| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0030101 | BP | natural killer cell activation | The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. |
PIK3CD, ITGB2, IL18R1, IL18, CASP8, ULBP3, ULBP2 |
GO:0030103 | BP | vasopressin secretion | The regulated release of vasopressin from secretory granules into the blood. |
TRPV4 |
GO:0030104 | BP | water homeostasis | Any process involved in the maintenance of an internal steady state of water within an organism or cell. |
AQP9, NEDD4L |
GO:0030107 | MF | HLA-A specific inhibitory MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. |
LILRB1 |
GO:0030108 | MF | HLA-A specific activating MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. |
CTSH |
GO:0030109 | MF | HLA-B specific inhibitory MHC class I receptor activity | Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. |
LILRB1 |
GO:0030111 | BP | regulation of Wnt signaling pathway | Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. |
PLPP3, SNX3, ITGA3, PPP2R1A, STK11, TCF7L1, DCDC2 |
GO:0030112 | CC | glycocalyx | A viscous, carbohydrate rich layer at the outermost periphery of a cell. |
B4GALT1 |
GO:0030117 | CC | membrane coat | Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. |
SYNJ1, CHMP2A, CHMP4B |
GO:0030118 | CC | clathrin coat | A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. |
CLTA, IGF2R |
GO:0030119 | CC | AP-type membrane coat adaptor complex | Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). |
AP5Z1, AP3M2, AP1S2, AP5M1 |
GO:0030120 | CC | vesicle coat | A membrane coat found on a coated vesicle. |
SEC31A |
GO:0030121 | CC | AP-1 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
AP1G2, AP1S1, LDLRAP1, AFTPH, SYNRG |
GO:0030122 | CC | AP-2 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
AP2A2, EGFR, EPS15, AP2S1, AP2B1, PICALM, LDLRAP1, TBC1D5, AP2M1 |
GO:0030123 | CC | AP-3 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
AP3D1, AP3S2 |
GO:0030125 | CC | clathrin vesicle coat | A clathrin coat found on a vesicle. |
CLTA |
GO:0030126 | CC | COPI vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. |
COPE, ARCN1, COPA, COPZ1, SCYL1, TMED3, COPG1 |
GO:0030127 | CC | COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. |
SEC24D, SEC31A, SEC23A |
GO:0030130 | CC | clathrin coat of trans-Golgi network vesicle | A clathrin coat found on a vesicle of the trans-Golgi network. |
CLTA, NCALD |
GO:0030131 | CC | clathrin adaptor complex | A membrane coat adaptor complex that links clathrin to a membrane. |
AP3M2, AP1B1, GGA2, GGA1, AP3M1 |
GO:0030132 | CC | clathrin coat of coated pit | The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. |
SYNJ1, CLTA, PICALM |
GO:0030133 | CC | transport vesicle | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. |
