| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0030863 | CC | cortical cytoskeleton | The portion of the cytoskeleton that lies just beneath the plasma membrane. |
ACTN4, GYPC, EZR, SELE, FLNA, TMOD1, ACTB, TPM4, DLG4, MPP1, CTTN, NSMF |
GO:0030864 | CC | cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
FLOT1, SLC2A1, CDH2, CORO1A, NF2, RDX, ACTN2, GYS2, DSTN, EEF1A1, AKAP13, SHROOM2, PLEKHH2, MYRIP, PDLIM2, DLC1, MYADM, MLPH, TRPV4 |
GO:0030865 | BP | cortical cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. |
EPB41L3 |
GO:0030866 | BP | cortical actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. |
ROCK2, TNF, RHOQ, CALR, CDK5, DLG1, STRIP1, PRKCDBP, FMNL2, EPB41L1, EPB41L3, TLN1 |
GO:0030867 | CC | rough endoplasmic reticulum membrane | The lipid bilayer surrounding the rough endoplasmic reticulum. |
PLOD2, UBA1, PLOD1, PI4KB |
GO:0030868 | CC | smooth endoplasmic reticulum membrane | The lipid bilayer surrounding the smooth endoplasmic reticulum. |
HSD3B1, HSD3B2, SEC23A, SVIP, TTYH1 |
GO:0030870 | CC | Mre11 complex | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
NBN, SP100, MRE11A, RAD50 |
GO:0030877 | CC | beta-catenin destruction complex | A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. |
AXIN1, APC, CTNNB1, CSNK1A1, GSK3B, SIAH1, CACYBP, DACT1 |
GO:0030878 | BP | thyroid gland development | The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. |
HOXA3, TBX1, RAF1, THRA, MAPK3, MAPK1, NKX2-1, SMAD3, MAP2K1, HHEX, PAX8, DUOX2 |
GO:0030879 | BP | mammary gland development | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. |
BCL2L11, GLI2, TDGF1, B4GALT1, ITGA2, SOX9, FASN, NRG1, CAV1, ARHGAP5, PYGO2, IRS2 |
GO:0030881 | MF | beta-2-microglobulin binding | Interacting selectively and non-covalently with beta-2-microglobulin. |
HLA-E, CD1D, HLA-A, HFE |
GO:0030882 | MF | lipid antigen binding | Interacting selectively and non-covalently with a lipid antigen. |
CD1D |
GO:0030883 | MF | endogenous lipid antigen binding | Interacting selectively and non-covalently with an endogenous cellular lipid antigen. |
CD1D |
GO:0030884 | MF | exogenous lipid antigen binding | Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids). |
CD1D |
GO:0030886 | BP | negative regulation of myeloid dendritic cell activation | Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. |
IL10 |
GO:0030888 | BP | regulation of B cell proliferation | Any process that modulates the frequency, rate or extent of B cell proliferation. |
AHR |
GO:0030889 | BP | negative regulation of B cell proliferation | Any process that stops, prevents or reduces the rate or extent of B cell proliferation. |
TNFRSF21, LYN, IL10, MNDA, PKN1, INPP5D, PAWR |
GO:0030890 | BP | positive regulation of B cell proliferation | Any process that activates or increases the rate or extent of B cell proliferation. |
TLR4, SASH3, ADA, TFRC, CD74, PTPRC, BCL2, MIF, GPR183, CDKN1A, BCL6, TIRAP, CD81, MEF2C, NFATC2, PELI1, CLCF1, VAV3, SLC39A10, TNFSF13B, IRS2 |
GO:0030891 | CC | VCB complex | A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. |
RBX1, CUL2, TCEB1, TCEB2 |
GO:0030892 | CC | mitotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. |
SGOL2 |
GO:0030893 | CC | meiotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. |
SMC1A, SMC3 |
GO:0030894 | CC | replisome | A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. |
PCNA |
GO:0030895 | CC | apolipoprotein B mRNA editing enzyme complex | Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). |
APOBEC3G |
GO:0030896 | CC | checkpoint clamp complex | Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. |
RAD1, RAD9B, RAD9A |
GO:0030897 | CC | HOPS complex | A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. |
HOOK3, HOOK2, AKTIP |
GO:0030898 | MF | actin-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. |
MYO1C, MYO1D, MYH9, MYL6, MYO10 |
GO:0030900 | BP | forebrain development | The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
ARID1A, DCLK1, DKK1, APP, FYN, CNP, NR2F2, SSTR1, OTX2, NKX2-1, ATRX, NOTCH1, NDST1, LRP2, E2F1, POU3F1, STIL, FRS2, DLC1, PCDH9, PPARGC1A, MAPK8IP3 |
