GO:0030262

BP

apoptotic nuclear changes

Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.

BLCAP

GO:0030263

BP

apoptotic chromosome condensation

The compaction of chromatin during apoptosis.

TOP2A, GPER1

GO:0030264

BP

nuclear fragmentation involved in apoptotic nuclear change

The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.

TARDBP, GPER1

GO:0030267

MF

glyoxylate reductase (NADP) activity

Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.

GRHPR

GO:0030272

MF

5-formyltetrahydrofolate cyclo-ligase activity

Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate.

MTHFS

GO:0030274

MF

LIM domain binding

Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.

RIPK2, LDB2, ACTN2, CSRP2BP, RPH3AL, TLN1

GO:0030275

MF

LRR domain binding

Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.

KRAS, POLR2J, STK11, LRRFIP2

GO:0030276

MF

clathrin binding

Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.

HIP1, SYT1, NCALD, AP2B1, PICALM, LDLRAP1, AFTPH, DNER, SYTL5, SYTL4, SYT11, SYTL2, RPH3AL, TRPC6

GO:0030277

BP

maintenance of gastrointestinal epithelium

Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.

SERPINA3, RBP4, PBLD, MUC4, MUC13

GO:0030278

BP

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

DHRS3, EGR2, MAPK3, MAPK1, PTGER4, PBX1, ACVR1, MAPK14, INTU

GO:0030279

BP

negative regulation of ossification

Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.

SMAD6, TGFB1, BCL2, NOTCH1, SOX9, MEF2C, CHSY1, SFRP1, SOST

GO:0030282

BP

bone mineralization

The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.

CYP27B1, BGLAP, CLEC3B, BMP2, ALOX15, ERCC2, FGFR2, PTGS2, KLF10, GPNMB, LGR4, FBXL15, DUOX2, MINPP1, SBDS

GO:0030283

MF

testosterone dehydrogenase [NAD(P)] activity

Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.

HSD17B10

GO:0030284

MF

estrogen receptor activity

Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.

ESR1, ESR2, GPER1

GO:0030285

CC

integral component of synaptic vesicle membrane

The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

ATP6V1G2, SYPL2, TMEM163

GO:0030286

CC

dynein complex

Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.

DNAL4, DNAH14, DCTN2, DCTN1, DNAH12, DNAH10, DNAH11, DNAH9, DNAH1, HDAC6

GO:0030289

CC

protein phosphatase 4 complex

A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.

PPP4C

GO:0030290

MF

sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.

GM2A

GO:0030291

MF

protein serine/threonine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein serine/threonine kinase.

SPRY2, H2AFY, SPRED1, CIB1, WNK1

GO:0030292

MF

protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein tyrosine kinase.

RACK1

GO:0030294

MF

receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.

HYAL2

GO:0030295

MF

protein kinase activator activity

Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

RPLP1, MT3, PIK3CA, STK11, DBF4B, DUSP19, FGF13, WNK1, RGCC, GPRC5B, CAB39

GO:0030296

MF

protein tyrosine kinase activator activity

Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.

ERBB3, CD24, PAK2, GAS6, ABI1, AFAP1L2, GHRL

GO:0030297

MF

transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.

GREM1, EFNA5, NRG1

GO:0030298

MF

receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase.

CCL5, FAM150B

GO:0030299

BP

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

LDLR, CD36, AKR1C1, ABCG8

GO:0030300

BP

regulation of intestinal cholesterol absorption

Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.

APOA1, APOA2, LEP, APOA5

GO:0030301

BP

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NPC1, VPS4B, LDLR, APOA1, APOB, CFTR, CD36, NPC2, CAV1

GO:0030302

BP

deoxynucleotide transport

The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell.

SLC25A19

GO:0030305

MF

heparanase activity

Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.

HPSE

GO:0030306

MF

ADP-ribosylation factor binding

Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.

RAB11FIP3, ADCYAP1R1, SORL1, GGA2

GO:0030307

BP

positive regulation of cell growth

Any process that activates or increases the frequency, rate, extent or direction of cell growth.

