GO:0031393

BP

negative regulation of prostaglandin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.

PIBF1

GO:0031394

BP

positive regulation of prostaglandin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.

ANXA1, PTGS2

GO:0031396

BP

regulation of protein ubiquitination

Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.

WASH1, SIAH2, PARK2, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, TGFBR1, PINK1

GO:0031397

BP

negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.

SMAD7, OGT, PRMT3, N4BP1, ISG15, FYN, HSPA1A, HSPA1B, TNFAIP3, TSPO, DNAJA1, GCLC, CDK5, CAV1, SOX4, CRY1, SPOPL, GLMN, RASD2, CHP1, HDAC8, GNL3L, BAG5

GO:0031398

BP

positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.

STRA13, SMAD7, AXIN1, RIPK2, PSMD10, BCL10, ADRB2, HSPA5, AVPR2, BRCA1, PTTG1IP, XIAP, CAV1, BIRC3, ANGPT1, RNF111, TSPYL5, APITD1, COMMD1, RASSF5, PELI1, PRICKLE1, NDFIP1, PINK1, NDFIP2, FANCI, SPHK1, STUB1

GO:0031401

BP

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

NUPR1, ATG10

GO:0031402

MF

sodium ion binding

Interacting selectively and non-covalently with sodium ions (Na+).

PDXK, ATP1B1, CAPN3, ATP1A2, SCN9A, SLC24A3

GO:0031403

MF

lithium ion binding

Interacting selectively and non-covalently with lithium ions (Li+).

PDXK, IMPA1

GO:0031404

MF

chloride ion binding

Interacting selectively and non-covalently with chloride ions (Cl-).

ACE, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, CTSC, NLGN4X

GO:0031406

MF

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

PCK1, HMGCL, AKR1C2, AKR1C1, GRHPR

GO:0031410

CC

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

WASH1, NRP1, AXIN1, PDE6D, KIF1B, PDCD6, LRP6, RP2, FLOT1, MYO1D, SNAP29, TGFA, APOA1, ERBB2, NTRK1, TH, ITGA5, IGFBP2, ATP6V1C1, SERPINB3, SLC11A2, PSEN1, MMP14, CAV2, CLCN3, CLCN7, EMP2, PRSS12, GABARAPL2, CXCR4, RAB11A, VAMP2, DSC2, CAV1, HYAL2, CALCOCO2, SQSTM1, NBR1, EEA1, OCLN, HFE, CCDC88A, RAB12, TECPR1, MIB1, TP53INP2, AMOTL1, KIAA0319L, ARRDC1, RIN3, BICD2, SH3TC2, SLC9A6, USP6NL, TP53INP1, MARVELD3, BICD1, C9orf72, ARAP1, MAP1LC3B, MAP1LC3A, TRPV4, UBQLN4, FLRT1, SPAST, ADAMTS1, TFR2, PIKFYVE, SH3GLB1, F11R, ARFGEF2

GO:0031415

CC

NatA complex

A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.

NAA15, NAA50

GO:0031416

CC

NatB complex

A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.

NAA25

GO:0031417

CC

NatC complex

A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.

NAA30

GO:0031418

MF

L-ascorbic acid binding

Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.

PLOD2, P4HA2, P4HA1, PAM, PLOD1, OGFOD3, P3H2, EGLN3

GO:0031419

MF

cobalamin binding

Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

MTR, CD320, LMBRD1

GO:0031424

BP

keratinization

The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.

PPL, KRT16, SFN, SPRR2B, CDC42, KRT17, KAZN, SPRR2G, SPRR3

GO:0031427

BP

response to methotrexate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.

DHFR, ASNS

GO:0031428

CC

box C/D snoRNP complex

A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs.

NOP56, SNU13

GO:0031429

CC

box H/ACA snoRNP complex

A box H/ACA RNP complex that is located in the nucleolus.

DKC1, NOP10, GAR1

GO:0031430

CC

M band

The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.

