| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0019853 | BP | L-ascorbic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. |
RGN |
GO:0019855 | MF | calcium channel inhibitor activity | Stops, prevents, or reduces the activity of a calcium channel. |
AMBP, TNNI3, ITPR1, PHPT1, SLC30A1 |
GO:0019858 | BP | cytosine metabolic process | The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. |
MAPK1 |
GO:0019859 | BP | thymine metabolic process | The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. |
ALDH6A1 |
GO:0019860 | BP | uracil metabolic process | The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. |
TYMS |
GO:0019862 | MF | IgA binding | Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype. |
AMBP |
GO:0019863 | MF | IgE binding | Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype. |
LGALS3 |
GO:0019864 | MF | IgG binding | Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype. |
FCGR3B, FCGR1A, FCGR2A, FCGR2B, FCGR1B |
GO:0019865 | MF | immunoglobulin binding | Interacting selectively and non-covalently with an immunoglobulin. |
CD4, VWF |
GO:0019867 | CC | outer membrane | The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. |
ANKH |
GO:0019869 | MF | chloride channel inhibitor activity | Stops, prevents, or reduces the activity of a chloride channel. |
STX7, CFTR, WNK3, WNK1, VTI1B |
GO:0019870 | MF | potassium channel inhibitor activity | Stops, prevents, or reduces the activity of a potassium channel. |
ENSA, RASA1, NEDD4L, WNK1 |
GO:0019871 | MF | sodium channel inhibitor activity | Stops, prevents, or reduces the activity of a sodium channel. |
CAMK2D, PCSK9, NEDD4L |
GO:0019878 | BP | lysine biosynthetic process via aminoadipic acid | The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. |
AASDHPPT |
GO:0019882 | BP | antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
HLA-B, CTSL, CTSH, HLA-G, RAB3B, AZGP1, CTSS, HLA-A, RAB27A, RAB5B, RELB, RAB32, RAB33A, MICB, MICA, RAB8B, MR1, RAB34, ULBP3, ULBP2, CD209 |
GO:0019883 | BP | antigen processing and presentation of endogenous antigen | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. |
CD74 |
GO:0019885 | BP | antigen processing and presentation of endogenous peptide antigen via MHC class I | The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. |
B2M, ERAP2, ERAP1 |
GO:0019886 | BP | antigen processing and presentation of exogenous peptide antigen via MHC class II | The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. |
DCTN6, DYNC1I1, DYNC1LI2, SEC24D, AP2A2, SEC31A, KIF4A, HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, CD74, CTSD, CTSL, CLTA, HLA-DRB4, HLA-DOB, HLA-DPA1, CTSS, CANX, HLA-DMB, ACTR1B, RAB7A, KIF11, AP2S1, SEC13, AP1S2, AP1S1, AP2B1, DYNLL1, HLA-DRB3, ARF1, CENPE, KIF23, AP1B1, DYNC1I2, DCTN2, DCTN1, DYNC1H1, KIF22, SEC23A, HLA-DRB5, KIF18A, DYNC2LI1, KIFAP3, AP2M1, KIF2C, SH3GL2, DCTN5, OSBPL1A, RACGAP1, KIF15, CTSF, KIF3A, SAR1B |
GO:0019887 | MF | protein kinase regulator activity | Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. |
HSP90AB1, RAC2, APC, CDC37, GCN1, KIDINS220, FAF1 |
GO:0019888 | MF | protein phosphatase regulator activity | Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
PPP1R3B |
GO:0019894 | MF | kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
TOR1A, RAB29, ARHGEF10, PRC1, SPAG9, KIF1B, CLSTN1, NEFH, NUP62, SNCA, ACTB, MAPK8IP2, CROCC, KLC3, KTN1, KIF18B, PIFO, KIFAP3, FAM83D, NEK6, SYBU, MAPK8IP3, MAPK8IP1 |
GO:0019896 | BP | axonal transport of mitochondrion | The directed movement of mitochondria along microtubules in nerve cell axons. |
OPA1, UCHL1, HIF1A, MGARP, SPAST |
GO:0019897 | CC | extrinsic component of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