SDCBP, DDX3X, ADAM10, PSMD10, EGFR, F2, INS, ERBB2, S100A8, S100A9, IGFBP1, BCL2, AKT1, SFN, TGFBR1, MMP14, MTPN, CDC42, TGFB2, ADAM17, H3F3A, IL9R, KRT17, EXOSC9, NCBP1, AKAP6, MAP2K5, EXOSC2, RPS6KA1, FXN, ADNP2, NOL8, SUPV3L1, SFRP1, HBEGF, CIB1, DERL2, CXCL16, TAF9B, EXOSC4, CDKN2AIP, SPHK1, ZNF639, N6AMT1

GO:0030308

BP

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

APBB1, DDX3X, CYP27B1, GDF9, GREM1, NME6, SLIT2, BMP10, AGT, TGFB1, CRYAB, TP53, ENO1, SERPINE2, INHBA, FBP1, BCL2, NPPB, GJA1, WT1, ENPP1, MT3, PPP2R1A, PHB, ACVR1B, PPARG, CDKN1A, BCL6, CDKN2C, CDKN1B, AGTR2, GNG4, PPT1, SMARCA2, SMARCA4, SESN2, TGFB2, BTG1, RACK1, SMAD3, FOXK1, PPARD, BST2, HYAL2, PTPRJ, SMAD4, FHL1, BMPR2, STK11, CCDC85B, JADE1, PSRC1, ADIPOR2, CRLF3, CCAR2, SFRP1, FLCN, ESR2, APBB2, ADIPOR1, RERG, DACT3, DCBLD2, TSPYL2, SOX17, WFDC1, RTN4, CDKN2AIP, NDUFA13, SH3BP4, IP6K2, OSGIN1

GO:0030311

BP

poly-N-acetyllactosamine biosynthetic process

The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.

B4GAT1, B3GNT2

GO:0030315

CC

T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

BIN1, SLC2A4, EZR, CAPN3, ATP2B4, SRI, RDX, ADRA1A, ATP1A2, ANK2, AHNAK, ANK3, AKAP6, CAMK2D, KCNJ11, STAC, SLC30A1

GO:0030316

BP

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

TNFSF11, FARP2, TNF, TFRC, CSF1R, JUNB, GPR183, CTNNB1, GLO1, MAPK14, OSTM1, FOXP1, TNFRSF11A

GO:0030317

BP

flagellated sperm motility

Any process involved in the controlled movement of a flagellated sperm cell.

ADCY3, APOB, ATP2B4, DNAJA1, CHRNA7, TMF1, SORD, DNAH5, DNAH11, SLIRP, DNAH1, DNAI1, TEKT2

GO:0030318

BP

melanocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.

MITF, GLI3, BCL2, KIT, RAB27A, MEF2C, USP13, CITED1, C10orf11, HPS4, BLOC1S6, MYO5A

GO:0030321

BP

transepithelial chloride transport

The directed movement of chloride ions from one side of an epithelium to the other.

BEST1, SLC12A2

GO:0030322

BP

stabilization of membrane potential

The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

KCNK1, KCNK3, KCNK17, KCNK12, KCNK6

GO:0030323

BP

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

PCSK5, HECA

GO:0030324

BP

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

FGF18, ALDH1A2, EGFR, RBP4, MYCN, EIF4E, SPARC, WNT2, GLI2, GLI3, VEGFA, FGFR2, ITGA3, LOX, HSD11B1, CTGF, NOS3, CHI3L1, BMPR1A, SREBF1, LIPA, WNT5A, NKX2-1, NOTCH1, MMP14, HRSP12, PPP1CA, SP3, EP300, EIF4EBP1, ACVR2B, SIM2, HES1, TAB1, SMAD2, JMJD6, CCBE1, NPHP3, PDPN, ZFPM2, PROX1, EPAS1, CRISPLD2, DHCR7, HEG1, TIMELESS, HSPB11

GO:0030325

BP

adrenal gland development

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

APOA1, INSR, WT1, MDK, TSPO, PBX1, CDKN1C, NR0B1, ARID5B, DKK3

GO:0030326

BP

embryonic limb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.

GREM1, DKK1, FGFR1, SKI, HOXD10, HOXA10, FGF9, FBN2, GJA5, PBX1, PBX2, GDF5, PSEN1, DLX5, TGFB2, PTCH1, FRAS1, ACD, MBNL1, CYP26B1

GO:0030327

BP

prenylated protein catabolic process

The chemical reactions and pathways resulting in the breakdown of prenylated proteins.

PCYOX1

GO:0030328

BP

prenylcysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.

PCYOX1

GO:0030329

BP

prenylcysteine metabolic process

The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.