GO:0030901 | BP | midbrain development | The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). |
UQCRQ, SMAD9, FGFR1, FGFR2, CXCR2, OTX2, NDST1, HES1, SMAD1, WLS, KDM7A, DLG5, UCHL5 |
GO:0030902 | BP | hindbrain development | The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). |
NFIB, SMAD9, ALDH1A2, GLI2, CTNNB1, SMAD1, WLS, AHI1 |
GO:0030903 | BP | notochord development | The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. |
COBL, YAP1, SOX9, ID3, STIL, TEAD2 |
GO:0030904 | CC | retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
SNX3, VPS26A, RAB7A, SNX1, DCTN1, DENND5A, TBC1D5, VPS35, ANKFY1, VPS29, SNX6, SNX5 |
GO:0030905 | CC | retromer, tubulation complex | The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. |
SNX1, SNX6, SNX5 |
GO:0030906 | CC | retromer, cargo-selective complex | The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. |
VPS26A, VPS35, VPS29 |
GO:0030910 | BP | olfactory placode formation | The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. |
AXIN1, PROX1 |
GO:0030911 | MF | TPR domain binding | Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. |
HSP90AA1, HSP90AB1, RAB8B, STUB1 |
GO:0030913 | BP | paranodal junction assembly | Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. |
GNPAT, CD9, ANK2, EPB41L3 |
GO:0030914 | CC | STAGA complex | A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. |
SUPT3H, TADA3, SUPT7L, TAF10, TAF12, TADA2B, TADA1, TRRAP |
GO:0030915 | CC | Smc5-Smc6 complex | A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. |
SMC5, EID3, SMC6, NSMCE4A |
GO:0030916 | BP | otic vesicle formation | The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. |
FGFR2, SOX9 |
GO:0030917 | BP | midbrain-hindbrain boundary development | The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. |
LRP6 |
GO:0030942 | MF | endoplasmic reticulum signal peptide binding | Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. |
SRP14, SRP54 |
GO:0030943 | MF | mitochondrion targeting sequence binding | Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. |
TOMM20 |
GO:0030947 | BP | regulation of vascular endothelial growth factor receptor signaling pathway | Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
VEGFC, FZD4 |
GO:0030948 | BP | negative regulation of vascular endothelial growth factor receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
PDCD6, HHEX |
GO:0030949 | BP | positive regulation of vascular endothelial growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
FGF18, IL1B, VTN, ITGB3, PRKCB, ITGA5, VEGFA, MT3, ARNT, FGF9, GRB10, HIF1A, PRKD2 |
GO:0030950 | BP | establishment or maintenance of actin cytoskeleton polarity | Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures. |
RICTOR, MAPKAP1 |
GO:0030951 | BP | establishment or maintenance of microtubule cytoskeleton polarity | Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. |
LMNA, CKAP5, KIF2C |
GO:0030953 | BP | astral microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. |
EZR, RAB11A, DLG1, KPNB1, CEP120 |
GO:0030955 | MF | potassium ion binding | Interacting selectively and non-covalently with potassium (K+) ions. |
PDXK, ATP1B1, PKM, ATP1A2, HDAC4, KCNJ11, SLC24A3 |
GO:0030956 | CC | glutamyl-tRNA(Gln) amidotransferase complex | A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. |
GATC, GATB, QRSL1 |
GO:0030957 | MF | Tat protein binding | Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. |
NPM1, DNAJA1, SMARCA4, ACTB, GABARAPL1 |
GO:0030968 | BP | endoplasmic reticulum unfolded protein response | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
PPP1R15A, STC2, VAPB, HSPA5, XBP1, ATF6, CTH, VCP, SYVN1, EDEM1, CREB3L1, ERO1A, VIMP, EDEM3, DERL2, RNF121, UGGT1, AMFR, STUB1, TBL2 |
GO:0030970 | BP | retrograde protein transport, ER to cytosol | The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. |
TMEM129, HSP90B1, VCP, SYVN1, UFD1L, FAF2, VIMP, DERL2, SEL1L |
GO:0030971 | MF | receptor tyrosine kinase binding | Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity. |