GOLIM4, COPE, SCAMP2, SURF4, KDELR3, VAMP4, SEC22B, AP1G2, IL33, INS, CD55, IGF2R, PRG2, BGN, KDELR1, PCSK1, ERP29, NTS, ARCN1, TMED10, RAB9A, CAV2, COPA, COPZ1, RAB11A, TMEM187, SSPN, TMED2, TRIP11, VAMP3, CNST, BLOC1S3, RABEPK, GALNT15, MYRIP, APH1B, ANKRD27, CHP1, SPX, CRISPLD2, RAB1B, TMEM168, PLEKHF2, ATP13A2, C14orf1, BLOC1S6, TMED3, COPG1 |
GO:0030134 | CC | ER to Golgi transport vesicle | A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. |
SEC31A, F8, SERPINA1, APP, F5, CTSC, GOLGA2, KLHL12, TEX261, PCSK9, YIPF5, YIPF6, LMAN2L, CTSZ, IER3IP1 |
GO:0030135 | CC | coated vesicle | Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. |
HSPD1 |
GO:0030136 | CC | clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
HIP1, PIK3C2A, SCAMP1, STX6, SNX3, SLC2A4, FOLR1, NUMB, BCAP31, VAMP2, DAB2, OCRL, TNK2, FCHO2, MALL, VAMP3, AAK1, WIPI1, DENND1A, SNX18, SH3BP4, GGA2, SNX9 |
GO:0030137 | CC | COPI-coated vesicle | A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. |
TMED10, ARF1, TMED2, CCDC115, PACSIN1 |
GO:0030139 | CC | endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
GOLIM4, STX7, MTSS1, PLEKHG5, ABCA1, APOA1, TF, RALA, IGF2R, CCL2, DRD2, RAB5A, DPP4, RAB5C, TIRAP, RAB5B, LRP2, HYAL2, PLD1, RABEP1, ITSN1, OCLN, AMOT, RAPGEF6, EHD3, MYO6 |
GO:0030140 | CC | trans-Golgi network transport vesicle | A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. |
RAB27B, FURIN, IGF2R, SLC2A4, TMED10, GOPC |
GO:0030141 | CC | secretory granule | A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
RAB27B, EBAG9, TOR1A, SNAPIN, PLAT, POMC, IL1B, COL1A1, CHGB, MPO, SCG5, THBS1, HSPD1, PLA2G2A, VEGFA, CPE, RAB3B, TRH, ZP3, GAL, RAB27A, BRCA2, CLCN3, VAMP7, ZP1, CDC42, VAMP2, VAMP3, CARTPT, STXBP5, SLC30A8, PCSK5, SYTL4, STXBP5L, HILPDA |
GO:0030144 | MF | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. |
MGAT5B |
GO:0030145 | MF | manganese ion binding | Interacting selectively and non-covalently with manganese (Mn) ions. |
PPM1B, LARGE, TDP2, SOD2, NUDT7, B4GALT1, LAP3, IMPA1, PCK1, HMGCL, ABL2, MRE11A, PAPOLA, NEK4, GALNT2, GALNT1, DCP2, FAM20C, XXYLT1, DYRK2, NUDT16, PRIMPOL, ATP13A2, XPNPEP3, MTPAP |
GO:0030148 | BP | sphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
ELOVL7, PLPP1, PLPP3, SPTLC2, VAPB, ALDH3B2, ALDH3A2, PRKD1, HACD4, HACD2, CERS6, FA2H, SGMS1, SGPP2, CERS5, SPTSSB, SGMS2, ELOVL1, ELOVL4, ELOVL6, CERS4, SPHK1, ELOVL5, HACD3, VAPA |
GO:0030149 | BP | sphingolipid catabolic process | The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
PPT1 |
GO:0030150 | BP | protein import into mitochondrial matrix | The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. |
TIMM23, TIMM17B, TOMM40, TOMM20, TIMM50, TIMM17A, TIMM21, GRPEL1, TOMM22, TOMM7, PAM16 |
GO:0030151 | MF | molybdenum ion binding | Interacting selectively and non-covalently with molybdenum (Mo) ions. |
SUOX, MARC1, MOCOS |
GO:0030154 | BP | cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