OBSL1, CRYAB, ALDOA, ENO1, SPTBN1, ANK2, NBR1, PPP2R5A, CMYA5

GO:0031432

MF

titin binding

Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.

CAPN3, ACTN2, CALM2, MYBPC1, CAMK2D, ANKRD1

GO:0031433

MF

telethonin binding

Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.

BMP10, TTN, MYOZ1

GO:0031434

MF

mitogen-activated protein kinase kinase binding

Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.

RAF1, ACE, IGBP1, DLG1, TRIB2, TRIB3, TRIB1, TAOK2, MAPK8IP3, MAPK8IP1

GO:0031435

MF

mitogen-activated protein kinase kinase kinase binding

Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.

TCF3, MAPK1, TGFBR2, CDC42, STK38, DUSP19, MARVELD3, MAPK8IP3, MAPK8IP1

GO:0031436

CC

BRCA1-BARD1 complex

A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.

BRCA1, BARD1

GO:0031440

BP

regulation of mRNA 3'-end processing

Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.

AHCYL1, PAPOLA, ZFP36L1

GO:0031441

BP

negative regulation of mRNA 3'-end processing

Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.

BARD1

GO:0031442

BP

positive regulation of mRNA 3'-end processing

Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.

CCNB1, NCBP1

GO:0031444

BP

slow-twitch skeletal muscle fiber contraction

A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.

TNNT1

GO:0031453

BP

positive regulation of heterochromatin assembly

Any process that activates or increases the frequency, rate or extent of heterochromatin formation.

TPR

GO:0031461

CC

cullin-RING ubiquitin ligase complex

Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.

RBX1, CAND1, GLMN

GO:0031462

CC

Cul2-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.

RBX1, CUL2, TCEB2, COMMD1, GLMN

GO:0031463

CC

Cul3-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.

ENC1, BACH1, RBX1, CUL3, KLHL12, SPOPL, KLHL24, KLHL7, KBTBD2, KLHDC8A, KLHL36, KLHL23, KCTD13, GLMN, KLHDC7B, KLHL15, KLHL32, KLHL5, BACH2, KLHL4, KCTD10, KLHL28, KLHL8, KLHL9, KLHL42, KLHL13, KLHL3

GO:0031464

CC

Cul4A-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.

CDKN1B, RBX1, CUL4A, GLMN, DTL

GO:0031465

CC

Cul4B-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.

RBX1, CUL4B, DTL

GO:0031466

CC

Cul5-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.

RBX1, TCEB2, CUL5

GO:0031467

CC

Cul7-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.

RBX1, SKP1, CUL7

GO:0031468

BP

nuclear envelope reassembly

The reformation of the nuclear envelope following its breakdown in the context of a normal process.

CHMP2A, CHMP4B, SPAST, NSFL1C

GO:0031489

MF

myosin V binding

Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.

RAB27B, RAB3B, FUS, RAB27A, RAB11A, RAB11B, RAB39B, RAB6B

GO:0031490

MF

chromatin DNA binding

Interacting selectively and non-covalently with DNA that is assembled into chromatin.

PER1, KDM6A, FOXO3, ACTN4, H2AFY, H2AFZ, HIST1H1E, THRA, HIST1H1C, KDM5A, STAT3, BCL6, NOTCH1, SMAD3, INSM1, HIST1H1A, RELA, EP300, SUZ12, JMJD1C, EZH2, NKAP, WBP2, PITX2, GRHL1, H2AFY2, PPARGC1A, RUVBL2

GO:0031491

MF

nucleosome binding

Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

ARID1A, ZNHIT1, SMARCA5, SMARCA1, RNF169, DNTTIP1, NOC2L, L3MBTL1, CABIN1

GO:0031492

MF

nucleosomal DNA binding

Interacting selectively and non-covalently with the DNA portion of a nucleosome.

