GO:0016023

CC

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

MYO1C, HAX1, KCNK1, WASL, AXIN1, SOCS1, AP2A2, NGF, TFRC, TF, ANG, CLTA, PDGFRB, FGFR1, C5AR1, FGFR2, BDNF, PRDX6, OPRL1, PLA2G4A, ARHGDIB, AGFG1, IST1, CXCR4, DST, KCNA1, HYAL2, MALL, HERC3, EBP, PKN1, CCDC88A, TMEM35, FNBP1L, WLS, CHIC1, TMEM198, SLC39A4, ARHGAP30, SLC30A8, ARL14, COMMD1, ARRDC4, RIN3, PIFO, PHLDA1, SNX33, USP6NL, HPS1, ARHGEF2, PIGT, SGK3, OPTN, STARD4, NRBF2, IFT74, SNX18, FNBP1, NEU1, SIGMAR1, MAPKAP1, ZFYVE21, ANP32E, DUSP16, CD93, RAB6B, SYBU, TAOK2, MYO6, SNX6, SNX9, ARFGEF2

GO:0016024

BP

CDP-diacylglycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

CDS2, GPAT3, LCLAT1, GPAT4, CDS1, GPAM, AGPAT4, AGPAT3

GO:0016028

CC

rhabdomere

The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.

MERTK

GO:0016031

BP

tRNA import into mitochondrion

The directed movement of tRNA, transfer ribonucleic acid, from the cytoplasm into a mitochondrion.

TOMM20

GO:0016032

BP

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IPO5, BIN1, ACOT8, XPO1, NUPL2, CFLAR, EIF4G3, BUB1, SGTA, SYNCRIP, CCNT1, BRD4, NUP155, AP1G2, SNAPIN, HLA-B, HLA-DRA, APOA2, AMBP, MMP1, TP53, SLC25A5, KRT18, KRT8, FYN, RB1, EIF4E, NPM1, LYN, VIM, KRT19, KRT7, HNRNPA1, POLA1, HSPD1, RALA, TOP1, SLC25A4, TPR, UNG, FDPS, CD1D, H2AFX, CREB1, PDGFRA, ATF7, PSMC3, ERCC2, RCC1, VCAM1, POLR2E, CCNA2, PSMB1, FBLN1, SP100, PSMA3, PSMA4, MAPK3, PIK3R1, PSMB8, PSMB9, PSMB4, PSMB5, MAPK1, RBL1, CDC25C, HLA-A, YWHAB, FCGR2B, PSMC2, TRIM23, LTBR, NUP62, IL6ST, PSMB10, STAT3, TSPAN7, SYK, RANBP1, CBX5, CENPA, PSMB3, NUP153, RANBP2, TSC2, MRE11A, GTF2A2, MSH6, RAD23A, NUP107, EIF4A1, ABCE1, RHOA, YWHAE, RBX1, GRB2, DYNLL1, RACK1, UBE2I, RAE1, GTF2B, MDM2, SET, SATB1, C1QBP, BAX, MFGE8, EP300, NUP160, DLG1, CALCOCO2, PAK2, DYNC1I2, HDAC1, CUL2, CUL4A, CDK13, SEPT6, MORC3, EIF4A2, CUL7, KARS, ZMYND11, TCEB1, TAF5, ZYX, MICB, UBR4, CRTC3, ATF7IP, CENPU, SUPT6H, COPS6, WAPL, CARM1, ABI1, NUP93, PDZD8, NUP43, NUP37, NUP35, GADD45GIP1, WDR48, NUP210, GBF1, NUP205, CREBBP, KAT2B, RAD50, CUL5, SEH1L, BICD1, PRMT6, SRPK1, RBM15, SPEN, NUP88, MAP3K5, PAAF1, NDC1, HTATIP2, NUP58, NUP85, ULBP3, PDCL3, SP110, PARD6A, CD93, LMBRD1, RNF216, UCKL1, ABI2, NXF1, ZC3H7B, ATP6V1H, FBXL2, PILRA, NUP50, BTRC, TLN1, HCFC2, WASF2

GO:0016034

MF

maleylacetoacetate isomerase activity

Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.

GSTZ1

GO:0016035

CC

zeta DNA polymerase complex

A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.

REV3L

GO:0016036

BP

cellular response to phosphate starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.

