GO:0008235

MF

metalloexopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

LAP3, METAP2, NUDT16, ERAP1

GO:0008236

MF

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

TPP1, KLK10, C1R, PLG, KLK3, PRSS1, DPP4, PRSS3, DPP6, PREP, PRSS12, HTRA3, CTRB2, HTRA1, SEC11C

GO:0008237

MF

metallopeptidase activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

ADAM10, ADAM12, ADAM23, STAMBP, ECEL1, MMP2, MME, ACE, BMP1, MMP9, BRCC3, ADAM8, ADAM17, PAPPA, ADAM9, ERAP2, ERMP1, AOPEP, STAMBPL1, YME1L1, XPNPEP3, ADAMTS9, ADAMTS1, LNPEP, ADAM21, ADAMTS7, ADAMTS6, ADAMTS5, ADAMTS8

GO:0008238

MF

exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.

MME, ACE, GGH

GO:0008239

MF

dipeptidyl-peptidase activity

Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.

DPP4

GO:0008240

MF

tripeptidyl-peptidase activity

Catalysis of the release of an N-terminal tripeptide from a polypeptide.

TPP1, ACE, TPP2

GO:0008241

MF

peptidyl-dipeptidase activity

Catalysis of the release of C-terminal dipeptides from a polypeptide chain.

ACE

GO:0008242

MF

omega peptidase activity

Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).

UCHL1, GGH

GO:0008250

CC

oligosaccharyltransferase complex

A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.

DDOST, STT3A, DAD1, STT3B, OSTC

GO:0008252

MF

nucleotidase activity

Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.

NT5C

GO:0008253

MF

5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

ACPP, NT5E, NT5DC3, NT5C, NT5DC2

GO:0008260

MF

3-oxoacid CoA-transferase activity

Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.

OXCT1

GO:0008263

MF

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.

MBD4, TDG

GO:0008265

MF

Mo-molybdopterin cofactor sulfurase activity

Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.

MOCOS

GO:0008266

MF

poly(U) RNA binding

Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.

HNRNPC, HNRNPH1, ATXN1, FMR1, KHDRBS1, PNPT1, MSI2

GO:0008267

MF

poly-glutamine tract binding

Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.

RERE

GO:0008269

MF

JAK pathway signal transduction adaptor activity

The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.

