GO:0017049

MF

GTP-Rho binding

Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.

PKN1, NET1, STXBP6, KCTD13, TRIOBP, EXOC1, CDC42EP3

GO:0017050

MF

D-erythro-sphingosine kinase activity

Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.

SPHK1

GO:0017053

CC

transcriptional repressor complex

A protein complex that possesses activity that prevents or downregulates transcription.

HDAC3, TBL1X, NCOR1, JUN, HMGB1, GLI3, SKI, SKIL, YWHAB, CBX5, HDGF, HDAC4, CTBP2, INSM1, SP3, ZBTB16, GPS2, C1D, DEPDC1, JAZF1, SMARCC2, N4BP2L2, CORO2A, LIN37, PHF12, SPEN, TBL1XR1, ZNF350, RLIM, ZNF224, RCOR3, NCOR2

GO:0017055

BP

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.

HMGB1, THRA

GO:0017056

MF

structural constituent of nuclear pore

The action of a molecule that contributes to the structural integrity of the nuclear pore complex.

NUP155, NUP62, NUP153, NUP107, NUP93, NUP205, NDC1, NUP85, NUP62CL

GO:0017057

MF

6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+).

PGLS, H6PD

GO:0017059

CC

serine C-palmitoyltransferase complex

An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.

SPTLC2, SPTSSB

GO:0017061

MF

S-methyl-5-thioadenosine phosphorylase activity

Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.

MTAP

GO:0017065

MF

single-strand selective uracil DNA N-glycosylase activity

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA.

SMUG1

GO:0017069

MF

snRNA binding

Interacting selectively and non-covalently with a small nuclear RNA (snRNA).

HEXIM1, SNRNP35, GEMIN5, RBPMS

GO:0017070

MF

U6 snRNA binding

Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).

LSM8, EIF5A, SART3, RBM22, LSM7, LSM2, LSM4

GO:0017075

MF

syntaxin-1 binding

Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.

SYT1, NSF, DAPK1, SNAP25, STXBP1, VAMP2, STXBP2, VAMP3, STXBP5, CPLX2, SYBU

GO:0017077

MF

oxidative phosphorylation uncoupler activity

Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.

UCP1, UCP3

GO:0017080

MF

sodium channel regulator activity

Modulates the activity of a sodium channel.

FXYD1, ATP2B4, FXYD4, FGF12, GPLD1, YWHAH, SNTA1, FGF13, SGK3, NEDD4L, PKP2, RANGRF

GO:0017081

MF

chloride channel regulator activity

Modulates the activity of a chloride channel.

CFTR, CHRNA7, TRPV1, SGK3

GO:0017082

MF

mineralocorticoid receptor activity

Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

GPER1

GO:0017084

MF

delta1-pyrroline-5-carboxylate synthetase activity

Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate.

ALDH18A1

GO:0017085

BP

response to insecticide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.

CPOX

GO:0017089

MF

glycolipid transporter activity

Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells.

GLTP

GO:0017091

MF

AU-rich element binding

Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases.

NUDT21, ZFP36, TIA1, ZFP36L2, EXOSC9, ELAVL3, EXOSC7, ELAVL1, MEX3D, EXOSC8, EXOSC4

GO:0017095

MF

heparan sulfate 6-O-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate.

HS6ST1, HS6ST2

GO:0017098

MF

sulfonylurea receptor binding

Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.

HSP90AA1, HSP90AB1

GO:0017099

MF

very-long-chain-acyl-CoA dehydrogenase activity

Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.

ACADVL

GO:0017101

CC

aminoacyl-tRNA synthetase multienzyme complex

A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.

EPRS, RARS, KARS

GO:0017108

MF

5'-flap endonuclease activity

Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.

FEN1, DNA2, FAN1

GO:0017109

CC

glutamate-cysteine ligase complex

An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.

GCLC, GCLM

GO:0017110

MF

nucleoside-diphosphatase activity

Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.

ENTPD3, NUDT15

GO:0017111

MF

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

DDX3X, ENTPD6, ENTPD3

GO:0017112

MF

Rab guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

DENND3, SBF1, RAB3GAP1, DENND4C, DENND2C, DENND5A, DENND5B, DENND4A, RIN3, DENND1A, RIN2, ALS2, RAB3IP, RAB3GAP2, RABGEF1, TRAPPC1

GO:0017113

MF

dihydropyrimidine dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.

DPYD

GO:0017116

MF

single-stranded DNA-dependent ATP-dependent DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.

PIF1

GO:0017119

CC

Golgi transport complex

A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8.

