| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0016316 | MF | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
INPP4B, INPP4A |
GO:0016320 | BP | endoplasmic reticulum membrane fusion | The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. |
VCPIP1 |
GO:0016321 | BP | female meiosis chromosome segregation | The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. |
MLH1, PLK1 |
GO:0016322 | BP | neuron remodeling | The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. |
FARP2, APP, GNAQ, SCARF1, ANKS1A, NTN4 |
GO:0016323 | CC | basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
CASK, SLC22A1, ABCC4, AQP9, CA11, FLOT1, BEST1, MYO1D, EGFR, CA2, PDGFB, LDLR, TGFA, TFRC, ANXA1, ERBB2, SLC4A2, ATP1B1, ANXA2, HSP90AA1, HSP90AB1, IL6R, SLC2A1, CFTR, B4GALT1, EZR, FOLR1, HPGD, CD1D, DSP, EPCAM, CDH2, ATP2B1, CHRM3, C5AR1, ERBB3, ENPP1, ATP2B4, ITGA3, CTNNA2, ADORA1, STX2, ABCC1, CTNNB1, AQP2, SLC19A1, LEPR, NUMB, ATP12A, CXADR, DLG4, PKD1, ANK2, TEK, TJP1, STX4, CDH17, ANK3, DLG1, SLC14A1, ADAM9, DAG1, MAP7, ERBB4, DSTYK, SLCO4C1, PIANP, SLC16A10, AQP3, SLC7A6, MEGF10, SLC29A1, HEPH, CADM1, RHBG, CNNM2, LIN7B, SLC40A1, LIN7C, SLC23A2, SLC7A8, NDRG4, SLC7A7, SLC4A4 |
GO:0016324 | CC | apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
KCNK1, RAB27B, CLDN4, MGAM, ATP8B1, AHCYL1, FZD6, SLC22A5, SORBS2, CLDN1, EGFR, FN1, TF, ANXA1, ERBB2, SLC4A2, ATP1B1, ADRB2, HSP90AA1, SLC3A2, HSP90AB1, IL6R, PDGFRB, LCT, SLC2A1, TDGF1, CFTR, EZR, FOLR1, MUC1, EPCAM, CD36, GJA1, IGFBP2, CDH2, ATP2B1, MAL, ERBB3, CD9, SLC2A5, CA4, DPP4, MIP, OXTR, RDX, CHRNA7, SCNN1A, AQP2, SLC19A1, PRKCI, EPS15, NOTCH1, SLC11A2, PSEN2, RAB27A, SCNN1G, STC1, CACNB3, EMP2, SLC12A2, PTEN, ATP6V0D1, JAG1, ADAM17, SLC7A9, CRB1, LRP2, ANK2, SLC7A5, TEK, PTK2, TJP1, PDE4D, KCNA1, BST2, KCNMA1, HYAL2, STX3, PLD1, TCIRG1, ITPK1, SHROOM2, BMPR2, DSG2, CLCA4, KISS1, STXBP2, VAMP3, SEPT7, OCLN, PTPRO, MFSD4B, CFAP126, SLC39A4, NHS, CSPG4, DRAM2, DSTYK, MTDH, AMOTL1, MUC20, INADL, RAPGEF6, SHROOM3, KCNE4, MAL2, SLC22A18, SLC46A1, OSMR, SLC29A1, CIB1, TRPM6, CDHR2, ABCG8, MUC13, TRPV4, NOX4, SLC52A3, DUOX2, DUOX1, TMEM30A, KL, SLC23A2, TNIK, LZTS1 |
GO:0016327 | CC | apicolateral plasma membrane | The apical end of the lateral plasma membrane of epithelial cells. |
CLDN4, CLDN3, FZD6, JUP, CXADR, TJP1, OCLN |
GO:0016328 | CC | lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
MYO1C, CLDN4, AXIN1, CLDN3, CLDN1, ANXA1, DMD, DRD2, JUP, EPCAM, GJA1, ERBB3, APC, CTNNB1, NSG1, IQGAP1, PKD1, ANK3, DLG1, SNTA1, DSG2, PTPRO, IQGAP3, BVES, TBCD, CORO1C |
GO:0016331 | BP | morphogenesis of embryonic epithelium | The process in which the anatomical structures of embryonic epithelia are generated and organized. |
ALDH1A2, FGFR2, VEGFC, GRSF1 |
GO:0016337 | BP | single organismal cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism. |
NPHP1, PIP5K1C, MPZL2, SRPX2, CTNND1, LRP6, VNN1, EGFR, CSTA, JUP, CD44, CD58, ITGA6, CD24, COL8A2, CTNNA2, CDH5, CTNNB1, SOX9, PSEN1, JAM2, ADAM8, PKD1, COL14A1, DLG1, RAPGEF1, FAT1, NECTIN1, COL13A1, CBLL1, PDPN, DLG5, FBLIM1, GPR98, NRCAM, CYFIP2, VMP1, PKP4, PKP2, SIGLEC1, TTYH1, C10orf54, VEZT, CD93, NECTIN3, PKP3 |
