| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0008021 | CC | synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
TOR1A, SYNGR3, STX11, SNAPIN, TH, MME, LAMP1, SYN1, RAB3B, RAB5A, SYT1, MT3, STX2, SNCA, VDAC2, PPT1, CLCN3, SNAP25, ATP6V0D1, VAMP2, DLG4, CDK16, APBA1, SLC18A2, STX4, GRIN2A, STX3, CLN3, MTMR2, SEPT6, RAB11B, STXBP5, SV2A, SV2B, DMXL2, SYT11, TRIM9, NDEL1, MFF, SLC40A1, VTI1B, WDR7, SNCAIP |
GO:0008022 | MF | protein C-terminus binding | Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
MIF4GD, MYO1C, FOXN3, KPNA3, SDCBP, PEX12, KCNK3, TAX1BP3, DAPK3, JAK2, TBL1X, VPS4B, YEATS4, EML2, BCL10, ERBB2, ATP1B1, ERCC1, VIM, TOP2A, XRCC5, TCF4, ATP2A2, ERCC2, SDC1, ATF4, NCF2, SYT1, FBLN1, CTGF, CORO1A, YWHAB, STIP1, CTNNB1, PHB, PPP1CC, COIL, ID1, OPRL1, CSK, MSH2, MKI67, YAP1, CENPF, MRE11A, CDK7, BCAM, BRCA2, ATXN1, SYNJ2BP, PPP2CB, DLG4, DAB2, HSPG2, MAP2K1, DST, ZBTB16, RAD51, TJP1, EP300, SREBF2, CDC20, DLG1, ITGB3BP, XRCC4, NPAT, KCNJ11, MDC1, MAPRE1, CEP135, NIPBL, PXK, SIAH1, CEP120, TOPBP1, ERCC4, MED12, OPTN, HIC2, MAGI1, PHB2, CIB1, CITED1, SDCBP2, GOPC, VTA1, MID1IP1, IFT46, HOMER3, RBFOX1, SAE1, PLEKHB1, AGO2, HPCAL4, PRRC2C |
GO:0008023 | CC | transcription elongation factor complex | Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. |
ELL2, IKBKAP, ELOF1, ICE2, ELP4, EAF1, ELP3, AFF4, NUFIP1, TTF2 |
GO:0008024 | CC | cyclin/CDK positive transcription elongation factor complex | A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. |
CCNT1, CCNT2, RB1 |
GO:0008026 | MF | ATP-dependent helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
BLM, ERCC6L2, TTF2 |
GO:0008028 | MF | monocarboxylic acid transmembrane transporter activity | Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
SLC16A6, SLC16A3, SLC16A7, BSG, SLC16A14, SLC16A9 |
GO:0008033 | BP | tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
POP7, FARS2, POP4, SARS, LSM6, RPP30, GRSF1, KARS, TYW3, PUS7, TP53RK, TPRKB |
GO:0008035 | MF | high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. |
APOA1, APOA2, CD36, SCARB1, APOL2 |
GO:0008037 | BP | cell recognition | The process in which a cell in an organism interprets its surroundings. |
VCAN, PVR, PECAM1, CD200, SMAGP, NECTIN1, CSGALNACT1, CLEC7A, CADM1, NECTIN3 |
GO:0008043 | CC | intracellular ferritin complex | A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains. |
FTL, FTH1 |
GO:0008045 | BP | motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
HOXA2, KIF5C, SLIT2, ERBB2, EGR2, CHN1, EPHA4, CDK5, ALCAM, RNF165 |
GO:0008046 | MF | axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
EPHB2, EPHB1, ROBO2 |
GO:0008047 | MF | enzyme activator activity | Binds to and increases the activity of an enzyme. |
OGT, CFLAR, ASAP2, PPP1R12B, PRKRA, PSAP, CXCL1, TRIM23, MMP15, MMP16, CASP9, PRKCD, TAB1, HSPB2, PITRM1, APOA5, RICTOR, MGST2, RAB3GAP2, SAE1, DBF4, GTF3C4, MMP24 |
GO:0008048 | MF | calcium sensitive guanylate cyclase activator activity | Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. |
GUCA1C, GUCA1B |
GO:0008050 | BP | female courtship behavior | The behavior of a female, for the purpose of attracting a sexual partner. |
THRA |
GO:0008053 | BP | mitochondrial fusion | Merging of two or more mitochondria within a cell to form a single compartment. |
OPA1, MFN2, BAX, FAM73A, MFF |
GO:0008057 | BP | eye pigment granule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye. |