DAPL1, SH3PXD2B, WIPF3, HIP1, FOXN3, ITGB1BP1, MUSK, TGFB1I1, PAX4, SOX15, CREBL2, JAK2, GAS7, GADD45B, CSPG5, GADD45G, ZBTB7A, EYA4, CLPTM1, RAF1, TP53, INHA, FYN, INHBA, MGP, INHBB, FGR, MYBL1, MYBL2, TDGF1, TPT1, ETS2, SRD5A1, ELK1, TYMP, NR1D1, MAK, MAL, MDK, JAK1, YY1, ARNT, CTGF, SRD5A2, AKT1, FOXN2, STX2, COL15A1, ETV5, CSK, ADCYAP1R1, ELK3, PRRC2A, CENPF, PGF, ERF, FXR1, FOXL2, RPS3A, RPS7, RHOB, SRPK2, DLK1, SIM1, FOXK1, PURA, SLC7A5, HHEX, CREM, GNA12, TNFAIP2, PPARD, GABPA, TNK2, SLFN5, MAPK7, UBE2V1, GPM6B, SQSTM1, FHL1, SIM2, ELAVL3, ZNF268, ANGPT1, SHB, CCDC85B, ADIRF, ZIC1, CSRP2, DUSP6, ZNF423, TMEM176B, MORN2, HERC4, PRRC2B, SFRP5, COL13A1, SFRP4, STYK1, ALKBH5, CPLX2, NHS, SLCO4C1, ILDR2, NOTCH2NL, PIWIL4, ARHGAP22, HUWE1, ZSCAN2, PEG10, CAND1, SPATA24, GPSM1, RBM45, ARHGEF28, ARHGAP24, EID2, TDRD9, OSR1, SPATA20, AGR3, SLC2A14, ABHD5, EDARADD, EXT2, PBXIP1, FAM120B, DAZAP1, HES6, KAZALD1, GMCL1, APOLD1, UHRF2, PURB, ATOH8, CDC5L, MMP19, CITED2, HTATIP2, RBM4, SPATA9, RBM24, NAA15, TEX15, CADM1, RBM38, SUV39H2, USP42, BEX1, HES4, SRA1, PDLIM7, PARP11, GLRX2, ASF1B, ZAK, THEG, DHCR7, TUBD1, OSGIN1, ELF5, ZHX1, TCFL5, MYT1L, NDRG4, PLAGL1, NDRG2, THSD7A, SH2B3, RNF114, EID1, BZW2 |
GO:0030155 | BP | regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
PPP1R12A, NUAK1, ROCK2, ICAM1, CXCL8, PRLR, S1PR1, LAMA2, PPP2R1A, ABL2, SOX9, PRKX, PPP1CB, PKD1, PTPRJ, IL18, KIF14, LAMA4, LAMA3, CBLL1, PKP4, SERPINI1, FAF1 |
GO:0030156 | MF | benzodiazepine receptor binding | Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR). |
DBI |
GO:0030157 | BP | pancreatic juice secretion | The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. |
SCT, NPR3, COPA |
GO:0030158 | MF | protein xylosyltransferase activity | Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. |
XYLT2 |
GO:0030159 | MF | receptor signaling complex scaffold activity | Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. |
AXIN1, SPAG9, NUP62, LDLRAP1, MAGI2, DLG5, CARD10, G3BP2, MAPK8IP3 |
GO:0030162 | BP | regulation of proteolysis | Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. |
GSAP, SERPINB4, PLAUR, SPOPL, ABTB2, BTBD9, KBTBD4, SERPINB13, BTBD3 |
GO:0030163 | BP | protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
TPP1, CLN5, AMBP, CTSD, UCHL3, AKT1, PPT1, CLN3, SIAH1, CLN6, LNPEP |
GO:0030165 | MF | PDZ domain binding | Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. |
PARK2, FZD7, SLC22A5, ADRB1, CFTR, GJA1, ATP2B1, ATP2B4, ACVR2A, SDC2, MAP2K2, NSF, PSEN1, CLCN3, PTEN, GNG5, CXADR, DLG4, ADAM17, TGFBR3, SNTA1, SNTB1, KIF14, ACOX1, ARHGAP29, ARHGEF16, ERC1, NLGN1, EXOC4, CADM1, FZD8, LIN7B, PLEKHA2, LIN7C, CRIM1, MPP6, CRIPT, ASIC3, KIDINS220, FZD4, DTNA, F11R |
GO:0030166 | BP | proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. |
IGF1, BMPR2, CSGALNACT1 |
GO:0030167 | BP | proteoglycan catabolic process | The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. |