COMT

GO:0016042

BP

lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

PLIN1, PLA2G2A, PRDX6, ADORA1, LIPA, PLA2G5, PPT1, PLCD1, PLA2G16, PAFAH1B2, LIPE, PLCXD2, PLA2G7, PLD1, PAFAH1B3, IAH1, PLA1A, PLCXD3, DAGLB, ABHD4, LIPH, TBL1XR1, PLA2G12A, PLCB1

GO:0016045

BP

detection of bacterium

The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.

CD1D, PGLYRP2

GO:0016046

BP

detection of fungus

The series of events in which a stimulus from a fungus is received and converted into a molecular signal.

TLR4

GO:0016049

BP

cell growth

The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.

ATP6V0E1, NUPR1, SOCS5, TGFB1, TYMS, ITGB3, IL6, EDN1, ITGAV, SLC3A2, AR, BCL2, IL7R, DDX5, ADRA1A, EMP1, EMP3, MTPN, SEC61A1, TGFB2, TGFBR3, NOTCH2, LAMTOR1, BRAT1, SGMS1, NDNF, PRMT6, RRAGC, ATAD3A, PAK7, NDRG4, LAMTOR2

GO:0016050

BP

vesicle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.

WASL, SNX4, EPS15, CAV2, CAV1, SNX1, FNBP1L, ZFYVE16, SNX33, ALS2, SNX18, PINK1, FBXO5, SNX12, SNX6, SNX9, SNX5

GO:0016051

BP

carbohydrate biosynthetic process

The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

ST8SIA6, CHST11

GO:0016052

BP

carbohydrate catabolic process

The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

DERA

GO:0016055

BP

Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

KIAA0922, DDX3X, TAX1BP3, AXIN1, TGFB1I1, HBP1, SNX3, CTNND1, LRP5, VPS26A, LRP6, TNKS, WISP1, WNT2, UBC, DRD2, CPE, PLCG2, APC, CD24, GRK5, CTNNB1, DDIT3, WNT5A, GRK6, CSNK1A1, CSNK1D, CSNK1E, GSK3B, PRKAA2, WNT3, RBX1, RPS27A, UBA52, SKP1, DAB2, XIAP, NDP, HHEX, TLE1, TLE3, AES, CUL3, KLHL12, WLS, TMEM198, CPZ, SOSTDC1, USP34, NPHP3, ZBTB33, TRABD2A, AMOTL1, APCDD1, CCAR2, RTF1, WNT2B, DACT3, ZBED3, KREMEN1, VPS35, PITX2, SOST, RSPO3, WNT5B, TNKS2, LGR6, CSNK1G1, BRD7, CYLD, RNF146, DACT1, MARK1, DKK3, VPS29, DKK2, ZRANB1, HMGXB4, TNIK, FZD4, NDRG2, MACF1, INVS, BTRC, WIF1, LRRFIP2, SPIN1, WNT6, CSNK1G3

GO:0016056

BP

rhodopsin mediated signaling pathway

The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.

CNGA1, GNB1

GO:0016062

BP

adaptation of rhodopsin mediated signaling

The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.

RDH11

GO:0016064

BP

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

BCL10, CD74, IL4R, CD27, PRKCD, INPP5D

GO:0016070

BP

RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

RBFOX2, DUSP11, TSN, DDX54, DDX24

GO:0016071

BP

mRNA metabolic process

The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

CEBPG, PABPC3

GO:0016072

BP

rRNA metabolic process

The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.

NIFK

GO:0016075

BP

rRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.

EXOSC6, XRN1, EXOSC4, DIS3

GO:0016077

BP

snoRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.

NUDT16

GO:0016079

BP

synaptic vesicle exocytosis

Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.

PIP5K1C, SNAPIN, SNAP25, VAMP2, CDK5, CPLX2, TRIM9, PCLO

GO:0016080

BP

synaptic vesicle targeting

The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.

PSEN1, NLGN1

GO:0016081

BP

synaptic vesicle docking

The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component.

SNAP25, STX3, BLOC1S6

GO:0016082

BP

synaptic vesicle priming

A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.

SNAP23, SYNJ1, SNAP29, SNAP25

GO:0016098

BP

monoterpenoid metabolic process

The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.

CYP2E1, CYP3A4, CYP2D6, CYP2C9

GO:0016101

BP

diterpenoid metabolic process

The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.