SHROOM2 |
GO:0008061 | MF | chitin binding | Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. |
CHI3L1, CTBS, CHIT1 |
GO:0008063 | BP | Toll signaling pathway | A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
PELI1, PELI2 |
GO:0008064 | BP | regulation of actin polymerization or depolymerization | Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. |
CXCL12, SSH2, SSH3 |
GO:0008065 | BP | establishment of blood-nerve barrier | The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier. |
GSTM3 |
GO:0008066 | MF | glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
GRM8, GRM6, GRM3 |
GO:0008073 | MF | ornithine decarboxylase inhibitor activity | The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. |
OAZ2, OAZ1 |
GO:0008074 | CC | guanylate cyclase complex, soluble | Complex that possesses guanylate cyclase activity and is not bound to a membrane. |
NPR2, GUCY2D |
GO:0008076 | CC | voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
KCNK1, DPP6, SNAP25, CALM2, VAMP2, DLG4, KCNA1, KCNMA1, KCNH2, KCNC3, CTTN, KCNJ11, KCNG3, KCNV2, KCNIP2, KCNG1, KCNK6 |
GO:0008080 | MF | N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
ESCO2, NAT14, NAT9 |
GO:0008081 | MF | phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
PLCXD2, PLCXD3 |
GO:0008083 | MF | growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
MSTN, EREG, GDF9, FGF18, DKK1, CSPG5, GDF11, BMP10, FGF19, BMP15, F2, AGT, TIMP1, PDGFB, TGFA, TGFB1, NGF, GH1, IGF2, PPBP, AMH, PDGFA, IGF1, INHA, IL6, GPI, INHBA, FGF2, CXCL1, INHBB, BMP2, BMP4, BMP3, TDGF1, BMP1, HGF, LIF, AREG, VEGFA, TYMP, OGN, IL11, KITLG, MDK, FGF7, BMP6, IL10, BDNF, GRN, CTGF, IL12A, FGF9, BMP8B, BTC, THBS4, LEP, GDF5, CXCL12, PGF, VEGFB, VEGFC, HDGF, INHBC, GFER, FGF12, TGFB2, JAG1, NDP, NRG1, EFEMP1, RABEP1, IL34, BMP8A, FGF13, FGF11, FGF14, HBEGF, GDF15, PDGFD, CD320, PDGFC, CLCF1, OSGIN1, NENF, HDGFRP3 |
GO:0008088 | BP | axo-dendritic transport | The directed movement of organelles or molecules along microtubules in neuron projections. |
APP, MAPT, APBA1, KLC3 |
GO:0008089 | BP | anterograde axonal transport | The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. |
AP3D1, KIF1B, KIF4A, SNAPIN, AP3M2, AP3S2, BLOC1S1, BLOC1S3, MGARP, SPAST, RAB21, BLOC1S6, AP3M1 |
GO:0008090 | BP | retrograde axonal transport | The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. |
SNAPIN, MGARP, NDEL1 |
GO:0008091 | CC | spectrin | Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. |
SPTBN1, SPTBN4 |
GO:0008092 | MF | cytoskeletal protein binding | Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
FRMD3, TOR1A, LDB3, NEBL, FARP2, ALDOA, FABP3, ANXA2, TPM1, ALDOC, B4GALT1, DES, PTPN4, CORO1A, ACTN2, CDK5, ANK3, DLG1, PKD2, FLNC, ABI1, DLG5, MYLIP, SORBS1, PACSIN1, EPB41L4B, CAPN10, EPB41L4A, LIN7C, RPH3AL, FARP1 |
GO:0008093 | MF | cytoskeletal adaptor activity | The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. |
SDCBP, OBSL1, SORBS2, ANK2, ANK3, BICD1, ABI2, BAIAP2L1 |
GO:0008094 | MF | DNA-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. |
RAD51C, RAD51D, TOP2A, ERCC2, SMARCA1, GTF2H1, CDK7, SMARCA2, SMARCA4, RBBP4, GTF2H2, GTF2H4, DHX36, CHD8, TTF2 |
GO:0008097 | MF | 5S rRNA binding | Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
EEF2, RPL5 |
GO:0008104 | BP | protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