ADAMTS12 |
GO:0030168 | BP | platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
PLSCR1, FZD6, F8, F2, COL1A1, COL3A1, PF4, RAF1, VWF, ITGB3, IL6, PRKCB, FYN, LYN, COL1A2, SAA1, F5, GP1BB, RAC2, VAV1, PLCG2, PRKCA, ADRA2B, FLNA, CD9, F2R, MAPK3, PIK3R1, MAPK1, CD40LG, GNA11, AKT1, PIK3CA, PIK3CB, SYK, PIK3CG, GNAQ, RAP2B, RHOA, RHOB, GNB1, RAC1, YWHAZ, GNA12, PRKCQ, PRKCD, PTPN11, TYRO3, MERTK, TRPC3, DGKZ, GAS6, ITPR2, ITPR3, ITPR1, DGKK, BLOC1S3, DGKH, PDPN, VAV3, TRPC6 |
GO:0030169 | MF | low-density lipoprotein particle binding | Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. |
LDLR, CRP, THBS1, CD36, CDH13, SCARF1, COLEC12, PCSK9, SCARB1, STAB2, SORL1, STAB1 |
GO:0030170 | MF | pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
PDXK, SPTLC2, PROSC, GOT2, ALB, PYGB, PYGM, AGXT, CTH, SHMT1, CBS, BCAT1, ABAT, KYNU, MARC1, THNSL2, PHYKPL, THNSL1, GPT2, MOCOS, CSAD |
GO:0030172 | MF | troponin C binding | Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex. |
TNNI3 |
GO:0030173 | CC | integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
B4GAT1, LARGE, ST6GAL1, ST8SIA6, GALNT2, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, TEX261, QSOX2, SGMS1, SGMS2, CSGALNACT1, ST8SIA4, MAN1C1, ST6GALNAC2, ST3GAL6, IER3IP1 |
GO:0030174 | BP | regulation of DNA-dependent DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
NBN, CDT1 |
GO:0030175 | CC | filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
MYO1G, DNALI1, ITGB1, DMD, LCP1, B4GALT1, ACPP, EZR, VCAM1, KITLG, ITGA6, RDX, ACTN2, EPHA4, CDC42, ACTA2, ACTG2, ACTC1, CXADR, CDK5, TWF1, MTM1, IQGAP2, DAG1, DYNC1H1, FAT1, FSCN1, TWF2, RAPH1, RUFY3, PDPN, CD302, ABI1, ENAH, NGDN, FGF13, FGD4, SPATA13, DEF6, TRPV4, ABI2, FARP1, FAM65B |
GO:0030176 | CC | integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
ELOVL7, HACD1, UBXN8, SLC27A2, SLC37A4, ERN1, TM7SF2, HSPA5, ATF6, G6PC, SEC61A1, CLN3, ARL6IP1, EXT1, PIGG, HACD4, TEX261, HACD2, SYVN1, SGMS1, ANKLE2, XXYLT1, SGMS2, RHBDD1, EDEM1, PIGK, PIGT, DGAT2, DHRS9, VIMP, ESYT1, G6PC3, ELOVL1, DERL2, ELOVL4, PIGU, ELOVL6, RTN4, ELOVL5, HACD3, RRBP1, DPM3, DHCR7, AMFR, TMCO1, RCE1, TBL2 |
GO:0030177 | BP | positive regulation of Wnt signaling pathway | Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. |
TLR2, BMP2, SKI, FGFR2, SMARCA4, WNT3, HHEX, SOX4, KANK1, WLS, SULF2, SULF1, SFRP1, ATP6V1C2, DEPDC1B, RSPO3, LGR6, DACT1, ZRANB1, MACF1, SPIN1 |
GO:0030178 | BP | negative regulation of Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. |
TAX1BP3, AXIN1, DKK1, NFATC1, FGF9, CSNK1E, TSC2, RACK1, TLE1, GRB10, NFATC4, SFRP5, SFRP4, SHISA2, TRABD2A, APCDD1, SFRP1, MED12, DACT3, MDFI, CITED1, CHD8, DACT1, NLK, HMGXB4, WIF1 |
GO:0030182 | BP | neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