EGFR, SRD5A1, STAR, PDE3A

GO:0016125

BP

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

CYP17A1, CYP11A1, CYP21A2, FDX1, CYP19A1, CYP11B1, CYP11B2, CYP1B1, CYP51A1, FDX1L, CYP4V2, EBPL, CYP8B1

GO:0016126

BP

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

TM7SF2, CH25H, SQLE, MSMO1

GO:0016137

BP

glycoside metabolic process

The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.

TH

GO:0016139

BP

glycoside catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.

FUCA1, FUCA2, GBA2

GO:0016150

MF

translation release factor activity, codon nonspecific

A translation release factor that is not specific to particular codons; binds to guanine nucleotides.

ICT1, C12orf65

GO:0016151

MF

nickel cation binding

Interacting selectively and non-covalently with nickel (Ni) cations.

CA3

GO:0016154

MF

pyrimidine-nucleoside phosphorylase activity

Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate.

TYMP

GO:0016155

MF

formyltetrahydrofolate dehydrogenase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH.

ALDH1L1, ALDH1L2

GO:0016160

MF

amylase activity

Catalysis of the hydrolysis of amylose or an amylose derivative.

MGAM

GO:0016174

MF

NAD(P)H oxidase activity

Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.

KMO, AIFM1, NOX4, DUOX2, DUOX1

GO:0016175

MF

superoxide-generating NADPH oxidase activity

Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.

CYBB, NCF2, NOX5, NOX4

GO:0016176

MF

superoxide-generating NADPH oxidase activator activity

Increases the activity of the enzyme superoxide-generating NADPH oxidase.

SH3PXD2B, PDGFB, NCF4, NOXA1

GO:0016180

BP

snRNA processing

Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.

CPSF3L, INTS3, INTS1, INTS4, INTS7, INTS10, INTS6

GO:0016188

BP

synaptic vesicle maturation

Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.

SNAPIN, STXBP1, DLG4, PICALM

GO:0016189

BP

synaptic vesicle to endosome fusion

Fusion of a synaptic vesicle with an endosome.

EEA1

GO:0016191

BP

synaptic vesicle uncoating

The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.

SYNJ1

GO:0016192

BP

vesicle-mediated transport

A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

TBC1D4, RAB11FIP3, AP1G2, ZFPL1, KIF20A, SFT2D2, LRPAP1, PRKCI, NSF, TSC2, GDI2, VAMP7, AP1S2, NCALD, RAB11A, RAB1A, VAMP2, AP1B1, GOLGA4, PICALM, RABEP1, SEC23A, TRIP10, VAMP3, ARL17A, AHI1, BVES, RAB2B, SFT2D1, ARAP3, YIPF5, RAB39B, FNBP1, OSBPL1A, SPTBN4, BLZF1, SYTL2, ARFGAP3, FMN2, ADAMTS9, VTI1B, GGA2, GGA1, MYO5B, MAPK8IP3, MAPK8IP1, ERGIC3, GOLT1B, MYO5A

GO:0016197

BP

endosomal transport

The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

VPS37C, WASH1, DCLK1, AP5Z1, CHMP2A, VPS4B, STAM2, RASSF9, ABCA1, UBC, NSG1, RPS27A, UBA52, BLOC1S1, PICALM, SQSTM1, ZFYVE16, VPS37A, SNX33, STAM, ALS2, SNX18, TINAGL1, AP5M1, CHMP4B, VTA1, SNX9

GO:0016198

BP

axon choice point recognition

The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth.

GAP43

GO:0016199

BP

axon midline choice point recognition

The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.

APP, ROBO3, ROBO2

GO:0016202

BP

regulation of striated muscle tissue development

Any process that modulates the frequency, rate or extent of striated muscle development.

TGFB1, CENPF, MTPN, SMAD3

GO:0016203

BP

muscle attachment

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).

DMD

GO:0016206

MF

catechol O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

COMT

GO:0016208

MF

AMP binding

Interacting selectively and non-covalently with AMP, adenosine monophosphate.

CYB5R3, APRT, FBP1, PRKAG1, PRPS1, ACSS2, ACSS1

GO:0016209

MF

antioxidant activity

Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

HP, APOE, ALB, S100A9, MT3, PRDX2, AAED1, TP53INP1, VIMP, FAM213A

GO:0016212

MF

kynurenine-oxoglutarate transaminase activity

Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

GOT2

GO:0016213

MF

linoleoyl-CoA desaturase activity

Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O.

FADS2

GO:0016222

CC

procollagen-proline 4-dioxygenase complex

A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.