GO:0016338 | BP | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. |
CLDN4, CLDN3, CLDN1 |
GO:0016339 | BP | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
CDH2, CDH13, ATP2C1, CDH17, NLGN1, AJUBA, CDH22, PCDHGC3, PCDHB9, PCDHB3, PCDHB14 |
GO:0016340 | BP | calcium-dependent cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction. |
DAG1, TRPM7 |
GO:0016342 | CC | catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
SMAD7, JUP, CDH2, APC, CTNNA1, CTNNB1, NECTIN1 |
GO:0016344 | BP | meiotic chromosome movement towards spindle pole | The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. |
ACTR3, ACTR2 |
GO:0016358 | BP | dendrite development | The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. |
NRP1, DAB1, PAK3, APP, MAP1B, SCARF1, HDAC2, SYNGAP1, FLRT1, GHRL |
GO:0016361 | MF | activin receptor activity, type I | Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. |
ACVR1B, ACVR1 |
GO:0016362 | MF | activin receptor activity, type II | Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. |
ACVR2B, BMPR2 |
GO:0016363 | CC | nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
ENC1, RGS12, CASK, TGFB1I1, JAK2, PRPF40A, KIF4A, YEATS4, TP53, KRT8, SPARC, POLA1, ALOX5, CEBPB, LMNB1, SFPQ, CFL1, YY1, CAD, MATR3, CENPF, HNRNPM, BLM, ATXN3, ATXN1, ATN1, DCAF7, SATB1, PRKCD, RNASEL, PPIG, MORC3, NONO, ZNF326, CENPW, LRIF1, NSMF, MAEA, SRRM1, PSPC1, AHCTF1, GMCL1, SRPK1, UHRF1, PHB2, TEP1, SORBS1, ZNF350, SPTBN4, SMARCAD1, NUFIP1, SCAF8, SMC3, RUVBL2, RUVBL1, NCOR2 |
GO:0016402 | MF | pristanoyl-CoA oxidase activity | Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. |
ACOX3, ACOX2 |
GO:0016403 | MF | dimethylargininase activity | Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. |
DDAH1, DDAH2 |
GO:0016404 | MF | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. |
ABCC4, HPGD |
GO:0016407 | MF | acetyltransferase activity | Catalysis of the transfer of an acetyl group to an acceptor molecule. |
EP300, KAT6B, CREBBP, KAT6A, KAT2B, NAA15 |
GO:0016409 | MF | palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. |
ZDHHC20, ZDHHC17, ZDHHC14, ZDHHC6, ZDHHC7, ZDHHC2, ZDHHC9 |
GO:0016410 | MF | N-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
HRASLS5 |
GO:0016411 | MF | acylglycerol O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. |
PNPLA2, PNPLA3 |
GO:0016422 | MF | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. |
METTL14 |
GO:0016423 | MF | tRNA (guanine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. |
THUMPD3 |
GO:0016427 | MF | tRNA (cytosine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. |
METTL2B, METTL2A |
GO:0016428 | MF | tRNA (cytosine-5-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. |
NSUN2 |
GO:0016430 | MF | tRNA (adenine-N6-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. |
TRMO |
GO:0016441 | BP | posttranscriptional gene silencing | The inactivation of gene expression by a posttranscriptional mechanism. |
PUM1 |
GO:0016442 | CC | RISC complex | A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. |
