| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0031090 | CC | organelle membrane | A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. |
MGST3, FLRT2, CYP26A1, CYP1A1, UGT2B4, EPHX1, CYP3A4, CYP21A2, CYP2D6, TFPI, CYP2A6, CYP2C9, SRD5A1, CYP2B6, CYP3A5, AADAC, PTGS1, CYP3A7, SRD5A2, FMO4, PTGS2, SQLE, SPCS2, CYP1B1, CYP51A1, CYP2R1, FA2H, CYP2U1, RDH10, FMO2, MGST2, DHRS9, SEC11C, SLC39A8, MAP1LC3B, MAP1LC3A, CYP3A43, CYP26B1, CYP8B1, POMP |
GO:0031091 | CC | platelet alpha granule | A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). |
FGA, FGB, FGG, VWF, SERPINA5, SERPINE2, THBS1, SPARC, VAMP7, STXBP1 |
GO:0031092 | CC | platelet alpha granule membrane | The lipid bilayer surrounding the platelet alpha granule. |
PHACTR2, ITGB3, SPARC, PECAM1, CD36, CD9, SNCA, APLP2 |
GO:0031093 | CC | platelet alpha granule lumen | The volume enclosed by the membrane of the platelet alpha granule. |
ISLR, ACTN4, F8, F13A1, PLG, SERPINA1, SERPINA3, A2M, TIMP1, KNG1, PDGFB, TGFB1, IGF2, FGA, FGB, FGG, FN1, ORM1, AHSG, ALB, PPBP, PF4, ALDOA, PDGFA, A1BG, VWF, IGF1, APP, SERPINE1, SERPING1, THBS1, SPARC, SRGN, CLU, F5, ACTN1, HGF, VEGFA, ORM2, ACTN2, VEGFB, VEGFC, TGFB2, TMSB4X, MMRN1, GAS6 |
GO:0031094 | CC | platelet dense tubular network | A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. |
SERPINA5, F2R, ITPR1 |
GO:0031095 | CC | platelet dense tubular network membrane | The lipid bilayer surrounding the platelet dense tubular network. |
ATP2A2, ITPR2, ITPR3, ITPR1 |
GO:0031098 | BP | stress-activated protein kinase signaling cascade | A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. |
AKR1B1, MAPKAP1 |
GO:0031100 | BP | animal organ regeneration | The regrowth of a lost or destroyed animal organ. |
ANGPT2, APOA1, APOA2, CDK1, GSTP1, IGF2R, CDK4, ANXA3, CCL2, LCP1, HGF, PFKFB1, CCNA2, C5AR1, CAD, ADM, TGFBR2, PPARG, CDKN1A, NNMT, MKI67, NOTCH1, CXCL12, PGF, PRPS1, TGFBR3, PPAT, GAS6, LPIN1, NR0B2, NR4A3, UPF2 |
GO:0031102 | BP | neuron projection regeneration | The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. |
ULK1, APOA1, APOE, PTPRF, ADM, APOA5 |
GO:0031103 | BP | axon regeneration | The regrowth of axons following their loss or damage. |
CHL1, JAK2, DHFR, JUN, BCL2, FOLR1, CTNNA1, NREP, RTN4RL1, MTR, JAM3 |
GO:0031104 | BP | dendrite regeneration | The regrowth of dendrites in response to their loss or damage. |
MATN2 |
GO:0031105 | CC | septin complex | A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. |
SEPT6, SEPT2, SEPT7 |
GO:0031109 | BP | microtubule polymerization or depolymerization | Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. |
CRYAB |
GO:0031110 | BP | regulation of microtubule polymerization or depolymerization | Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. |
SKA3, SKA2, SKA1, STMN3 |
GO:0031111 | BP | negative regulation of microtubule polymerization or depolymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. |
FKBP4 |
GO:0031113 | BP | regulation of microtubule polymerization | Any process that modulates the frequency, rate or extent of microtubule polymerization. |
MAPT |
GO:0031115 | BP | negative regulation of microtubule polymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. |
EML2, STMN1, SNCA, FKBP4, MAPRE1, TBCD |
GO:0031116 | BP | positive regulation of microtubule polymerization | Any process that activates or increases the frequency, rate or extent of microtubule polymerization. |
