| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0016600 | CC | flotillin complex | A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. |
FLOT1, CTNNA1, CTNNB1, CORO1C |
GO:0016601 | BP | Rac protein signal transduction | A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. |
FARP2, CDH13, EPS8, TIAM1, RHOU, CYFIP1, HACE1, ELMO1, ALS2, ABI2, HACD3, NISCH, WASF2 |
GO:0016602 | CC | CCAAT-binding factor complex | A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. |
NFYB, NFYC |
GO:0016603 | MF | glutaminyl-peptide cyclotransferase activity | Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. |
QPCT |
GO:0016604 | CC | nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
TP53, SKI, MDM2, ZBTB16, ZFHX3, MSANTD1, MTDH, CREBRF, GEMIN5, GEMIN6, CREBBP, TOLLIP, HIPK2, NCOR2 |
GO:0016605 | CC | PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
ARNTL, DAPK3, NBN, N4BP1, TDP2, TP53, RB1, SKI, SP100, CBX5, ATRX, MRE11A, BLM, HIRA, SUMO3, PTEN, SUMO2, UBE2I, SATB1, SP3, ZBTB16, RAD51, MAPK7, SQSTM1, TDG, MORC3, RFWD3, TP53INP2, SMC5, TOPBP1, KAT6A, TP53INP1, ISG20, SMC6, TRIM8, SPTBN4, HIPK2, MKNK2, TCF7L2, EIF4ENIF1, THAP1, PPARGC1A, ZMYM2, RNF6, ZNF451 |
GO:0016607 | CC | nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
APBB1, SAP18, DDX3X, PRPF3, PPIH, PLRG1, PQBP1, DUSP11, PRPF40A, SRSF10, LUC7L3, CD2BP2, LMNA, GLI2, GLI3, PSKH1, PRKACA, SON, WT1, PPP1CC, NRIP1, CSNK1A1, RBM25, CLK2, AFF2, SRP54, SARNP, SRSF2, ZBTB16, MEF2C, RING1, SRSF1, SF3A3, TARDBP, SRSF5, SRSF6, PPIG, CDK13, RBM39, ZNF638, PSME4, WTAP, SART3, NONO, RNPS1, HIF1A, IFI16, TIMM50, FAM76B, ZC3H13, ARL6IP4, THOC7, ALKBH5, ZC3H14, CBLL1, DDX46, PABPN1, ALYREF, TRIM69, GATAD2A, SRRM1, TRIM22, KMT2E, MAML2, AGGF1, THOC2, PNISR, ATXN2L, PRPF31, PSPC1, RSRC1, THOC3, EAF1, MAML3, YTHDC1, CCNL2, SMC6, ATOH8, RBM15, CDC5L, PRPF18, EPAS1, WAC, RBM4, POLDIP3, CRNKL1, FTO, PNN, NEK6, CWC22, PLCB1, EIF4ENIF1, GPATCH2, BCLAF1, CDK12, NXF1, CCNL1, NXT1, ZMIZ1, PRPF19, SRRM2, HIF3A, THRAP3, LUC7L2, RBM8A |
GO:0016608 | MF | growth hormone-releasing hormone activity | The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. |
GHRH, GHRL |
GO:0016614 | MF | oxidoreductase activity, acting on CH-OH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
AGPS, XDH, AOX1, DHCR24 |
GO:0016616 | MF | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
CTBP2, ADHFE1, RDH11 |
GO:0016618 | MF | hydroxypyruvate reductase activity | Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. |
GRHPR |
GO:0016627 | MF | oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
TM7SF2, TECRL |
GO:0016628 | MF | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
DHCR24, BDH2 |
GO:0016641 | MF | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. |
LOXL1, LOXL4 |
GO:0016651 | MF | oxidoreductase activity, acting on NAD(P)H | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
AIFM1, DECR1, MIOX |
GO:0016655 | MF | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
CBR1, AKR1C3, AKR1C2, AKR1C1, DCXR, DHRS4 |
GO:0016671 | MF | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. |
TXN, ERO1B, DNAJC10, ERO1A, TXN2 |
GO:0016679 | MF | oxidoreductase activity, acting on diphenols and related substances as donors | Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
CYP1A1 |
GO:0016684 | MF | oxidoreductase activity, acting on peroxide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. |
SESN2 |
GO:0016701 | MF | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. |
MIOX |
GO:0016702 | MF | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
P4HA2, P4HA1 |
GO:0016705 | MF | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. |
PTGIS, OGFOD3, CYP2R1, CYP4V2, CYP2W1 |
GO:0016706 | MF | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. |
KDM5A, ALKBH5, KDM7A, MINA, EGLN3, KDM5B |
GO:0016709 | MF | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
CYP26A1, MICAL2, CYP11A1, CYP2E1, CYP11B1, CYP11B2, MICAL1, CYP26B1 |
