GO:0001601

MF

peptide YY receptor activity

Combining with gut peptide YY to initiate a change in cell activity.

NPY1R, NPY2R, NPY5R

GO:0001602

MF

pancreatic polypeptide receptor activity

Combining with pancreatic polypeptide PP to initiate a change in cell activity.

NPY1R, NPY5R

GO:0001609

MF

G-protein coupled adenosine receptor activity

Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

ADORA2B, ADORA1

GO:0001614

MF

purinergic nucleotide receptor activity

Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

P2RX4

GO:0001616

MF

growth hormone secretagogue receptor activity

Combining with ghrelin to initiate a change in cell activity.

GHSR

GO:0001618

MF

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

NPC1, SIVA1, CLDN1, LDLR, CD4, GYPA, TFRC, ITGB3, ICAM1, ITGB1, ITGAV, CD55, ITGA5, RPSA, HSPA1A, HSPA1B, LAMP1, NCAM1, IDE, PVR, CD46, ITGA2, CR1, ITGB5, MRC1, DPP4, SERPINB3, EFNB2, CXCR4, CXADR, TYRO3, SLC20A2, HYAL2, DAG1, SELPLG, NECTIN1, SLC1A5, SCARB1, CD209, F11R

GO:0001626

MF

nociceptin receptor activity

Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.

OPRL1

GO:0001635

MF

calcitonin gene-related peptide receptor activity

Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.

CRCP

GO:0001641

MF

group II metabotropic glutamate receptor activity

A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.

GRM3

GO:0001642

MF

group III metabotropic glutamate receptor activity

A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.

GRM8, GRM6

GO:0001649

BP

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.

CYR61, SNAI2, SYNCRIP, SHOX2, SEMA7A, RSL1D1, PENK, COL1A1, BGLAP, ALPL, HNRNPC, CCL3, SPP1, COL6A1, BMP2, BMP4, BMP3, VCAN, JUNB, GJA1, IGFBP3, BMP6, IGFBP5, TNC, FGF9, AKT1, PHB, PSMC2, RBMX, FASN, HSD17B4, HIRA, DLX5, SOX8, HSPE1, RRAS2, RPS11, TPM4, H3F3A, HNRNPU, MEF2C, RUNX2, CBFB, MEF2D, GPNMB, TWIST1, ALYREF, TP53INP2, SFRP1, CCDC47, CREB3L1, MYBBP1A, LGR4, RRBP1, ITGA11, ASF1A

GO:0001650

CC

fibrillar center

A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.

UTP15, UTP4

GO:0001651

CC

dense fibrillar component

A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.

SNU13

GO:0001652

CC

granular component

A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.

CLEC3B, CDKN2AIP

GO:0001654

BP

eye development

The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.

SH3PXD2B, CST3, RBP4, ATF6, BMP6, FGF9, TGFB2, FOXC1, BLOC1S3, BBS7, ADAMTS18, HIPK2

GO:0001655

BP

urogenital system development

The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.

AMH, SRD5A1, EPHB2, PAX8, OSR1, ACD

GO:0001656

BP

metanephros development

The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.

SPRY1, GDF11, CTSH, GLI3, BCL2, FBN1, IRX3, ID2, ID3, NIPBL, RDH10, APH1A, CITED1, ROBO2

GO:0001657

BP

ureteric bud development

The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.

SMAD7, SMAD9, SMAD6, SPRY1, TCF21, SLIT2, GDF11, TGFB1, FGFR1, BMP4, EPCAM, SDC1, WT1, FGFR2, SDC4, SIM1, SMAD3, FOXC1, SMAD2, SMAD1, SFRP1, BMPER, OSR1, SMAD5, ROBO2

GO:0001658

BP

branching involved in ureteric bud morphogenesis

The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

TCF21, GREM1, MYC, FGF2, GLI3, BCL2, BMP2, BMP4, WT1, CTNNB1, PBX1, SOX9, PGF, PAX8, DLG1, ILK, SMAD4, PKD2, PTCH1, CITED1, WNT6

GO:0001659

BP

temperature homeostasis

A homeostatic process in which an organism modulates its internal body temperature.