EIF4E, DCP2, AGO4, LIMD1, AGO2 |
GO:0016446 | BP | somatic hypermutation of immunoglobulin genes | Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. |
POLQ, UNG, MLH1, MSH2, MSH6, EXO1 |
GO:0016447 | BP | somatic recombination of immunoglobulin gene segments | The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. |
UNG, MSH2, MSH6 |
GO:0016458 | BP | gene silencing | Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. |
DNMT1, SOX6, SIRT2, KMT2B |
GO:0016459 | CC | myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
MYO1G, MYO1D, MYL4, MYL6B, MYL12A, MYL6, MYL7, MYO1E, MYO9B, MYO19, MYO10, MYO5B, MYO5A |
GO:0016460 | CC | myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
MYH9 |
GO:0016461 | CC | unconventional myosin complex | A portmanteau term for myosins other than myosin II. |
MYO1C, MYL6B, MYL6, MYO6 |
GO:0016462 | MF | pyrophosphatase activity | Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. |
ALPL, GMPS, PRUNE2 |
GO:0016469 | CC | proton-transporting two-sector ATPase complex | A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. |
ATP6V1C1, ATP6V1F |
GO:0016471 | CC | vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
ATP6V1G1, ATP6V1G2, ATP6V0D1, TCIRG1, ATP6V1F, ATP6V0A1 |
GO:0016476 | BP | regulation of embryonic cell shape | Any process that modulates the surface configuration of an embryonic cell. |
DAG1, SEPT7 |
GO:0016477 | BP | cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
ITGB1BP1, NRDC, JAK2, SDC3, PRPF40A, SORBS2, TGFB1, ANG, ITGB3, ITGB1, FYN, CDK1, ITGAV, THBS1, PDGFRB, FGR, PTPRF, LAMC1, FGFR1, LCP1, JUP, ARF4, SDC1, CDH2, EFNA1, COL5A1, S1PR1, MDK, JAK1, APC, CD24, CTGF, EPHA3, IL12A, SDC4, SDC2, CSK, PRKCI, PIK3CB, ABL2, CD151, GSK3B, JAK3, EMP2, ADAMTS12, PTEN, RHOA, TGFB2, BTG1, RAB1A, TGFBR3, TNK2, FOXC1, TIAM1, BAMBI, PTK7, ADAM9, NFATC2, DGKZ, CUL3, SHROOM2, GAS6, HES1, FAT1, PTPRK, ERBB4, FSCN1, CCDC88A, CDC42BPA, LRRC16A, STYK1, BRAT1, CSPG4, ARC, WWC1, SCYL3, DEPDC1B, PALLD, NANOS1, KCTD13, ELMO1, RHBDF1, CTHRC1, SPATA13, CORO1B, FUT8, NDEL1, FAM83D, PSTPIP2, CD248, NDE1, ABI2, PAK7, ZRANB1, LIMD1, TAOK2, CDC42BPB, GPC6, ADGRG1 |
GO:0016479 | BP | negative regulation of transcription from RNA polymerase I promoter | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter. |
FLNA |
GO:0016482 | BP | cytosolic transport | The directed movement of substances or organelles within the cytosol. |
SRSF10, ACTR2 |
GO:0016485 | BP | protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
ADAM10, NRDC, PMPCB, FURIN, GLI3, SRGN, CPM, IDE, CPN1, UQCRC2, CTSS, PCSK1, PCSK6, CASP1, UQCRC1, ECE1, PSEN1, PSEN2, MMP14, METAP2, MMP16, CLN3, PTCH1, PITRM1, CPZ, LONP2, AEBP1, PIK3C3, APH1B, PCSK5, APH1A, FKRP, XPNPEP3 |
GO:0016486 | BP | peptide hormone processing | The generation of a mature peptide hormone by posttranslational processing of a prohormone. |
POMC, CGA, FSHB, LHB, SCG5, FURIN, PCSK1, PCSK6, ECE1, PCSK5 |
GO:0016488 | BP | farnesol catabolic process | The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. |
AKR1C3 |