SOCS2

GO:0008270

MF

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

MEX3A, ZSWIM8, ERI2, NEURL1B, ZBBX, PDLIM1, RNF103, NR5A2, ZNF593, PEX12, TRIM38, MAN2B1, PDXK, CCS, ABLIM1, MDM4, ZNF185, MID1, SIAH2, TGFB1I1, DHH, KLF4, CA12, ZNF207, NRDC, PARK2, LPXN, TRIM13, LDB3, ZPR1, ZNF253, PMPCB, MYCBP2, TCEA3, CAPN15, KLF7, RNF8, ZFAND5, MICAL2, SEC24D, ABLIM3, KDM4B, TRIM37, UBR5, ZFPL1, ZNF205, ZRANB2, TNKS, PAPLN, POLR1A, CNOT4, ZMYM6, CRYZL1, WHSC1, ADH1B, ADA, CA2, KNG1, CD4, MT2A, ESR1, MMP1, NR3C1, TK1, S100B, TP53, MT1E, MT1F, S100A8, PRKCB, PGR, S100A9, S100A6, CA3, GALT, MMP2, SOD3, MME, SNRPC, MMP10, PARP1, GLI2, AR, NR2F1, THRA, VDR, ESRRA, DMD, SKI, ACE, BMP1, MT1G, ALAD, CPM, IDE, MMP9, CPN1, RAG1, CPE, ZNF22, ZNF24, PRKCA, EGR1, PAM, WT1, NR1D1, PTMS, CSRP1, TNFAIP3, ENPP1, UQCRC2, NR4A1, CA4, MMP8, MMP11, NR2F2, YY1, MT3, LMO2, DNMT1, CAD, CALR, RXRB, KDM5A, CLIP1, S100A7, UQCRC1, DCTD, CA8, RORA, FUS, ZNF93, TRIM23, POLR2I, PPARG, ZEB1, SNCA, BRCA1, ADH7, RPS27, MATR3, NR4A2, GATA4, LIMS1, MAN2A2, NUP153, RANBP2, MMP14, LHX2, PDLIM4, RNF144A, MMP15, MMP16, ZNF84, RBM5, PGGT1B, RABGGTB, LIMK2, POLR2K, TTC3, NR1H2, MLLT10, NPEPPS, HDAC4, ADAMTS12, ADAMTS20, LMO4, POLR2L, RBX1, ADAM8, MT1H, MT1X, SMAD3, XIAP, GTF2B, SORD, MDM2, EWSR1, PPARD, ZNF117, ZNF92, GLO1, ZNF91, RING1, POLE, PPARA, CRYZ, EP300, PMPCA, SF3A3, GRIN2A, TRIM26, PRDM2, TRAF1, NR1H3, CBLB, PAPPA, TRIM28, MTA1, BIRC3, SQSTM1, FHL1, ENPP2, GTF2H2, TRIM14, MORC3, ZMYM3, TRIM25, NBR1, CHD4, PTGR1, ZNF638, KPNB1, NR1D2, SHPRH, EEA1, ZMYND11, SEC23A, RGN, TRIP6, ZFHX3, ZYX, CSRP2, QPCT, LONRF1, LONRF2, PCGF3, LONRF3, LACTB2, ZNF385B, TRIM61, DNAJC21, ZMAT1, EARS2, PITRM1, MARCH8, UBR4, PHF19, MEX3C, ZCCHC6, RNF219, BSPRY, ZDHHC20, CPZ, ZFAND6, XAF1, OTUD7B, JADE1, NAPEPLD, ERAP2, GTF2H2C_2, RFWD3, CYHR1, PDZRN4, KDM7A, RNF19B, RNF111, NFXL1, RNF165, UBR3, USP51, USP45, CBLL1, CXXC5, RNF144B, RBBP6, PCGF5, PEG10, TADA2B, SYVN1, TRIM73, TRIM69, MEX3D, RNF130, ZGRF1, GATAD2A, MIB1, ZDHHC17, SIAH1, AEBP1, SLC30A8, UBR1, TRIM42, SIRT2, MSRB3, YAF2, TRIM22, KMT2E, ZDHHC14, CA13, ZCCHC24, MT1M, VPS8, ZCCHC7, ZADH2, ZNF276, ZCCHC9, TAB3, RNF182, AOPEP, RNF152, SREK1IP1, TRIML1, RNF149, RNF169, RNF214, PHC3, KMT2C, ZMIZ2, DBF4B, MYRIP, NEIL3, FBXO30, ZCRB1, ZCCHC10, TMEM163, MARCH1, ZNF675, MICAL1, ADAMTS17, ADAMTS15, ADAMTS18, MORC4, RNF128, SH3RF2, PHF10, CHURC1, FBLIM1, GATAD1, TRIM41, ZFAND2B, RNF141, ZFPM2, RTN4IP1, NANOS1, MYLIP, KAT6B, ZCCHC14, RFFL, NR4A3, JADE3, ESR2, DPF3, CREBBP, KAT6A, TAF15, GATA6, ARHGEF2, USP13, LPP, L3MBTL2, MIB2, TRIM43, PTER, RSPRY1, RNFT2, PDLIM5, AJUBA, CPB2, PDLIM2, EHMT2, ZFR, AGBL1, PRICKLE1, ZMAT2, PGLYRP2, UHRF2, PHF12, HHIP, NR1H4, RSF1, SETDB2, UHRF1, MMP19, P2RX4, S100A13, SCAF11, MTR, BARD1, RBM4B, PYGO2, ZNF2, DIDO1, RNF126, MECR, TRIM62, PHF20, RBM4, CDADC1, SCAPER, TRIM34, WHSC1L1, TRIM8, TRIM9, TRIM6, TRIM4, TRIM2, ZCCHC2, ZNF407, MKRN2, USP44, RNF38, C11orf54, ADAMTS10, SUV39H2, ZDHHC6, ZFAND3, RNF121, MARCH7, LIN28A, SP110, RC3H2, ZFYVE1, APOBEC3G, ZSWIM6, TRIM39, MMP25, MYNN, ATP13A2, CYLD, ZNF331, PDLIM7, ASH1L, MMP26, BAZ1A, RASSF1, RAD18, RNF146, RNF19A, THAP1, RLIM, ZDHHC7, ING3, RBAK, ERAP1, LMCD1, RNF181, ZNRD1, PHRF1, ZSWIM5, ZNFX1, ADAMTS9, RERE, HDAC6, RNF14, DBF4, ZMYM2, ZRANB1, TES, KDM5B, LIMD1, TCF20, APOBEC3B, LIMA1, MKRN1, CHORDC1, TRPS1, ADAMTS1, BAZ1B, ZDHHC2, LNPEP, RABGEF1, ZMYM5, ADAMTS7, ADAMTS6, AMFR, PNMA3, MYT1L, ZMIZ1, RNF150, CIZ1, KMT2B, ADAMTS5, TTF2, ADAMTS8, TRIM33, LIMCH1, TRIM35, PDZRN3, USP22, AGTPBP1, RNF24, TCF19, RNF6, MAN2B2, PIKFYVE, USP20, KDM2A, POLR3K, ZDHHC9, ZNF330, SAMHD1, L3MBTL1, MTF2, DTNA, ARIH1, RNF114, MMP24, LOC440434

