Search Geneontologies

Geneontologies

GO ID Ontology GO Term Term Definition Proteins

GO:0001828

BP

inner cell mass cellular morphogenesis

The morphogenesis of cells in the inner cell mass.

LATS1, SOX17, LATS2

GO:0001829

BP

trophectodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.

CNOT3, ADA, JUNB, SP3, HOPX

GO:0001831

BP

trophectodermal cellular morphogenesis

The morphogenesis of trophectoderm cells.

CUL3

GO:0001832

BP

blastocyst growth

An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.

NBN, RTF1

GO:0001833

BP

inner cell mass cell proliferation

The proliferation of cells in the inner cell mass.

ZPR1, BRCA2, GINS1, NCAPG2, GINS4, NDEL1, PRPF19, SBDS

GO:0001834

BP

trophectodermal cell proliferation

The proliferation of cells in the trophectoderm.

ZPR1

GO:0001836

BP

release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

SOD2, JUN, CCK, BCL2, CLU, SFN, BID, BAX, PMAIP1, TIMM50, BAD, MFF, BOK

GO:0001837

BP

epithelial to mesenchymal transition

A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

SNAI2, TGFB1, BMP2, HGF, FGFR2, S100A4, CTNNB1, TGFBR1, WNT5A, NOTCH1, SOX9, GSK3B, HMGA2, TGFB2, TGFBR3, TRIM28, CUL7, HIF1A, FAM101B, HNRNPAB, FAM83D, LOXL2

GO:0001840

BP

neural plate development

The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.

CTNNB1

GO:0001841

BP

neural tube formation

The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.

SOX4, STK4, MIB1

GO:0001843

BP

neural tube closure

The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.

ARID1A, PLXNB2, KDM6A, SPINT2, FZD6, COBL, TULP3, LRP6, BCL10, TGFB1, PFN1, RALA, MTHFD1, BMP4, SKI, PRKACA, SDC4, ADM, TSC2, LHX2, TGFB2, LMO4, RPS7, PTCH1, TMED2, STIL, TEAD2, TWIST1, MTHFD1L, PHACTR4, SHROOM3, GLMN, MED12, PRICKLE1, KIF20B, DLC1, IFT122, MKS1, CC2D2A, SUFU

GO:0001844

BP

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.

BCL2L11, BAX, PMAIP1, BAD, MOAP1

GO:0001845

BP

phagolysosome assembly

The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.

CORO1A

GO:0001846

MF

opsonin binding

Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.

ITGAV

GO:0001847

MF

opsonin receptor activity

Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CD14

GO:0001848

MF

complement binding

Interacting selectively and non-covalently with any component or product of the complement cascade.

CFB, C8G, C4A, C4B

GO:0001849

MF

complement component C1q binding

Interacting selectively and non-covalently with the C1q component of the classical complement cascade.

CRP, APCS, C4A, PTX3, CALR, C1QBP, CD93

GO:0001850

MF

complement component C3a binding

Interacting selectively and non-covalently with the C3a product of the complement cascade.

PHB

GO:0001851

MF

complement component C3b binding

Interacting selectively and non-covalently with the C3b product of the complement cascade.

CR1, PHB

GO:0001855

MF

complement component C4b binding

Interacting selectively and non-covalently with the C4b product of the classical complement cascade.

MASP2, CR1

GO:0001856

MF

complement component C5a binding

Interacting selectively and non-covalently with the C5a product of the complement cascade.

C5AR1

GO:0001861

MF

complement component C4b receptor activity

Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CR1

GO:0001867

BP

complement activation, lectin pathway

Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

MASP2, KRT1, MBL2, FCN2

GO:0001869

BP

negative regulation of complement activation, lectin pathway

Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.

A2M, SERPING1

GO:0001872

MF

(1->3)-beta-D-glucan binding

Interacting selectively and non-covalently with (1->3)-beta-D-glucans.

PTX3

GO:0001875

MF

lipopolysaccharide receptor activity

Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.

TLR4, TLR2, PTAFR, SCARB1

GO:0001878

BP

response to yeast

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.

ANG, APP, MPO, IL6, PTX3

GO:0001880

BP

Mullerian duct regression

The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.

AMH, BMPR1A, AMHR2, SMAD5

GO:0001881

BP

receptor recycling

The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.

RAB11B, ALS2, EHD3, ARFGEF2

GO:0001882

MF

nucleoside binding

Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.

ACTN4, PNP, POLA1

GO:0001883

MF

purine nucleoside binding

Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.

ADA, ADORA1

GO:0001885

BP

endothelial cell development

The progression of an endothelial cell over time, from its formation to the mature structure.