P4HB, P4HA1

GO:0016226

BP

iron-sulfur cluster assembly

The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

CIAO1, IBA57, ISCA1, FAM96A, NFU1, FAM96B

GO:0016229

MF

steroid dehydrogenase activity

Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.

HSD17B11

GO:0016230

MF

sphingomyelin phosphodiesterase activator activity

Increases the activity of the enzyme sphingomyelin phosphodiesterase.

STX4, NSMAF

GO:0016231

MF

beta-N-acetylglucosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides.

MGEA5

GO:0016233

BP

telomere capping

A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.

TERF1, HIST1H4A, PRKDC, ACD, OBFC1, POT1

GO:0016234

CC

inclusion body

A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.

HSP90AB1, HSPA1A, HSPA1B, GYS1, MT3, SNCA, PSMC4, SQSTM1, HDAC6, MIOX, BAG5

GO:0016235

CC

aggresome

An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.

UBD, PARK2, TRIM37, EEF2, POLD1, EPS15, PSEN1, SQSTM1, RAB11B, DBF4B, SYNE2, MVB12A, SEC62, HDAC6, GIT1, ORC6, EID1, CABIN1

GO:0016236

BP

macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

PARK2, ATG13, ULK1, ATG12, MFN2, TOMM40, UBC, PRKAG1, PRKAA2, GABARAPL2, RPS27A, UBA52, DYNLL1, CLN3, TCIRG1, SQSTM1, NBR1, RHEB, TOMM20, WIPI1, LAMTOR1, TOMM5, PIK3C3, RB1CC1, OPTN, PIK3R4, MLST8, PINK1, MAP1LC3B, GABARAPL1, ATG10, MAP1LC3A, RRAGC, ZFYVE1, RRAGD, TOMM22, TOMM7, HDAC6, PRKAG3, LAMTOR3, LAMTOR2, WIPI2

GO:0016239

BP

positive regulation of macroautophagy

Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.

SUPT5H, BNIP3L, TRIM13, ULK1, EPM2A, DCN, HMOX1, PRKAA2, SESN2, PAFAH1B2, BNIP3, SQSTM1, HIF1A, RAB12, LARP1, WAC, PINK1, SCOC

GO:0016241

BP

regulation of macroautophagy

Any process that modulates the frequency, rate or extent of macroautophagy.

ATP6V0E1, ATP6V1G1, VPS26A, ERN1, ATP6V1G2, GAPDH, UCHL1, ATP6V1B2, ATP6V1C1, MAPK8, PRKAA2, ATP6V0D1, CDK5, ATP6V1C2, ATP6V0A1, EXOC4, VPS35, ATP13A2, EXOC1, ATP6V1H, SNX6, EXOC7, SH3GLB1, ATP6V1D, SNX5

GO:0016242

BP

negative regulation of macroautophagy

Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.

NPC1, CLN3, PINK1, NRBP2, LZTS1, POLDIP2

GO:0016243

BP

regulation of autophagosome size

Any process that modulates the size of the autophagosome.

ATP13A2

GO:0016247

MF

channel regulator activity

Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.

CACNG8

GO:0016248

MF

channel inhibitor activity

Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.

BCL2

GO:0016250

MF

N-sulfoglucosamine sulfohydrolase activity

Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate.

SGSH

GO:0016254

BP

preassembly of GPI anchor in ER membrane

The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.

PIGA, PIGF, PIGH, PIGG, PIGW, PIGX, PIGC

GO:0016255

BP

attachment of GPI anchor to protein

A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain.

PLAUR, PGAP1, PIGK, PIGT, PIGU

GO:0016256

BP

N-glycan processing to lysosome

The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome.

GNPTAB, GNPTG

GO:0016259

BP

selenocysteine metabolic process

The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.

SARS, SEPSECS

GO:0016262

MF

protein N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein.

OGT

GO:0016264

BP

gap junction assembly

Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.

GJA1, CTNNA1, GJA5, GJC1, PKP2

GO:0016266

BP

O-glycan processing

The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure.

B4GALT5, ST6GAL1, MUC1, MUC5AC, MUC3A, GALNT2, GALNT1, ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, MUC21, GALNT5, GALNT7, GALNT10, MUC20, MUC15, GALNT15, GALNT4, XXYLT1, CHST4, B3GNT7, MUCL1, GALNT14, MUC4, B3GNT5, MUC13, ST6GALNAC4, B3GNT2, ST6GALNAC2

GO:0016272

CC

prefoldin complex

A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.