MAPT, CLIP1, RGS2, CDKN1B, PSRC1, SLAIN2, FAM179B |
GO:0031117 | BP | positive regulation of microtubule depolymerization | Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. |
KATNB1, TRPV4, SPAST |
GO:0031118 | BP | rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. |
DKC1, NOP10, GAR1 |
GO:0031119 | BP | tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
RPUSD3, RPUSD4, PUS3 |
GO:0031120 | BP | snRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. |
DKC1, NOP10 |
GO:0031122 | BP | cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
AXIN1, TUBG1, PCM1, HOOK3, ATAD1, TUBGCP3, CHP1, CIB1, KATNAL1, STMN3, CRIPT, SLAIN2, SPAST |
GO:0031123 | BP | RNA 3'-end processing | Any process involved in forming the mature 3' end of an RNA molecule. |
ZCCHC6, LIN28A |
GO:0031124 | BP | mRNA 3'-end processing | Any process involved in forming the mature 3' end of an mRNA molecule. |
DDX39A, NUDT21, ZC3H11A, PAPOLA, SARNP, SRSF2, SRSF11, SRSF1, NCBP1, CPSF1, CSTF3, SRSF9, SRSF5, SRSF6, RNPS1, THOC7, FIP1L1, PABPN1, ALYREF, SRRM1, THOC2, THOC3, POLDIP3, CPSF2, RBM8A |
GO:0031125 | BP | rRNA 3'-end processing | Any process involved in forming the mature 3' end of an rRNA molecule. |
EXOSC6, EXOSC4 |
GO:0031128 | BP | developmental induction | A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). |
NKX2-1 |
GO:0031134 | BP | sister chromatid biorientation | The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. |
RB1, CHAMP1 |
GO:0031143 | CC | pseudopodium | A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. |
ACTN4, LDB3, RAF1, CNP, ACTN1, MAPK3, MAPK1, ACTN2, VAMP7, F2RL1, MYOZ1 |
GO:0031145 | BP | anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
PSMD11, PSMD12, UBE2C, AURKA, PSMD3, BUB3, BUB1B, PSMD10, PTTG1, CDK1, UBC, CCNB1, PSMC3, PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, CDC27, PSMC2, PSMB10, PSMC4, PSMB3, PSMD7, UBE2E1, PLK1, PSME3, PSMC1, PSMC6, RPS27A, UBA52, CDC20, PSMD2, MAD2L1, SKP2, PSME4, UBE2S, FBXO31, ANAPC16, AURKB, ANAPC1, CDC23, ANAPC5, ANAPC4, FZR1, ANAPC10 |
GO:0031146 | BP | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
CCNF, RBX1, SKP1, KIF14, FBXO31, FBXO36, FBXW5, FBXL15, FBXL7, FBXO9, FBXL2, BTRC |
GO:0031167 | BP | rRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. |
DIMT1 |
GO:0031175 | BP | neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
TOR1A, PHGDH, PQBP1, ULK1, UBE4B, SNAPIN, APP, IL6, RB1, LAMB1, LYN, HMGB1, MAP2, AREG, STMN1, PTPRM, RAC3, RAB11A, BLOC1S1, BTG2, CDK5, CDK16, CAMSAP2, CNTN1, STX3, CUL4B, ALKBH1, SEPT2, PTPRK, CAMSAP1, FRY, BLOC1S3, CNTN4, NLGN1, UHMK1, DOCK7, PRMT1, STMN3, FLRT3, VAPA, CAMSAP3, ATXN10, BLOC1S6, HDGFRP3 |
GO:0031177 | MF | phosphopantetheine binding | Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). |
FASN |
GO:0031201 | CC | SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
SNAP23, GOSR2, STX7, STX6, VAMP4, SEC22B, STX11, SNX4, SNAP29, SYT1, STX2, VAMP7, SNAP25, VAMP2, STX4, STX3, STXBP2, VAMP3, STXBP5, SEC22A, NAPB, BET1L, VTI1B, BLOC1S6, STXBP5L |
GO:0031205 | CC | endoplasmic reticulum Sec complex | An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. |
CFTR, DNAJC3 |
GO:0031208 | MF | POZ domain binding | Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. |
CUL3 |
