GO:0008631

BP

intrinsic apoptotic signaling pathway in response to oxidative stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.

PRODH, JAK2, ARL6IP5, GPX1, BCL2, PRKCD, MELK, PDK1, CYP1B1, MAP3K5, STK24

GO:0008635

BP

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.

CASP9, CYCS, BAX

GO:0008637

BP

apoptotic mitochondrial changes

The morphological and physiological alterations undergone by mitochondria during apoptosis.

HSPD1, SLC25A4, NDUFS1, PPIF, AKT1, GCLC, GCLM, BID, PPP2CB, BAX, MCL1, AIFM2

GO:0008643

BP

carbohydrate transport

The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.

AKT2, SLC35A1, PEA15, SLC35D2, SLC5A11, SLC35A5, SLC35D1, SLC35A3

GO:0008645

BP

hexose transport

The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.

SLC2A5

GO:0008652

BP

cellular amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.

GLS, GOT2, ASNS, CBS, ALDH18A1, PYCRL, GPT2

GO:0008654

BP

phospholipid biosynthetic process

The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

FADS1, PTDSS1, PCYT1A, PLA2G16, PPARD, LPCAT3, MBOAT2, SERINC5, ABHD5, LPGAT1, MBOAT7, PCYT2, ISYNA1, SERINC1, AGPAT4, AGPAT3, PEMT, PCYT1B

GO:0008656

MF

cysteine-type endopeptidase activator activity involved in apoptotic process

Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.

CTSH, CASP1, CDKN1B, RACK1, RPS27L, BAD, PYCARD

GO:0008670

MF

2,4-dienoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.

DECR1

GO:0008689

MF

3-demethylubiquinone-9 3-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.

COQ3

GO:0008705

MF

methionine synthase activity

Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.

MTR

GO:0008709

MF

cholate 7-alpha-dehydrogenase activity

Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.

HSD17B10

GO:0008725

MF

DNA-3-methyladenine glycosylase activity

Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.

MPG

GO:0008732

MF

L-allo-threonine aldolase activity

Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde.

SHMT1

GO:0008745

MF

N-acetylmuramoyl-L-alanine amidase activity

Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.

PGLYRP2

GO:0008747

MF

N-acetylneuraminate lyase activity

Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

NPL

GO:0008753

MF

NADPH dehydrogenase (quinone) activity

Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.

NQO2

GO:0008757

MF

S-adenosylmethionine-dependent methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

METTL7A, AS3MT, COQ3, LCMT1

GO:0008761

MF

UDP-N-acetylglucosamine 2-epimerase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.

GNE

GO:0008781

MF

N-acylneuraminate cytidylyltransferase activity

Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.

CMAS

GO:0008783

MF

agmatinase activity

Catalysis of the reaction: agmatine + H(2)O = putrescine + urea.

AGMAT

GO:0008794

MF

arsenate reductase (glutaredoxin) activity

Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.

GLRX2

GO:0008798

MF

beta-aspartyl-peptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.

ASRGL1

GO:0008802

MF

betaine-aldehyde dehydrogenase activity

Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.

ALDH7A1

GO:0008808

MF

cardiolipin synthase activity

Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.

CRLS1

GO:0008817

MF

cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin.

MMAB

GO:0008821

MF

crossover junction endodeoxyribonuclease activity

Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

EME2, RAD51C, EME1

GO:0008823

MF

cupric reductase activity

Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.

STEAP4

GO:0008829

MF

dCTP deaminase activity

Catalysis of the reaction: dCTP + H2O = dUTP + NH3.

APOBEC3G

GO:0008832

MF

dGTPase activity

Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate.

SAMHD1

GO:0008843

MF

endochitinase activity

Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.

CHIT1

GO:0008853

MF

exodeoxyribonuclease III activity

Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides.

RAD1, RAD9A, TREX2

GO:0008859

MF

exoribonuclease II activity

Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction.

ISG20

GO:0008865

MF

fructokinase activity

Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.

HK1, HKDC1

GO:0008889

MF

glycerophosphodiester phosphodiesterase activity

Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.

GDE1

GO:0008894

MF

guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity

Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.

ENTPD6

GO:0008897

MF

holo-[acyl-carrier-protein] synthase activity

Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.

AASDHPPT

GO:0008898

MF

S-adenosylmethionine-homocysteine S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.

MTR

GO:0008900

MF

hydrogen:potassium-exchanging ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).

ATP12A

GO:0008934

MF

inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0008940

MF

nitrate reductase activity

Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.

MARC1

GO:0008941

MF

nitric oxide dioxygenase activity

Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.

CYGB

GO:0008948

MF

oxaloacetate decarboxylase activity

Catalysis of the reaction: oxaloacetate = pyruvate + CO2.

ME2, ME3

GO:0008955

MF

peptidoglycan glycosyltransferase activity

Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

CSGALNACT1

GO:0008962

MF

phosphatidylglycerophosphatase activity

Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

PTPMT1

GO:0008969

MF

phosphohistidine phosphatase activity

Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate.

PHPT1, MINPP1

GO:0008970

MF

phosphatidylcholine 1-acylhydrolase activity

Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

PLA2G4A, PLA2G16, PLA1A, PLA2G4C, LIPG

GO:0008973

MF

phosphopentomutase activity

Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.

PGM2

GO:0009000

MF

selenocysteine lyase activity

Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.

SCLY

GO:0009007

MF

site-specific DNA-methyltransferase (adenine-specific) activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

METTL4

GO:0009008

MF

DNA-methyltransferase activity

Catalysis of the transfer of a methyl group to a DNA molecule.