HMGN4, H2AFY, MBD3, ACTL6A, HMGN2, HNRNPC, H2AFZ, RCC1, CENPA, SMARCA4, HMGA2, ACTB, HIST1H3D, H3F3A, RBBP4, HDAC1, CHD4, SMARCC2, HDAC2, SMARCC1

GO:0031493

MF

nucleosomal histone binding

Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.

UHRF1, VRK1, L3MBTL1

GO:0031497

BP

chromatin assembly

The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.

TP53, RBBP4, CHAF1A, CHAF1B, NOC2L

GO:0031501

CC

mannosyltransferase complex

A complex that posseses mannosyltransferase activity.

DPM3

GO:0031503

BP

protein complex localization

A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.

BIRC5, FKBP4

GO:0031507

BP

heterochromatin assembly

The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.

HMGA2

GO:0031508

BP

pericentric heterochromatin assembly

The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.

H3F3A, CENPV, HELLS

GO:0031509

BP

telomeric heterochromatin assembly

The assembly of chromatin into heterochromatin at the telomere.

H3F3A

GO:0031510

CC

SUMO activating enzyme complex

A conserved heterodimeric complex with SUMO activating enzyme activity.

SAE1

GO:0031512

CC

motile primary cilium

A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization.

GLI2, PKD1, PKD2, DYNC2LI1, DNAH11, IFT46

GO:0031513

CC

nonmotile primary cilium

A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.

DRD2, TUBG1, NPY2R, PKD2, SEPT2, SEPT7, AHI1, CEP89, ANO2

GO:0031514

CC

motile cilium

A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.

CCDC42B, NPHP1, ANXA1, PRKACA, MAK, SCNN1A, SORD, SPA17, HIF1A, RSPH4A, KLC3, CCDC103, C6orf165, IQUB, MNS1, IFT81, RSPH1, IFT74, FOPNL, CEP89, IFT27, BBS2, IQCG, SPAG4, MKKS, IFT46, TEKT2, INTU, DAAM1

GO:0031515

CC

tRNA (m1A) methyltransferase complex

A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.

TRMT6

GO:0031519

CC

PcG protein complex

A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.

CBX7, YY1, SKP1, RING1, PCGF3, PCGF5, PHC3, SCML2

GO:0031523

CC

Myb complex

A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.

MYBL2, FLNA

GO:0031526

CC

brush border membrane

The portion of the plasma membrane surrounding the brush border.

KCNK1, ATP8B1, SLC22A5, HSP90AA1, HSP90AB1, B4GALT1, FOLR1, CD36, CA4, SLC11A2, SLC7A9, LRP2, GNA12, CYBRD1, SLC27A4, ITLN1, SLC46A1, TRPM6, CDHR2, PEMT, SLC6A14

GO:0031527

CC

filopodium membrane

The portion of the plasma membrane surrounding a filopodium.

ITGB3, ITGAV, DMD, GAP43, ITGA3, NF2, PDPN, SYNE2, TTYH1, MYO10

GO:0031528

CC

microvillus membrane

The portion of the plasma membrane surrounding a microvillus.

ITGB3, ITGAV, EZR, S100P, CTNNB1, PDPN, MUC20, SCARB1, CDHR2

GO:0031529

BP

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

CSF1R, TPM1, RAC1, LRRC16A, CYFIP1, CORO1B, LIMA1

GO:0031532

BP

actin cytoskeleton reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.

FARP2, ANXA1, S100A9, RAP2A, KIT, RALA, EZR, FLNA, S1PR1, FGF7, MYH9, RHOA, CXADR, ATP2C1, EPS8, PTK7, CTTN, CDC42BPA, RICTOR, MINK1, TRPV4, CAPN10, PARVA, TNIK, MKLN1, CDC42BPB

GO:0031536

BP

positive regulation of exit from mitosis

Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).

UBE2C, TGFB1, CDCA5, PHB2

GO:0031545

MF

peptidyl-proline 4-dioxygenase activity

Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.

EGLN3

GO:0031547

BP

brain-derived neurotrophic factor receptor signaling pathway

The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.