GO:0016491 | MF | oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
DHRS12, SCD, HSD17B6, KDM1A, FADS1, CREG1, F8, CYP1A1, CYP2E1, CYP3A4, CYP2D6, CYP2C9, CYP3A5, CHM, CHML, GDI1, FDFT1, SNCA, GDI2, SESN3, GSTO1, PIGF, PDIA5, ETFDH, DHRS13, HSDL2, SCD5, ERO1B, ZADH2, OXR1, SUMF1, RDH13, ENOX1, RTN4IP1, KIAA1191, ERO1A, FAR2, DHRS1, HTATIP2, ADI1, C1orf43, GSTO2, SEPN1, OSGIN1, DHRS7 |
GO:0016494 | MF | C-X-C chemokine receptor activity | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. |
CXCR2, CXCR4 |
GO:0016501 | MF | prostacyclin receptor activity | Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. |
PTGDR |
GO:0016504 | MF | peptidase activator activity | Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
CLPX, FN1, APP, FBLN1, MMP14, CAV1, PSME4, PCOLCE, PINK1, PCOLCE2 |
GO:0016505 | MF | peptidase activator activity involved in apoptotic process | Increases the activity of a peptidase that is involved in the apoptotic process. |
EBAG9, MAL, CTSC |
GO:0016508 | MF | long-chain-enoyl-CoA hydratase activity | Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. |
HSD17B4 |
GO:0016509 | MF | long-chain-3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
HADHB, HSD17B12 |
GO:0016513 | CC | core-binding factor complex | A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. |
CBFB |
GO:0016514 | CC | SWI/SNF complex | A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. |
ARID1A, ACTL6A, RB1, SMARCA2, SMARCA4, SMARCD3, ARID1B, SMARCC2, SMARCC1, SMARCD1 |
GO:0016517 | MF | interleukin-12 receptor activity | Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IL12RB1 |
GO:0016520 | MF | growth hormone-releasing hormone receptor activity | Combining with growth hormone-releasing hormone to initiate a change in cell activity. |
GHSR |
GO:0016524 | MF | latrotoxin receptor activity | Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
ADGRL2 |
GO:0016525 | BP | negative regulation of angiogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. |
KRIT1, SEMA3E, ANGPT2, ROCK2, AGT, APOH, PF4, KLK3, DCN, THBS1, COL4A2, SPARC, CCL2, NPPB, PTPRM, THBS4, TIE1, SERPINF1, SYNJ2BP, GTF2I, FOXO4, COL4A3, TEK, HHEX, FOXC1, PDE3B, AMOT, SULF1, SEMA4A, RGCC, STAB1, GHRL |
GO:0016528 | CC | sarcoplasm | The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. |
FABP3, FLNC |
GO:0016529 | CC | sarcoplasmic reticulum | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. |
HAX1, NOL3, THBS1, ATP2A2, GSTM2, SRI, THBS4, XDH, CACNA2D1, ANK3, AKAP6, ITPR3, ITPR1, RYR3, SYNE2, RYR2, JSRP1, RASD1, POMT1 |
GO:0016530 | MF | metallochaperone activity | Assists in the delivery of metal ions to target proteins or compartments. |
ATOX1 |
GO:0016531 | MF | copper chaperone activity | Assists in the delivery of copper ions to target proteins or compartments. |
ATOX1, COX17 |
GO:0016532 | MF | superoxide dismutase copper chaperone activity | A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. |
CCS |
GO:0016533 | CC | cyclin-dependent protein kinase 5 holoenzyme complex | A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits. |
CDK5 |