GO:0008271

MF

secondary active sulfate transmembrane transporter activity

Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

SLC26A2, SLC26A11, SLC26A1

GO:0008272

BP

sulfate transport

The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC26A2, SLC26A11, RACGAP1, SLC26A1

GO:0008273

MF

calcium, potassium:sodium antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).

SLC24A3

GO:0008274

CC

gamma-tubulin ring complex

A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.

BRCA1, MZT1, MZT2A

GO:0008275

CC

gamma-tubulin small complex

A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.

TUBGCP3, CENPJ

GO:0008276

MF

protein methyltransferase activity

Catalysis of the transfer of a methyl group (CH3-) to a protein.

CARM1, PRMT1, N6AMT1

GO:0008277

BP

regulation of G-protein coupled receptor protein signaling pathway

Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

RGS12, RGS5, GNG7, RAMP1, RAMP3, TULP3, GRK5, RGS2, GRK6, RGS3, RGS4, GNG4, DYNLT1, PDCL, GIT2, GPR158, GPSM1, PLCB1, USP20, GIT1

GO:0008278

CC

cohesin complex

A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).

RAD21, WAPL, CDCA5, SMC3

GO:0008280

CC

cohesin core heterodimer

The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.

SMC1A, SMC3

GO:0008282

CC

ATP-sensitive potassium channel complex

A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.