AKAP10, KIF5C, ULK1, TP53, NPM1, DRD2, TSC2, NR0B1, IST1, CD81, CAV1, GRIN2A, SQSTM1, DHCR24, NEDD8, CROCC, BBS7, NRCAM, KIFAP3, ALS2, BBS2, CLIC5, AKAP7, SLC9A2, MLH3, MAPK8IP3, AKAP2 |
GO:0008105 | BP | asymmetric protein localization | Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. |
COLQ |
GO:0008107 | MF | galactoside 2-alpha-L-fucosyltransferase activity | Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. |
FUT1, FUT2 |
GO:0008108 | MF | UDP-glucose:hexose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. |
GALT |
GO:0008109 | MF | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. |
GCNT2 |
GO:0008112 | MF | nicotinamide N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. |
NNMT |
GO:0008113 | MF | peptide-methionine (S)-S-oxide reductase activity | Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. |
TXN2 |
GO:0008115 | MF | sarcosine oxidase activity | Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). |
PIPOX |
GO:0008116 | MF | prostaglandin-I synthase activity | Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). |
PTGIS |
GO:0008118 | MF | N-acetyllactosaminide alpha-2,3-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. |
ST3GAL3 |
GO:0008119 | MF | thiopurine S-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. |
TPMT |
GO:0008120 | MF | ceramide glucosyltransferase activity | Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. |
UGCG |
GO:0008121 | MF | ubiquinol-cytochrome-c reductase activity | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. |
UQCRHL, UQCRQ, UQCR11, UQCRH, UQCRB, UQCRC1, UQCRFS1, UQCR10 |
GO:0008131 | MF | primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
AOC2, VCAM1, MAOA, MAOB, AOC3 |
GO:0008134 | MF | transcription factor binding | Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
MED19, AIP, APBB1, WWP2, DDX3X, HDAC3, PER1, RBFOX2, KDM1A, SORBS3, CCNT1, TBL1X, NBN, MED6, CREG1, PSMD10, UBXN7, APBB3, BCL10, FOS, MYC, ESR1, TP53, JUN, RB1, HMGB1, PARP1, TRAPPC2, AR, BCL2, THRA, ETS1, TCF3, HMGA1, JUNB, JUND, ATF7, CEBPB, NFKB1, BCL3, FLNA, GPX3, HMGB2, ARNT, PIK3R1, MAPK1, RBL1, CTNNB1, GTF2F1, RORA, DDIT3, AHR, PPARG, ZEB1, PBX2, STAT3, ID1, HTT, GATA4, MAPK9, CENPF, AGTR2, SMARCA4, NR0B1, GTF2A1, GTF2A2, HMGA2, FOSB, CEBPG, HDAC4, SOX8, LMO4, YWHAZ, UBE2I, PRKDC, SMAD3, FOXO4, GTF2B, PURA, E2F1, DR1, ID3, HHEX, PPARD, RELA, TLE1, C1QBP, PPARA, PPID, EP300, FOXC1, STK4, NFATC2, HDAC1, TDG, ENPP2, NFYC, HNRNPD, TFDP1, E2F2, HES1, NFATC4, NR0B2, NCOA2, TWIST1, SMAD2, TAF12, CRY1, HIF1A, IFI16, SMARCD3, KCTD1, CXXC5, PPARGC1B, SIRT2, PPP1R13L, ZFPM2, KAT6B, TRIB2, HDAC2, CREBBP, KAT6A, KAT2B, APBB2, GATA6, ARHGEF2, HES6, PURB, TRIB1, TCF12, PITX2, MDFI, EPAS1, SOST, MYBBP1A, HDAC8, TRIM6, NIF3L1, NUCKS1, SOX17, TAF9B, HES4, PARD6A, BRD7, HEYL, TCF7L2, RNF19A, RCOR3, NLK, PPARGC1A, MLX, HDAC9, SUFU, HDAC5, DRG1, CSDC2, HES2, PAXBP1, HEY1, MAFB, NCOR2, CHCHD2 |
GO:0008135 | MF | translation factor activity, RNA binding | Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. |
EIF4G3, EIF4E2, GATB, EEF1D, EIF2S3, EIF1, EIF1AX, EIF5, EIF4A1, EEF1A2, GTF2H2, CPEB4, CPEB2, CPEB3, ABCF1, GCN1, MTIF3, EIF2B3 |
GO:0008137 | MF | NADH dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
NDUFS8, NDUFA4, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, NDUFV3, NDUFA5, NDUFAF2, NMES1, NDUFA13 |
