| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0014704 | CC | intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
OBSL1, ATP1B1, ITGB1, JUP, DSP, GJA1, DES, CDH2, CTNNA1, GJA5, GJC1, ATP1A2, HAMP, ANK2, DSC2, YWHAH, TJP1, ANK3, DLG1, AKAP6, CAMK2D, DSG2, KCNJ11, TMEM65, FGF13, PKP2, RANGRF |
GO:0014706 | BP | striated muscle tissue development | The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. |
EYA2, IFRD1 |
GO:0014707 | BP | branchiomeric skeletal muscle development | The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish. |
TCF21 |
GO:0014718 | BP | positive regulation of satellite cell activation involved in skeletal muscle regeneration | Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. |
SOX15, CAPN3 |
GO:0014719 | BP | skeletal muscle satellite cell activation | The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. |
MEGF10 |
GO:0014722 | BP | regulation of skeletal muscle contraction by calcium ion signaling | Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction. |
DMPK |
GO:0014731 | CC | spectrin-associated cytoskeleton | The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. |
SPTBN1, ANK3, RHBG |
GO:0014732 | BP | skeletal muscle atrophy | A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. |
MSTN, CFLAR, PPARGC1A |
GO:0014736 | BP | negative regulation of muscle atrophy | Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy. |
NOL3 |
GO:0014740 | BP | negative regulation of muscle hyperplasia | Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia. |
KLF4, NOS3 |
GO:0014741 | BP | negative regulation of muscle hypertrophy | Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. |
MSTN |
GO:0014805 | BP | smooth muscle adaptation | Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. |
IL1B |
GO:0014806 | BP | smooth muscle hyperplasia | A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ. |
HMOX1, NOS3 |
GO:0014807 | BP | regulation of somitogenesis | Any process that modulates the frequency, rate or extent of somitogenesis. |
NOTCH1 |
GO:0014808 | BP | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. |
NOL3, CCL3, RYR2 |
GO:0014809 | BP | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
DMD, GSTM2 |
GO:0014810 | BP | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
GSTO1 |
GO:0014816 | BP | skeletal muscle satellite cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a satellite cell. |
MEGF10, SEPN1 |
GO:0014819 | BP | regulation of skeletal muscle contraction | Any process that modulates the frequency, rate or extent of skeletal muscle contraction. |
DMD |
GO:0014820 | BP | tonic smooth muscle contraction | A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction. |
MYLK |
GO:0014823 | BP | response to activity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. |
ANGPT2, BGLAP, NTRK1, EDN1, CDK1, TH, HSPD1, CCL2, ALAD, CREB1, BMP6, IL10, UQCRC1, PCK1, LEP, GCLC, GCLM, STAR, OXCT1, UCP3, PRKDC, HSF1, PPARD, ADIPOQ, HADH, TPH2, DNMT3B, MYH2, HDAC5, MYH4 |
GO:0014824 | BP | artery smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart. |
AGT, EDN1, EDN2, EDNRA, BBS2, MKKS |
GO:0014826 | BP | vein smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds. |
EDN1, EDN2 |
GO:0014827 | BP | intestine smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. |
HTR2B, PTGER3 |
GO:0014829 | BP | vascular smooth muscle contraction | A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. |
PIK3C2A, RAP1GDS1, ACTA2 |
GO:0014834 | BP | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells. |
FZD7, IGF1, EZH2, SEPN1 |
GO:0014835 | BP | myoblast differentiation involved in skeletal muscle regeneration | The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
MAPK14 |
GO:0014839 | BP | myoblast migration involved in skeletal muscle regeneration | The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
ANXA1 |