GPX1, VEZF1, CCM2

GO:0001886

BP

endothelial cell morphogenesis

The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.

MET, COL18A1, ID1, STC1, ARHGEF26, HEG1

GO:0001887

BP

selenium compound metabolic process

The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.

SEPP1, TXNRD1, SCLY

GO:0001889

BP

liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

COBL, ALDH1A2, ADA, ASS1, KRAS, JUN, ASNS, QDPR, IGF2R, HGF, XBP1, SRD5A1, MPST, AK4, CAD, HMGCL, PIK3CA, NOTCH1, CEBPG, GFER, SMAD3, PKD1, HMGCS1, SP3, TGFBR3, RELA, PKD2, HNRNPD, HES1, ARID5B, AACS, LSR, PCSK9, RB1CC1, PROX1, GATA6, CITED2, CADM1, UPF2, SEC63

GO:0001890

BP

placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

E2F8, ADA, ANG, DCN, HSP90AB1, HSD17B2, PPARG, CCNF, LEP, RPS6, NDP, MC2R, PTK2, ALKBH1, CUL7, MAPK14, PHLDA2, HTRA1, CITED1, RTCB, MAP3K4

GO:0001891

CC

phagocytic cup

An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.

MYO1G, PIP5K1C, TNF, ANXA1, LCP1, CORO1A, RAC1, RACK1, TRIP10, PEAR1, MEGF10, SYT11, CDC42SE2, BIN2, SNX5

GO:0001892

BP

embryonic placenta development

The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

EGFR, PDGFB, CEBPB, TFEB, ARNT, PKD1, HSF1, SP3, PKD2, HIF1A, EPAS1

GO:0001893

BP

maternal placenta development

Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.

NR2F2, AKT1, BMPR2, TMED2, DAZAP1

GO:0001894

BP

tissue homeostasis

A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.

RB1, AKR1B1, CTGF, SOX9, GNAS, STK11, GNAS, ANKRD11, TP53INP2, NANOS1, P2RX4, BARD1

GO:0001895

BP

retina homeostasis

A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.

ALB, TF, KRT1, HSPB1, AZGP1, ACTB, LYZ, B2M, ACTG1, PRDX1, POTEE, BBS1, WDR36, BBS10, POC1B, PROL1

GO:0001909

BP

leukocyte mediated cytotoxicity

The directed killing of a target cell by a leukocyte.

STXBP2

GO:0001910

BP

regulation of leukocyte mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.

ICAM1

GO:0001912

BP

positive regulation of leukocyte mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.

CCL2

GO:0001913

BP

T cell mediated cytotoxicity

The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

CTSH, CTSC, EMP2, MICB, MICA

GO:0001915

BP

negative regulation of T cell mediated cytotoxicity

Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.

PTPRC, IL7R, LILRB1

GO:0001916

BP

positive regulation of T cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

STX7, HLA-E, IL12A, IL12RB1, B2M, FADD

GO:0001917

CC

photoreceptor inner segment

The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.

INHA, ENO2, MAK, PDC, GNB1, CROCC, DRAM2, PHLPP2, RDH11, GUCA1B

GO:0001919

BP

regulation of receptor recycling

Any process that modulates the frequency, rate, or extent of receptor recycling.

LAMTOR1, TBC1D16

GO:0001920

BP

negative regulation of receptor recycling

Any process that stops, prevents, or reduces the rate of receptor recycling.

PCSK9, OPTN

GO:0001921

BP

positive regulation of receptor recycling

Any process that activates or increases the frequency, rate or extent of receptor recycling.

RAB29, RAMP3, SNCA, EPS15, NSG1, ECE1, NSF, PSEN1, VAMP3, BVES, ARAP1

GO:0001922

BP

B-1 B cell homeostasis

The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.

TNFAIP3, HIF1A

GO:0001927

BP

exocyst assembly

The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.

EXOC2

GO:0001928

BP

regulation of exocyst assembly

Any process that modulates the frequency, rate or extent of exocyst assembly.

RALB

GO:0001931

CC

uropod

A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.