ANGPT2, SOCS5, ZPR1, TP53, PCNA, PTPN2, MST1, RACK1, SHC2, NRG1, PTPN11, HYAL2, TIAM1, CBLB, SQSTM1, EIF3A, GAS6, ANGPT1, ARHGEF16, FAM150B |
GO:0030975 | MF | thiamine binding | Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
TPK1 |
GO:0030976 | MF | thiamine pyrophosphate binding | Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. |
ILVBL, OGDH |
GO:0030981 | CC | cortical microtubule cytoskeleton | The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane. |
MAPRE1 |
GO:0030983 | MF | mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
MSH3, MSH2, MSH6, PMS1, TDG, MLH3 |
GO:0030984 | MF | kininogen binding | Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors. |
C1QBP |
GO:0030990 | CC | intraciliary transport particle | A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. |
DYNC2LI1, KIFAP3 |
GO:0030991 | CC | intraciliary transport particle A | The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa. |
TULP3, IFT43, IFT122, WDR35 |
GO:0030992 | CC | intraciliary transport particle B | The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. |
IFT81, CLUAP1, IFT74, IFT27, IFT46, HSPB11 |
GO:0030997 | BP | regulation of centriole-centriole cohesion | Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker. |
CTNNB1 |
GO:0031000 | BP | response to caffeine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. |
IL6, CAD, PPARG, DHODH, HDAC1, RYR2, HDAC2, DNMT3B |
GO:0031001 | BP | response to brefeldin A | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. |
HID1 |
GO:0031005 | MF | filamin binding | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
DPYSL4, NEBL, DPYSL3, FAM101A, FAM101B, FBLIM1, PDLIM2 |
GO:0031011 | CC | Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity. |
ACTL6A, YY1, NFRKB, INO80C, INO80E, INO80B, RUVBL2, RUVBL1, UCHL5 |
GO:0031012 | CC | extracellular matrix | A structure lying external to one or more cells, which provides structural support for cells or tissues. |
MATN2, CYR61, PLSCR1, TGFB1I1, COCH, EDIL3, CILP, FLNB, CSTA, PDGFB, TGFB1, COL1A1, COL3A1, LMNA, APOE, APCS, APOH, FN1, AHSG, SLPI, VTN, KRT1, VWF, GAPDH, HSPB1, SERPINE1, SLC25A5, CLEC3B, COL5A2, S100A9, LPL, SERPINE2, P4HB, CTSD, ANXA2, TUBB, DCN, HSP90AA1, LAMB1, THBS1, COL1A2, MMP2, SOD3, MGP, COL4A2, VIM, RPS17, LGALS1, WNT2, HSPD1, CLU, HAPLN1, HSPA5, LAMC1, COL6A1, COL6A2, COL6A3, VCAN, EEF2, NID1, PKM, HSP90B1, JUP, DSP, TIMP2, DDX5, LGALS3, RPL35A, ARF4, OGN, COL5A1, FLNA, ZP3, FGFR2, BGN, TGM2, TNXB, FBLN1, SFPQ, CFL1, LAMA2, TNC, COL8A2, CANX, CFP, PCSK6, RPL12, RPL22, THBS4, FBN1, FBN2, MYH9, TIMP3, SERPINF1, COL15A1, COL18A1, CCT6A, RPS5, RPS10, ATP5O, TFPI2, NES, TGM4, COMP, MMP14, MMP15, LUM, HNRNPM, ADAMTS12, ADAMTS20, MYL6, EIF4A1, RPS20, RPS3A, RPL27, TGFB2, RPS7, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, HIST1H4A, RPS25, RPL30, RPL11, RAC1, ACTG1, TUBB4B, CCT2, PRKDC, FBLN2, HSPG2, NDP, HNRNPU, COL14A1, FMOD, PRDX1, LOXL1, MFGE8, EFEMP1, MMRN1, ILK, NID2, DYNC1H1, GANAB, LTBP1, POSTN, PCOLCE, TOMM20, TGFBI, IGFBP7, LAMA4, SBSN, THSD4, FBN3, FRAS1, AEBP1, SBSPON, SFRP1, NDNF, HTRA1, COL21A1, COL12A1, RARRES2, SOST, EMILIN2, TINAGL1, ADAMTS10, SPON1, CD93, LTBP3, LMCD1, ADAMTS9, ADAMTS8, LOXL2 |
GO:0031014 | MF | troponin T binding | Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex. |
TNNT1, TNNI3 |
GO:0031016 | BP | pancreas development | The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. |
ALDH1A2, GDF11, CTNNB1, HHEX, ACVR2B, HES1, SMAD2, ILDR2, PROX1, TCF7L2 |
GO:0031017 | BP | exocrine pancreas development | The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. |
INSR, XBP1, WLS, PPDPF |
GO:0031018 | BP | endocrine pancreas development | The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. |
PAX4, ANXA1, IL6, IL6R, AKT1, SOX9, INSM1, SOX4, FOXO1 |
GO:0031021 | CC | interphase microtubule organizing center | A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus. |
MZT1 |
GO:0031022 | BP | nuclear migration along microfilament | The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. |
SYNE2, SUN2 |