GPX1, ADRB1, ADRB3, DRD2, EDN2, ADORA1, STAT3, ACADVL, FOXO1, ARRDC3, FTO, PPARGC1A

GO:0001660

BP

fever generation

The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.

IL1A, IL1B, TRPV1

GO:0001661

BP

conditioned taste aversion

A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.

FOS

GO:0001662

BP

behavioral fear response

An acute behavioral change resulting from a perceived external threat.

BRINP1, PENK, CCK, EIF4E, BCL2, MDK, DPP4, HTR2C, GABRA5, NPY2R, USP46, MAPK8IP2, LYPD1, FBXL20, ALS2

GO:0001664

MF

G-protein coupled receptor binding

Interacting selectively and non-covalently with a G-protein coupled receptor.

PARK2, POMC, GNAI2, FYN, PSAP, GNAI3, SAA1, HSPA1A, HSPA1B, ITGB4, FLNA, S1PR1, ADORA1, DNAJA1, GNAI1, NPB, PACRG, GPRC5B, GHRL, APLN, STUB1, USP20

GO:0001665

MF

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.

ST6GALNAC5, ST6GALNAC4, ST6GALNAC2

GO:0001666

BP

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

PDLIM1, PLOD2, ANGPT2, CLDN3, ACTN4, TLR2, NOL3, LDHA, PLAU, PLAT, ADA, CST3, TGFB1, PENK, CRYAB, ANG, RAF1, CYP1A1, ATP1B1, PRKCB, TH, THBS1, MMP2, SOD3, HSPD1, BMP2, CCL2, ALAD, DRD2, HSP90B1, ETS1, VEGFA, CREB1, ITGA2, ERCC2, EGR1, PAM, VCAM1, TRH, AHCY, CD24, EDNRA, MT3, DPP4, ARNT, CASP1, ADORA1, ADSL, ADM, CHRNA7, TGFBR2, LEP, MTHFR, NR4A2, CDKN1B, CXCL12, PGF, VEGFB, VEGFC, PSEN2, MMP14, UCP2, UCP3, CXCR4, TGFB2, ADAM17, HSD11B2, ABAT, SMAD3, TEK, PLOD1, CAV1, TGFBR3, PPARA, EP300, KCNMA1, BNIP3, SMAD4, CAMK2D, ITPR2, ITPR1, POSTN, ADIPOQ, HIF1A, ALKBH5, AGTRAP, CYGB, RYR2, CREBBP, AJUBA, APOLD1, TXN2, EPAS1, CITED2, EGLN3, NOX4, DDIT4, DNMT3B, LIMD1, LOXL2

GO:0001667

BP

ameboidal-type cell migration

Cell migration that is accomplished by extension and retraction of a pseudopodium.

CENPV, WASF2

GO:0001669

CC

acrosomal vesicle

A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.

SPAG9, CRCP, SPINK1, KIT, SKIL, DRD2, TCP1, NCF2, ZP3, CALR, CTNNA1, NUDT1, NOTCH1, CXADR, LOXL1, MORN2, SV2B, ARC, IQUB, CASC5, ENKUR, SLIRP, RACGAP1, VEZT, TSKS, POMT1

GO:0001671

MF

ATPase activator activity

Binds to and increases the ATP hydrolysis activity of an ATPase.

DNAJB6, ATP1B1, DNAJB1, ATP1B3, AHSA2, DNAJC10, DNAJC1, DNAJC7

GO:0001672

BP

regulation of chromatin assembly or disassembly

Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.

TLK1

GO:0001673

CC

male germ cell nucleus

The nucleus of a male germ cell, a reproductive cell in males.

H2AFX, MLH1, TRIP13, TOPBP1, MLH3, TCFL5

GO:0001675

BP

acrosome assembly

The formation of the acrosome from the spermatid Golgi.

RFX2, AGFG1, TMF1, CASC5

GO:0001676

BP

long-chain fatty acid metabolic process

The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

SLC27A2, ACSL4, PAM, ACSL1, CPT1A, SLC27A4, SLC27A1, ACOT4, ACSL6, SLC27A6

GO:0001678

BP

cellular glucose homeostasis

A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.

HK1, PIK3R1, FOXO1, CARTPT, HKDC1, NUCKS1, PPARGC1A

GO:0001680

BP

tRNA 3'-terminal CCA addition

Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.