GO:0014841 | BP | skeletal muscle satellite cell proliferation | The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. |
MEGF10 |
GO:0014842 | BP | regulation of skeletal muscle satellite cell proliferation | Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation. |
CFLAR, PPARD, ANGPT1, PAXBP1 |
GO:0014843 | BP | growth factor dependent regulation of skeletal muscle satellite cell proliferation | Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. |
FGF2 |
GO:0014846 | BP | esophagus smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract. |
SULF2, SULF1 |
GO:0014850 | BP | response to muscle activity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. |
MSTN, ITGA2, SRD5A1, CAPN3, ADSL, PRKAA2, POSTN, HIF1A, TNS2, ADSSL1, RYR2, PPARGC1A |
GO:0014853 | BP | regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction | Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
DMPK |
GO:0014854 | BP | response to inactivity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. |
DRD2, IL10 |
GO:0014858 | BP | positive regulation of skeletal muscle cell proliferation | Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. |
SEPN1 |
GO:0014866 | BP | skeletal myofibril assembly | The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. |
CFLAR |
GO:0014873 | BP | response to muscle activity involved in regulation of muscle adaptation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation. |
AGT, SEPN1 |
GO:0014876 | BP | response to injury involved in regulation of muscle adaptation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation. |
NOL3 |
GO:0014878 | BP | response to electrical stimulus involved in regulation of muscle adaptation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. |
PPARGC1A |
GO:0014883 | BP | transition between fast and slow fiber | The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. |
TNNT1, ATP2A2, PPP3CA |
GO:0014886 | BP | transition between slow and fast fiber | The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. |
GTF2I |
GO:0014894 | BP | response to denervation involved in regulation of muscle adaptation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. |
HDAC4, FBXO32, MTMR4 |
GO:0014896 | BP | muscle hypertrophy | The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. |
IGF1 |
GO:0014898 | BP | cardiac muscle hypertrophy in response to stress | The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. |
ATP2A2, HDAC4, MEF2C, PPP3CA, EZH2, GATA6, KLF15 |
GO:0014902 | BP | myotube differentiation | The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
SKI, MEF2C, MYEF2 |
GO:0014904 | BP | myotube cell development | The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
IGF1, NFATC2, SMYD3 |
GO:0014909 | BP | smooth muscle cell migration | The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. |
PLAU, PLAT, ITGB3, DDR1 |
GO:0014910 | BP | regulation of smooth muscle cell migration | Any process that modulates the frequency, rate or extent of smooth muscle cell migration. |
PLAU, PDGFA, ACE, SORL1, PLXNA1 |
GO:0014911 | BP | positive regulation of smooth muscle cell migration | Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. |
NRP1, PDGFB, VTN, IGF1, PDGFRB, BCL2, CCL5, ITGA2, HDAC4, FOXO4, CAMK2D, POSTN, SEMA6D, HAS2, RETN, NOX4 |
GO:0014912 | BP | negative regulation of smooth muscle cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. |
SLIT2, SERPINE1, IGFBP3, IGFBP5, BMPR1A, PPARD, ILK, ADIPOQ, SEMA6D, TRIB1, PPARGC1A, NDRG4 |
GO:0014916 | BP | regulation of lung blood pressure | The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
BMPR2 |
GO:0015012 | BP | heparan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. |
NDST1, EXT1, EXT2, XYLT2, DSE, HS3ST3B1 |
GO:0015014 | BP | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan. |
EXT1, CSGALNACT1, EXT2 |
GO:0015015 | BP | heparan sulfate proteoglycan biosynthetic process, enzymatic modification | The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. |