GO:0008138 | MF | protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
PTPDC1, CDC14B, DUSP11, SBF1, DUSP3, TPTE, PTEN, MTMR2, CDKN3, DUSP5, DUSP6, DUSP7, SSH2, DUSP18, SSH3, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP22, DUSP13, CDC14A |
GO:0008139 | MF | nuclear localization sequence binding | Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
IPO5, KPNA3, KPNA4, TNPO2, KPNA5, RANBP6, NUP153, KPNA2, KPNA1, KPNB1, IPO4, NUP58, TNPO3 |
GO:0008140 | MF | cAMP response element binding protein binding | Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein). |
DAPK3, DDIT3, SIK1, CREM, CRTC3 |
GO:0008142 | MF | oxysterol binding | Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol. |
OSBP, GPR183, RORA |
GO:0008143 | MF | poly(A) binding | Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
DDX3X, SYNCRIP, TIA1, KHDRBS1, ZC3H14, RBPMS, PABPC3 |
GO:0008144 | MF | drug binding | Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
DHFR, PNP, ALB, MT2A, TYMS, ATP1B1, CHRM2, HSP90AB1, GSTP1, CYP2D6, TOP2A, CYP2C9, ACE, DRD2, FOLR1, CHRM3, CNR1, NME2, MT3, HMGB2, DCK, HTR2C, CHKA, PPARG, HTR2B, NAMPT, ATP5O, GLRB, FASN, ATP1A2, PGGT1B, SRP54, HMGCS1, DHODH, PPARD, PPARA, PPP3CA, PDE4D, FSCN1, SFRP1, P2RX4, SIGMAR1 |
GO:0008146 | MF | sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
HS3ST1, HS6ST1, SULT1A3, SULT2A1, CHST3, DSEL, CHST4, CHST5, CHST2 |
GO:0008147 | MF | structural constituent of bone | The action of a molecule that contributes to the structural integrity of bone. |
BGLAP, MGP |
GO:0008150 | BP | biological_process | Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. |
TMEM129, TMEM120B, ILVBL, SBNO1, NUDT19, MATN2, DSCR3, KHNYN, FYB, CTDSPL, ABCC4, FLRT2, PI15, SGTA, CALU, AHCYL1, ZNF862, ZFAND5, SORBS2, PROSC, SFT2D2, LRG1, A1BG, PRB1, NUDT7, HIST1H2AG, ZNF688, TPR, HIST1H2AD, BGN, MST1, TM4SF1, SDC2, SLC6A8, MEOX1, LRBA, TMEM50B, EPPK1, SNRPN, MRPS10, SERF2, ZXDB, ZNF200, REEP5, LMNB2, ELP6, MN1, NPRL3, SCGB2A2, COTL1, FAM53B, TMEM187, NOMO1, PPP1R7, FAM189A2, ZNF77, CCDC6, TMEM132A, QRICH1, LRRFIP1, FILIP1L, ARID4B, LRRC23, TMEM35, ANKRD39, BOLA3, TMEM128, NOM1, SLC25A30, IDNK, ANKRD45, CDKAL1, ANKRD40, HIST2H2AA3, TTC27, INO80C, WDR74, SBSN, C5orf46, TMEM107, TMEM108, HSDL2, TMEM91, FAM65A, LHFPL2, PTCHD4, USP53, H2AFV, SLC35D2, KNDC1, TMC6, KDELC2, THNSL2, CARKD, SLC35F2, THNSL1, BEST3, TMEM256, TMEM132C, ZADH2, TMEM57, FAM184A, PDDC1, SLC43A3, GSTCD, ABHD11, WDR36, AGR3, DNAH5, SCFD2, CHAC2, SNRNP27, FAM3C, DCUN1D4, NR4A3, LPGAT1, DPF3, LPP, TMEM106A, KIAA1191, EXOSC8, FLYWCH2, DTD2, DCUN1D1, ZNF486, CYYR1, ZNF75A, ZFP3, KLHL5, CDCA3, TMEM47, TMEM121, H2AFJ, HGH1, C9orf16, TMEM106C, TMEM120A, FSD1L, EMILIN2, RTFDC1, ASPSCR1, UACA, GPR63, PLA2G12A, UBXN6, TM6SF1, ZC3H12C, KLHL4, C20orf27, C6orf62, MKRN2, SPATC1L, CYSTM1, ADAMTS10, TMEM245, GHITM, PLEKHA4, C11orf1, FAM96A, SEC61A2, PLEKHA5, POPDC2, POPDC3, MAGEE1, TMEM8A, EPB41L4A, CD248, MRPL47, RETN, APMAP, IFT46, MXRA5, STRN4, SMCO4, INPP5E, TM7SF3, TMEM51, C1orf123, VNN3, DONSON, MIS18A, GLTSCR2, SEPN1, EMC3, AKAP7, TMEM9, SIPA1L2, IMPACT, STOML1, ARPP21, ZMYM2, CFDP1, EPHA6, FETUB, GPATCH8, C14orf1, EXOG, DIP2C, EPB41L3, RCL1, MRPS28, CCDC53, ZNF330, GPSM3, AIM1, AMMECR1, LRRFIP2 |
GO:0008152 | BP | metabolic process | The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. |
INSIG1, AQP9, DXO, PRNP, UGT2B4, GSTA1, CPE, PCSK1, DIP2A, CENPV, ECHDC3, L3HYPDH, FAHD2A, TMEM68, ACSS3, ECHDC1, STARD9, SPAST, GRHPR, ENPP5, DIP2C |