ANXA2, TDGF1, NUMB, S100A10, RAC1, FMR1, MFGE8, EEA1, AAK1, SCUBE1, SYTL2 |
GO:0019898 | CC | extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
FRMD3, BCL2L11, SNX3, NMT2, FARP2, SNX4, ANXA1, PRNP, TPR, EZR, MAL, NF2, RDX, PLAUR, SNX1, WIPI1, NBEAL1, VPS13C, OSR1, SNX33, MITD1, MYLIP, NSMAF, ATG2B, SYTL4, MGLL, ASPSCR1, EPB41L4B, EPB41L1, EPB41L4A, DMBT1, BLOC1S6, SNX12, SNX6, EPB41L3, WDR45, WIPI2 |
GO:0019899 | MF | enzyme binding | Interacting selectively and non-covalently with any enzyme. |
SUPT5H, MAP2K7, SLC27A2, MDM4, PLSCR1, AXIN1, HDAC3, BIRC5, LDB2, PARK2, TRAK2, KDM1A, H2AFY, TULP3, ERN1, PRKRA, STC2, UBE4B, VAPB, PPP1R3D, BCL10, CYB5A, GOT2, EGFR, A2M, TGFB1, CD4, APOA1, ESR1, SLPI, TP53, CYP1A1, SLC4A2, APP, ITGB3, PCCA, CYP2E1, JUN, FYN, PGR, EIF4E, TH, P4HB, CYP3A4, IL6R, GSTM1, HMOX1, PDGFRB, PARP1, HIST1H2AG, HSPA1A, HSPA1B, AR, MAPT, HSPA5, BCR, LAMP1, TOP2A, CYP2A6, IGF2R, PCNA, UNG, LAMP2, CFTR, RPS2, H2AFX, CREB1, ATP2A2, HSPA6, HMGA1, PRKCA, JUND, TAL1, ATF7, DDX5, MSH3, GSTM3, NME2, ZFP36, CAD, GSTM2, POLD1, PEBP1, AKT1, YWHAB, GBP1, CTNNB1, PHB, RFC4, RFC2, PTGS2, CBS, PPARG, BRCA1, RFC5, MSH2, NKX2-1, MAPK8, NOTCH1, SERPINB4, MCM2, ARPC4, PTEN, NPC2, TSPAN5, YWHAE, SNRPD3, BTG1, RAC1, RACK1, UBE2I, TUBA4A, PRKDC, CBX1, FOXO4, MDM2, ANK2, GSTM4, CAV1, PLAUR, YWHAH, PRKCD, PPP3CA, PDE4D, CPSF1, CDC20, HYAL2, TAF10, CBX3, HDAC1, COTL1, MLEC, KPNB1, DHCR24, NCOA1, ZFHX3, PDCD2, MAPK14, HIF1A, PDE4DIP, HACD4, PHLDB3, APOA5, HACD2, MCM10, NOXA1, LONP2, RPS19BP1, PPP1R3B, KMT2E, CCAR2, TSPAN14, TTN, ESR2, RYR2, HDAC2, N4BP2L2, SPDL1, PAWR, PUS7, RANBP9, RAD9A, PRMT1, TEP1, NABP2, VIMP, HNRNPUL1, CDK19, BLZF1, TNKS2, SUDS3, PLCB1, PLSCR4, MAT2B, HACD3, RCOR3, ATXN10, HDAC6, PYCARD, SNX12, STUB1, USP22, LUC7L2 |
GO:0019900 | MF | kinase binding | Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
PER1, PARK2, BCL10, LDHA, NTRK1, RB1, LDHB, HSP90AB1, SLC2A1, PFKFB1, CEBPB, PFKL, FLNA, TNFAIP3, SP100, FAS, CTNNB1, HTT, EMP2, BTG1, DLG4, PRKCD, TIAM1, PPP2R5A, TRADD, TRIP6, CDC37, MIDN, SGOL1, TNS2, WWC2, TAX1BP1, WWC1, JAKMIP2, CHP1, BARD1, CDC6, TOLLIP, ABI2, WWC3, STUB1, IGSF9B, PTPN22, CAB39 |
GO:0019901 | MF | protein kinase binding | Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
RHOD, ADAM10, ITGB1BP1, MAP2K7, AURKA, PPP1R12A, AXIN1, SOCS1, MAP3K13, FOXO3, SPRY2, PRC1, PPP1R12B, PARK2, JAK2, CTNND1, PFKFB2, ATG13, H2AFY, PPP1R15A, AP2A2, CEP152, KIF20A, PARN, LATS1, BCL10, CCNE2, EGFR, CD4, TP53, HSPB1, ITGB2, NPM1, HSP90AA1, HSP90AB1, PTPRC, PDGFRB, FGR, PARP1, POLA1, MAPT, CD28, GHR, NEFH, SKI, EEF2, GYS1, HCLS1, CCNB1, JUP, NME1, SYN1, PRKACA, PTPN2, PGAM1, PAM, TNNI3, CCNA2, MAG, APC, CD24, ZFP36, PEBP1, CCND2, CCND3, CDC25A, CDC25B, CDC25C, SFN, CKS2, CTNNB1, PPP1CC, SREBF1, STAT3, CDKN2B, CDKN2C, MSH2, SYK, GATA4, NSF, IQGAP1, LIMS1, IFNAR2, GSK3B, DUSP3, CAV2, MAP2K6, KIF11, PLK1, CACNB3, PRKAG1, EMP2, SLC12A2, CASP9, HDAC4, SIK1, PTEN, CDC42, CKS1B, STXBP1, PPP1CB, CALM2, NCS1, RPS18, ACTA2, RPS6, GRB2, RAC1, YWHAZ, EEF1A1, SMAD3, PKD1, CDK5, E2F1, ANK2, MEF2A, MAP2K1, CAV1, RELA, PTK2, LIPE, EEF1A2, PRKCD, FOXM1, GOLGA2, AP1B1, PTPRJ, DLG1, PAK2, DNAJC3, MAPK8IP2, ILK, SQSTM1, ARHGEF7, KIF14, PTPRK, RHEB, ELAVL1, SMAD1, CRY1, CDC37, DPYSL2, HIF1A, KIZ, BORA, RICTOR, CSPG4, FAM83H, SV2A, RAB11FIP2, MAVS, SPRED1, CAMK2N1, CACUL1, TEX14, TRIM22, DBF4B, TPCN2, OSR1, PIFO, NEK9, RB1CC1, HDAC7, TTN, RFFL, NR4A3, GCN1, KAT2B, GATA6, BAD, FBXW5, ADIPOR1, EXOC2, TRIB3, CCNL2, CDC5L, RAD9A, MAP3K5, CIB1, VRK1, MAPKAP1, PDCD10, TRIM6, RACGAP1, WNK1, FAM83D, RGCC, TRPV4, CENPJ, NEK6, TCF7L2, CYLD, KIF13B, GPRC5B, AKAP7, ZBTB4, TBC1D14, PRKAG3, ERRFI1, TSKS, CCNL1, FBXO5, BAG5, TPX2, SUFU, FAF1, TPRKB, IRS2, TBL2, PPME1 |