HS6ST1, HS6ST2, HS3ST3B1 |
GO:0015016 | MF | [heparan sulfate]-glucosamine N-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. |
NDST1 |
GO:0015019 | MF | heparan-alpha-glucosaminide N-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. |
HGSNAT |
GO:0015020 | MF | glucuronosyltransferase activity | Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
B4GAT1, LARGE, UGT2B4, EXT1, UGT2A3, CSGALNACT1, EXT2 |
GO:0015026 | MF | coreceptor activity | Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. |
NRP1, RAMP1, RAMP3, CD4, ITGB3, ITGB1, ITGAV, CD28, ACVR2A, CXCR4, TGFBR3, NECTIN1, RGMB |
GO:0015030 | CC | Cajal body | A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
XPO1, PRPF3, OIP5, ZPR1, SNRPC, CDK2, COIL, FMR1, NPAT, SART3, ICE2, DDX46, TRIM22, PRPF31, ISG20, EAF1, PHAX, SRRM2 |
GO:0015031 | BP | protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
VPS37C, UNC119B, WASH1, BBIP1, GPR89A, SNAP23, EXOC5, ARHGAP33, COPE, ITGB1BP1, RAB29, NACAD, SCAMP1, SCAMP2, AP5Z1, CHMP2A, ACTN4, KDELR3, SNX3, EXOC3, RAMP1, RAMP3, VPS4B, SEC22B, RP2, SEC31A, SNX4, KIF20A, TNKS, SFT2D2, SNAP29, COL1A1, GPR89B, HSP90B1, XBP1, ARF4, BTF3, RAB3B, RAB5A, GDI1, MYH9, EPS15, NASP, CENPF, PSEN1, GDI2, PPT1, RAB5C, RAB7A, RAB9A, IST1, GABARAPL2, RAB4B, RAB2A, RAB5B, STXBP1, RAB11A, RAP1A, VAMP2, ARF1, ARF5, DAB2, PPID, NUP160, SELENBP1, UNC119, GPM6B, MTM1, COG2, RABEP1, STXBP2, SLC15A2, DUOXA1, DUOXA2, C11orf73, CCDC93, DOPEY1, STXBP5, DENND4C, RAB12, AFTPH, RAB11FIP1, PGAP1, MON2, CCDC91, VPS13B, TMED4, HOOK3, FRAS1, ERC1, ARL17A, BBS7, VPS52, VPS8, COMMD1, SLC15A4, ARFGAP2, ATG16L2, VPS37A, NUP43, NUP37, MCFD2, KIF18A, TTC8, DENND1A, NUP210, IPO4, SCFD2, RAB2B, PDCD6IP, SFT2D1, AHCTF1, GBF1, SCAMP4, YIPF5, SNX21, EXOC4, RHBDF1, RAB39B, HOOK2, SEH1L, MVB12A, C5orf30, SEC22A, SEC16B, EXOC2, ANKRD27, LYST, NDC1, EIF5A2, AP5M1, RAB1B, LMAN2L, ATG10, PHAX, AKTIP, ECT2, PLEKHF2, SEC61A2, LIN7B, GOPC, VTA1, ENY2, PARP11, EIF4ENIF1, RAB6B, LIN7C, EXOC1, SDAD1, BET1L, FMN2, RRBP1, ADAMTS9, DMBT1, RAB21, RAB22A, RAB23, MYO5B, SNX12, NPIPA1, AGAP1, EXOC7, STXBP5L, COG6, SNX24, TMED5, CCDC53, GOLT1B, TMED3, AP4S1, DNAJC15, ARFGEF2 |
GO:0015035 | MF | protein disulfide oxidoreductase activity | Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. |
CCS, TXN, GFER, TXNRD1, ERO1B, DNAJC10, STAB2, ERO1A, TXN2, SH3BGRL3, GLRX2, STAB1, GSTK1 |
GO:0015036 | MF | disulfide oxidoreductase activity | Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. |
PDIA3, DNAJC10, ERO1A |
GO:0015037 | MF | peptide disulfide oxidoreductase activity | Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds. |
TXN |
GO:0015038 | MF | glutathione disulfide oxidoreductase activity | Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. |
GLRX, GLRX2 |
GO:0015052 | MF | beta3-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. |
ADRB3 |
GO:0015054 | MF | gastrin receptor activity | Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. |
CCKBR |
GO:0015057 | MF | thrombin receptor activity | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
F2R, F2RL1 |
GO:0015068 | MF | glycine amidinotransferase activity | Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. |
GATM |
GO:0015074 | BP | DNA integration | The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. |
BANF1 |
GO:0015075 | MF | ion transmembrane transporter activity | Enables the transfer of an ion from one side of a membrane to the other. |
S100A6, GJA1, SFXN4, SFXN3, SFXN1, ATP11B, TRPV2 |
GO:0015078 | MF | hydrogen ion transmembrane transporter activity | Enables the transfer of hydrogen ions from one side of a membrane to the other. |
ATP5L, ATP5J, ATP6V1B2, SLC11A2, ATP5I, ATP6V1F, SLC36A1, SLC46A1 |
GO:0015079 | MF | potassium ion transmembrane transporter activity | Enables the transfer of potassium ions (K+) from one side of a membrane to the other. |