GO:0016538 | MF | cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
CCNT1, CCNT2, CCNE2, CDK4, CCNL2, CCNL1 |
GO:0016540 | BP | protein autoprocessing | Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. |
PARP1, FXN, PCSK9 |
GO:0016553 | BP | base conversion or substitution editing | Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). |
APOBEC3G |
GO:0016554 | BP | cytidine to uridine editing | The conversion of a cytosine residue to uridine in an RNA molecule by deamination. |
RBM47 |
GO:0016557 | BP | peroxisome membrane biogenesis | The process in which a peroxisome membrane is synthesized, aggregates, and bonds together. |
PEX3 |
GO:0016558 | BP | protein import into peroxisome matrix | The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. |
PEX12, PEX14, LONP2 |
GO:0016559 | BP | peroxisome fission | The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. |
ACOT8, PEX11B, SEC16B, MFF |
GO:0016561 | BP | protein import into peroxisome matrix, translocation | The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. |
PEX14 |
GO:0016567 | BP | protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
UBA6, UBE2QL1, TMEM189, ASB14, NEURL1B, RNF103, WWP2, UBE2C, SOCS2, SOCS3, SOCS6, ENC1, BACH1, MDM4, UBD, BIRC5, SOCS1, MED7, PARK2, SOCS5, FBXO24, MYCBP2, FBXO45, UBA1, AKT1, TRIM23, BRCA1, CCNF, UBA7, CDC34, UBE2E1, PLK1, VCP, CDC42, UBE2D3, UBE2M, DCAF7, RBX1, UBE2B, SKP1, XIAP, MDM2, ZBTB16, RAB40B, TRIM28, OS9, BIRC3, MED21, CUL3, CUL7, TCEB2, UBE2V2, DCAF6, DCAF8, KCTD11, RFWD3, SPSB3, KLHL24, CYHR1, PDZRN4, RNF111, UBR3, CBLL1, SYVN1, CAND1, RNF130, MIB1, UBR1, KLHL7, KBTBD2, TRIM22, HACE1, KLHL36, RNF182, TRIML2, TRIML1, KLHL23, RNF149, RNF169, FBXO18, FBXO30, FBXO25, DCAF11, SH3RF2, DCAF4, TRIM41, MYLIP, KCTD13, MED12, FBXO32, FBXW5, ANAPC16, KLHDC7B, MED30, ITCH, VCPIP1, DCAF5, FEM1C, LRR1, ASB16, KLHL5, UHRF2, NEDD4L, MPHOSPH8, CDCA3, BARD1, FEM1A, TRIM62, PINK1, BACH2, TRIM8, TRIM9, TRIM4, TRIM2, KLHL4, MKRN2, RNF38, WWP1, KCTD10, FBXL15, ASB8, AKTIP, RNF121, MED20, MARCH7, PELI2, TRIM39, TULP4, DCAF13, MED17, RLIM, WSB2, KLHL8, KLHL9, KLHL13, SAE1, RNF14, KLHL3, RABGEF1, FBXL7, FEM1B, FBXO10, FBXO9, FBXL2, STUB1, TRIM33, PDZRN3, BTRC, UBE2D4, ARIH1, ASB3, NUB1 |
GO:0016569 | BP | chromatin modification | The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. |
ARID1A, CHD1, CHD2, DAPK3, SMARCA5, BRD4, H2AFY, NCOR1, CBX7, NR3C1, RB1, BRD2, DNMT1, SMARCA1, RBL1, DEK, ATRX, SMARCA4, HIRA, CBX3, TRIM28, IKZF1, TDG, BRD3, ZMYND11, CHD9, BCORL1, PHF19, SMARCD3, EMSY, PBRM1, BAP18, BANP, RCBTB1, ARID1B, SMARCC2, DPF3, SMARCC1, L3MBTL2, SMARCD1, L3MBTL3, RSF1, ANP32E, TSPYL2, CHD8, HMG20A, ASF1B, H2AFY2, CHD7, LRWD1, TLK1, ASF1A, L3MBTL1, MTF2, SPIN1, CABIN1 |
GO:0016570 | BP | histone modification | The covalent alteration of one or more amino acid residues within a histone protein. |
MT3, AURKB, LOXL2 |
GO:0016571 | BP | histone methylation | The modification of histones by addition of methyl groups. |
SATB1, SUZ12, CARM1, CTCFL, EHMT2, PRMT6, PRMT1, WHSC1L1 |
GO:0016572 | BP | histone phosphorylation | The modification of histones by addition of phosphate groups. |
