| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0008430 | MF | selenium binding | Interacting selectively and non-covalently with selenium (Se). |
SELENOF, GPX3, SEPP1, SELT, SELENBP1, DIO2 |
GO:0008431 | MF | vitamin E binding | Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. |
SEC14L2 |
GO:0008432 | MF | JUN kinase binding | Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. |
SPAG9, GSTP1, PTK2, MAPK8IP3, MAPK8IP1 |
GO:0008434 | MF | calcitriol receptor activity | Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. |
VDR |
GO:0008437 | MF | thyrotropin-releasing hormone activity | The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. |
TRH |
GO:0008440 | MF | inositol-1,4,5-trisphosphate 3-kinase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). |
ITPKA, CALM2, IP6K2 |
GO:0008442 | MF | 3-hydroxyisobutyrate dehydrogenase activity | Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. |
HIBADH |
GO:0008444 | MF | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). |
PGS1 |
GO:0008446 | MF | GDP-mannose 4,6-dehydratase activity | Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. |
GMDS |
GO:0008449 | MF | N-acetylglucosamine-6-sulfatase activity | Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. |
GNS, SULF2, SULF1 |
GO:0008453 | MF | alanine-glyoxylate transaminase activity | Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. |
AGXT |
GO:0008454 | MF | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. |
MGAT4A, MGAT4B |
GO:0008455 | MF | alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. |
MGAT2 |
GO:0008457 | MF | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. |
B3GNT5 |
GO:0008458 | MF | carnitine O-octanoyltransferase activity | Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. |
CROT |
GO:0008459 | MF | chondroitin 6-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. |
CHST3, CHST7 |
GO:0008460 | MF | dTDP-glucose 4,6-dehydratase activity | Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. |
TGDS |
GO:0008465 | MF | glycerate dehydrogenase activity | Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. |
GRHPR |
GO:0008466 | MF | glycogenin glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. |
GYG2 |
GO:0008467 | MF | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
HS3ST1, HS3ST3B1 |
GO:0008469 | MF | histone-arginine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. |
PRMT3, CARM1, PRMT6 |
GO:0008474 | MF | palmitoyl-(protein) hydrolase activity | Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. |
LYPLA1, LYPLA2, PPT1, PPT2 |
GO:0008475 | MF | procollagen-lysine 5-dioxygenase activity | Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. |
PLOD2, PLOD1 |
GO:0008476 | MF | protein-tyrosine sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. |
TPST1, TPST2 |
GO:0008478 | MF | pyridoxal kinase activity | Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. |
PDXK |
GO:0008479 | MF | queuine tRNA-ribosyltransferase activity | Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. |
PDC, PDCL, PDCL3 |
GO:0008480 | MF | sarcosine dehydrogenase activity | Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. |
SARDH |
GO:0008481 | MF | sphinganine kinase activity | Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. |
SPHK1 |
GO:0008482 | MF | sulfite oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. |
SUOX |
GO:0008483 | MF | transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
AGXT, PHYKPL |
GO:0008484 | MF | sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. |
STS, ARSA, GNS, GALNS, SGSH |
GO:0008486 | MF | diphosphoinositol-polyphosphate diphosphatase activity | Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
NUDT3, NUDT10, NUDT11 |
GO:0008488 | MF | gamma-glutamyl carboxylase activity | Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. |
GGCX |
GO:0008494 | MF | translation activator activity | Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. |
LARP1, RPS27L, PAIP1 |
GO:0008496 | MF | mannan endo-1,6-alpha-mannosidase activity | Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. |
MAN2B2 |
GO:0008499 | MF | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. |
B3GALT2, B3GALT4, B3GNT7, B3GNT5, B3GNT2 |
GO:0008502 | MF | melatonin receptor activity | Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. |
MTNR1A, MTNR1B |
GO:0008503 | MF | benzodiazepine receptor activity | Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. |
TSPO |
GO:0008504 | MF | monoamine transmembrane transporter activity | Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other. |
SLC18A2 |
GO:0008506 | MF | sucrose:proton symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). |
SLC45A2 |
GO:0008507 | MF | sodium:iodide symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). |
SLC5A5 |