GO:0016711 | MF | flavonoid 3'-monooxygenase activity | Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. |
CYP1A1 |
GO:0016712 | MF | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
CYP2E1, CYP2D6, CYP2A6, CYP19A1, CYP2B6, CYP1B1 |
GO:0016715 | MF | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. |
MOXD1 |
GO:0016722 | MF | oxidoreductase activity, oxidizing metal ions | Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. |
CYBRD1 |
GO:0016740 | MF | transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
ILVBL, PTDSS1, ILF2, BIRC3, NDUFAF6, IBA57, UHMK1, MOCOS, SCLY, TAOK3, FKRP |
GO:0016742 | MF | hydroxymethyl-, formyl- and related transferase activity | Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). |
ALDH1L1, ALDH1L2 |
GO:0016746 | MF | transferase activity, transferring acyl groups | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). |
EP300, HGSNAT, KMT2C, TMEM68, LIPT1 |
GO:0016757 | MF | transferase activity, transferring glycosyl groups | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
LARGE, EXT1, GTDC1, B3GNTL1, GLT8D1, EXT2, GLT1D1 |
GO:0016763 | MF | transferase activity, transferring pentosyl groups | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
TYMP |
GO:0016773 | MF | phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). |
FAM20B, G6PC, GK5 |
GO:0016779 | MF | nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
PAPSS2, EIF2B3, NUDT5 |
GO:0016780 | MF | phosphotransferase activity, for other substituted phosphate groups | Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). |
PIGG |
GO:0016783 | MF | sulfurtransferase activity | Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). |
TRMU |
GO:0016784 | MF | 3-mercaptopyruvate sulfurtransferase activity | Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. |
MPST |
GO:0016787 | MF | hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
NUDT21, PRDX6, GNPDA1, HINT1, FHIT, ENPP2, IDI1, MPPED2, IAH1, ATHL1, MEST, CPSF3L, ABHD17B, ABHD17C, HAGHL, ABHD13, PLPP6, ABHD11, ABHD4, NUDT8, FAHD2A, ABHD14B, TP53RK, CDADC1, HINT2, IDI2, HINT3, ENPP5 |
GO:0016788 | MF | hydrolase activity, acting on ester bonds | Catalysis of the hydrolysis of any ester bond. |
PLA2G7, PGAP1, PTER, PGAP3, C11orf54 |
GO:0016790 | MF | thiolester hydrolase activity | Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. |
UFSP2, PPT2 |
GO:0016791 | MF | phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
DUSP11, CA3, ACPP, PPP1CC, PPM1F, DUSP3, PPP1CA, PPP1CB, PTPRJ, DUSP8, DUSP5, PTPRO, DUSP18, PXYLP1, DUSP23, DUSP16, DUSP13, PTPN22, DUSP10 |
GO:0016798 | MF | hydrolase activity, acting on glycosyl bonds | Catalysis of the hydrolysis of any glycosyl bond. |
MACROD2, ATHL1, MACROD1 |
GO:0016799 | MF | hydrolase activity, hydrolyzing N-glycosyl compounds | Catalysis of the hydrolysis of any N-glycosyl bond. |
MAN2A2 |
GO:0016805 | MF | dipeptidase activity | Catalysis of the hydrolysis of a dipeptide. |
PM20D2 |
GO:0016810 | MF | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. |
DPYSL4, DPYSL3 |
GO:0016811 | MF | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. |
KLK3 |
GO:0016829 | MF | lyase activity | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. |
HMGB1, PHYKPL, MOCOS |
GO:0016831 | MF | carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
BCKDHA, BCKDHB, ECHDC1 |
GO:0016836 | MF | hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
L3HYPDH |
GO:0016844 | MF | strictosidine synthase activity | Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine. |
APMAP |
GO:0016846 | MF | carbon-sulfur lyase activity | Catalysis of the elimination of hydrogen sulfide or substituted H2S. |
CTH, CENPV |
GO:0016853 | MF | isomerase activity | Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
PBLD, HSD17B4, HMGCS1, ECH1, ITPK1, ENOSF1 |
GO:0016854 | MF | racemase and epimerase activity | Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. |