KCNJ11

GO:0008283

BP

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

E2F8, BIN1, CYR61, PDXK, MDM4, POLR3G, INSIG1, TBX1, BUB1, NRDC, KDM1A, BUB1B, DKC1, NBN, ZPR1, TACC1, GPC4, CREG1, TUSC2, UBR5, TACC2, EGFR, TGFA, PRL, GCG, IL1A, RAF1, CD74, S100B, ERBB2, TP53, CYP1A1, TYMS, GNAI2, IGF1, CDK1, CSF1R, ERCC1, MET, KRT16, CXCL1, POLA1, UCHL1, FURIN, GLI2, AR, TXN, PCNA, SKI, XRCC5, MIF, TYR, AREG, ITGA2, ERCC2, CHRM3, CDK11B, KITLG, IGFBP4, DTYMK, ADRA1D, EDNRA, MT3, LTK, CDC27, CDC25A, CDC25C, TSPO, AKT1, CCKBR, CKS2, MCM7, ADRA1B, SERPINF1, ZEB1, LIPA, STAT3, EPS15, RPS27, SYK, MKI67, YAP1, ZFP36L2, IFNAR2, NASP, CENPF, MRE11A, CDK7, HDGF, PLK1, BCAT1, EMP1, CSE1L, DLX5, CMC4, MTCP1, CD81, PTEN, TGFB2, RPL23A, GNB1, RAC1, PRKDC, H3F3A, DAB2, LRP2, CDK3, CDK5, NDP, IL9R, IL5RA, COL4A3, HHEX, PPARD, MXD1, PRDX1, ZFP36L1, KHDRBS1, BST2, EPS8, FOXC1, KLF10, SKP2, ILK, PDAP1, GAB1, SMAD4, PICALM, DCTN2, BOP1, TFDP1, GAS6, MELK, PDK1, PRKD1, ERBB4, ZMYND11, DLGAP5, STIL, MAPRE2, TGFBI, MAPRE1, UBE2V2, CTF1, FSCN1, IFI16, TXNRD1, CD276, BRAT1, LARP1, CSPG4, MCM10, PDPN, ASCC3, APPL2, POC1B, CSGALNACT1, PRG4, USP13, CUL5, ISG20, RHBDF1, DAZAP1, AURKB, NOX5, UHRF2, PURB, USP28, UHRF1, YME1L1, KIF2C, CITED1, CITED2, PELO, GNL3, DPH1, WDR12, BLZF1, FAM83D, NAA60, SRA1, TCF7L2, DUSP22, KIF15, PDS5B, PAK1IP1, DDIT4, ZAK, RRN3, EHF, PAK7, PEMT, CKLF, MORF4L1, VTI1B, DACH1, FBXL7, ELF5, TPX2, BOK, CDC14A, PA2G4, TCF19, TNFSF13B, SBDS, HDGFRP3, IRS2, LIPG, TACC3, LOC93622

GO:0008284

BP

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

CDC7, SDCBP, ADAM10, ITGB1BP1, EREG, BIRC5, HOXA3, TBX1, PRC1, GDF9, GREM1, DNAJA2, LRP5, CDC123, TNFSF13, CIAO1, FGF18, ALDH1A2, STAMBP, FGF19, TBC1D8, EGFR, F2, TIMP1, CST3, MYC, KRAS, PDGFB, TGFB1, CGA, FSHB, GHRH, INS, IGF2, FN1, PDGFA, S100B, GNAI2, IGF1, SLC25A5, IL6, EDN1, ITGB1, INSR, CCK, NPM1, ITGAV, CSF1R, LYN, THBS1, IGF1R, IL6R, NMB, FGF2, WNT2, PDGFRB, CTSH, AR, KIT, FGFR1, CDK4, ODC1, PTHLH, TDGF1, HGF, HCLS1, ETS1, LIF, RAC2, FOSL1, AREG, VEGFA, PDGFRA, EPCAM, XBP1, ATF3, EDN2, IL11, FGF7, FGFR2, TNFSF4, TNC, CDK2, CXCR2, ADRA1D, F2R, DPP4, CALR, MAPK1, CTGF, SERPINB3, CCND2, CDC25B, AVPR2, FGF9, CCKBR, TTK, GRK5, BTC, ADM, IRS1, FLT4, CHRNA7, TGFBR1, TGFBR2, COL18A1, IL6ST, PBX1, STAT3, HTR2B, AKR1C3, LIFR, CXCL5, PTGFR, SSR1, NAMPT, NOP2, CRKL, CDKN1B, NOTCH1, RPS9, YAP1, ID4, SOX9, DHPS, UBE2A, PGF, VEGFC, AGTR2, EFNB2, AKR1C2, MVD, PGGT1B, EMP2, NAP1L1, HDAC4, CD81, PTEN, ROMO1, TGFB2, RPS15A, EIF5A, SRPK2, ADAM17, PURA, MDM2, BNC1, NRG1, RELA, EGR4, PTK2, SOX4, FOXM1, CD47, CDC20, STX4, DLG1, TSPAN31, TIAM1, BAMBI, STX3, MAB21L1, ILK, TCIRG1, HDAC1, CUL3, CUL4A, RUNX2, CDK13, HES1, ZNF268, SUZ12, KIF14, ERBB4, FXN, CTF1, NTRK2, IL34, TSPYL5, CARM1, CACUL1, CCAR1, GCNT2, SFRP1, DBF4B, GADD45GIP1, TRPM4, PHIP, HDAC2, PROX1, HAS2, TBRG4, NUDT16, VWCE, CDCA7L, KIF20B, HBEGF, S1PR3, GPER1, S100A13, OSMR, CIB1, PDCD10, TIPIN, SSBP3, PDGFD, DERL2, EIF5A2, HIPK2, GAREM1, CD248, ESM1, CLCF1, ASH2L, CNOT7, CCPG1, CNOT6, APLN, FZR1, TNFSF13B, IRS2, HILPDA, TNFRSF11A