GO:0031209 | CC | SCAR complex | A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. |
CYFIP1, ABI1, ABI2, WASF2 |
GO:0031210 | MF | phosphatidylcholine binding | Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
ESYT2, CHMP2A, APOA1, APOA2, APOC1, SERPINA5, PCYT1A, PITPNA, APOA5, PCTP |
GO:0031213 | CC | RSF complex | An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters). |
SMARCA5, RSF1 |
GO:0031214 | BP | biomineral tissue development | Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. |
ITGB1BP1, SRGN, SPP1, ENPP1, FAM83H, FAM20C, DSPP |
GO:0031223 | BP | auditory behavior | The behavior of an organism in response to a sound. |
DRD2, SLC1A3 |
GO:0031224 | CC | intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
BNIP3L, KCNJ12, LOH12CR1 |
GO:0031225 | CC | anchored component of membrane | The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
TNFRSF10C, FCGR3B, SEMA7A, TECTA, GPC4, VNN1, RECK, PRNP, ALPL, LPL, CD55, CD48, TFPI, TDGF1, NCAM1, CPM, CD58, NT5E, GPC1, SPAM1, EFNA4, CDH13, PLAUR, BST2, CNTN1, LSAMP, CEACAM7, LY6E, CNTN4, GPC2, LYPD1, CD177, SVIP, ITLN1, BCAN, MMP25, NRN1, VNN3, CNTN3, PRND, GPC6 |
GO:0031226 | CC | intrinsic component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
TLR4, TLR2, TNFRSF21, PDGFRB, PDGFRA, S1PR1, TGM2, CD6, ALCAM, ADIPOR2, TRPV1, ADIPOR1 |
GO:0031227 | CC | intrinsic component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
ESYT2, CYP2E1, PGAP3 |
GO:0031228 | CC | intrinsic component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
CHST4, CHST5, ZDHHC9, CHST2 |
GO:0031232 | CC | extrinsic component of external side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. |
PLG, TF, ANXA1, SERPINE2, PCSK9 |
GO:0031233 | CC | intrinsic component of external side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. |
ADAM9 |
GO:0031234 | CC | extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
ESYT2, CYTH3, JAK2, KRAS, FYN, S100A6, LYN, FGR, ALOX15, ATP2A2, JAK1, CSK, ABL2, SYK, IQGAP1, CAV2, JAK3, RHOA, DLG4, CDK16, PTK2, TNK2, TIAM1, STYK1, SNX18, RACGAP1, CYLD, ERRFI1, FARP1, DTNA, SNX9, SNX5 |
GO:0031235 | CC | intrinsic component of the cytoplasmic side of the plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. |
RASA4, RASA1, RASA3, RASA2, SYNGAP1 |
GO:0031247 | BP | actin rod assembly | The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules. |
HSP90B1 |
GO:0031251 | CC | PAN complex | A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. |
PAN3 |
GO:0031252 | CC | cell leading edge | The area of a motile cell closest to the direction of movement. |
ARPC2, LDB2, VIM, ITGB4, TUBG1, MYH9, PRKCI, CXCR4, LMO4, ARF1, DST, DCTN1, AAK1, CDC42BPA, LRRC16A, BSPRY, PHLDB2, JMY, DOCK8, GBF1, CORO1B, NDEL1, HDAC6, SSX2IP, CDC42BPB |
GO:0031253 | CC | cell projection membrane | The portion of the plasma membrane surrounding a cell surface projection. |
DLG1, MAPRE1, FSCN1, BVES, NDRG4 |
GO:0031256 | CC | leading edge membrane | The portion of the plasma membrane surrounding the leading edge of a motile cell. |
MYO1G, CDC42, PTPRK |
GO:0031258 | CC | lamellipodium membrane | The portion of the plasma membrane surrounding a lamellipodium. |
ITGB3, ITGAV, CFL1, DPP4, SLC39A6, CSPG4, PDPN, SYNE2, PIEZO1, PLEK2 |
GO:0031261 | CC | DNA replication preinitiation complex | A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. |