DHRS9 |
GO:0016860 | MF | intramolecular oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. |
ECI1 |
GO:0016866 | MF | intramolecular transferase activity | Catalysis of the transfer of a functional group from one position to another within a single molecule. |
GPI |
GO:0016874 | MF | ligase activity | Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
TMEM129, NEURL1B, RNF103, TRIM38, MID1, SIAH2, PARK2, TRIM13, MYCBP2, RNF8, TRIM37, UBE4B, CNOT4, UCHL1, EGR2, RAG1, TNFAIP3, TRIM23, BRCA1, RANBP2, RNF144A, TTC3, RBX1, UBE2I, XIAP, MDM2, RING1, CBLB, TRIM28, PPIL2, BIRC3, SHPRH, TTLL9, MARCH8, UBR4, MEX3C, RFWD3, RNF19B, RNF111, UBR3, CBLL1, RNF144B, RBBP6, SYVN1, TRIM69, RNF130, MIB1, SIAH1, UBR1, TRIM22, RNF182, TRIML2, RNF152, TRIML1, RNF149, RNF169, MARCH1, RNF128, SH3RF2, TRIM41, MYLIP, RFFL, MIB2, PELI1, ZFP91, UHRF2, UHRF1, BARD1, RNF126, TRIM62, TRIM8, TRIM9, TRIM6, TRIM4, TRIM2, MKRN2, RNF38, ATG10, MARCH7, PELI2, RC3H2, TRIM39, RAD18, RNF146, RNF19A, RLIM, RNF216, RNF181, RNF14, MKRN1, AMFR, PRPF19, STUB1, TRIM33, PDZRN3, RNF6, BTRC, ZNF451, ARIH1, RNF114 |
GO:0016878 | MF | acid-thiol ligase activity | Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
AASDH |
GO:0016881 | MF | acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
TRIM25 |
GO:0016887 | MF | ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. |
VWA8, DDX39A, DDX3X, TOR1A, KIF1C, DHX16, SMARCA5, KIF1B, VPS4B, ATP5H, ATP5L, CLPX, RHOBTB3, KIF20A, ABCA1, ATP1B1, HSP90AA1, HSPA1A, HSPA1B, HSPD1, HSPA5, IDE, PSMC3, ATP5J, ABCD3, ATP5D, ABCC1, MYH9, PSMC2, ATP5C1, MLH1, RFC3, MSH2, PSMC4, NSF, ATP5O, ATP1A2, DNA2, MSH6, BLM, PMS1, VCP, ATP5E, ATP5I, ABCE1, PSMC1, PSMC6, ACTC1, CENPE, KIF23, MYO9B, DYNC1H1, EIF4A2, KIF22, KIF14, PPP2R4, RALBP1, ATAD2, ATF7IP, DNAH12, CHD1L, DNAH10, ATAD1, ABCF1, DNAH5, DNAH11, MYO19, KIF20B, KIF2C, KIFC1, ABCG8, TOR3A, ATP13A2, KIF13B, KIF15, MDN1, DNAH9, DNAH1, STARD9, ABCF2, MLH3, ATP6V1H, MACF1, RUVBL2, RUVBL1, MYH4 |
GO:0016888 | MF | endodeoxyribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. |
TATDN1 |
GO:0016890 | MF | site-specific endodeoxyribonuclease activity, specific for altered base | Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. |
DNA2 |
GO:0016892 | MF | endoribonuclease activity, producing 3'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. |
HRSP12 |
GO:0016896 | MF | exoribonuclease activity, producing 5'-phosphomonoesters | Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. |
DCP2 |
GO:0016901 | MF | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. |
HHIP |
GO:0016903 | MF | oxidoreductase activity, acting on the aldehyde or oxo group of donors | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
XDH |
GO:0016907 | MF | G-protein coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
CHRM2, CHRM3, HRH3 |
GO:0016913 | MF | follicle-stimulating hormone activity | The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. |
FSHB |
GO:0016918 | MF | retinal binding | Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. |
ALDH1A2, RBP4, RBP1 |
GO:0016920 | MF | pyroglutamyl-peptidase activity | Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. |
PGPEP1 |
GO:0016922 | MF | ligand-dependent nuclear receptor binding | Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. |
ARID1A, NCOR1, TADA3, JUND, C1D, NCOA2, NCOA1, SLC30A9, PROX1, NR1H4, PPARGC1A, NCOR2, NCOA3 |
GO:0016925 | BP | protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
BIRC5, NUPL2, RAD21, MITF, NUP155, TP53, HNRNPC, PARP1, EGR2, TOP1, TOP2A, PCNA, TPR, SP100, NUP62, BRCA1, RANGAP1, NUP153, RANBP2, BLM, SUMO3, NUP107, SUMO2, UBE2I, RAE1, MDM2, XPC, SP3, RING1, NUP160, TRIM28, MTA1, XRCC4, TDG, MDC1, SMC1A, CDCA8, SUMO4, SMC5, EID3, NUP93, NFATC2IP, PHC3, NUP43, NUP37, NUP35, TRPM4, NUP210, HDAC7, NUP205, L3MBTL2, SEH1L, AURKB, SENP5, SMC6, NUP88, NDC1, NUP58, NUP85, SENP6, BCL11A, NSMCE4A, SAE1, NUP50, SMC3, ZNF451 |