GO:0008509 | MF | anion transmembrane transporter activity | Enables the transfer of a negatively charged ion from one side of a membrane to the other. |
ABCA1, SLC4A2, SLC4A8, SLC26A11 |
GO:0008510 | MF | sodium:bicarbonate symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). |
SLC4A4 |
GO:0008511 | MF | sodium:potassium:chloride symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). |
SLC12A2 |
GO:0008513 | MF | secondary active organic cation transmembrane transporter activity | Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. |
SLC22A1 |
GO:0008514 | MF | organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
SLC22A23, ABCC5, SLCO2B1 |
GO:0008517 | MF | folic acid transporter activity | Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
SLC19A2, FOLR1, SLC19A1, SLC46A1 |
GO:0008518 | MF | reduced folate carrier activity | Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. |
SLC19A1 |
GO:0008519 | MF | ammonium transmembrane transporter activity | Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. |
SLC12A2, RHBG |
GO:0008520 | MF | L-ascorbate:sodium symporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in). |
SLC23A2 |
GO:0008521 | MF | acetyl-CoA transporter activity | Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
SLC33A1 |
GO:0008523 | MF | sodium-dependent multivitamin transmembrane transporter activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. |
SLC23A2 |
GO:0008525 | MF | phosphatidylcholine transporter activity | Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
PITPNA, PCTP |
GO:0008526 | MF | phosphatidylinositol transporter activity | Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
PITPNA, PITPNC1 |
GO:0008528 | MF | G-protein coupled peptide receptor activity | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
GPR37, NPR3, LHCGR, FSHR |
GO:0008531 | MF | riboflavin kinase activity | Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). |
RFK |
GO:0008532 | MF | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
B4GAT1, B3GNT7, B3GNT2 |
GO:0008534 | MF | oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
NTHL1 |
GO:0008535 | BP | respiratory chain complex IV assembly | The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. |
METTL17, COX11 |
GO:0008536 | MF | Ran GTPase binding | Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. |
IPO5, TNPO2, XPO1, BIRC5, RANBP1, RANGAP1, RANBP2, CSE1L, NUTF2, KPNB1, IPO4, IPO9, RANBP9, XPO4, RANGRF, NXT1, NUP50 |
GO:0008537 | CC | proteasome activator complex | A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. |
PSME3 |
GO:0008540 | CC | proteasome regulatory particle, base subcomplex | The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. |
PSMD10, PSMC3, PSMC2, PSMC4, PSMC1, PSMC6, PSMD2 |
GO:0008541 | CC | proteasome regulatory particle, lid subcomplex | The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. |
PSMD11, PSMD12, PSMD3, SHFM1 |
GO:0008542 | BP | visual learning | Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. |
KRAS, HMGCR, APP, ITGB1, KIT, DRD2, CREB1, HRH1, ATP1A2, CDK5, GRIN2A, HIF1A, SYNGAP1, NDRG4 |
GO:0008543 | BP | fibroblast growth factor receptor signaling pathway | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. |
POLR2D, FLRT2, RBFOX2, FGF18, FGF19, FGF2, HNRNPA1, UBC, FGFR1, GTF2F2, POLR2E, FGF7, FGFR2, ANOS1, POLR2A, PTBP1, MAPK3, MAPK1, CTGF, POLR2B, FGF9, TIA1, HNRNPH1, GTF2F1, POLR2I, IQGAP1, HNRNPM, POLR2J, NDST1, POLR2K, FGF12, POLR2G, POLR2L, RPS27A, UBA52, GRB2, PTPN11, NCBP1, SETX, SPRED1, CEP57, SHCBP1, FRS2, ESRP2, FLRT3, FLRT1, KL |
GO:0008544 | BP | epidermis development | The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. |
INSR, KRT16, STS, PTHLH, DSP, ATP2A2, FGF7, CTGF, S100A7, SPRR2B, KRT9, ALDH3A2, EMP1, ELF3, ATP2C1, FABP5, SATB1, BNC1, PLOD1, KRT17, PPARA, GAB1, UGCG, LAMA3, SPRR2G, GRHL1, SPRR3, COL17A1 |
GO:0008553 | MF | hydrogen-exporting ATPase activity, phosphorylative mechanism | Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. |
ATP6V1G1, ATP6V1G2, ATP6V1C1, ATP6V0D1, ATP6V1C2 |
GO:0008555 | MF | chloride-transporting ATPase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in). |
PCYOX1 |
GO:0008559 | MF | xenobiotic-transporting ATPase activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
ABCA8 |
GO:0008565 | MF | protein transporter activity | Enables the directed movement of proteins into, out of or within a cell, or between cells. |
IPO5, KPNA3, KPNA4, ITGB1BP1, TNPO2, DSCR3, KPNA5, RANBP6, RAMP1, RAMP3, VPS26A, AP1G2, AP2A2, KPNA2, KPNA1, AP2S1, AP1S2, AP3S2, SEC61G, AP1S1, RAP1A, AP2B1, AP1B1, COG2, KPNB1, C11orf73, ZFYVE16, TOMM5, IPO4, TMCO6, IPO9, VPS35, SEC62, RANGRF, ARFGAP3, EIF4ENIF1, VPS29, AP4S1, TNPO3 |
GO:0008568 | MF | microtubule-severing ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. |