PCYOX1

GO:0030330

BP

DNA damage response, signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

MDM4, FOXO3, TRIAP1, NBN, TP53, MIF, BCL3, ATRX, SESN2, NDRG1, MYO6

GO:0030331

MF

estrogen receptor binding

Interacting selectively and non-covalently with an estrogen receptor.

CNOT1, PARP1, PCNA, DDX5, CTNNB1, FUS, PPARG, NRIP1, FOXL2, PPID, TAF10, NCOA1, WIPI1, PPARGC1B, DDX54, DDX17, RERG, PHB2, PAGR1, PPARGC1A

GO:0030332

MF

cyclin binding

Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.

HDAC3, USP2, CDK1, CDK4, CDK2, CDKN1A, CDK6, INSM1, CUL3, PTCH1, CDK13, FBXO31, CDK12

GO:0030334

BP

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

PLXNB2, LDB2, PLXNC1, PLXNA2, UNC5C, TGFB1, LMNA, SERPINE2, MMP10, FLNA, LAMA2, AKT1, AKT2, PLXNA3, PRKX, CXCR4, RHOA, LMO4, RHOB, RAC1, JAG1, CDK5, NEXN, GAB1, ENPP2, KIF14, ERBB4, LAMA4, LAMA3, AMOT, PHLDA2, HACE1, MINK1, SGK3, DOCK10, AJUBA, SPATA13, PITX2, PARD6B, TBCCD1, PLXNA1, PLXND1

GO:0030335

BP

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

WASH1, MYO1C, RHOD, PIK3CD, SDCBP, CYR61, ADAM10, SEMA3E, DAPK3, SNAI2, ACTN4, SPAG9, JAK2, SEMA7A, SEMA3D, IKBKAP, EGFR, PLAU, PDGFB, TGFB1, CGA, FSHB, INS, COL1A1, PDGFA, IGF1, EDN1, INSR, ITGAV, CSF1R, LAMB1, LYN, THBS1, IGF1R, ITGA5, PDGFRB, CTSH, FGR, CCL3, KIT, HSPA5, BMP2, TDGF1, CCL5, HGF, VEGFA, PDGFRA, PRKCA, XBP1, S1PR1, ITGA6, APC, F2R, PIK3R1, MAPK1, SERPINB3, CORO1A, AKT2, RDX, TGFBR1, COL18A1, MCAM, NOTCH1, NUMB, MMP14, F2RL1, CDH13, RRAS2, RACK1, ADAM17, SMAD3, TNFAIP6, DAB2, INSM1, ACVR1, PTK2, ELP6, STX4, TIAM1, SEMA3B, ILK, SEMA5A, ZNF268, TRIP6, MAPRE1, MYLK, FAM110C, LRRC16A, FAM83H, CBLL1, RUFY3, CCAR1, GCNT2, ARHGEF39, SEMA6D, CEMIP, SYNE2, HAS2, PTP4A1, MYADM, HBEGF, GPER1, CIB1, SEMA3C, PDCD10, PDGFD, WNT5B, CXCL16, SEMA4A, SEMA6B, ELP3, LGR6, PDGFC, SPHK1, GTSE1, SUN2, IRS2

GO:0030336

BP

negative regulation of cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.

SMAD7, SLIT2, BMP10, RECK, SERPINE1, KRT16, TPM1, RAP2A, RRAS, BCL2, IFITM1, DRD2, IGFBP5, NF2, TIE1, NKX2-1, STC1, PTEN, RAP2B, RHOB, ADARB1, BST2, PTPRJ, DAG1, DPYSL3, KANK1, PTPRK, ADIPOQ, CYP1B1, PODN, SRGAP1, ARPIN, MAGI2, SULF1, SFRP1, FLCN, ARAP3, TP53INP1, DLC1, PKP2, CITED2, ABHD6, OSBPL8, FAM60A, DACH1, TMEFF2, NISCH, TCAF1, STK24

GO:0030337

MF

DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.

PCNA, TEFM

GO:0030343

MF

vitamin D3 25-hydroxylase activity

Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.

CYP3A4, CYP2R1

GO:0030346

MF

protein phosphatase 2B binding

Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.

ATP2B4, BAD

GO:0030348

MF

syntaxin-3 binding

Interacting selectively and non-covalently with the SNAP receptor syntaxin-3.

STXBP2

GO:0030351

MF

inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.