DNMT1, DNMT3B

GO:0009032

MF

thymidine phosphorylase activity

Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.

TYMP

GO:0009041

MF

uridylate kinase activity

Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

DTYMK, CMPK1

GO:0009048

BP

dosage compensation by inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.

BRCA1, EIF1

GO:0009051

BP

pentose-phosphate shunt, oxidative branch

The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).

G6PD, PGD

GO:0009052

BP

pentose-phosphate shunt, non-oxidative branch

The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.

TKT, TALDO1, SHPK

GO:0009055

MF

electron carrier activity

Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

HSD17B6, UQCR11, ACOX3, P4HA2, PHGDH, AKR7A2, IDH3B, UGDH, AOC2, NDUFS2, NDUFS6, DHRS3, AIFM1, GSR, CYBB, ALDH2, QDPR, FDX1, CYP19A1, AKR1B1, NQO2, SRD5A1, NDUFV2, NCF2, COX5A, SDHB, ME2, MAOB, NDUFS1, GLRX, ACADSB, XDH, ACADVL, AOX1, ASPH, ACOX1, ETFDH, TXNRD1, FDX1L, NDUFAF2, ACOX2, SDHC, SH3BGRL3, NOX4, GLRX2, DMGDH, LOXL2, COX11

GO:0009056

BP

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

TMEM150A, PTER

GO:0009058

BP

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

ALDH1L1, PBLD, NDUFAF6, ALDH1L2, APMAP

GO:0009060

BP

aerobic respiration

The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.

PMPCB, SLC25A14, UQCRH, UQCRB, SDHB, UQCRC2, ADSL, UQCRC1, BLOC1S1, MTFR1, FXN, ME3, COX19, COX20, MTFR2, SDHC, CHCHD5, PANK2, METTL17, UQCR10, COX11

GO:0009062

BP

fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

PPARD, ECH1, LPIN1

GO:0009063

BP

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

ENOSF1

GO:0009069

BP

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

MTHFD1

GO:0009070

BP

serine family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

PHGDH, MTHFD1

GO:0009071

BP

serine family amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

THNSL2

GO:0009072

BP

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

TPH2, HPDL

GO:0009082

BP

branched-chain amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.

BCAT1

GO:0009083

BP

branched-chain amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.

DLD, DBT, BCKDHA, BCKDHB, HIBADH, ACADSB, BCAT1, ALDH6A1, AUH, HIBCH, PPM1K, MCCC1, HSD17B10, MCCC2

GO:0009086

BP

methionine biosynthetic process

The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.

MTHFD1, MTR, MTHFD2L

GO:0009098

BP

leucine biosynthetic process

The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

BCAT1

GO:0009099

BP

valine biosynthetic process

The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

BCAT1

GO:0009100

BP

glycoprotein metabolic process

The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.

PCSK6, ST8SIA6, ERP44

GO:0009101

BP

glycoprotein biosynthetic process

The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.

LARGE

GO:0009106

BP

lipoate metabolic process

The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.

DLD

GO:0009108

BP

coenzyme biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

SLC25A16, COASY, PANK2

GO:0009113

BP

purine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

GART, PAICS, SHMT1, GMPS, PPAT

GO:0009115

BP

xanthine catabolic process

The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.

XDH, AOX1

GO:0009116

BP

nucleoside metabolic process

The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).

NME4, UPP2, PRPS2, PPAT

GO:0009117

BP

nucleotide metabolic process

The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

ACPP, FHIT, SMARCAD1, NUDT5, REXO2

GO:0009132

BP

nucleoside diphosphate metabolic process

The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.

NUDT7

GO:0009134

BP

nucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.

ENTPD3

GO:0009142

BP

nucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

NME4, AK1, NME1, NME2, AK4, CMPK1, SUCLG1, CMPK2, AK8

GO:0009143

BP

nucleoside triphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

ENPP3, ENTPD3, ENPP1, DCTPP1

GO:0009154

BP

purine ribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

HINT1

GO:0009156

BP

ribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.

PFAS, PRPS2

GO:0009157

BP

deoxyribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.

TK2, TK1, TYMS, DCK, DGUOK

GO:0009165

BP

nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

TK2, DHFR, TK1, PRPS2, DCK, DCTD, DGUOK, AK8

GO:0009166

BP

nucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

UPP2, UPP1

GO:0009168

BP

purine ribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.

PFAS, ADA, GART, PAICS, ADSS, ADSL, GMPS, PPAT, ADSSL1

GO:0009186

BP

deoxyribonucleoside diphosphate metabolic process

The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.

RRM2

GO:0009187

BP

cyclic nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

PDE8A, PDE8B

GO:0009191

BP

ribonucleoside diphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.

NUDT5

GO:0009214

BP

cyclic nucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

CNP

GO:0009220

BP

pyrimidine ribonucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

CMPK1

GO:0009223

BP

pyrimidine deoxyribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

NT5C

GO:0009225

BP

nucleotide-sugar metabolic process

The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.

TGDS

GO:0009229

BP

thiamine diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

TPK1

GO:0009231

BP

riboflavin biosynthetic process

The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).

RFK

GO:0009235

BP

cobalamin metabolic process

The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

ABCD4, PRSS1, ABCC1, PRSS3, CTRB2, MMAA, MMAB, MTR, CD320, LMBRD1

GO:0009236

BP

cobalamin biosynthetic process

The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

MMAA, MMAB