

negative regulation of intracellular steroid hormone receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.

CALR, NR0B1

GO:0033146

BP

regulation of intracellular estrogen receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.

UFM1, CARM1, UBA5, UFSP2

GO:0033147

BP

negative regulation of intracellular estrogen receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.

CNOT1, BRCA1, STRN3, KANK2, CRIPAK, PHB2

GO:0033148

BP

positive regulation of intracellular estrogen receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.

PARP1, AR, DDX5, SKP2, DDX17, PAGR1

GO:0033149

MF

FFAT motif binding

Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.

VAPB, VAPA

GO:0033151

BP

V(D)J recombination

The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

HMGB1, RAG1, HMGB2, DCLRE1C

GO:0033152

BP

immunoglobulin V(D)J recombination

The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.

TCF3, PRKDC

GO:0033153

BP

T cell receptor V(D)J recombination

The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

PRKDC

GO:0033157

BP

regulation of intracellular protein transport

Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.

LCP1, SH3TC2, NDEL1, ATP13A2

GO:0033158

BP

regulation of protein import into nucleus, translocation

Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

TXN, CDKN1A

GO:0033159

BP

negative regulation of protein import into nucleus, translocation

Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

GAS6

GO:0033160

BP

positive regulation of protein import into nucleus, translocation

Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

JAK2, UBR5, IGF1, IL6, CDK1, HSP90AA1, HSP90AB1, MAVS

GO:0033162

CC

melanosome membrane

The lipid bilayer surrounding a melanosome.

TH, TYR, RAB7A, RAB32, SLC45A2

GO:0033167

CC

ARC complex

A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.

DICER1

GO:0033168

BP

conversion of ds siRNA to ss siRNA involved in RNA interference

The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference.

DICER1

GO:0033169

BP

histone H3-K9 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.

KDM1A, JMJD1C, KDM7A

GO:0033173

BP

calcineurin-NFAT signaling cascade

Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).

NFATC1, RCAN1, PPP3CA, NFATC2, NFATC4

GO:0033176

CC

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

ATP6V1D

GO:0033179

CC

proton-transporting V-type ATPase, V0 domain

A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.

ATP6V0E1, ATP6V0D1

GO:0033180

CC

proton-transporting V-type ATPase, V1 domain

A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.

ATP6V1B2, ATP6V1C1, ATP6V1F, ATP6V1C2

GO:0033184

BP

positive regulation of histone ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.

KDM1A

GO:0033185

CC

dolichol-phosphate-mannose synthase complex

A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.

DPM3

GO:0033186

CC

CAF-1 complex

A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.

RBBP4, CHAF1A, CHAF1B

GO:0033188

MF

sphingomyelin synthase activity

Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin.

SGMS1, SGMS2

GO:0033189

BP

response to vitamin A

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.

ALDH1A2, CYP1A1, TYMS, PPARG, GATA4, HAMP, PPARD, PITX2, DNMT3B

GO:0033192

MF

calmodulin-dependent protein phosphatase activity

Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.

PPM1F, PPP3CA

GO:0033193

CC

Lsd1/2 complex

A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.

TAL1

GO:0033194

BP

response to hydroperoxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.

JAK2, GPX1, STX2, STX4

GO:0033197

BP

response to vitamin E

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.

ADA, ALAD, LEP, SRSF2, HMGCS1, MEF2C

GO:0033198

BP

response to ATP

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.

IL1B, HSPD1, SELL, CASP1, PTEN, TRPC3, KCNJ11, PANX1, P2RX4

GO:0033204

MF

ribonuclease P RNA binding

Interacting selectively and non-covalently with the RNA subunit of ribonuclease P.

POP4

GO:0033206

BP

meiotic cytokinesis

A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.

ACTR3, ACTR2

GO:0033209

BP

tumor necrosis factor-mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

PSMD11, PSMD12, TNFRSF11B, TNFSF11, TNFRSF10C, PSMD3, FOXO3, JAK2, TNFRSF21, PSMD10, TNFSF13, TNF, KRT18, KRT8, NGFR, UBC, PSMC3, TNFRSF1B, PSMB1, TNFSF4, FAS, PSMA1, PSMA2, PSMA3, PSMA4, CD27, PSMB8, PSMB9, PSMB4, PSMB5, TNFRSF8, CD40LG, PSMC2, LTBR, PSMB10, PSMC4, PSMB3, PSMD7, PSME3, PSMC1, PSMC6, RPS27A, UBA52, ADAM17, PSMD2, BIRC3, RIPK1, PSME4, TRADD, EDARADD, TNFRSF25, TNFRSF12A, TNFRSF19, PYCARD, TNFSF13B, TNFRSF11A

GO:0033210

BP

leptin-mediated signaling pathway

A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.

MT3, STAT3, LEP, LEPR, ADIPOR1