MINPP1

GO:0030368

MF

interleukin-17 receptor activity

Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL17RB

GO:0030369

MF

ICAM-3 receptor activity

Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.

ITGB2

GO:0030371

MF

translation repressor activity

Antagonizes ribosome-mediated translation of mRNA into a polypeptide.

FMR1, EIF4EBP1, EIF4EBP2, CIRBP, SAMD4B, NANOS1, PAIP2, SAMD4A

GO:0030374

MF

ligand-dependent nuclear receptor transcription coactivator activity

The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

ACTN4, MED14, KDM1A, TADA3, PRKCB, FGF2, ACTN1, HMGA1, PPARG, BUD31, NCOA2, NCOA1, PKN1, DCAF6, SLC30A9, CARM1, PPARGC1B, CCAR1, ZMIZ2, NCOA7, GLMP, MED12, MED30, HELZ2, SRA1, ENY2, MED4, MED17, PSMC3IP, PPARGC1A, USP22, THRAP3, NCOA3

GO:0030375

MF

thyroid hormone receptor coactivator activity

The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

ACTN2, NCOA2, MED16

GO:0030377

MF

urokinase plasminogen activator receptor activity

Combining with the urokinase plasminogen activator to initiate a change in cell activity.

PLAUR

GO:0030388

BP

fructose 1,6-bisphosphate metabolic process

The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.

FBP2, ALDOA, FBP1, ALDOC, PFKL

GO:0030395

MF

lactose binding

Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.

LGALS1, LGALS12

GO:0030414

MF

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

SSPO, PI15, PTTG1, PI16, PROL1

GO:0030421

BP

defecation

The expulsion of feces from the rectum.

MDK

GO:0030422

BP

production of siRNA involved in RNA interference

Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.

PRKRA, MRPL44, DICER1

GO:0030423

BP

targeting of mRNA for destruction involved in RNA interference

The process in which small interfering RNAs target cognate mRNA molecules for degradation.

DICER1

GO:0030424

CC

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

BIN1, NRP1, SYNJ2, NCAM2, ADCY9, COBL, ZPR1, TNFRSF21, MYO1D, CA2, CST3, TGFB1, CRYAB, NTRK1, APP, CYP17A1, CCK, MME, C4A, C4B, MAPT, NEFH, ANXA3, DRD2, CREB1, GAP43, RAB5A, CNR1, COMT, MT3, CTNNA2, CANX, MAPK1, EPHB2, SLC6A1, CORO1A, SNCA, HTT, IQGAP1, PSEN1, PPT1, FXR1, NEK3, EPHA5, EPHB1, EPHA4, PRSS12, MTPN, TGFB2, NCS1, YWHAE, RAB11A, IRX3, CDK5, DST, FMR1, TUBB3, MTMR2, ALCAM, SEMA3A, GRM3, NECTIN1, PTPRK, PTPRO, LDLRAP1, SARM1, KLHL24, RUFY3, SETX, HOMER1, CNTN4, MINK1, TMEM57, NGDN, UHMK1, PALLD, FGF13, ROBO3, DOCK7, ALS2, KIF20B, GPER1, FEZ1, OLFM1, CIB1, SYT11, KATNB1, PINK1, SEMA6A, ADGRL3, KIF13B, STMN3, TENM3, HDAC6, GHRL, ADAM21, DICER1, RNF6, DTNA

GO:0030425

CC

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

KCNK1, CHL1, RGS12, GRM6, HNRNPR, OPA1, BRINP1, ADCY9, COBL, SRSF10, URI1, ZWINT, STAU1, GNRH1, PENK, APOE, BGLAP, NTRK1, CYBB, GNAI2, APOD, RPLP0, CCK, TH, CHRM2, MME, C4A, C4B, MAPT, LAMP1, ANXA3, CCL2, DRD2, IFNGR1, GNB3, SYN1, ELK1, CHRM3, RAB5A, NR1D1, HTR2C, EPHB2, GABRA5, HTR7, BMPR1A, IL6ST, HTR2B, HTT, SLC1A4, RANGAP1, RPL28, GRIA4, GLRB, GNAQ, PPT1, RAB27A, KPNA1, EPHA5, EPHB1, EPHA4, PRSS12, NCS1, RPS6, GNB1, RACK1, GNAS, RBM3, CDK5, PURA, NRG1, FMR1, KCNA1, ANK3, BNIP3, STRN3, STX3, TUBB3, MTMR2, ALCAM, BMPR2, CAPRIN1, SEMA3A, PTPRK, DPYSL2, DBN1, CPEB4, GNAS, CPLX2, SARM1, NSMF, KNDC1, RUFY3, CAMK2N1, MAGI2, NLGN4X, NLGN1, MINK1, CPEB3, NGDN, TRPV1, TMEM185A, DNER, DENND1A, SLC9A6, FGF13, ERO1A, ALS2, GPER1, FEZ1, TXN2, CIB1, MLPH, TRIM9, MAGEE1, GOPC, GPHN, GLRX2, ELOVL5, PLK2, CRIPT, ATXN10, HDAC6, GABBR1, LAMP5, AMFR, AGO2, TAOK2, MAPK8IP3, SAMD4A, IGSF9B, DICER1, FARP1, RBM8A