GO:0019902 | MF | phosphatase binding | Interacting selectively and non-covalently with any phosphatase. |
MAPK3, MAPK1, TSC2, CTSC, SMAD3, PPARA, DLG1, SMAD2, CRY1, MAST2, CNST, SPRED1, MAGI2, PPP1R35, SH3RF2, SH3YL1, CSRNP2, SPTBN4, WNK1, SYTL2, CARHSP1 |
GO:0019903 | MF | protein phosphatase binding | Interacting selectively and non-covalently with any protein phosphatase. |
MAP2K7, SNX3, EGFR, ERBB2, TP53, CSF1R, HSP90AA1, MET, HSP90B1, JUP, CDH2, JAK1, PIK3R1, CDC27, CDH5, CTNNB1, FLT4, PPARG, STAT3, CSK, CDKN1B, IQGAP1, STAT5B, NEK2, JAK3, VCP, GRB2, RACK1, DLG4, MAPK14, PPP1R3F, PARD3, MAP3K5, ANAPC5, ANAPC4, FBXL2, PPP6R1, IRS2, PPME1 |
GO:0019904 | MF | protein domain specific binding | Interacting selectively and non-covalently with a specific domain of a protein. |
CNOT1, RAB27B, BHLHE40, XPO1, CHMP2A, TBL1X, TADA3, MYO1D, STAMBP, PLG, IL1B, TH, TUBB, ERCC1, GNAI3, THRA, HSPA5, LAMP1, ESRRA, SKI, LAMP2, EZR, TNNI3, TGM2, OSBP, XPA, SP100, ITGA3, HMGB2, PRKAR2B, YWHAB, SFN, RDX, MYH9, ACTN2, PPP1CC, SNCA, CAPG, WNT5A, PRKCI, IQGAP1, RAB27A, NR0B1, HNRNPM, ARFIP1, IST1, ATN1, VCP, WNT3, RAP2B, STXBP1, CALM2, YWHAE, HIST1H4A, YWHAZ, IGBP1, PKD1, ID3, PLAUR, YWHAH, ICA1, ZBTB16, PTPN11, TJP1, PPARA, CBX3, TDG, RUNX2, TFDP1, KPNB1, NR0B2, DIXDC1, TWIST1, OCLN, TUBA1A, CNTROB, MPP5, ICA1L, MITD1, KCTD13, MRPS31, MED12, ZNF521, LIN7B, CENPJ, ARHGEF4, MRPL17, HOMER3, LIN7C, NDE1, STMN3, VAPA, PHRF1, TJP2, DDX20, HPCAL4, ANGEL1, FAF1, DICER1, SSX2IP, PLXND1, IRS2 |
GO:0019905 | MF | syntaxin binding | Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
SNAP23, STX7, STX6, SEC22B, ABCA1, SNAP29, PTPN2, TMED10, VAMP7, STXBP1, RAB11A, VAMP2, GOLGA2, STXBP5, VPS52, SYTL5, SYTL4, SYT11, NAPB, SYTL2, TXLNG, BLOC1S6, RPH3AL, STXBP5L |
GO:0019907 | CC | cyclin-dependent protein kinase activating kinase holoenzyme complex | A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. |
HSPD1, ERCC2, KDM5A, PUF60 |
GO:0019908 | CC | nuclear cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinase (CDK) complex found in the nucleus. |
CDK13, CDK12, BCCIP |
GO:0019911 | MF | structural constituent of myelin sheath | The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. |
MAL, PLP1 |
GO:0019912 | MF | cyclin-dependent protein kinase activating kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). |
CDKN1A |
GO:0019915 | BP | lipid storage | The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
APOA1, CD36, GM2A, NRIP1, STAT5B, PLIN5, CAV1, CRY1, ABHD4, PNPLA2, DGAT2, PLIN2 |
GO:0019919 | BP | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. |
PRMT3, CARM1, PRMT6, PRMT1 |
GO:0019932 | BP | second-messenger-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. |
PPP2R1A |
GO:0019933 | BP | cAMP-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. |
NDUFS4, ADCY3, ADCY9, GHRH, NPR3, GAL, ADM, ADCYAP1R1, SOX9, ADCY7, EPHA5, PDE4D, AKAP6, MAPK7, EIF4EBP2, PDE3A, GPR126, RAPGEF4, RIMS2, PCLO |
GO:0019934 | BP | cGMP-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. |
PDE9A, APOE, CD36, PDE3A |
GO:0019941 | BP | modification-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. |
ISG15, UBA1, UBA7 |
GO:0019948 | MF | SUMO activating enzyme activity | Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. |
SAE1 |
GO:0019953 | BP | sexual reproduction | A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. |
STAT3, LEP, LEPR, SEPP1 |
GO:0019955 | MF | cytokine binding | Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. |
NRP1, NRP2, CD74, CSF1R, KIT, GBP1, CXCR4, FZD4, TNFRSF11A |
GO:0019956 | MF | chemokine binding | Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