GO:0008285

BP

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

PLPP1, PTGES, ITGB1BP1, PDCD5, IRF6, TAX1BP3, EREG, MDM4, CYP27B1, TGFB1I1, EEF1E1, KLF4, SMAD6, SPRY2, SPRY1, TLR2, JAK2, SKAP2, PRKRA, UTP20, ALDH1A2, GDF11, PLG, TGFB1, GNRH1, IL1A, IL1B, FTH1, RAF1, SOD2, NTRK1, TP53, IL6, JUN, FABP3, NPM1, SERPINE2, CSF1R, LYN, INHBA, CXCL1, GLI3, CXCL8, AR, IRF1, VDR, PTHLH, BMP2, BMP4, SKI, IFITM1, DRD2, ETS1, LIF, B4GALT1, FOSL1, NME1, TIMP2, HMGA1, PTPN2, IGFBP3, WT1, CD33, CD9, IL10, IGFBP6, APC, F2R, AZGP1, TNFRSF8, NOS3, ADORA1, SSTR1, S100A11, CDH5, CTNNB1, PHB, NF2, ADM, SSTR5, ADRA1A, PTGS2, NUP62, ZEB1, CDKN1A, COL18A1, STAT3, BCL6, CSK, CDKN2B, CDKN2C, CDKN1B, NOTCH1, VEGFC, RARRES1, TSC2, MXI1, FABP6, SMARCA2, RBM5, EMP3, CDH13, HDAC4, CTBP2, PTEN, TGFB2, BTG1, BTG2, ADARB1, GPLD1, FOXO4, CDK6, HSF1, INSM1, PMP22, COL4A3, MAP2K1, NOTCH2, CD164, ZBTB16, SOX4, DDR1, RBBP4, PTPRJ, STK4, KLF10, PPP2R5C, SMAD4, HDAC1, PKD2, CUL2, CUL4A, TOB2, MXD4, ZNF268, GPNMB, CDK10, PTPRK, ERBB4, RPS6KA2, DHCR24, KISS1, SMAD2, SMAD1, STK11, IGFBP7, CDKN3, CYP1B1, TBRG1, SFRP5, TNS2, KANK2, SFRP4, NRK, PODN, PBRM1, MAGI2, P3H2, CHERP, SIRT2, LAS2, ABI1, SFRP1, DLG5, RASSF5, BAP1, NDRG1, PROX1, KAT2B, KIFAP3, CUL5, HIST1H2AC, TP53INP1, RERG, ZNF503, DLC1, GPER1, MNT, COPS8, CDC6, CIB1, PKP2, FOXP3, RGCC, NOX4, BRD7, DLL4, PDS5B, SH3BP4, PEMT, TES, DDX20, ADAMTS1, CNOT7, ADAMTS8, KLF13, ADGRG1

GO:0008286

BP

insulin receptor signaling pathway

The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.

PIK3C2A, IRS4, ATP6V0E1, ATP6V1G1, ATP6V1G2, INS, IGF2, INSR, IGF1R, IGFBP1, IDE, RHOQ, PTPN2, ATP6V1B2, ATP6V1C1, PIK3R1, AKT1, AKT2, IRS1, SREBF1, CAV2, ATP6V0D1, GRB2, GPLD1, FOXO4, SOS1, FOXO1, GAB1, TCIRG1, EIF4EBP1, EIF4EBP2, PDK4, ATP6V1F, ATP6V1C2, PHIP, SMARCC1, ATP6V0A1, SORBS1, KL, BAIAP2L1, ATP6V1H, IRS2, ATP6V1D

GO:0008289

MF

lipid binding

Interacting selectively and non-covalently with a lipid.