RPS6KA5, CDK1, CDK2, PRKCD, NEK11, BAZ1B |
GO:0016573 | BP | histone acetylation | The modification of a histone by the addition of an acetyl group. |
MBD3, TAF5, NCOA2, EPC2, TADA2B, KAT6B, CREBBP, KAT6A, GTF3C4, CDYL, TRRAP, NCOA3 |
GO:0016574 | BP | histone ubiquitination | The modification of histones by addition of ubiquitin groups. |
SUZ12, HUWE1, UHRF1, USP22 |
GO:0016575 | BP | histone deacetylation | The modification of histones by removal of acetyl groups. |
SAP18, KDM1A, TBL1X, SIN3B, MBD3, PHB, HDAC4, RBBP4, MTA1, HDAC1, CHD4, MORF4L2, ARID4B, BRMS1L, SIRT2, HDAC2, HOPX, TBL1XR1, SUDS3, SAP30L, HMG20B, HDAC6, MORF4L1, HDAC9, HDAC5 |
GO:0016576 | BP | histone dephosphorylation | The modification of histones by removal of phosphate groups. |
EYA2, EYA4, PPM1F |
GO:0016577 | BP | histone demethylation | The modification of histones by removal of methyl groups. |
KDM4B, ARID5B |
GO:0016578 | BP | histone deubiquitination | The modification of histones by removal of ubiquitin groups. |
USP27X, SUPT3H, TAF10, USP34, USP51, ENY2, USP22, TRRAP |
GO:0016579 | BP | protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
USP27X, USP12, USP2, USP1, STAMBP, UCHL1, UCHL3, TNFAIP3, USP6, USP11, ATXN3, USP46, DMWD, JOSD1, USP34, USP31, USP53, USP51, USP54, USP45, USP48, USP32, WDR48, WDR20, BAP1, OTUB2, USP28, USP44, USP42, USP36, USP35, USP25, USP22, USP20, USP15, UCHL5 |
GO:0016580 | CC | Sin3 complex | A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. |
SIN3B, NCOR1, RBBP4, HDAC1, HDAC2, PHF12, SUDS3, FAM60A, MORF4L1 |
GO:0016581 | CC | NuRD complex | An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. |
MBD3, RBBP4, HDAC1, CHD4, GATAD2A, APPL2, HDAC2 |
GO:0016584 | BP | nucleosome positioning | Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. |
SMARCA5, HIST1H1E, HIST1H1C, RSF1 |
GO:0016589 | CC | NURF complex | An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. |
SMARCA5, SMARCA1, RBBP4, BAP18, HMGXB4 |
GO:0016590 | CC | ACF complex | An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair. |
BAZ1A |
GO:0016591 | CC | DNA-directed RNA polymerase II, holoenzyme | Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. |
RPRD1A, MYO6 |
GO:0016592 | CC | mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
MED19, MED7, MED14, MED6, GLI3, CDK8, MED21, PPARGC1B, MED12, MED30, MED15, MED20, MED4, MED17, MED9, THRAP3, MED16 |
GO:0016593 | CC | Cdc73/Paf1 complex | A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. |
RTF1 |
GO:0016594 | MF | glycine binding | Interacting selectively and non-covalently with glycine, aminoethanoic acid. |
CEP104, GLRB |
GO:0016595 | MF | glutamate binding | Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid. |
CEP104, SLC1A3, GCLC |
GO:0016596 | MF | thienylcyclohexylpiperidine binding | Interacting selectively and non-covalently with thienylcyclohexylpiperidine. |
CEP104 |
GO:0016597 | MF | amino acid binding | Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. |
DDAH1, DDAH2, GOT2, ASS1, TH, AGXT, SHMT1, SLC1A3, KARS, TPH2 |