| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0010710 | BP | regulation of collagen catabolic process | Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. |
ITGB1 |
GO:0010711 | BP | negative regulation of collagen catabolic process | Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. |
CST3 |
GO:0010714 | BP | positive regulation of collagen metabolic process | Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. |
RETN |
GO:0010715 | BP | regulation of extracellular matrix disassembly | Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. |
ETS1, DDR1 |
GO:0010716 | BP | negative regulation of extracellular matrix disassembly | Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. |
CST3, TGFB1, DPP4 |
GO:0010717 | BP | regulation of epithelial to mesenchymal transition | Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
FAM195B, SMAD7, GREM1, EPHA3, TGFBR1, DAG1, PHLDB2, PHLDB1 |
GO:0010718 | BP | positive regulation of epithelial to mesenchymal transition | Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
SDCBP, TGFB1I1, TGFB1, COL1A1, BMP2, SERPINB3, CTNNB1, TGFBR1, TGFBR2, NOTCH1, TGFB2, SMAD3, DAB2, BAMBI, SMAD4, TWIST1, SMAD2, EZH2, GCNT2, HDAC2, OLFM1, GLIPR2, RGCC |
GO:0010719 | BP | negative regulation of epithelial to mesenchymal transition | Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
SMAD7, EFNA1, PBLD, NKX2-1, SFRP1, ADIPOR1, DACT3, TRIM62 |
GO:0010722 | BP | regulation of ferrochelatase activity | Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. |
FXN |
GO:0010724 | BP | regulation of definitive erythrocyte differentiation | Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis. |
RBFOX2 |
GO:0010725 | BP | regulation of primitive erythrocyte differentiation | Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis. |
KDM1A |
GO:0010727 | BP | negative regulation of hydrogen peroxide metabolic process | Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. |
HDAC6 |
GO:0010729 | BP | positive regulation of hydrogen peroxide biosynthetic process | Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
ZNF205 |
GO:0010730 | BP | negative regulation of hydrogen peroxide biosynthetic process | Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
STAT3 |
GO:0010734 | BP | negative regulation of protein glutathionylation | Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. |
G6PD |
GO:0010735 | BP | positive regulation of transcription via serum response element binding | Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. |
MICAL2 |
GO:0010737 | BP | protein kinase A signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
GCG, LCP1, EZR, GAL, RDX |
GO:0010738 | BP | regulation of protein kinase A signaling | Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
AIP, FSHR, AKAP6, SPHKAP, AKAP1, AKAP7, AKAP11 |
GO:0010739 | BP | positive regulation of protein kinase A signaling | Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
MIF, ADIPOQ |
GO:0010742 | BP | macrophage derived foam cell differentiation | The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
TGFB1, SOAT1, PPARG, EP300 |
GO:0010744 | BP | positive regulation of macrophage derived foam cell differentiation | Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
AGT, PF4, APOB, LPL, PLA2G2A, CD36, NFKB1, AGTR1, MAPK9, IL18 |
GO:0010745 | BP | negative regulation of macrophage derived foam cell differentiation | Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
ABCA1, CRP, ITGB3, ITGAV, PPARG, NR1H2, PPARA, NR1H3, ADIPOQ, ABCA5 |
GO:0010748 | BP | negative regulation of plasma membrane long-chain fatty acid transport | Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. |
THBS1, AKT1, AKT2, IRS2 |
GO:0010751 | BP | negative regulation of nitric oxide mediated signal transduction | Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO). |
SPINK1, THBS1, ATP2B4 |
GO:0010754 | BP | negative regulation of cGMP-mediated signaling | Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. |
THBS1 |
GO:0010756 | BP | positive regulation of plasminogen activation | Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. |
CLEC3B, MFI2, PLGRKT |
GO:0010757 | BP | negative regulation of plasminogen activation | Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. |
SERPINE1, SERPINE2, THBS1, CPB2 |
GO:0010759 | BP | positive regulation of macrophage chemotaxis | Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. |
THBS1, CCL2, CCL5, C5AR1, RARRES2, TRPV4 |
GO:0010760 | BP | negative regulation of macrophage chemotaxis | Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. |
CYP19A1 |
GO:0010761 | BP | fibroblast migration | Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. |
ZFAND5, ILK, ARID5B, SYNE2, TNS1 |
GO:0010762 | BP | regulation of fibroblast migration | Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
SDC4, RAC1, GNA12, RFFL, CORO1C |
GO:0010763 | BP | positive regulation of fibroblast migration | Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
PAK3, TGFB1, THBS1, AKT1, ARHGEF7 |
GO:0010764 | BP | negative regulation of fibroblast migration | Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
ITGB1BP1, FGF2, HYAL2, CYGB, C5orf30 |