GO:0030426

CC

growth cone

The migrating motile tip of a growing nerve cell axon or dendrite.

APBB1, TOR1A, NRP1, ARPC3, HNRNPR, CTNND1, ZPR1, ANG, MAPT, TIMP2, CNR1, ITGA3, OTX2, SNCA, IQGAP1, CSNK1E, PSEN1, GSK3B, RAC3, SNAP25, CALM2, CXADR, CDK5, FMR1, EPS8, STX3, DCTN2, DPYSL3, CTTN, DPYSL2, DBN1, FSCN1, PTPRO, TWF2, RUFY3, SETX, SIRT2, ABI1, PALLD, APBB2, FGF13, DOCK7, ALS2, KIF20B, ORAI2, SIGMAR1, CIB1, KATNB1, TRPV4, PCDH9, CRTAC1, STMN3, PTBP2, AMFR, NDRG2, DICER1, MYO5A

GO:0030427

CC

site of polarized growth

Any part of a cell where non-isotropic growth takes place.

FRY

GO:0030429

MF

kynureninase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.

KYNU

GO:0030431

BP

sleep

Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.

FOS, DLAT, OXTR, GRIN2A, PTGDR, IL18, SLC29A1

GO:0030432

BP

peristalsis

A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.

DRD2, DLG1

GO:0030433

BP

ER-associated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.

TMEM129, UBXN8, RNF103, TRIM13, ERLIN2, HSPA5, HSP90B1, PSMC3, PSMC2, PSMC4, VCP, PSMC1, PSMC6, OS9, SYVN1, DNAJC10, UBE2J2, STT3B, EDEM1, CCDC47, FAF2, VIMP, EDEM3, DERL2, RNF121, JKAMP, DNAJB9, SEL1L, MAN1B1, AMFR

GO:0030449

BP

regulation of complement activation

Any process that modulates the frequency, rate or extent of complement activation.

CFB, C3, VTN, CFI, C8G, CD55, CFH, C4A, C4B, C7, C6, CD46, CR1, C5AR1, CFP, C1QBP, SUSD4

GO:0030472

BP

mitotic spindle organization in nucleus

A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level.

PPP2R4

GO:0030478

CC

actin cap

Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.

WASL, ACTR2, CALD1

GO:0030485

CC

smooth muscle contractile fiber

The contractile fiber of smooth muscle cells.

ACTA2

GO:0030488

BP

tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

NSUN2, METTL2B, GTPBP3, METTL2A, TRMO, THUMPD3, TRMT13, TRMT6

GO:0030490

BP

maturation of SSU-rRNA

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.

SNU13, RPS14, LSM6, UTP4, NOL11, TSR3, NOB1

GO:0030492

MF

hemoglobin binding

Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

HP, HBB

GO:0030496

CC

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

AURKA, BIRC5, PRC1, CTNND1, RAB11FIP3, TACC1, RNF8, KIF20A, KIF4A, GNAI2, CDK1, ANXA2, GNAI3, RAP2A, HSPA5, SLC2A1, RALA, RALB, HSP90B1, MAK, GDI1, RDX, PPP1CC, IQGAP1, CENPF, ANXA11, NEK2, PLK1, IST1, GEM, CDC42, RHOA, GNAI1, RACK1, ERH, CENPE, KIF23, PTCH1, SEPT6, FAM175B, SEPT2, KIF14, SEPT7, PKN1, PKN2, CEP55, CDCA8, TTC19, PSRC1, C6orf89, TEX14, SIRT2, ASPM, SPG20, PIK3C3, SHCBP1, FLCN, MPLKIP, MITD1, ARL8A, AURKB, ZFYVE19, KIF20B, SPAG5, PKP4, KATNB1, CEP44, RACGAP1, TRIOBP, CHMP4B, ECT2, CYLD, ARL8B, KLHL9, KLHL13, SPAST, MAPRE3, SH3GLB1, ZNF330

GO:0030497

BP

fatty acid elongation

The elongation of a fatty acid chain by the sequential addition of two-carbon units.