PIP5K1B, PIP5K1C, FLOT1, EZR, MYH9, SELPLG

GO:0001932

BP

regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

PLXNB2, SOCS1, NDUFS4, TADA3, APOA1, FN1, LYN, STAT2, SESN2, PTK2, RAD51, CCDC88A, FLCN, FNIP1, PHIP, CELSR3, FNIP2, CORO1C

GO:0001933

BP

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

PLPP3, CTDSP2, CTDSPL, PARK2, LRP6, SLIT2, TGFB1, PRNP, LYN, CCNB1, IGFBP3, FBLN1, SNCA, XDH, PTEN, PRKDC, INSM1, TARDBP, ANGPT1, PID1, DNAJC10, MICAL1, ZBED3, MYADM, CHP1, CIB1, INPP5K, FAM129A, CTDSP1, PARD6A, IMPACT, PPARGC1A, RABGEF1, CORO1C

GO:0001934

BP

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

CYR61, CDK2AP1, MUSK, AXIN1, HDAC3, TBX1, ROCK2, FLOT1, FGF19, EGFR, F2, C3, KRAS, TGFB1, IGF2, TNF, IL1B, ERBB2, NTRK1, ITGB3, INSR, CSF1R, ANXA2, RAP2A, RALB, BMP2, BMP4, MMP9, VEGFA, MT3, ACVR2A, MAPK3, ERP29, CCND2, CCND3, AKT1, AKT2, FLT4, OPRL1, SOX9, CSNK1D, EFNA5, RAC1, RACK1, ADAM17, DAB2, TEK, PLAUR, PTK2, STK4, SQSTM1, RIPK1, GAS6, ERBB4, ADIPOQ, NTRK2, BRAT1, IL34, KNDC1, MAVS, FLCN, FBXO18, RB1CC1, FNIP1, ITLN1, MYDGF, GPER1, CIB1, RARRES2, PINK1, FAM129A, AKTIP, PELI2, TNIK

GO:0001935

BP

endothelial cell proliferation

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

ERN1, APOA1, HMOX1, XBP1, PIK3CB, MMP14, PRKX, TEK, DLG1, BMPR2, SCARB1, NOX5, THAP1, LOXL2

GO:0001936

BP

regulation of endothelial cell proliferation

Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.

ALDH1A2, LEP

GO:0001937

BP

negative regulation of endothelial cell proliferation

Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.

KRIT1, APOE, APOH, THBS1, SPARC, SCG2, GJA1, NR2F2, PTPRM, TGFBR1, XDH, CAV2, SYNJ2BP, CAV1, SULF1, ATOH8, RGCC, GHRL

GO:0001938

BP

positive regulation of endothelial cell proliferation

Any process that activates or increases the rate or extent of endothelial cell proliferation.

NRP1, NRP2, PDCD6, PDGFB, LRG1, ANG, ITGB3, JUN, FGF2, WNT2, BMP2, BMP4, CCL2, SCG2, VEGFA, PRKCA, BMP6, NR4A1, HMGB2, ARNT, AKT1, THBS4, FLT4, TGFBR1, WNT5A, HTR2B, STAT5A, CXCL12, PGF, VEGFC, CAV2, CDH13, TEK, EGR3, SEMA5A, BMPR2, PRKD1, HIF1A, RICTOR, VASH2, AGGF1, PROX1, MYDGF, PRKD2, PDCL3, ZNF580

GO:0001939

CC

female pronucleus

The pronucleus originating from the ovum that is being fertilized.

SLC2A1, CCNA2, CBX1, RIF1

GO:0001940

CC

male pronucleus

The pronucleus originating from the spermatozoa that was involved in fertilization.

CCNA2, CBX1, RIF1

GO:0001941

BP

postsynaptic membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).

CHRNB1

GO:0001942

BP

hair follicle development

The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.

LDB2, FZD6, LGR5, DKK1, EGFR, PDGFA, INHBA, ACVR1B, SOX9, LHX2, TGFB2, RELA, SOS1, NSDHL, APCDD1, LGR4, TNFRSF19

GO:0001944

BP

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.

TCF21, ZFAND5, FLT4, PIK3CA, STK11, ANP32B, B9D1

GO:0001945

BP

lymph vessel development

The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.

TBX1, FLT4, SYK, EFNB2, FOXC1, HEG1

GO:0001946

BP

lymphangiogenesis

Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.

FLT4, ACVR2B, BMPR2, CCBE1, PDPN, PROX1

GO:0001947

BP

heart looping

The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.

MICAL2, FOLR1, GJA1, TGFBR2, WNT5A, GATA4, NOTCH1, PSEN1, SMAD3, MEF2C, PKD2, TMED2, STIL, HIF1A, NPHP3, MIB1, CCDC103, BBS7, AHI1, SETDB2, SOX17, MKKS, NDRG4, SUFU

GO:0001948

MF

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

SDCBP, EGFR, PLAT, SERPINA1, LDLR, TGFB1, CD4, APOH, TFRC, VWF, ITGB2, FYN, HSP90AA1, THBS1, HSP90AB1, VIM, LGALS1, HSPA5, ITGAM, IGF2R, IDE, SDC1, RASA1, FLNA, AZGP1, ITGA3, CALR, CANX, BMPR1A, CSNK1D, B2M, VLDLR, CNTN1, OS9, SHB, EDEM1, FBXO17, BBC3, TFR2

GO:0001949

BP

sebaceous gland cell differentiation

The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.