FABP12, UNC119B, NME4, PLIN1, AP2A2, APOE, APOA2, APOH, DBI, PSAP, ANXA6, CD55, CD36, MAL, PTGS2, ATP5G3, PITPNB, PCYT1A, FABP6, VCP, PEX3, PTEN, HDLBP, FABP5, PPARD, ATP5G2, BAX, PPARA, ARHGEF5, TIAM1, UNC119, MELK, TRIP10, FNBP1L, ACBD5, IQSEC1, APOA5, RASGRP2, BPIFB1, STARD8, BAD, AP2M1, MVB12A, APOLD1, DLC1, FNBP1, OSBPL9, S1PR3, S100A13, SH3GL2, APOL2, ESYT1, OSBPL11, OSBPL6, STARD7, GLTP, STARD9, PCTP, SH3GLB1, STARD13

GO:0008290

CC

F-actin capping protein complex

A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.

CAPG, CAPZB, CAPZA1, MTPN

GO:0008295

BP

spermidine biosynthetic process

The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

AMD1, SRM, AGMAT

GO:0008296

MF

3'-5'-exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.

POLD1, TREX2

GO:0008297

MF

single-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.

MGME1

GO:0008298

BP

intracellular mRNA localization

Any process in which mRNA is transported to, or maintained in, a specific location within the cell.

BICD1

GO:0008299

BP

isoprenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

HMGCR, FDFT1, MVD, HMGCS1, MVK, IDI1, PDSS1, PDSS2, COQ2, IDI2

GO:0008301

MF

DNA binding, bending

The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

HMGB3, HMGB1, TOP2A, HMGB2, HMGA2, TERF1, TFAM, HHEX, FOXC1

GO:0008305

CC

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

ITGA10, ITGB3, ITGB2, ITGB1, ITGAV, ITGA5, ITGAM, ITGB4, ITGA2, ITGAX, ITGA3, ITGB8, MYH9, ITGAE, ITGA9, ITGA11

GO:0008306

BP

associative learning

Learning by associating a stimulus (the cause) with a particular outcome (the effect).

DRD2, GABRA5, CHRNA7, NPTX2, PPT1, SNAP25, BTG2, CLN3, TNR

GO:0008307

MF

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

NEBL, SORBS2, TPM2, KRT19, TPM1, DMD, MYL6B, CAPN3, MYL9, ACTN2, MYH11, SMTN, MYL6, TPM4, MYBPC1, MYL5, NEXN, ASPH, DAG1, TTN, MYOT

GO:0008308

MF

voltage-gated anion channel activity

Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

GPR89A, GPR89B, VDAC2, VDAC3

GO:0008309

MF

double-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.

FEN1

GO:0008310

MF

single-stranded DNA 3'-5' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.

ISG20

GO:0008312

MF

7S RNA binding

Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP).

SRP72, SRP14, SRP9, SRP54, EXOSC2

GO:0008320

MF

protein transmembrane transporter activity

Enables the transfer of a protein from one side of a membrane to the other.

TOMM40, AZGP1, NUTF2, TOMM22, TOMM7

GO:0008321

MF

Ral guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

RALGPS1, RGL1

GO:0008324

MF

cation transmembrane transporter activity

Enables the transfer of cation from one side of the membrane to the other.

SLC30A9, SLC41A3

GO:0008327

MF

methyl-CpG binding

Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.

MBD3, DNMT1, ERH, ZBTB33, ZBTB38, UHRF1, PRMT1, ZBTB4, LRWD1, ZBTB21

GO:0008328

CC

ionotropic glutamate receptor complex

A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.

DLG4, DLG1

GO:0008329

MF

signaling pattern recognition receptor activity

Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.

TLR2, COLEC12, CLEC7A, DMBT1

GO:0008330

MF

protein tyrosine/threonine phosphatase activity

Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

DUSP1, DUSP2

GO:0008331

MF

high voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.