ATAD1, KATNB1, KATNAL1, SPAST |
GO:0008574 | MF | ATP-dependent microtubule motor activity, plus-end-directed | Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP. |
KIF5C, KIF4A, KIF11, KIF14, KIF18B, KIF18A, KIF20B, KIF3A |
GO:0008579 | MF | JUN kinase phosphatase activity | Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. |
DUSP19 |
GO:0008582 | BP | regulation of synaptic growth at neuromuscular junction | Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions. |
MUSK, COLQ |
GO:0008584 | BP | male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
TLR3, BCL2L11, SOX15, NUPR1, TLR5, LHB, ESR1, INHA, INSR, ERCC1, INHBA, BCL2, KIT, SRD5A1, WT1, KITLG, LHCGR, RRM1, FSHR, HMGB2, KDM5A, SRD5A2, HOXA10, FGF9, CTNNA1, NUDT1, TGFBR1, WNT5A, AKR1C3, MSH2, GATA4, SOX9, NASP, STAR, MMP14, TNFSF10, NR0B1, SOX8, TGFB2, H3F3A, HMGCS1, PRDX4, MAMLD1, NCOA4, ARID5B, NCOA1, AMHR2, ASPM, SFRP1, GATA6, WNT2B, PITX2, RNF38, PATZ1, AGO4, BOK |
GO:0008585 | BP | female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
IDH1, FSHR, BRCA2, ARID5B, AMHR2, SFRP1, PITX2 |
GO:0008588 | BP | release of cytoplasmic sequestered NF-kappaB | The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus. |
CD27, TRIP6 |
GO:0008589 | BP | regulation of smoothened signaling pathway | Any process that modulates the frequency, rate or extent of smoothened signaling. |
GLI2, FGFR2, OTX2, RORA, GAS1, PTCH1, ZIC1, CREBBP, INTU |
GO:0008593 | BP | regulation of Notch signaling pathway | Any process that modulates the frequency, rate or extent of the Notch signaling pathway. |
CD46, IL6ST, SYNJ2BP, POSTN |
GO:0008595 | BP | anterior/posterior axis specification, embryo | The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. |
TDGF1, WNT5A, FRS2 |
GO:0008597 | MF | calcium-dependent protein serine/threonine phosphatase regulator activity | Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
RCAN1 |
GO:0008599 | MF | protein phosphatase type 1 regulator activity | Modulation of the activity of the enzyme protein phosphatase type 1. |
PPP1R15A, PPP1R7 |
GO:0008601 | MF | protein phosphatase type 2A regulator activity | Modulation of the activity of the enzyme protein phosphatase type 2A. |
ENSA, PPP2R1A, PPP2R1B, ARPP19, IGBP1, SET, PPP2R3A, PPP2R5C, PPP2R5D, PPP2R5A, PPP2R5B, PPP2R4, ANKLE2, PPME1 |
GO:0008603 | MF | cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
PRKAR1A, PRKAR2A, PRKAR2B, PRKAG1 |
GO:0008607 | MF | phosphorylase kinase regulator activity | Modulation of the activity of the enzyme phosphorylase kinase. |
IKBKAP, ELP4, ELP3 |
GO:0008608 | BP | attachment of spindle microtubules to kinetochore | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. |
NDC80, ZNF207, BUB3, FAM175B, SGOL1, TEX14, CASC5, AURKB |
GO:0008609 | MF | alkylglycerone-phosphate synthase activity | Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. |
AGPS |
GO:0008610 | BP | lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
AGPS, ACSL1, SREBF1, PRKAA2, GPAT4, ACSS2, PRPF19 |
GO:0008611 | BP | ether lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. |
AGPS, GNPAT |
GO:0008612 | BP | peptidyl-lysine modification to peptidyl-hypusine | The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. |
DHPS, EIF5A, DOHH, EIF5A2 |
GO:0008613 | MF | diuretic hormone activity | The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. |
NPPB |
GO:0008615 | BP | pyridoxine biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. |
PSAT1 |
GO:0008616 | BP | queuosine biosynthetic process | The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. |
PDC, PDCL, PDCL3 |
GO:0008617 | BP | guanosine metabolic process | The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution. |
DGUOK |
GO:0008622 | CC | epsilon DNA polymerase complex | A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. |
POLE2, POLE, POLE4, POLE3, CHRAC1 |
GO:0008623 | CC | CHRAC | An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair. |
CHRAC1, BAZ1A |
GO:0008625 | BP | extrinsic apoptotic signaling pathway via death domain receptors | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. |
DDX3X, TNFRSF10C, NGF, TNF, BCL2, FAS, CD27, PIK3R1, DAPK1, BID, CRADD, BAX, FADD, TRADD, BAD, MOAP1, DDX47 |
GO:0008626 | BP | granzyme-mediated apoptotic signaling pathway | A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. |
UBE4B, SRGN, LAMP1, BNIP3 |
GO:0008628 | BP | hormone-mediated apoptotic signaling pathway | A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. |
PTH |
GO:0008630 | BP | intrinsic apoptotic signaling pathway in response to DNA damage | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
BCL2L11, TNF, HMOX1, BCL2, TNFRSF1B, XPA, PIK3R1, SFN, BRCA1, MLH1, MSH6, CASP9, PRKDC, E2F1, BAX, MCL1, NFATC4, BCL2L2, BAD, MOAP1, FNIP2, BOK |