BDNF, NTRK2, SLC9A6

GO:0031550

BP

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.

BDNF

GO:0031571

BP

mitotic G1 DNA damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.

TP53, CDK2, FBXO31, RFWD3, GIGYF2, RPS27L

GO:0031572

BP

G2 DNA damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.

CHEK1, CDC14B, BRCA1, BRCC3, MAPKAPK2, PLK1, NEK11, NEK6, DTL, TAOK2, FZR1

GO:0031573

BP

intra-S DNA damage checkpoint

A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.

EME2, MSH2, MRE11A, XPC, MDC1, RAD9B, NEK11, EME1, RAD9A, TIPIN

GO:0031577

BP

spindle checkpoint

A cell cycle checkpoint that originates from the mitotic or meiotic spindle.

SPDL1, AURKB

GO:0031579

BP

membrane raft organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.

NPC1, PPT1, DLG1, MYADM

GO:0031581

BP

hemidesmosome assembly

Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.

LAMC1, ITGB4, ITGA6, CD151, LAMA3, COL17A1

GO:0031583

BP

phospholipase D-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).

EDN1

GO:0031584

BP

activation of phospholipase D activity

Any process that initiates the activity of inactive phospholipase D.

CCL5, ARF4

GO:0031585

BP

regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

MYO5A

GO:0031587

BP

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.

HTT, PKD2

GO:0031588

CC

nucleotide-activated protein kinase complex

A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).

PRKAR1A, PRKAR2A, PRKAG1, PRKAA2, SESN2, PRKAG3

GO:0031589

BP

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

MYO1G, SMAD6, SORBS3, VWF, ITGB3, ITGB1, ITGAV, ITGA5, ITGA2, ITGA6, CORO1A, PRKX, EPHB1, PPARD, GAS6, ANGPT1, TTYH1

GO:0031593

MF

polyubiquitin binding

Interacting selectively and non-covalently with a polymer of ubiqutin.

EPS15, BRCC3, RAD23A, RAD23B, VCP, FAM175B, ZFAND6, FAAP20, OPTN, UBQLN4, RAD18, HDAC6

GO:0031594

CC

neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

MUSK, SYNGR2, SYNGR3, FCHSD2, APP, ITGB1, SERPINE2, PRKAR1A, PRKACA, DES, F2R, MYH9, PSEN1, EPHA4, CDH15, HDAC4, CDK5, NRG1, ANK3, DLG1, SNTA1, CAMK2D, POSTN, SV2A, SYNC, PDZRN3, COLQ

GO:0031595

CC

nuclear proteasome complex

A proteasome found in the nucleus of a cell.

PSMD12, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, UBQLN4

GO:0031597

CC

cytosolic proteasome complex

A proteasome complex found in the cytosol of a cell.

IDE, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, UBQLN4, UCHL5

GO:0031616

CC

spindle pole centrosome

A centrosome from which one pole of a mitotic or meiotic spindle is organized.

AURKA, NPM1, FAM175B, DLGAP5, AURKB, TBCCD1, NDE1

GO:0031618

CC

nuclear pericentric heterochromatin

Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.

NCAPD3, CBX5, CBX3, IKZF1, ESCO2

GO:0031622

BP

positive regulation of fever generation

Any process that activates or increases the frequency, rate, or extent of fever generation.

TNF, IL1B, CNR1, PTGS2, PTGER3

GO:0031623

BP

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

RAMP1, RAMP3, TFRC, ITGB2, ITGB1, CXCL8, EZR, CD36, CD9, CXCR2, ADM, ADRBK2, SNCA, SYK, CD81, GRB2, CAV1, PICALM, SNX1, RAB31, LDLRAP1, LILRB1

GO:0031624

MF

ubiquitin conjugating enzyme binding

Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.