GO:0010765 | BP | positive regulation of sodium ion transport | Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
AHCYL1, AKT1, FGF12, CNTN1, ANK3, CNKSR3, SGK3, PKP2, WNK3 |
GO:0010766 | BP | negative regulation of sodium ion transport | Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
SERPINE2 |
GO:0010767 | BP | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. |
CHEK1 |
GO:0010793 | BP | regulation of mRNA export from nucleus | Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. |
SUPT6H, ZC3H3 |
GO:0010795 | BP | regulation of ubiquinone biosynthetic process | Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
COQ3 |
GO:0010796 | BP | regulation of multivesicular body size | Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles. |
RAB11A |
GO:0010800 | BP | positive regulation of peptidyl-threonine phosphorylation | Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
AXIN1, RIPK2, TGFB1, GCG, MAPK1, CHI3L1, WNT5A, GSK3B, PLK1, CALM2, CEMIP, WNK3, TRIM6, SPHK1, TRPC6, CAB39 |
GO:0010801 | BP | negative regulation of peptidyl-threonine phosphorylation | Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
SMAD7, SPRY2, CALM2, SPRED1, SIRT2, PARD3, INPP5K, DDIT4 |
GO:0010803 | BP | regulation of tumor necrosis factor-mediated signaling pathway | Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. |
TNF, UBC, TNFAIP3, SYK, RPS27A, UBA52, RACK1, TRAF1, BIRC3, RIPK1, CASP8, TRADD, TAX1BP1, CYLD, SPHK1, PYCARD |
GO:0010804 | BP | negative regulation of tumor necrosis factor-mediated signaling pathway | Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. |
NOL3, APOA1, GSTP1, PTPN2, F2RL1, GAS6, ADIPOQ, ZNF675, RFFL, NR1H4 |
GO:0010807 | BP | regulation of synaptic vesicle priming | Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. |
STXBP1 |
GO:0010810 | BP | regulation of cell-substrate adhesion | Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
RAC2, ATXN3 |
GO:0010811 | BP | positive regulation of cell-substrate adhesion | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
CYR61, EDIL3, JAK2, ECM2, VTN, ITGA5, NID1, ALOX15, ITGA6, ITGA3, LIMS1, NPY2R, PPM1F, RAC1, FBLN2, HSD17B12, CCDC80, NDNF, SPOCK2, SMOC2 |
GO:0010812 | BP | negative regulation of cell-substrate adhesion | Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
ANGPT2, FZD7, PLG, COL1A1, LGALS1, NOTCH1, PTPRO, GCNT2, TBCD, FZD4 |
GO:0010813 | BP | neuropeptide catabolic process | The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction. |
CTSH |
GO:0010814 | BP | substance P catabolic process | The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P. |
ECE1 |
GO:0010815 | BP | bradykinin catabolic process | The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. |
CTSH, IDE, CPN1, ECE1 |
GO:0010816 | BP | calcitonin catabolic process | The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. |
ECE1 |
GO:0010817 | BP | regulation of hormone levels | Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. |
SOX8 |
GO:0010818 | BP | T cell chemotaxis | The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. |
PIK3CD, CCL3, GPR183, PIK3CG, CXCL16 |
GO:0010820 | BP | positive regulation of T cell chemotaxis | Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. |
ADAM10, CCL5, S100A7, WNT5A, ADAM17 |
GO:0010821 | BP | regulation of mitochondrion organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
PARK2, SQSTM1, MGARP, PINK1, MFF, ATP13A2 |
GO:0010822 | BP | positive regulation of mitochondrion organization | Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
MGARP, PPARGC1A |
GO:0010823 | BP | negative regulation of mitochondrion organization | Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
FLCN |
GO:0010824 | BP | regulation of centrosome duplication | Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
XPO1, CHMP2A, VPS4B, PDCD6IP, FBXW5, CHMP4B, CHORDC1 |
GO:0010825 | BP | positive regulation of centrosome duplication | Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
ROCK2, CEP120 |
GO:0010826 | BP | negative regulation of centrosome duplication | Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
NPM1, CCNF |
GO:0010827 | BP | regulation of glucose transport | Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
NUPL2, NUP155, TPR, NUP62, NUP153, RANBP2, NUP107, RAE1, NUP160, NUP93, NUP43, NUP37, NUP35, NUP210, NUP205, SEH1L, TRIB3, NUP88, NDC1, NUP58, NUP85, NUP50 |
GO:0010828 | BP | positive regulation of glucose transport | Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
C3, C2CD5, NR4A3 |
GO:0010829 | BP | negative regulation of glucose transport | Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IL1B, PRKCB, INPP5K |
GO:0010830 | BP | regulation of myotube differentiation | Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
SIK1, DMPK, RBM24, RBM38, HDAC5 |
GO:0010831 | BP | positive regulation of myotube differentiation | Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
THRA, MMP14, MAPK14 |
GO:0010832 | BP | negative regulation of myotube differentiation | Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
XBP1, NOTCH1, HDAC4, HDAC5 |
GO:0010833 | BP | telomere maintenance via telomere lengthening | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. |
RAD51, OBFC1 |