TRNT1

GO:0001682

BP

tRNA 5'-leader removal

Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.

KIAA0391, POP7, RPP40, POP4, RPP30, POP5, RPP25

GO:0001692

BP

histamine metabolic process

The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

TRH

GO:0001695

BP

histamine catabolic process

The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

HNMT

GO:0001696

BP

gastric acid secretion

The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.

CCKBR, NMU, GHRL

GO:0001701

BP

in utero embryonic development

The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.

ADAM10, MAFG, KDM6A, BCL2L11, KDM1A, EIF4E2, ZFAND5, SEC24D, CCNB2, MBD3, APOB, EDN1, ITGB1, GPI, TPM1, GLI2, GLI3, AR, FGFR1, BMP2, C6, CCNB1, FOSL1, VEGFA, GJA1, ERCC2, BTF3, FGFR2, EDNRA, NOS3, CTNNB1, MYH9, TIE1, SOX6, BMPR1A, ACVR1B, TGFBR1, HSD17B2, TGFBR2, MSH2, NOTCH1, UBE2A, DUSP3, SOX8, NLRP5, UBE2B, YBX1, SMAD3, PKD1, OCRL, APBA1, HHEX, GNA12, ACVR1, GABPA, SRSF1, FOXC1, MYO1E, SMAD4, CUL4A, PTCH1, ALKBH1, RCN1, ANGPT1, STIL, TWIST1, TAB1, SMAD2, AMOT, RNASEH2B, ANKRD11, UBR3, RBBP6, MIB1, RDH10, FLCN, ZFPM2, GATA6, ALS2, PITX2, RARRES2, PYGO2, CCM2, INPP5K, FUT8, ZNF335, TANC2, CHD8, MBNL1, RRN3, CHD7, KIDINS220, HEG1, ZMIZ1, MAFF, B9D1, MAPK8IP3, RTCB, KLF2, SLC30A1

GO:0001702

BP

gastrulation with mouth forming second

A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.

PLPP3, UGDH, LRP5, ACVR2A, CTNNB1, ACVR1, ZBTB17, SMAD4, ACVR2B, AMOT, TENM4, FRS2

GO:0001704

BP

formation of primary germ layer

The formation of the ectoderm, mesoderm and endoderm during gastrulation.

ATOH8

GO:0001706

BP

endoderm formation

The formation of the endoderm during gastrulation.

DKK1, DUSP1, DUSP2, SMAD2, DUSP5, SOX17

GO:0001707

BP

mesoderm formation

The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

DKK1, GPI, PRKAR1A, PRKACA, NF2, BMPR1A, WNT3, SMAD3, ACVR1, BMPR2, SMAD2, TXNRD1, WLS, NR4A3, EXT2

GO:0001708

BP

cell fate specification

The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

TBX1, ITGB1, APC, CTNNB1, NOTCH1, SOX9, PSEN1, PPDPF

GO:0001709

BP

cell fate determination

A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.

HOXA2, JAG1, NOTCH2, MCL1, PTCH1, PROX1, EBF2, CYP26B1

GO:0001710

BP

mesodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the mesoderm.

SMAD1

GO:0001711

BP

endodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the endoderm.

CTNNB1, RTF1

GO:0001712

BP

ectodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the ectoderm.

ETS2, ELF5

GO:0001714

BP

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

POU5F1

GO:0001725

CC

stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

ABLIM1, ACTN4, FLNB, NEBL, ABLIM3, TPM3, TPM1, ACTN1, LCP1, MYL9, MYH9, TPM4, TEK, PTK2, ILK, MYLK, ZYX, SEPT7, FSCN1, FBLIM1, PDLIM2, CORO1B, SORBS1, NOX4, PDLIM7, LIMA1, DAAM1, FHOD1

GO:0001726

CC

ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

ITGB1BP1, MTSS1, CYTH3, COBL, S100B, ITGB1, S100A6, ANXA2, ITGA5, ACTN1, LCP1, EZR, RAB5A, RASA1, ATP6V1B2, NME2, CLIP1, S100A11, RDX, MYH9, IQGAP1, CDK6, MTM1, ARHGEF7, CTTN, FSCN1, AMOT, FGD6, CYFIP1, FGD2, PDPN, KIF18A, ARAP3, PALLD, ARHGEF26, FGD4, ALS2, TRPM7, MYADM, INPP5K, MYO10, TNFRSF12A, PARD6A, PDLIM7, INPP5E, SAMSN1, RAB22A, MKLN1, MYO6, FRMD4B, TLN1, MYO5A, SNX9, SNX5, WASF2

GO:0001731

BP

formation of translation preinitiation complex

The joining of the small ribosomal subunit, ternary complex, and mRNA.