ACKR4 |
GO:0019957 | MF | C-C chemokine binding | Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
ZFP36 |
GO:0019958 | MF | C-X-C chemokine binding | Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
HMGB1 |
GO:0019959 | MF | interleukin-8 binding | Interacting selectively and non-covalently with interleukin-8. |
A2M, CXCR2 |
GO:0019960 | MF | C-X3-C chemokine binding | Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. |
ITGB3, ITGB1, ITGAV |
GO:0019962 | MF | type I interferon binding | Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. |
IFNAR1 |
GO:0019966 | MF | interleukin-1 binding | Interacting selectively and non-covalently with interleukin-1. |
HAX1, A2M, IL1R1, IL1R2 |
GO:0019970 | MF | interleukin-11 binding | Interacting selectively and non-covalently with interleukin-11. |
IL6ST |
GO:0019981 | MF | interleukin-6 binding | Interacting selectively and non-covalently with interleukin-6. |
IL6R, IL6ST |
GO:0019983 | MF | interleukin-9 binding | Interacting selectively and non-covalently with interleukin-9. |
IL9R |
GO:0019985 | BP | translesion synthesis | The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. |
ISG15, UBC, PCNA, POLD1, RPA3, RFC4, RFC2, RFC5, RFC3, UBA7, VCP, RPS27A, UBA52, TRIM25, KIAA0101, POLD3, FAAP20, PRIMPOL, POLD4, DTL, POLK, POLI, POLH |
GO:0019992 | MF | diacylglycerol binding | Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. |
RASGRP2 |
GO:0020003 | CC | symbiont-containing vacuole | Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont. |
RAB29 |
GO:0020018 | CC | ciliary pocket membrane | That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket). |
SNAP29, EHD3 |
GO:0020037 | MF | heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
BACH1, PGRMC2, CYP27B1, CYB5B, CYP26A1, JAK2, STC2, CYB5A, AMBP, CYP1A1, CYBB, CYP17A1, CYP11A1, MPO, CYP2E1, CYC1, CYP3A4, CYP21A2, HMOX1, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B1, CYP11B2, NR1D1, CYP2B6, CYP3A5, PTGS1, CYP3A7, NOS3, PTGS2, CBS, SUOX, HBB, HBG1, HBA1, CYCS, PTGIS, CYP1B1, CYP51A1, CYP2R1, CYP4V2, FA2H, CYP2U1, CYP2W1, CYB5D2, CYGB, NOX5, SDHC, CYP3A43, ABCB6, NGB, NOX4, CYP26B1, DUOX2, DUOX1, CYP8B1, FLVCR2 |
GO:0021501 | BP | prechordal plate formation | The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. |
SSBP3 |
GO:0021502 | BP | neural fold elevation formation | The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm. |
HIF1A |
GO:0021508 | BP | floor plate formation | The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. |
GLI2 |
GO:0021510 | BP | spinal cord development | The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. |
SOX12, PHGDH, ZPR1, ACTL6A, ERCC2, SRD5A1, MPST, AKT1, PKD1, SOX4, PKD2, ZIC1, DPYSL2, MED12, ROBO2, PTBP2 |
GO:0021512 | BP | spinal cord anterior/posterior patterning | The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord. |
GDF11 |
GO:0021513 | BP | spinal cord dorsal/ventral patterning | The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. |
GLI2, INTU |
GO:0021514 | BP | ventral spinal cord interneuron differentiation | The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
LMO4 |
GO:0021515 | BP | cell differentiation in spinal cord | The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
NOTCH1 |
GO:0021516 | BP | dorsal spinal cord development | The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. |
PROX1 |
GO:0021517 | BP | ventral spinal cord development | The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. |
DAB1, GLI2, VLDLR |
GO:0021520 | BP | spinal cord motor neuron cell fate specification | The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. |
HOXD10 |