KCNA1 |
GO:0015081 | MF | sodium ion transmembrane transporter activity | Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. |
TRAPPC10 |
GO:0015085 | MF | calcium ion transmembrane transporter activity | Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. |
ITPR2, ITPR1 |
GO:0015086 | MF | cadmium ion transmembrane transporter activity | Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. |
SLC11A2 |
GO:0015087 | MF | cobalt ion transmembrane transporter activity | Enables the transfer of cobalt (Co) ions from one side of a membrane to the other. |
SLC11A2 |
GO:0015088 | MF | copper uptake transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in). |
SLC31A1 |
GO:0015091 | MF | ferric iron transmembrane transporter activity | Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
TF |
GO:0015093 | MF | ferrous iron transmembrane transporter activity | Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. |
SLC11A2, SLC39A14, SLC40A1, SLC25A37 |
GO:0015094 | MF | lead ion transmembrane transporter activity | Enables the transfer of lead (Pb) ions from one side of a membrane to the other. |
SLC11A2 |
GO:0015095 | MF | magnesium ion transmembrane transporter activity | Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. |
ZDHHC17, NIPA2, SLC41A2, CNNM2, MRS2 |
GO:0015098 | MF | molybdate ion transmembrane transporter activity | Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. |
MFSD5 |
GO:0015101 | MF | organic cation transmembrane transporter activity | Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. |
SLC22A1, SLC22A3, SLC7A8 |
GO:0015105 | MF | arsenite transmembrane transporter activity | Enables the transfer of arsenite from one side of a membrane to the other. |
ASNA1 |
GO:0015106 | MF | bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
BEST1, CFTR, SLC26A2, SLC26A11, SLC26A1 |
GO:0015108 | MF | chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
CFTR, SLC26A1 |
GO:0015111 | MF | iodide transmembrane transporter activity | Enables the transfer of iodide ions from one side of a membrane to the other. |
SLC5A5 |
GO:0015114 | MF | phosphate ion transmembrane transporter activity | Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. |
ANKH |
GO:0015116 | MF | sulfate transmembrane transporter activity | Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. |
SLC26A2, SLC26A11, SLC26A1 |
GO:0015125 | MF | bile acid transmembrane transporter activity | Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
SLCO2B1 |
GO:0015129 | MF | lactate transmembrane transporter activity | Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
SLC16A6, SLC16A3, SLC16A7, SLC16A12 |
GO:0015132 | MF | prostaglandin transmembrane transporter activity | Enables the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
SLCO2A1 |
GO:0015137 | MF | citrate transmembrane transporter activity | Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. |
SLC25A1 |
GO:0015142 | MF | tricarboxylic acid transmembrane transporter activity | Enables the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. |
SLC25A1 |
GO:0015152 | MF | glucose-6-phosphate transmembrane transporter activity | Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. |
SLC37A4 |
GO:0015165 | MF | pyrimidine nucleotide-sugar transmembrane transporter activity | Enables the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
SLC35D2, SLC35D1 |
GO:0015166 | MF | polyol transmembrane transporter activity | Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. |
AQP9, SLC5A11 |
GO:0015168 | MF | glycerol transmembrane transporter activity | Enables the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
AQP2 |
GO:0015171 | MF | amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
SLC6A6, SLC1A3, SLC1A2, SLC1A4, SLC1A6, SLC7A2, PEX3, SLC7A5, SLC1A5, SLC36A1, SLC38A9, SLC16A10, SLC38A5, SLC7A6, SLC38A1, SLC38A10, SLC7A8, SLC6A14 |