PFDN6, PFDN5, PFDN4

GO:0016274

MF

protein-arginine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.

PRMT3, CARM1, PRMT6, PRMT1

GO:0016278

MF

lysine N-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.

SETD9, KMT5A

GO:0016279

MF

protein-lysine N-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.

EZH2, METTL10, ETFBKMT, SETD6, SETD7, N6AMT2, METTL21A, EHMT2, KMT5A

GO:0016281

CC

eukaryotic translation initiation factor 4F complex

The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.

EIF4G3, EIF4E, EIF4B, EIF4A1, EIF4A2

GO:0016282

CC

eukaryotic 43S preinitiation complex

A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.

EIF3J, EIF3B, EIF3A, DHX29, EIF3K

GO:0016287

MF

glycerone-phosphate O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA.

GNPAT

GO:0016289

MF

CoA hydrolase activity

Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group.

ACOT8, NUDT7

GO:0016290

MF

palmitoyl-CoA hydrolase activity

Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

ACOT7, ACOT8, GNPAT, PPT1, THEM4, ACOT4

GO:0016295

MF

myristoyl-[acyl-carrier-protein] hydrolase activity

Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate.

FASN

GO:0016296

MF

palmitoyl-[acyl-carrier-protein] hydrolase activity

Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate.

FASN

GO:0016298

MF

lipase activity

Catalysis of the hydrolysis of a lipid or phospholipid.

LYPLA1, AADAC, LIPA

GO:0016301

MF

kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

CDC7, PIK3CD, CHEK1, FAM20B, RAF1, CCL3, BCR, PRPS2, PKM, CDK2, MAPK3, MAPK1, WEE1, AKT1, CSK, PIK3CA, PIK3CB, MAPK8, CSNK1A1, PIK3CG, GSK3B, CDK7, IRAK1, PLK1, PRPS1, CDK5, DGKZ, PRKD1, RPS6KA2, RPS6KA1, PKN2, CERKL, SGMS1, PIK3C3, SGMS2, MASTL, NEK1, PKMYT1, PINK1, TPK1, TRRAP

GO:0016303

MF

1-phosphatidylinositol-3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).

PIK3CD, PIK3C2A, FGF18, FGF19, FGF2, FGFR1, FGF7, FGFR2, PIK3R1, FGF9, IRS1, PIK3CA, PIK3CB, PIK3CG, GRB2, PTPN11, GAB1, PIK3C3, FRS2, PIK3R4, KL, IRS2

GO:0016308

MF

1-phosphatidylinositol-4-phosphate 5-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).

PIP5K1B, PIP5K1C, PIP4K2B, PIKFYVE

GO:0016309

MF

1-phosphatidylinositol-5-phosphate 4-kinase activity

Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

PIP4K2B

GO:0016310

BP

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

TK2, PIK3CD, PDXK, FAM20B, PAPSS2, PGK1, TK1, TOP1, PRPS2, CKB, CKMT1A, CKMT2, MAPK3, DCK, EPHB2, AKT1, GK, CHKA, STAT3, HTR2B, PIK3CA, PIK3CB, PIK3CG, SEPHS1, LIMK2, ALDH18A1, PRPS1, CDK5, MVK, TNK2, COASY, PAK2, ITPK1, CERKL, NADK2, DGKK, IDNK, PPIP5K1, GK5, SGMS1, DGKH, SGMS2, DCAKD, RFK, PINK1, PANK2, UCK2, TOLLIP, TPK1, PANK3, UCK1, ETNK1, NMRK1, UCKL1, LIMD1, SHPK, AK3, CHKB, TRRAP

GO:0016311

BP

dephosphorylation

The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.

FBP2, INPP4B, PFKFB2, ALPL, CA3, BPGM, PTPRC, FBP1, ACPP, PFKFB1, PGAM1, NT5E, PTPRB, PON1, DUSP3, PPP1CA, PPP3CA, DUSP8, ITPK1, LPIN1, DUSP5, PFKFB3, PFKFB4, PPIP5K1, NT5DC3, THNSL2, SGPP2, DUSP18, NT5C, PXYLP1, NUDT16, INPP4A, INPP5K, G6PC3, DUSP23, DUSP16, NT5DC2, ACP6, DUSP13, MINPP1, DUSP10

GO:0016312

MF

inositol bisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate.

INPP5K

GO:0016314

MF

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.

PTEN, INPP5D