CACNB3, CACNA1C, CACNA1E

GO:0008332

MF

low voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.

CACNA1G

GO:0008333

BP

endosome to lysosome transport

The directed movement of substances from endosomes to lysosomes.

DENND3, SNAPIN, ADRB2, RAB7A, VAMP7, SNX16, RHOB, MTM1, RAB12, HOOK3, HOOK2, AKTIP, HMGXB4, TRAK1

GO:0008334

BP

histone mRNA metabolic process

The chemical reactions and pathways involving an mRNA encoding a histone.

SSB, SNRPB, SNRPF, SNRPD3, NCBP1, SLBP

GO:0008340

BP

determination of adult lifespan

The control of viability and duration in the adult phase of the life-cycle.

TP53, IDE, MSH2, MSH6, PRDM2, RAD54L, INPP5D

GO:0008343

BP

adult feeding behavior

Feeding behavior in a fully developed and mature organism.

AGRP, LEP, USP46, CARTPT, GHSR, GHRL

GO:0008344

BP

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

CHL1, PARK2, CSTB, APP, CNP, TMOD1, HOXD10, SNCA, NR4A2, CXCL12, ARCN1, PPT1, ATP1A2, FGF12, ID2, EPS8, PUM1, GIGYF2, PREX2, BTBD9

GO:0008347

BP

glial cell migration

The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.

MATN2, TSPO, EPHA4, TGFB2, CSPG4

GO:0008349

MF

MAP kinase kinase kinase kinase activity

Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.

MAP4K3, MAP4K5

GO:0008352

CC

katanin complex

A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).

KATNB1

GO:0008353

MF

RNA polymerase II carboxy-terminal domain kinase activity

Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats.

CDK1, ERCC2, MAPK1, GTF2H1, CDK8, CDK7, GTF2H2, CDK13, GTF2H4, CDK12

GO:0008354

BP

germ cell migration

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.

PLPP1, PLPP3, TGFB1, ITGB1, KIT, TGFBR1, CXADR, FOXC1

GO:0008355

BP

olfactory learning

Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.

ADCY3

GO:0008356

BP

asymmetric cell division

The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.

ACTR3, ACTR2, GOLGA2, PARD3

GO:0008360

BP

regulation of cell shape

Any process that modulates the surface configuration of a cell.

WIPF3, CDC7, PLXNB2, SEMA3E, DAPK3, COCH, C21orf2, PRPF40A, F2, FN1, ALDOA, ANXA1, S100B, ITGB2, IL6, ICAM1, FYN, CSF1R, TPM1, FGR, CCL3, KIT, CCL2, EZR, VEGFA, RHOQ, RASA1, CORO1A, RDX, MYH9, CSNK1A1, CSNK1D, CSNK1E, GNA12, PTK2, EPS8, DLG1, BAMBI, PLEKHO1, BRWD3, FGD6, RHOU, CYFIP1, FGD2, PDPN, PALM2, ARHGAP18, BVES, SHROOM3, FBLIM1, ARAP3, PHIP, FGD4, ARAP1, DLC1, S100A13, VRK1, SEMA4A, RHOJ, CSNK1G1, MYO10, CDC42SE2, CDC42SE1, BRWD1, PARVA, TBCCD1, CFDP1, LIMD1, CDC42EP3, TAOK2, MKLN1, EPB41L3, CSNK1G3

GO:0008361

BP

regulation of cell size

Any process that modulates the size of a cell.

VAV1, CREB1, IL7R, RDX, RAC1, IQGAP3, VAV3

GO:0008366

BP

axon ensheathment

Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.

PLP1, NRG1, POU3F1, PPARD

GO:0008373

MF

sialyltransferase activity

Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

ST6GAL1, ST8SIA6, ST6GALNAC5, ST6GALNAC4, ST6GALNAC2

GO:0008374

MF

O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.

LCLAT1, PIGW

GO:0008375

MF

acetylglucosaminyltransferase activity

Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.