GO:0010835 | BP | regulation of protein ADP-ribosylation | Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. |
PUM3, KAT2B |
GO:0010837 | BP | regulation of keratinocyte proliferation | Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. |
ZFP36, YAP1, ZFP36L1, SRSF6, PRKD1 |
GO:0010838 | BP | positive regulation of keratinocyte proliferation | Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. |
FGF7, HAS2 |
GO:0010839 | BP | negative regulation of keratinocyte proliferation | Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. |
CASK, SNAI2, VDR, SFN, EFNB2, KLF9, PTPRK, INTU |
GO:0010841 | BP | positive regulation of circadian sleep/wake cycle, wakefulness | Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. |
NLGN1 |
GO:0010842 | BP | retina layer formation | The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. |
TSPAN12, PTPRM, SDK2, SDK1, FJX1, AHI1, RDH13, HIPK2 |
GO:0010845 | BP | positive regulation of reciprocal meiotic recombination | Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. |
UBE2B |
GO:0010847 | BP | regulation of chromatin assembly | Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. |
SPTY2D1 |
GO:0010849 | BP | regulation of proton-transporting ATPase activity, rotational mechanism | Any process that modulates the rate of ATP hydrolysis by an ATPase. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
PPIF |
GO:0010857 | MF | calcium-dependent protein kinase activity | Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. |
PINK1 |
GO:0010862 | BP | positive regulation of pathway-restricted SMAD protein phosphorylation | Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
SDCBP, MSTN, GDF9, GDF11, BMP10, BMP15, TGFB1, INHA, INHBA, INHBB, BMP2, BMP4, BMP3, BMP1, BMP6, ACVR2A, TTK, BMP8B, BMPR1A, ACVR1B, TGFBR1, GDF5, INHBC, TGFB2, DAB2, ACVR1, SMAD4, BMPR2, HFE, BMP8A, RBPMS, GDF15 |
GO:0010863 | BP | positive regulation of phospholipase C activity | Any process that increases the rate of phospholipase C activity. |
ESR1, FGF2, PDGFRB, KIT, FGFR1, PDGFRA, PTAFR, ABL2 |
GO:0010866 | BP | regulation of triglyceride biosynthetic process | Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. |
C3 |
GO:0010867 | BP | positive regulation of triglyceride biosynthetic process | Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. |
CTDNEP1, LDLR, SREBF1, NR1H2, GPLD1, PLIN5, NR1H3, RGN, CNEP1R1, SCARB1, DGAT2 |
GO:0010868 | BP | negative regulation of triglyceride biosynthetic process | Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. |
SIK1 |
GO:0010870 | BP | positive regulation of receptor biosynthetic process | Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
EDN1, NR1H3, HDAC1, HIF1A, HDAC2, HDAC6 |
GO:0010871 | BP | negative regulation of receptor biosynthetic process | Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
NR1D1, PPARG, PPARA |
GO:0010872 | BP | regulation of cholesterol esterification | Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. |
LAMTOR1 |
GO:0010873 | BP | positive regulation of cholesterol esterification | Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. |
AGT, APOA1, APOE, APOA2, APOC1, AGTR1, APOA5, STARD4 |
GO:0010874 | BP | regulation of cholesterol efflux | Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. |
LAMTOR1 |
GO:0010875 | BP | positive regulation of cholesterol efflux | Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. |
ABCA1, APOE, PON1, NR1H2, NR1H3, PTCH1, ADIPOQ |
GO:0010877 | BP | lipid transport involved in lipid storage | The directed movement of lipids into cells that is part of their accumulation and maintenance. |
APOE |
GO:0010878 | BP | cholesterol storage | The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
SOAT1 |
GO:0010879 | BP | cholesterol transport involved in cholesterol storage | The directed movement of cholesterol into cells that is part of their accumulation and maintenance. |
STARD4 |
GO:0010880 | BP | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. |
DMD, GSTM2, SRI, CALM2, GSTO1, PDE4D, AKAP6, CAMK2D, CHD7 |
GO:0010881 | BP | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
DMD, PRKACA, PLN, GSTM2, ATP1A2, CALM2, GSTO1, ANK2, CAMK2D, CACNA1C, RYR2 |
GO:0010882 | BP | regulation of cardiac muscle contraction by calcium ion signaling | Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. |
ATP1B1, ATP2A2, HDAC4, ANK2, RYR2 |
GO:0010883 | BP | regulation of lipid storage | Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
MEST, ALKBH7, FTO |
GO:0010884 | BP | positive regulation of lipid storage | Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
ACACB, C3, APOB, NFKB1, NR1H2, PLIN5, HILPDA |
GO:0010886 | BP | positive regulation of cholesterol storage | Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
APOB, LPL, CD36, SREBF2, SCARB1 |
GO:0010887 | BP | negative regulation of cholesterol storage | Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
ABCA1, PPARG, NR1H2, PPARA, NR1H3 |
GO:0010888 | BP | negative regulation of lipid storage | Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
TNF, CRP, ITGB3, IL6, ITGAV, PTPN2, LEP |
GO:0010890 | BP | positive regulation of sequestering of triglyceride | Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. |
LPL, PLIN5, OSBPL11 |