HACD4, HACD2, HACD3

GO:0030500

BP

regulation of bone mineralization

Any process that modulates the frequency, rate or extent of bone mineralization.

CYP27B1, AHSG, BGLAP, MGP, GJA1, S1PR1, ENPP1, NBR1, TWIST1, OMD, ANKH, BMP2K, TXLNG

GO:0030501

BP

positive regulation of bone mineralization

Any process that activates or increases the frequency, rate or extent of bone mineralization.

TGFB1, PTH, ADRB2, BMP2, BMP4, BMP6, ACVR2A, FBN2, BMPR1A, SMAD3, ACVR1, MEF2C, GPM6B, ACVR2B, BMPR2, ANO6, CD276, FAM20C, OSR1, KL

GO:0030502

BP

negative regulation of bone mineralization

Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.

GREM1, AHSG, SRGN, CCL3, SOX9, HIF1A, TRPM4

GO:0030504

MF

inorganic diphosphate transmembrane transporter activity

Enables the transfer of inorganic diphosphate across a membrane.

ANKH

GO:0030505

BP

inorganic diphosphate transport

The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ENPP1, ANKH

GO:0030506

MF

ankyrin binding

Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.

SPTBN1, FLNC, KCNJ11, KCTD6, NRCAM, SPTBN4, RHBG

GO:0030507

MF

spectrin binding

Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.

DYNC1I1, GNB3, GBP1, GNB1, ANK2, CAMSAP2, ANK3, DCTN2, CAMSAP1, SPTBN4, MYO10, CAMSAP3, KIF3A

GO:0030509

BP

BMP signaling pathway

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

SLC33A1, SMAD7, SMAD9, SMAD6, GDF9, BMP10, BMP15, BMP2, BMP4, BMP3, SKI, BMP1, EGR1, BMP6, ACVR2A, MAPK3, BMP8B, BMPR1A, ID1, DLX5, UBE2D3, TGFBR3, ACVR1, FSTL1, SMAD4, ACVR2B, BMPR2, RUNX2, SMAD1, HFE, RGMB, ZFYVE16, BMP8A, RYR2, SMAD5, GREM2, SMURF2, USP15

GO:0030510

BP

regulation of BMP signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.

ITGA3, ACVR2A, PCSK6, XIAP

GO:0030511

BP

positive regulation of transforming growth factor beta receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

SDCBP, TGFB1I1, LRG1, THBS1, CDKN2B, CDKN1C, ADAM17, DAB2, TGFBR3, SMAD4, STK11, RNF111, FLCN, CITED1, CITED2, HIPK2

GO:0030512

BP

negative regulation of transforming growth factor beta receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

SMAD7, TGFB1I1, SMAD6, TGFB1, UBC, HSPA5, SKI, SKIL, PBLD, TGFBR1, TGFBR2, NKX2-1, CAV2, RPS27A, UBA52, ADAM17, HTRA3, SMAD3, CAV1, TGFBR3, BAMBI, SMAD2, PEG10, EID2, HTRA1, GLG1, PMEPA1, RASL11B, SMURF2, CHST11, MTMR4, STUB1, SNX6, LEMD3, ZNF451

GO:0030513

BP

positive regulation of BMP signaling pathway

Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.

CYR61, BMP4, GDF5, GATA4, NOTCH1, ILK, SMAD4, BMPR2, HES1, SMAD2, ZNF423, RNF165, KCP, SULF1, GATA6, FBXL15

GO:0030514

BP

negative regulation of BMP signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

SMAD7, SMAD6, GREM1, DKK1, SKI, SKIL, WNT5A, NBL1, NOTCH1, HTRA3, SOSTDC1, RBPMS2, TMPRSS6, SPG20, SFRP1, BMPER, HTRA1, SOST, HIPK2, TRIM33, LEMD3