DENR, EIF3J, EIF4B, EIF2S3, EIF5, EIF3B, EIF3A, EIF3K

GO:0001732

BP

formation of cytoplasmic translation initiation complex

Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

CDC123, EIF3A

GO:0001735

MF

prenylcysteine oxidase activity

Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

PCYOX1

GO:0001736

BP

establishment of planar polarity

Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.

FZD6, WNT5A, PTK7

GO:0001738

BP

morphogenesis of a polarized epithelium

The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.

AHI1

GO:0001739

CC

sex chromatin

Chromatin that is part of a sex chromosome.

H2AFY, RING1, SUZ12

GO:0001740

CC

Barr body

A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

SMCHD1, H2AFY, H3F3A, H2AFY2

GO:0001741

CC

XY body

A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

PLK4, SIN3B, H2AFX, UBE2A, UBE2B, ESCO2, SMARCC1

GO:0001743

BP

optic placode formation

The initial developmental process that will lead to the formation of an eye.

AXIN1

GO:0001750

CC

photoreceptor outer segment

The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.

OPN1SW, INHA, MAK, PDC, PTGS1, GNA11, MAP1B, GNAQ, RAB27A, OCRL, MERTK, PTPRK, BBS7, MYRIP, RPGR, MYO5A

GO:0001754

BP

eye photoreceptor cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.

STAT3, AGTPBP1

GO:0001755

BP

neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.

SEMA3E, TBX1, SEMA7A, SEMA3D, FGF19, KITLG, HTR2B, SOX8, ACVR1, SEMA3B, SEMA5A, SEMA3A, ERBB4, HIF1A, PHACTR4, SEMA6D, SEMA3C, SEMA6A, SEMA4A, SEMA6B, CORO1C

GO:0001756

BP

somitogenesis

The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

PLXNA2, BMPR1A, WNT5A, PSEN1, PRKDC, SMAD3, EP300, TCF15, FOXC1, MIB1, ABI1, SEMA3C

GO:0001757

BP

somite specification

The process in which individual somites establish identity during embryogenesis.

COBL, MEOX1

GO:0001758

MF

retinal dehydrogenase activity

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

ALDH1A2, ALDH1A1, AKR1C3, ALDH1A3, ALDH8A1

GO:0001759

BP

organ induction

The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.

SPRY1, FGFR1, FRS2

GO:0001763

BP

morphogenesis of a branching structure

The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.

TCF21, TDGF1, COL13A1

GO:0001764

BP

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

MATN2, CHL1, NRP1, DCLK1, FYN, CCK, HSP90AA1, FBXO45, MAPT, FGFR1, GJA1, NR2F2, ITGA3, CTNNB1, NR4A2, NKX2-1, CXCL12, PSEN1, ASCL1, YWHAE, CDK5, PTK2, MEF2C, BAX, ALKBH1, GAS6, SEMA3A, PCM1, TWIST1, NTRK2, SDCCAG8, ASPM, POMGNT2, NAV1, DNER, NDNF, NRCAM, APBB2, FGF13, PITX2, TUBB2B, UNK, NDEL1, ELP3, ADGRL3, DDIT4, NDE1, CELSR3, MARK1, DCDC2

GO:0001765

BP

membrane raft assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.

FLOT1, ANXA2, EMP2, S100A10, RFTN1

GO:0001766

BP

membrane raft polarization

The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.

MAL, DOCK2

GO:0001768

BP

establishment of T cell polarity

The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.