COG2, COG6

GO:0017121

BP

phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).

PLSCR1, ANO6, PLSCR4

GO:0017124

MF

SH3 domain binding

Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

WIPF3, ADAM10, PLSCR1, ARHGAP6, ADAM12, SH3BP5, PARK2, KHDRBS3, PAK3, PTTG1, GPX1, LYN, MAPT, HCLS1, GJA1, EPS15, CASP9, SH3BGR, GRB2, SIRPA, ADAM17, LRP2, KHDRBS1, SOS1, CBLB, ILK, ADAM9, TP53BP2, RAPGEF1, DPYSL3, CCDC6, ARHGAP31, SH3BP5L, NOXA1, AFAP1L2, ENAH, ENKUR, MICAL1, DENND1A, ELMO1, INPP5D, REPS1, MVB12A, QKI, SYNGAP1, RAD9A, FUT8, ADAM19, PLSCR4, ABI2, EVL, ERRFI1, PTPN22

GO:0017127

MF

cholesterol transporter activity

Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

ABCA1, APOA1, APOE, APOA2, APOB, STAR, APOA5, STARD4, ABCG8

GO:0017128

MF

phospholipid scramblase activity

Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.

PLSCR1, ANO6, PLSCR4

GO:0017129

MF

triglyceride binding

Interacting selectively and non-covalently with any triester of glycerol.

LPL

GO:0017134

MF

fibroblast growth factor binding

Interacting selectively and non-covalently with a fibroblast growth factor.

ITGB3, ITGAV, THBS1, FGFR1, RPS2, FGFR2, GPC1, TGFBR3, CEP57, GLG1, S100A13, KL

GO:0017136

MF

NAD-dependent histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.

SIRT2

GO:0017137

MF

Rab GTPase binding

Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.

RAB29, PDE6D, TBC1D4, TBC1D12, RAB11FIP3, ULK1, RHOBTB3, TBC1D8, ANXA2, NGFR, TBC1D3H, CHM, CHML, GDI1, NSF, RABGGTB, RAC1, TBC1D8B, RAB3GAP1, ACAP2, RABGAP1L, STXBP5, GRTP1, TBC1D9B, TBC1D3C, DENND5A, RAB11FIP1, TBC1D9, RAB11FIP2, ERC1, HACE1, TBC1D3, EXPH5, MYRIP, RIN3, TBC1D16, TBC1D15, PIFO, BICD2, DMXL2, SYTL5, MICAL1, DENND1A, NDRG1, TBC1D5, USP6NL, SYTL4, RUNDC1, EVI5L, OPTN, BICD1, C9orf72, ANKRD27, ALS2, MLPH, RAB3GAP2, SYTL2, HPS4, TBC1D14, ANKFY1, RABGEF1, MYO5B, RPH3AL, TBC1D2B, RIMS2, STXBP5L, AP3M1, RABGAP1, KIF3A, MYO5A

GO:0017143

BP

insecticide metabolic process

The chemical reactions and pathways involving insecticides, chemicals used to kill insects.

CYP1A1, STAR

GO:0017144

BP

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

CYP1A1, CYP2E1, CYP3A4, CYP2D6, CYP2A6, CYP2C9, CBR1, CYP2B6, CAD, FMO4, FMO2, VKORC1

GO:0017145

BP

stem cell division

The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.

CUL3

GO:0017146

CC

NMDA selective glutamate receptor complex

An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.

GRIN2A, EPS8, NLGN1

GO:0017147

MF

Wnt-protein binding

Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.

FZD6, FZD7, LRP5, LRP6, ROR1, PTPRO, SFRP5, WLS, SFRP4, TRABD2A, APCDD1, SFRP1, CTHRC1, FZD8, FZD4, WIF1

GO:0017148

BP

negative regulation of translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

CNOT1, IGF2BP3, DDX3X, ENC1, DAPK3, SYNCRIP, EIF4E2, CNOT3, ANG, GAPDH, EIF4E, EPRS, IGFBP5, CALR, TIA1, RPL13A, FXR1, HRSP12, DAPK1, RACK1, BTG2, PURA, FMR1, ILF3, CIRBP, CAPRIN1, SAMD4B, GIGYF2, CPEB3, NANOS1, RBM4, LIN28A, EIF4ENIF1, SAMD4A, IGF2BP2

GO:0017150

MF

tRNA dihydrouridine synthase activity

Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.

DUS4L

GO:0017151

MF

DEAD/H-box RNA helicase binding

Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.