GO:0031032 | BP | actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
FRMD3, MYH9, CNN1, ACTC1, CNN3, CDC42BPA, FRMD6, TRPM7, EPB41L4B, EPB41L1, EPB41L4A, LIMCH1, EPB41L3, CDC42BPB, F11R |
GO:0031034 | BP | myosin filament assembly | The aggregation, arrangement and bonding together of a filament composed of myosin molecules. |
RAP1GDS1 |
GO:0031045 | CC | dense core granule | Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. |
SCG2, SYT1, NCS1, MYRIP |
GO:0031047 | BP | gene silencing by RNA | Any process in which RNA molecules inactivate expression of target genes. |
NUPL2, POLR2D, CNOT3, PRKRA, NUP155, TPR, POLR2E, POLR2A, POLR2B, POLR2I, NUP62, NUP153, RANBP2, POLR2J, POLR2K, NUP107, POLR2G, HIST1H4A, POLR2L, HIST1H3D, RAE1, H3F3A, FMR1, NCBP1, NUP160, TSN, PIWIL4, NUP93, TDRD9, TNRC6A, NUP43, NUP37, NUP35, NUP210, NUP205, SEH1L, NUP88, NDC1, NUP58, NUP85, CNOT7, AGO2, NUP50, TNRC6B, DICER1 |
GO:0031052 | BP | chromosome breakage | Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. |
BRCA1, BRCA2, HMGA2 |
GO:0031053 | BP | primary miRNA processing | Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
HNRNPA2B1, SMAD3, SMAD2, SMAD1, MRPL44 |
GO:0031054 | BP | pre-miRNA processing | Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. |
PRKRA, MRPL44, LIN28A, AGO4, AGO2, DICER1 |
GO:0031060 | BP | regulation of histone methylation | Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. |
MTHFR |
GO:0031062 | BP | positive regulation of histone methylation | Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. |
PAXBP1 |
GO:0031063 | BP | regulation of histone deacetylation | Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. |
ZNHIT1, TADA3, MAPK8 |
GO:0031064 | BP | negative regulation of histone deacetylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones. |
SKI, FOXP3 |
GO:0031065 | BP | positive regulation of histone deacetylation | Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. |
TGFB1, TP53, SREBF1, BCL6, NIPBL, JDP2 |
GO:0031069 | BP | hair follicle morphogenesis | The process in which the anatomical structures of the hair follicle are generated and organized. |
BCL2, FGF7, FGFR2, IGFBP5, CTNNB1, NOTCH1, CDC42, TGFB2, KRT17, SOSTDC1, INTU |
GO:0031072 | MF | heat shock protein binding | Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. |
GPR37, PARK2, DNAJA2, DNAJB6, HSPA1A, HSPA1B, TPR, HSPA6, ZFP36, ADORA1, HSPA1L, IRAK1, TFAM, HSF1, OGDH, FKBP4, PPID, DMPK, FKBP5, KCNJ11, CDC37, DNAJA4, DNAJC9, HDAC2, PACRG, DNAJC7, FAF1 |
GO:0031074 | CC | nucleocytoplasmic shuttling complex | Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. |
NUP62 |
GO:0031076 | BP | embryonic camera-type eye development | The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. |
TULP3, ALDH1A2, NES, RDH10, PPP1R13L, PITX2 |
GO:0031077 | BP | post-embryonic camera-type eye development | The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. |
KLF4, VEGFA |
GO:0031080 | CC | nuclear pore outer ring | A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). |
SEC13, NUP107, NUP160, NUP43, NUP37, AHCTF1, SEH1L, NUP85 |
GO:0031081 | BP | nuclear pore distribution | Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope. |
NDC1 |
GO:0031083 | CC | BLOC-1 complex | A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. |
SNAPIN, SNAP25, BLOC1S1, BLOC1S3, BLOC1S6 |
GO:0031084 | CC | BLOC-2 complex | A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru. |
HPS3 |
GO:0031085 | CC | BLOC-3 complex | A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins. |
HPS1, HPS4 |
GO:0031086 | BP | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. |
ZFP36, ZFP36L1 |
GO:0031087 | BP | deadenylation-independent decapping of nuclear-transcribed mRNA | Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. |
EDC3, PNRC2 |
GO:0031088 | CC | platelet dense granule membrane | The lipid bilayer surrounding the platelet dense granule. |
ABCC4, LAMP2, ITPR1 |
GO:0031089 | CC | platelet dense granule lumen | The volume enclosed by the membrane of the platelet dense granule. |
APOH, CLEC3B, TIMP3, SEPP1, SPP2, FAM3C, RARRES2 |