DAPK3, FZD7, ALDH1A2, WNT2, CEBPB, S1PR1, PTPRD, SMARCA1, PPP1CC, ID1, WNT5A, WNT3, MTPN, CDK5, ID3, MAP2K1, EMX2, MEF2C, RUNX2, NTRK2, ADNP2, PAPD4, NLGN4X, GPC2, PCSK9, PROX1, WNT2B, PIGT, IER2, NIF3L1, WNT5B, HIPK2, FZD8, NGRN, NRBP2, DDIT4, MYEF2, HDAC9, FZD4, HDAC5, TRPC6, WNT6 |
GO:0030183 | BP | B cell differentiation | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. |
IFNA1 , NTRK1, IFNA16, ITGB1, RAG1, TCF3, PLCG2, PTPN2, VCAM1, IL11, IL10, PIK3R1, CD40LG, BCL6, MSH2, JAK3, CEBPG, TPD52, HDAC4, ADAM17, SP3, HHEX, EP300, GON4L, IFNE, BLNK, DCLRE1C, KLF6, CLCF1, HDAC9, HDAC5 |
GO:0030185 | BP | nitric oxide transport | The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
EDN1, HBB |
GO:0030193 | BP | regulation of blood coagulation | Any process that modulates the frequency, rate or extent of blood coagulation. |
F2, F2R, STX2, F2RL1, CAV1, ASIC2, STXBP5, STAB2, FAM46A |
GO:0030194 | BP | positive regulation of blood coagulation | Any process that activates or increases the frequency, rate or extent of blood coagulation. |
F2, APOH, SERPINE1, S100A9, THBS1, CD36, F2R, HPSE, ENPP4 |
GO:0030195 | BP | negative regulation of blood coagulation | Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. |
KNG1, APOE, APOH, VTN, SERPINE1, EDN1, SERPINE2, TSPAN8 |
GO:0030197 | MF | extracellular matrix constituent, lubricant activity | Functions as a lubricant for an extracellular matrix, such as a mucous membrane. |
MUC3A, MUC4 |
GO:0030198 | BP | extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
TNFRSF11B, CYR61, NCAN, DNAJB6, ITGA10, ECM2, RECK, PDGFB, TNF, COL1A1, COL3A1, FGA, FGB, FGG, FN1, TTR, VTN, PDGFA, VWF, APP, ITGB3, ITGB2, SERPINE1, ICAM1, ITGB1, COL5A2, ITGAV, DCN, LAMB1, THBS1, COL1A2, COL4A2, ITGA5, FGF2, SPARC, FURIN, SPP1, HAPLN1, LAMC1, ITGAM, COL11A1, COL6A1, COL6A2, COL6A3, VCAN, NID1, B4GALT1, CD44, ITGB4, PECAM1, ITGA2, ERCC2, ITGB5, VCAM1, ITGAX, BCL3, COL9A1, COL5A1, BGN, FBLN1, ITGA6, LAMA2, TNC, COL8A2, COL5A3, ITGA3, ITGB8, LOX, FBN1, FBN2, BSG, SERPINB5, ITGAE, COL18A1, SOX9, COMP, LUM, MFAP2, JAM2, ADAMTS20, ELF3, HSPG2, COL4A3, COL10A1, PTK2, COL14A1, COL16A1, DDR1, LOXL1, CD47, PRDX4, MFAP5, ITGA9, COL4A6, NID2, DAG1, POSTN, TGFBI, LAMA4, LAMA3, HSD17B12, COL13A1, OLFML2A, ADAMTSL4, CCDC80, NPHP3, ERO1B, TMPRSS6, NDNF, CSGALNACT1, SPOCK2, TNR, APBB2, BCAN, ERO1A, KAZALD1, JAM3, CRISPLD2, SMOC2, DSPP, ITGA11, HPSE, F11R, POMT1, LAMC3 |
GO:0030199 | BP | collagen fibril organization | Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. |
GREM1, COL1A1, COL3A1, COL5A2, ANXA2, COL1A2, COL11A1, P4HA1, COL11A2, COL5A1, TNXB, MMP11, COL5A3, LOX, TGFBR1, SERPINH1, LUM, TGFB2, COL14A1, FMOD, FOXC1, CYP1B1, COL12A1, LOXL2 |
GO:0030200 | BP | heparan sulfate proteoglycan catabolic process | The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. |
GPC1, SGSH, HPSE |