ORC3 |
GO:0031262 | CC | Ndc80 complex | A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore. |
NDC80, SPC24, NUF2, SPC25 |
GO:0031264 | CC | death-inducing signaling complex | A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. |
CFLAR, FAS, FADD, RIPK1, CASP8, TRADD |
GO:0031265 | CC | CD95 death-inducing signaling complex | A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. |
CFLAR, FAS, FADD, CASP8, FAF1 |
GO:0031267 | MF | small GTPase binding | Interacting selectively and non-covalently with a small monomeric GTPase. |
ABCA1, FLNA, TSC2, GDI2, FGD6, FGD2, RNF152, FGD4, ERRFI1 |
GO:0031274 | BP | positive regulation of pseudopodium assembly | Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. |
WASH1, KIT, APC, F2RL1, CDC42, CDC42EP3 |
GO:0031281 | BP | positive regulation of cyclase activity | Any process that activates or increases the activity of a cyclase. |
MAPK3, MAPK8, MAPK14 |
GO:0031284 | BP | positive regulation of guanylate cyclase activity | Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. |
GUCA1C, ADORA2B, NOS3, GUCA1B |
GO:0031290 | BP | retinal ganglion cell axon guidance | The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
NRP1, SLIT2, PTPRM, EPHB2, EFNA5, EPHB1, RPL24, ALCAM, NRCAM, ROBO2 |
GO:0031291 | BP | Ran protein signal transduction | A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state. |
KPNB1 |
GO:0031293 | BP | membrane protein intracellular domain proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. |
NGFR, NFKB1, PSEN2, ADAM17, RELA, SPPL2A, RHBDD1, APH1B, APH1A |
GO:0031295 | BP | T cell costimulation | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. |
PAK3, CD4, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, FYN, LYN, LGALS1, CD28, HLA-DRB4, VAV1, HLA-DPA1, CD24, DPP4, PIK3R1, CD40LG, AKT1, CSK, MAP3K8, PIK3CA, EFNB2, CDC42, GRB2, RAC1, HLA-DRB3, CAV1, PTPN11, PAK2, HLA-DRB5, RICTOR, MAPKAP1, MLST8, TNFSF13B |
GO:0031296 | BP | B cell costimulation | The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. |
TNFSF13B |
GO:0031297 | BP | replication fork processing | The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
EME2, STRA13, PCNA, ATRX, BLM, RAD51, ALYREF, FANCM, APITD1, BOD1L1, FBXO18, EME1, TONSL, PRIMPOL, NUCKS1 |
GO:0031298 | CC | replication fork protection complex | A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. |
TOP1, MCM10, GINS4, TIPIN, GINS2 |
GO:0031301 | CC | integral component of organelle membrane | The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TRABD2A, RNF152, ITM2B |
GO:0031302 | CC | intrinsic component of endosome membrane | The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
ECE1 |
GO:0031305 | CC | integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TIMM23, TIMM17B, TMEM11, ETFDH, UQCC3, MCUR1, TIMM17A, APOO, COA3 |
GO:0031306 | CC | intrinsic component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
MFN2 |
GO:0031307 | CC | integral component of mitochondrial outer membrane | The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TOMM40, CPT1A, SYNJ2BP, DMPK, BNIP3, TOMM20, MGARP, FUNDC2, PINK1, ABCB6, TOMM22, TOMM7, ARMCX3 |
GO:0031313 | CC | extrinsic component of endosome membrane | The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
ANXA1, SNX16, SNX5 |