POT1

GO:0017154

MF

semaphorin receptor activity

Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

NRP1, PLXNB2, NRP2, PLXNC1, PLXNA2, PLXNA3, PLXNA1, PLXND1

GO:0017156

BP

calcium ion regulated exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.

VAMP7, VAMP2, VAMP3, RAPGEF4, CHP1, SDF4, RIMS2

GO:0017157

BP

regulation of exocytosis

Any process that modulates the frequency, rate or extent of exocytosis.

RALA, RAB3B, SYT1, NSF, VAMP2, STX4, STXBP5, CPLX2, RAPGEF4, RAB21, RIMS2, STXBP5L, PCLO

GO:0017158

BP

regulation of calcium ion-dependent exocytosis

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.

SYT1, SYTL5, SYTL4, TRPV6

GO:0017159

MF

pantetheine hydrolase activity

Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine.

VNN1, VNN3

GO:0017160

MF

Ral GTPase binding

Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.

MYO1C, EXOC5, FLNA, RALBP1, EXOC4, EXOC2, RAB34, LSM2

GO:0017161

MF

inositol-1,3,4-trisphosphate 4-phosphatase activity

Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.

INPP4B, INPP4A

GO:0017162

MF

aryl hydrocarbon receptor binding

Interacting selectively and non-covalently with an aryl hydrocarbon receptor.

AIP, ARNTL, ARNT

GO:0017166

MF

vinculin binding

Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.

SORBS3, DMD, ACTN1, CTNNA1, DAG1, RTCB, TLN1

GO:0017168

MF

5-oxoprolinase (ATP-hydrolyzing) activity

Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate.

OPLAH

GO:0017171

MF

serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

CELA2A, AADAC

GO:0017172

MF

cysteine dioxygenase activity

Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+).

CDO1

GO:0017176

MF

phosphatidylinositol N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol.

PIGA, PIGH, PIGC

GO:0017177

CC

glucosidase II complex

A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins.

GANAB

GO:0017183

BP

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

EEF2, DPH3, DPH1, DPH5

GO:0017186

BP

peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase

The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.

QPCT

GO:0017187

BP

peptidyl-glutamic acid carboxylation

The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase.

F2, BGLAP, GGCX, VKORC1

GO:0017196

BP

N-terminal peptidyl-methionine acetylation

The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine.

NAA30, NAA25, NAA15, NAA60

GO:0018008

BP

N-terminal peptidyl-glycine N-myristoylation

The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.

NMT2

GO:0018022

BP

peptidyl-lysine methylation

The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.

METTL10, ETFBKMT, N6AMT2, METTL21A

GO:0018023

BP

peptidyl-lysine trimethylation

The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

ETFBKMT

GO:0018024

MF

histone-lysine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

WHSC1, PRDM2, RBBP5, EZH2, KMT5B, KMT2E, KMT2C, SETD7, EZH1, EHMT2, SETDB2, WHSC1L1, SUV39H2, SMYD3, KMT5A, PRDM6, ASH2L, KMT2B

GO:0018026

BP

peptidyl-lysine monomethylation

The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.

SETD6, SETD7, KMT5A

GO:0018027

BP

peptidyl-lysine dimethylation

The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.

SETD7, EHMT2

GO:0018032

BP

protein amidation

Addition of an amide group from a glycine to a protein amino acid.

PAM

GO:0018076

BP

N-terminal peptidyl-lysine acetylation

The acetylation of the N-terminal lysine of proteins.

EP300, CREBBP, KAT2B

GO:0018095

BP

protein polyglutamylation

The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.

TTLL1

GO:0018101

BP

protein citrullination

The hydrolysis of peptidyl-arginine to form peptidyl-citrulline.

PADI4

GO:0018105

BP

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

CDC7, MAST4, DCLK1, MAPK13, ULK1, TNKS, PDGFB, PRKCB, CDK1, BCL2, TDGF1, PRKCA, PRKACA, CDK2, MAPK3, MAPK1, AKT1, AKT2, TGFBR1, TGFBR2, PRKCI, SYK, MAPK8, CSNK1A1, CSNK1D, MAPKAPK2, CSNK1E, GSK3B, PRKX, PLK1, PRKDC, PKD1, CDK5, PRKCQ, PRKCD, DMPK, STK4, MAPK7, PAK2, ILK, CAMK2D, MORC3, GAS6, PRKD1, STK38, RPS6KA2, PKN1, PKN2, MAPK14, MAST2, RICTOR, STK32C, UHMK1, SGK3, MASTL, SMG1, MKNK1, PINK1, PRKD2, HIPK2, MKNK2, NEK6, CSNK1G1, LATS2, PLK2, TBK1, AKT3, STK38L, CAB39, CSNK1G3

GO:0018106

BP

peptidyl-histidine phosphorylation

The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine).