GO:0030201 | BP | heparan sulfate proteoglycan metabolic process | The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. |
SULF2, SULF1 |
GO:0030203 | BP | glycosaminoglycan metabolic process | The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties. |
NCAN, SDC3, GPC4, CSPG5, DCN, VCAN, SDC1, BGN, SDC4, SDC2, GPC1, HSPG2, FOXC1, CSPG4, GPC2, BCAN, CLN6, GPC6 |
GO:0030204 | BP | chondroitin sulfate metabolic process | The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. |
DSEL |
GO:0030206 | BP | chondroitin sulfate biosynthetic process | The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. |
NCAN, CSPG5, DCN, VCAN, BGN, CSPG4, CHSY3, CHST15, CHST3, CHSY1, CSGALNACT1, BCAN, XYLT2, CHST11, CHST7, SLC35D1, DSE |
GO:0030207 | BP | chondroitin sulfate catabolic process | The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. |
NCAN, CSPG5, HEXA, DCN, VCAN, ARSB, BGN, CSPG4, BCAN |
GO:0030208 | BP | dermatan sulfate biosynthetic process | The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. |
NCAN, CSPG5, DCN, VCAN, BGN, CSPG4, DSEL, BCAN, DSE |
GO:0030210 | BP | heparin biosynthetic process | The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
NDST1, ANGPT1, CSGALNACT1, XYLT2 |
GO:0030212 | BP | hyaluronan metabolic process | The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
HGF, AKT1, MKI67, ITIH5 |
GO:0030213 | BP | hyaluronan biosynthetic process | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
ABCC5, IL1B, CEMIP, HAS2 |
GO:0030214 | BP | hyaluronan catabolic process | The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
HMMR, TGFB1, HEXA, FGF2, CD44, HYAL2, CEMIP, STAB2, CHP1, LYVE1 |
GO:0030215 | MF | semaphorin receptor binding | Interacting selectively and non-covalently with semaphorin receptors. |
SEMA3E, SEMA3D, SEMA3B, SEMA5A, SEMA3A, SEMA6D, SEMA3C, SH3BGRL3, SEMA6A, SEMA4A, SEMA6B |
GO:0030216 | BP | keratinocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. |
IRF6, EREG, LATS1, CSTA, ANXA1, KRT16, DSP, S100A7, SPRR2B, WNT5A, AKR1C3, NOTCH1, YAP1, JAG1, MAP2K1, POU3F1, STK4, ADAM9, SPRR2G, TXNIP, LATS2, SPRR3, INTU |
GO:0030217 | BP | T cell differentiation | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. |
PIK3CD, CD4, PTPRC, KIT, VAV1, IL7R, PTPN2, EGR1, LEP, LEPR, SP3, SOX4, RUNX2, PATZ1, DLL4, CHD7, PTPN22 |
GO:0030218 | BP | erythrocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. |
JAK2, INHA, LYN, INHBA, KIT, THRA, BMP4, HCLS1, TAL1, PTPN2, RPS14, IKZF1, NFE2L1, KMT2E, SMAD5, EPAS1, HIPK2, SFXN1 |
GO:0030219 | BP | megakaryocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. |
TAL1, IL11, CDKN2B, SP3 |
GO:0030220 | BP | platelet formation | The process in which platelets bud from long processes extended by megakaryocytes. |
ACTN1, TAL1, MYH9, CASP9, PTPN11, MEF2C, EP300, CIB1 |
GO:0030221 | BP | basophil differentiation | The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell. |
TAL1 |