GO:0016926 | BP | protein desumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. |
FAM76B, FAM76A, SENP5, SENP6, SENP3 |
GO:0016929 | MF | SUMO-specific protease activity | Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates. |
FAM76B, FAM76A, SENP5, SENP6, SENP3 |
GO:0016933 | MF | extracellular-glycine-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
GLRB |
GO:0016934 | MF | extracellular-glycine-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
GLRB |
GO:0016935 | CC | glycine-gated chloride channel complex | A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts. |
GLRB |
GO:0016939 | CC | kinesin II complex | A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes. |
KIFAP3, KIF3A |
GO:0016941 | MF | natriuretic peptide receptor activity | Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. |
NPR3, NPR2 |
GO:0016942 | CC | insulin-like growth factor binding protein complex | A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. |
IGF1, IGFBP3, IGFBP5 |
GO:0016971 | MF | flavin-linked sulfhydryl oxidase activity | Catalysis of the formation of disulfide bridges. |
GFER, QSOX2 |
GO:0016973 | BP | poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
ZC3H11A, HHEX, PABPN1, ZC3H3, NUP93, THOC2, POLDIP3, ENY2, NXF1 |
GO:0016990 | MF | arginine deiminase activity | Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. |
PADI4 |
GO:0016998 | BP | cell wall macromolecule catabolic process | The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. |
LYZL6, LYZ, LYG2 |
GO:0017002 | MF | activin-activated receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
ACVR2A, ACVR1B |
GO:0017005 | MF | 3'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. |
TDP1 |
GO:0017015 | BP | regulation of transforming growth factor beta receptor signaling pathway | Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. |
SMAD7, TGFB1, FOLR1, ITGA3, ZEB1, SMAD3, SMAD4, SMAD2, NREP, EID2, SMURF2, DKK3, TRIM33 |
GO:0017016 | MF | Ras GTPase binding | Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases. |
RAP1A, RAPGEF6, RASSF5, RAPGEF4, CIB1, MAPKAP1, SH3BP4 |
GO:0017017 | MF | MAP kinase tyrosine/serine/threonine phosphatase activity | Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. |
DUSP1, DUSP2, DUSP8, DUSP5, DUSP6, DUSP7, DUSP18, DUSP9, DUSP16, DUSP21, DUSP10 |
GO:0017018 | MF | myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
PPP1CB |
GO:0017020 | MF | myosin phosphatase regulator activity | Modulation of the activity of the enzyme myosin phosphatase. |
DMPK |
GO:0017022 | MF | myosin binding | Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
RALA, DMD, RHOA, ACTC1, CALD1, STX4, MYRIP, TRPM7, MLPH, VEZT, ARFGEF2 |
GO:0017024 | MF | myosin I binding | Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. |
PYCARD |
GO:0017025 | MF | TBP-class protein binding | Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
THRA, PSMC3, PSMC2, PSMC4, GTF2A1, GTF2A2, PSMC1, PSMC6, GTF2B, DR1, HHEX, TAF1B, CAND1, YEATS2 |
GO:0017034 | MF | Rap guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
RAP1A, RAPGEF1 |
GO:0017038 | BP | protein import | The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. |
APOE, CLU, LAMP2, SNX33 |
GO:0017040 | MF | ceramidase activity | Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. |
ASAH1 |
GO:0017042 | MF | glycosylceramidase activity | Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. |
LCT |
GO:0017046 | MF | peptide hormone binding | Interacting selectively and non-covalently with any peptide with hormonal activity in animals. |
INHBA, GHR, PRLR, NPR3, NPR2, OXTR, MC4R, ECE1, AGTR2, ACVR1, GHSR, SLC40A1 |
GO:0017048 | MF | Rho GTPase binding | Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. |
DAPK3, DIAPH2, ROCK2, PAK3, PFN1, FLNA, AKAP13, MYO9B, IQGAP2, DOCK11, ARHGEF16, IQGAP3, ARHGEF2, FMNL2, ECT2, PARD6A, DIAPH3, DAAM1, CDC42BPB |