NME2

GO:0018107

BP

peptidyl-threonine phosphorylation

The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

CHEK1, TNKS, CDK1, BCL2, PRKACA, CAD, MAPK1, AKT1, ACVR1B, TGFBR1, TGFBR2, MAPK8, GSK3B, CDK5, ACVR1, PRKCD, CAMK2D, OSR1, HIPK2, WNK1, NLK

GO:0018108

BP

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

MAP2K7, EREG, MUSK, RIPK2, JAK2, FGF18, ERLIN2, EGFR, PDGFB, ERBB2, NTRK1, INSR, FYN, CSF1R, HSP90AA1, LYN, MET, FGF2, PDGFRB, FGR, KIT, BCR, FGFR1, PDGFRA, FGF7, FGFR2, ERBB3, EPHA3, EPHB2, LTK, WEE1, FGF9, TTK, BTC, TIE1, FLT4, MAP2K2, STAT5A, ABL2, IL12RB1, CLK2, STAT5B, JAK3, MAP2K6, EPHA5, EPHB4, EPHB1, EPHA4, IL5RA, ROR1, NRG1, MAP2K1, TEK, PTK2, PRKCD, TYRO3, EFEMP1, MERTK, MAP2K5, CUX1, MELK, ERBB4, TESK1, CDC37, NTRK2, DSTYK, SGK223, ABI1, TTN, DYRK2, SCYL1, NEK1, HBEGF, CLK4, FGFR1OP2, ABI2, ZMYM2, EPHA6, BAZ1B

GO:0018117

BP

protein adenylylation

The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid.

FICD

GO:0018119

BP

peptidyl-cysteine S-nitrosylation

The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine.

S100A8

GO:0018125

BP

peptidyl-cysteine methylation

The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine.

RAB3B

GO:0018126

BP

protein hydroxylation

The addition of a hydroxy group to a protein amino acid.

EGLN3

GO:0018146

BP

keratan sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.

B4GALT5, B4GAT1, B4GALT4, B4GALT1, OGN, LUM, FMOD, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, SLC35D2, B3GNT7, OMD, CHST5, CHST6, B3GNT2, B4GALT6, ST3GAL6, CHST2

GO:0018149

BP

peptide cross-linking

The formation of a covalent cross-link between or within protein chains.

F13A1, CSTA, COL3A1, FN1, ANXA1, THBS1, DSP, SPRR2B, TGM4, SPRR2G, SPRR3

GO:0018153

BP

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine.

TGM2

GO:0018158

BP

protein oxidation

The modification of a protein amino acid by oxidation.

APOA1, APOA2, GPX1

GO:0018169

MF

ribosomal S6-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6.

UBE2M

GO:0018193

BP

peptidyl-amino acid modification

The alteration of an amino acid residue in a peptide.

ASPH, ASPHD1, ASPHD2, MINA

GO:0018205

BP

peptidyl-lysine modification

The modification of peptidyl-lysine.

MDM2

GO:0018206

BP

peptidyl-methionine modification

The modification of peptidyl-methionine.

APOA1, APOA2, METAP2

GO:0018216

BP

peptidyl-arginine methylation

The addition of a methyl group to an arginine residue in a protein.

PRMT1

GO:0018230

BP

peptidyl-L-cysteine S-palmitoylation

The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.

ZDHHC7, ZDHHC9

GO:0018242

BP

protein O-linked glycosylation via serine

The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.

GALNT2, GALNT1

GO:0018243

BP

protein O-linked glycosylation via threonine

The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.

GALNT2, GALNT1

GO:0018272

BP

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine.

CTH

GO:0018277

BP

protein deamination

The removal of an amino group from a protein amino acid.

LOXL1, LOXL2

GO:0018279

BP

protein N-linked glycosylation via asparagine

The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.

ST6GAL1, DDOST, STT3A, VCP, DAD1, MGAT2, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, SYVN1, MCFD2, STT3B, ST6GAL2, ST6GALNAC5, FUT8, ST6GALNAC4, OSTC, UGGT1, DPM3, ST6GALNAC2, ST3GAL6

GO:0018283

BP

iron incorporation into metallo-sulfur cluster

The incorporation of iron into a metallo-sulfur cluster.

FXN