GO:0030224 | BP | monocyte differentiation | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. |
JUN, CSF1R, BMP4, MT1G, VEGFA, MYH9, PPARG, SP3, MEF2C, IFI16 |
GO:0030225 | BP | macrophage differentiation | The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
CSF1R, PARP1, BMP4, MMP9, VEGFA, CDC42, CASP8, GAB3, L3MBTL3 |
GO:0030229 | MF | very-low-density lipoprotein particle receptor activity | Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. |
LDLR, VLDLR, APOBR |
GO:0030233 | MF | deoxynucleotide transmembrane transporter activity | Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. |
SLC25A19 |
GO:0030234 | MF | enzyme regulator activity | Binds to and modulates the activity of an enzyme. |
PSMD3, APOC3, BRCC3, GCLM, PSMD2, SEPT2, PPP1R7, RGN, MTMR9, RAB3GAP2, ATP6V1H |
GO:0030235 | MF | nitric-oxide synthase regulator activity | Modulates the activity of nitric oxide synthase. |
EGFR, ESR1, HSP90AA1, HSP90AB1, AKT1, CALM2 |
GO:0030238 | BP | male sex determination | The specification of male sex of an individual organism. |
DHH, GNRH1, INSR, FGF9, NR0B1, PTGDR |
GO:0030239 | BP | myofibril assembly | Formation of myofibrils, the repeating units of striated muscle. |
CAPN3, TMOD1, LMOD1, MYOZ1 |
GO:0030240 | BP | skeletal muscle thin filament assembly | The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. |
ACTC1, TTN, PROX1 |
GO:0030241 | BP | skeletal muscle myosin thick filament assembly | The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle. |
MYH11, TTN |
GO:0030242 | BP | pexophagy | The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions. |
ACBD5, RB1CC1, PIK3R4 |
GO:0030246 | MF | carbohydrate binding | Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
LGALS8, MAN2B1, NCAN, MGAM, LY75, ADGRL2, APCS, KRT1, CLEC3B, C4A, C4B, GAA, VCAN, PRG2, SELL, LGALS3, CD33, MAG, ZP3, KLRC1, CALR, CANX, CHI3L1, LGALS7, NPTX2, MAN2A2, EVA1C, PRPS1, OLR1, PKD1, SORD, GBE1, GFPT1, MGAT2, GALNT2, GALNT1, CNTN1, OS9, MLEC, GANAB, NOMO1, NECTIN1, UAP1, LGALSL, ATRNL1, GALNT5, GALNT7, GALNT10, CD302, GALNT15, GALNT4, ITLN1, CLEC4D, CLEC2B, GALNT14, BCAN, SIGLEC11, CLEC7A, SIGLEC1, CHODL, ADGRL3, CD248, CD209, CD93, LGALS13, SIGLEC7, MAN2B2, AIM1 |
GO:0030247 | MF | polysaccharide binding | Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
ENPP3, VTN, ENPP1, AGL, ENPP2, SBSPON, PRG4, TINAGL1 |
GO:0030252 | BP | growth hormone secretion | The regulated release of growth hormone from secretory granules into the blood. |
GHRH, RAB1A, CDK16, GHSR, GHRL |
GO:0030258 | BP | lipid modification | The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. |
FA2H |
GO:0030260 | BP | entry into host cell | The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
CD4, CXCR4, PPIA |
GO:0030261 | BP | chromosome condensation | The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. |
AIFM1, CDK1, HMGA2, NCAPG2 |