SIAH2, PARK2, RNF144A, FOXL2, PPARA, RNF19B, RNF144B, DCUN1D4, RASD2, DCUN1D1, TOLLIP, RNF19A, RNF14, ZMYM2, ARIH1, RNF114

GO:0031625

MF

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

TMEM189, ASB14, WASH1, UBE2C, AURKA, SMAD7, AXIN1, MID1, GPR37, PER1, SMAD6, PARK2, FZD6, EIF4E2, NDUFS2, USP2, RNF8, UBXN7, ERLIN2, TRIM37, MFN2, BCL10, EGFR, TP53, SLC25A5, RB1, GPI, TUBB, LYN, NGFR, UCHL1, HSPA1A, HSPA1B, BCL2, PRKAR1A, HSPD1, CLU, HSPA5, EGR2, DBT, RALA, RALB, CKB, SKI, XRCC5, PRKAR2A, PRKACA, TCP1, ATF6, TNFRSF1B, JAK1, POLR2A, CALR, PRDX6, PRKAR2B, DNAJA1, UQCRC1, MC4R, HSPA1L, CBS, ACVR1B, LTBR, BRCA1, CDKN1A, LRPPRC, RANGAP1, CDC34, UBE2A, FHIT, GSK3B, ATXN3, VCP, BID, TPI1, GABARAPL2, CXCR4, SUMO2, UBE2H, YWHAE, RBX1, YWHAZ, UBE2B, ACTG1, TUBA1B, CCT2, SMAD3, MDM2, POU5F1, RELA, FOXO1, KCNH2, TRAF1, TRIM28, UBE2V1, SQSTM1, RIPK1, NAE1, CUL2, CUL3, CUL4A, CUL4B, CASP8, CUL7, SHPRH, TCEB2, SMAD2, UBE2V2, NEDD8, HIF1A, UBE2S, SPOPL, CACUL1, CCDC50, SLF2, SPG20, UBE2J2, ABTB2, HM13, ZNF675, RFFL, TRIB2, DIO2, TANK, GLMN, USP13, CUL5, UBE2W, SLC22A18, MOAP1, FAF2, OTUB1, PACRG, ASB16, BTBD9, TRIB3, TRIB1, SMC6, MPHOSPH8, SMAD5, SLF1, SYT11, PINK1, MAP1LC3B, TOLLIP, GABARAPL1, TRIOBP, BLZF1, TXNIP, FZD8, MAP1LC3A, UBE2Z, AKTIP, UBE2T, RAD18, KBTBD4, ABI2, JKAMP, NLK, PPARGC1A, HDAC6, USP25, BAG5, FZD4, STUB1, FAF1, SMG5, PA2G4, BTBD3, PTPN22, ARIH1, ASB3, SNX9, SNCAIP

GO:0031626

MF

beta-endorphin binding

Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.

IDE

GO:0031627

BP

telomeric loop formation

The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.

TERF1

GO:0031628

MF

opioid receptor binding

Interacting selectively and non-covalently with an opioid receptor.

PENK

GO:0031629

BP

synaptic vesicle fusion to presynaptic active zone membrane

Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.

SNAP23, STX11, SNAPIN, SNAP29, STX2, SNAP25, STX4, STX3

GO:0031630

BP

regulation of synaptic vesicle fusion to presynaptic membrane

Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.

STXBP1

GO:0031638

BP

zymogen activation

The proteolytic processing of an inactive enzyme to an active form.

CTSH, PRSS3, MMP14, PRSS12

GO:0031639

BP

plasminogen activation

The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.

PLAT, FGA, FGB, FGG, APOH, DHCR24

GO:0031640

BP

killing of cells of other organism

Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

DEFA4, HAMP

GO:0031641

BP

regulation of myelination

Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

ZPR1, AKT1, CTNNB1, DLG1, KIF14, TENM4, SIRT2

GO:0031642

BP

negative regulation of myelination

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

TNFRSF21, PTEN, MTMR2

GO:0031643

BP

positive regulation of myelination

Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

HGF, MAG, NRG1, TENM4, PARD3, DICER1, MYRF

GO:0031644

BP

regulation of neurological system process

Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.

HTR2C