GO:0031314 | CC | extrinsic component of mitochondrial inner membrane | The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
OPA1, NDUFAF5, DUSP21, PAM16 |
GO:0031315 | CC | extrinsic component of mitochondrial outer membrane | The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
SARM1 |
GO:0031324 | BP | negative regulation of cellular metabolic process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. |
BTN2A2 |
GO:0031325 | BP | positive regulation of cellular metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. |
ACACB, FASN |
GO:0031328 | BP | positive regulation of cellular biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. |
CCL5, AJUBA |
GO:0031333 | BP | negative regulation of protein complex assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. |
DDX3X, ULK1, RAF1, GSK3B, CDC42, LMO4, EIF4EBP1, XAF1, SVIP, SOST, IMPACT, LCMT1, DNAJC15 |
GO:0031334 | BP | positive regulation of protein complex assembly | Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
TPPP, TGFB1, TNF, FGF2, VEGFA, TAL1, GSK3B, VCP, SPIDR, PPP2R5B, SLF2, FNIP1, AJUBA, SLF1, FNIP2, FAF1 |
GO:0031338 | BP | regulation of vesicle fusion | Any process that modulates the frequency, rate or extent of vesicle fusion. |
TBC1D4, TBC1D12, TBC1D8, TBC1D3H, TBC1D8B, RABGAP1L, GRTP1, TBC1D9B, TBC1D3C, TBC1D9, TBC1D3, TBC1D16, TBC1D15, TBC1D5, USP6NL, RUNDC1, EVI5L, TBC1D14, TBC1D2B, RABGAP1 |
GO:0031339 | BP | negative regulation of vesicle fusion | Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. |
TBC1D4, CORO1A |
GO:0031340 | BP | positive regulation of vesicle fusion | Any process that activates or increases the frequency, rate or extent of vesicle fusion. |
ANXA1, ANXA2, SYT1, AKT2, C2CD5 |
GO:0031344 | BP | regulation of cell projection organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. |
PIFO |
GO:0031345 | BP | negative regulation of cell projection organization | Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. |
SPRY2, ITGA3 |
GO:0031346 | BP | positive regulation of cell projection organization | Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. |
ITGA2, RAB8B |
GO:0031362 | CC | anchored component of external side of plasma membrane | The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
CD14, FOLR1, CA4, CD24, EFNA5, HYAL2, GGT7 |
GO:0031365 | BP | N-terminal protein amino acid modification | The alteration of the N-terminal amino acid residue in a protein. |
METAP2 |
GO:0031369 | MF | translation initiation factor binding | Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. |
DDX3X, POLR2D, ZPR1, EIF3B, POLR2G, FMR1, EIF2B5, LARP1, SYT11, LIN28A, EIF2B4, TBL2 |
GO:0031370 | MF | eukaryotic initiation factor 4G binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
EIF4E |
GO:0031371 | CC | ubiquitin conjugating enzyme complex | Any complex that possesses ubiquitin conjugating enzyme activity. |
UBE2V1, STUB1 |
GO:0031372 | CC | UBC13-MMS2 complex | A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p. |
UBE2V2 |
GO:0031380 | CC | nuclear RNA-directed RNA polymerase complex | A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain. |
PAPD4 |
GO:0031386 | MF | protein tag | Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question. |
ISG15, SUMO3, SUMO2, SUMO4, NFATC2IP |
GO:0031390 | CC | Ctf18 RFC-like complex | A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. |
RFC4, RFC2, RFC5, RFC3, CHTF18, DSCC1 |