MYH9, DOCK2, CYP26B1

GO:0001771

BP

immunological synapse formation

The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

CD6, EPHB1, DLG1, DOCK8, DOCK2

GO:0001772

CC

immunological synapse

An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

SOCS6, STX7, BCL10, ICAM1, PRKAR1A, CD28, EZR, LGALS3, CD53, CD6, CORO1A, MYH9, DUSP3, CD81, PRKCQ, PTPRJ, DLG1, ALCAM, PDCD6IP

GO:0001773

BP

myeloid dendritic cell activation

The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

HMGB1, CD244, PYCARD

GO:0001774

BP

microglial cell activation

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

TLR2, JUN, CLU, SNCA, TRPV1

GO:0001775

BP

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

TIMP1, CST3, PDGFA, IGF1, CCL3, PDGFRA, CD24, LYPD1

GO:0001777

BP

T cell homeostatic proliferation

The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.

BAX

GO:0001778

BP

plasma membrane repair

The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.

SYT11, MYH2

GO:0001779

BP

natural killer cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.

PIK3CD, TUSC2, STAT5B, ID2, SP3, TYRO3, MERTK

GO:0001780

BP

neutrophil homeostasis

The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.

ANXA1, MTHFD1, JAM3

GO:0001781

BP

neutrophil apoptotic process

Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

IL6

GO:0001782

BP

B cell homeostasis

The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

BCL2L11, LYN, BCL2, MEF2C, BAX, SOS1, PKN1, FOXP3, RC3H2, TNFSF13B

GO:0001783

BP

B cell apoptotic process

Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.

BCL2L11, TRAF3IP2, TNFRSF21, BCL10, BAX, PKN1

GO:0001784

MF

phosphotyrosine binding

Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.

FGR, MAPK3, MAPK1, GRB2, CBLB, LDLRAP1, SAMSN1

GO:0001785

MF

prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.

PTGDR

GO:0001786

MF

phosphatidylserine binding

Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

THBS1, HMGB1, GAP43, SYT1, PLCD1, MFGE8, FCHO2, GAS6, SCARB1, OSBPL10, OSBPL8, SYTL2, MARK1

GO:0001798

BP

positive regulation of type IIa hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.

C3

GO:0001809

BP

positive regulation of type IV hypersensitivity

Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.

ZP3

GO:0001816

BP

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

PIK3CD, MAF, NFAT5, CD4, S100A8, S100A9, FABP4, PTAFR, LIPA, PIK3CG, NFATC2, NFATC2IP, S1PR3, FOXP3

GO:0001817

BP

regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.

LYN, CSK, IQGAP1, CD83, LITAF, F11R

GO:0001818

BP

negative regulation of cytokine production

Any process that stops, prevents, or reduces the rate of production of a cytokine.

RPS6KA5, SLC11A1, NDRG2

GO:0001819

BP

positive regulation of cytokine production

Any process that activates or increases the frequency, rate or extent of production of a cytokine.

EREG, FLOT1, AGT, TNF, HTR2B, SLC11A1, TMF1, IFI16, PELI1, HILPDA

GO:0001821

BP

histamine secretion

The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.

ADA, EDN1

GO:0001822

BP

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

BCL2L11, TCF21, ALDH1A2, CA2, ASS1, AGT, DCN, MME, GLI2, ODC1, BMP4, ACE, VEGFA, WT1, BMP6, MPST, AGTR1, TGFBR1, SERPINF1, CENPF, TMED10, CDKN1C, HRSP12, TGFB2, PKD1, PPAT, PAX8, BAX, HYAL2, ACVR2B, ARID5B, RGN, TNS2, JMJD6, NPHP3, SULF2, SULF1, PCSK9, PROX1, HAS2, PCSK5, PYGO2, ADAMTS1

GO:0001823

BP

mesonephros development

The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.

BMP4, ZBTB16, PAX8, OSR1

GO:0001824

BP

blastocyst development

The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.

PSMC3, TGFBR1, PSMC4, NASP, NEK2, DAD1, ELF3, POU5F1, MED21

GO:0001825

BP

blastocyst formation

The initial formation of a blastocyst from a solid ball of cells known as a morula.

MFN2, SKIL, ZP3, TJP1, RRP7A, SF3B6

GO:0001827

BP

inner cell mass cell fate commitment

The cell fate commitment of precursor cells that will become inner cell mass cells.

LATS1, LATS2