OGT, LARGE, HEXA, EXT1, POMGNT2, EXT2, XYLT2

GO:0008376

MF

acetylgalactosaminyltransferase activity

Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.

CSGALNACT1

GO:0008378

MF

galactosyltransferase activity

Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

B4GALT5, B4GALT4, B4GALT1, B3GNT9, B4GALT6

GO:0008379

MF

thioredoxin peroxidase activity

Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.

PRDX2, PRDX1, PRDX4

GO:0008380

BP

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

SAP18, DHX15, RBFOX2, PRPF3, DHX16, SYNCRIP, NOL3, ZPR1, ZRANB2, LUC7L3, PTBP3, HNRNPC, SNRPA1, SNRPB, LGALS3, SON, WT1, SFPQ, PTBP1, PPP2R1A, HNRNPH3, RBM25, NOVA1, AFF2, SNRPF, LSM6, SNRPD1, SNRPD2, SNRPD3, SNRPN, SRPK2, SRSF2, SRSF11, FMR1, C1QBP, NCBP1, SF3A3, TARDBP, PPIG, PRPF4B, RBM39, ZNF638, WTAP, NONO, RNPS1, SNRNP35, ZNF326, MBNL2, ARL6IP4, THOC7, JMJD6, SUPT6H, SUGP2, SRRM1, CCAR2, SREK1IP1, THOC2, RP9, ZCRB1, SREK1, KHSRP, SNRNP40, RSRC1, THOC3, RNPC3, QKI, SRPK1, SCAF11, PRPF18, RBM4B, DDX23, SNRNP25, RBM4, DDX47, RBM38, RRAGC, MBNL1, MBNL3, RBFOX1, CDK12, PPARGC1A, PUF60, TTF2, SCAF8, THRAP3, LSM4, IVNS1ABP

GO:0008381

MF

mechanically-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

PIEZO1

GO:0008385

CC

IkappaB kinase complex

A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

MAP3K13, MAP3K7, ERC1, PYCARD

GO:0008386

MF

cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.

CYP11A1

GO:0008389

MF

coumarin 7-hydroxylase activity

Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.

CYP2A6

GO:0008392

MF

arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.

CYP2E1, CYP2D6, CYP2A6, CYP2C9, CYP2B6

GO:0008395

MF

steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

CH25H, CYP2E1, CYP3A4, CYP21A2, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B2, CYP2B6, CYP3A7, CYP2R1, CYP2U1, CYP2W1

GO:0008397

MF

sterol 12-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.

CYP8B1

GO:0008398

MF

sterol 14-demethylase activity

Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.

CYP51A1

GO:0008401

MF

retinoic acid 4-hydroxylase activity

Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.

CYP26A1, CYP26B1

GO:0008406

BP

gonad development

The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.

WT1, FSHR, NR0B1, RDH10, OSR1, MKKS

GO:0008408

MF

3'-5' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

RAD1, REV3L, POLA1, MRE11A, POLG, POLE, RAD9B, RAD50, RAD9A, REXO2

GO:0008409

MF

5'-3' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.

DXO, FEN1, DCLRE1C, EXO1, EXOG, FAN1

GO:0008413

MF

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.

NUDT1, NUDT15

GO:0008417

MF

fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

FUT1, FUT4, FUT2

GO:0008420

MF

CTD phosphatase activity

Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate.

CTDSP2, CTDSP1, SSU72

GO:0008422

MF

beta-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.

LCT, GBA2, KL

GO:0008424

MF

glycoprotein 6-alpha-L-fucosyltransferase activity

Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+).

FUT8

GO:0008425

MF

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.

COQ3

GO:0008426

MF

protein kinase C inhibitor activity

Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.

HSPB1, SFN

GO:0008427

MF

calcium-dependent protein kinase inhibitor activity

Stops, prevents or reduces the activity of a calcium-dependent protein kinase.

CAMK2N1, CIB1

GO:0008428

MF

ribonuclease inhibitor activity

Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA.

RNH1

GO:0008429

MF

phosphatidylethanolamine binding

Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

ESYT2, PEBP1, ANXA11, MFGE8, MAP1LC3A, PEMT