FA2H

GO:0001951

BP

intestinal D-glucose absorption

Uptake of D-glucose into the blood by absorption from the small intestine.

EZR, PLS1

GO:0001952

BP

regulation of cell-matrix adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.

BCL2, PIK3CB, DDR1, MINK1

GO:0001953

BP

negative regulation of cell-matrix adhesion

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

CASK, SEMA3E, THBS1, RASA1, PIK3R1, NF2, BCL6, POSTN

GO:0001954

BP

positive regulation of cell-matrix adhesion

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.

CD36, VEGFC, GSK3B, EMP2, CDH13, CDK6, ILK, SFRP1, CIB1, PLEKHA2

GO:0001955

BP

blood vessel maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.

RECK, MMP2, S1PR1, CDH5, DDIT3

GO:0001956

BP

positive regulation of neurotransmitter secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.

SNCA, GPER1

GO:0001957

BP

intramembranous ossification

Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.

FGF18, COL1A1, MMP2, CTSK, MN1

GO:0001958

BP

endochondral ossification

Replacement ossification wherein bone tissue replaces cartilage.

FGF18, COL1A1, ALPL, BMP4, BMP6, MMP14, MMP16, DLX5, GNAS, TEK, COL10A1, MEF2C, RUNX2, MEF2D, GNAS, COL13A1, CSGALNACT1

GO:0001959

BP

regulation of cytokine-mediated signaling pathway

Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.

IRAK2, CD24, IRAK1

GO:0001960

BP

negative regulation of cytokine-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.

PTPRC, CAV1, SIGIRR, IRAK3

GO:0001961

BP

positive regulation of cytokine-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.

RIPK2, CD74, GAS6

GO:0001963

BP

synaptic transmission, dopaminergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.

TH, DRD2, CDK5, RASD2

GO:0001964

BP

startle response

An action or movement due to the application of a sudden unexpected stimulus.

PARK2, PENK, GLRB, NRG1, KCNA1, GRIN2A

GO:0001965

MF

G-protein alpha-subunit binding

Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.

RGS10, IGF2R, F2R, RGS2, HTR2B, RGS4, F2RL1, GPSM2, NUCB1

GO:0001966

BP

thigmotaxis

The directed movement of a motile cell or organism in response to touch.

ID2

GO:0001967

BP

suckling behavior

Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.

GLS, APP, OXTR, UBR3, DERL2, DACH1

GO:0001968

MF

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

ITGB3, ITGB1, ITGAV, CTSL, THBS1, VEGFA, IGFBP3, FBLN1, IGFBP5, CTSS, ITGA3, CTGF, SDC4, CTSK, HSD17B12, CCDC80, PLEKHA2

GO:0001970

BP

positive regulation of activation of membrane attack complex

Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.

C3, C6

GO:0001972

MF

retinoic acid binding

Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.

CYP26A1, SERPINA5, IGF2R, NR2F2, CYP26B1

GO:0001973

BP

adenosine receptor signaling pathway

The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.

GNAI2, ADORA2B, ADORA1

GO:0001974

BP

blood vessel remodeling

The reorganization or renovation of existing blood vessels.

HOXA3, NOL3, AGT, ACE, LIF, BGN, TGM2, NOS3, AGTR2, TGFB2, JAG1, MDM2, MEF2C, BAX, FOXC1, ACVR2B, BMPR2, EPAS1, SEMA3C, RSPO3, DLL4, CHD7

GO:0001975

BP

response to amphetamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.

ICAM1, TH, DRD2, OXTR, NR4A2, RANBP2, CALM2, SLC18A2, PPP3CA, GRIN2A, HDAC1, DPYSL2, HDAC2, HDAC9

GO:0001976

BP

neurological system process involved in regulation of systemic arterial blood pressure

The regulation of blood pressure mediated by detection of stimuli and a neurological response.

DRD2

GO:0001980

BP

regulation of systemic arterial blood pressure by ischemic conditions

The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.

TNNI3

GO:0001985

BP

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.

ADRA1A

GO:0001988

BP

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.

CHRNA7

GO:0001991

BP

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.

AGTR2

GO:0001992

BP

regulation of systemic arterial blood pressure by vasopressin

The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.

AVPR2, OXTR

Showing 501–600 of 13,237