GO:0021522 | BP | spinal cord motor neuron differentiation | The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
LMO4, SOX4, PTCH1, GIGYF2 |
GO:0021527 | BP | spinal cord association neuron differentiation | The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
TAL1, ASCL1, LMO4 |
GO:0021530 | BP | spinal cord oligodendrocyte cell fate specification | The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. |
ASCL1 |
GO:0021532 | BP | neural tube patterning | The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. |
PTCH1, TMEM107 |
GO:0021534 | BP | cell proliferation in hindbrain | The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. |
C5AR1 |
GO:0021536 | BP | diencephalon development | The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. |
SEMA5A |
GO:0021537 | BP | telencephalon development | The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. |
BMP2, BMP4, AVPR2, OXTR, SLC1A2, HES1 |
GO:0021539 | BP | subthalamus development | The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis. |
UQCRQ |
GO:0021542 | BP | dentate gyrus development | The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. |
MDK, PTEN, BTG2, CDK6, EMX2, MEF2C, PROX1 |
GO:0021544 | BP | subpallium development | The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. |
DLX2 |
GO:0021545 | BP | cranial nerve development | The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. |
ERBB3, SLC1A3, CHD7 |
GO:0021547 | BP | midbrain-hindbrain boundary initiation | The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. |
SSBP3 |
GO:0021548 | BP | pons development | The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. |
UQCRQ |
GO:0021549 | BP | cerebellum development | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
FOXP2, GART, SSTR1, ABAT, CNTN1, HNRNPD, NCOA1, NLGN4X, SDF4, PPARGC1A, PTBP2 |
GO:0021551 | BP | central nervous system morphogenesis | The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
ERBB4 |
GO:0021553 | BP | olfactory nerve development | The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. |
NTRK1, CHD7 |
GO:0021554 | BP | optic nerve development | The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. |
RPL24, NAV2 |
GO:0021555 | BP | midbrain-hindbrain boundary morphogenesis | The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. |
HES1 |
GO:0021557 | BP | oculomotor nerve development | The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. |
HES1 |
GO:0021558 | BP | trochlear nerve development | The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. |
HES1 |
GO:0021563 | BP | glossopharyngeal nerve development | Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. |
NAV2 |
GO:0021564 | BP | vagus nerve development | The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. |
NAV2 |
GO:0021568 | BP | rhombomere 2 development | The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. |
HOXA2 |
GO:0021571 | BP | rhombomere 5 development | The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. |
MAFB |
GO:0021572 | BP | rhombomere 6 development | The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. |
MAFB |
GO:0021575 | BP | hindbrain morphogenesis | The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. |
HES1, DLC1 |
GO:0021587 | BP | cerebellum morphogenesis | The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
GNPAT, LRP6 |
GO:0021589 | BP | cerebellum structural organization | The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
DAB1, HSPA5 |
GO:0021591 | BP | ventricular system development | The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. |
CENPF, ARMC4, SEMA6D, ANP32B, AK8, MBOAT7 |
GO:0021599 | BP | abducens nerve formation | The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. |
HOXA1 |