GO:0008154 | BP | actin polymerization or depolymerization | Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. |
WASL, DSTN, ABI1, GHSR, ABI2, GHRL, EVL |
GO:0008156 | BP | negative regulation of DNA replication | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
GMNN, TGFB1, S100A11, NF2, TERF1, PDS5A, WAPL, CDC6, TSPYL2 |
GO:0008157 | MF | protein phosphatase 1 binding | Interacting selectively and non-covalently with the enzyme protein phosphatase 1. |
PPP1R15A, STAU1, PPP1CC, PPP1CA, PHACTR4, LILRB1, SH3RF2, CDC5L, AKAP11 |
GO:0008158 | MF | hedgehog receptor activity | Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. |
PTCH1, B9D1 |
GO:0008160 | MF | protein tyrosine phosphatase activator activity | Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. |
IGFBP3, PPP2R4 |
GO:0008168 | MF | methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
PRMT3, COMT, PRDM15, NDUFAF5, TYW3, METTL23, PRMT1, METTL17, METTL8, PRDM10, METTL5, FAM86C1 |
GO:0008170 | MF | N-methyltransferase activity | Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. |
PRMT1 |
GO:0008171 | MF | O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
COMT, BCDIN3D, COQ3 |
GO:0008173 | MF | RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
BCDIN3D |
GO:0008175 | MF | tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
TRMT13 |
GO:0008177 | MF | succinate dehydrogenase (ubiquinone) activity | Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. |
SDHB, SDHA |
GO:0008179 | MF | adenylate cyclase binding | Interacting selectively and non-covalently with the enzyme adenylate cyclase. |
ADRB2, ADCYAP1R1, CALM2, AKAP6 |
GO:0008180 | CC | COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
FLOT1, HSP90AB1, HSPA5, HSPA6, TMOD1, HSPA1L, MYH9, GRB2, DYNLL1, AMOT, COPS6, AMOTL1, DOCK7, COPS8, COPS7B |
GO:0008184 | MF | glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
PYGB, PYGM |
GO:0008186 | MF | RNA-dependent ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
DDX17, YTHDC2 |
GO:0008187 | MF | poly-pyrimidine tract binding | Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. |
PTBP1 |
GO:0008188 | MF | neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
NPBWR1, KISS1R |
GO:0008190 | MF | eukaryotic initiation factor 4E binding | Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
DDX3X, OTX2, HHEX, EIF4EBP1, EIF4EBP2, LARP1, ANGEL1 |
GO:0008191 | MF | metalloendopeptidase inhibitor activity | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
RECK, TIMP1, NGF, TIMP2, TIMP3, COL4A3, BST2, SPOCK2, SPOCK3, LXN, FETUB |
GO:0008194 | MF | UDP-glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. |
PIGA |
GO:0008195 | MF | phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
PLPP1, PLPP3, LPIN1, PLPPR4, PLPP5, PLPPR2 |
GO:0008198 | MF | ferrous iron binding | Interacting selectively and non-covalently with ferrous iron, Fe(II). |
TF, TH, SNCA, ALKBH1, FXN, CDO1, HEPH, ISCA1, FTO |
GO:0008199 | MF | ferric iron binding | Interacting selectively and non-covalently with ferric iron, Fe(III). |
TF, FTL, FTH1, TH, FXN, MIOX |
GO:0008200 | MF | ion channel inhibitor activity | Stops, prevents, or reduces the activity of an ion channel. |
ENSA, RACK1 |
GO:0008201 | MF | heparin binding | Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
CYR61, PDCD5, NRP1, MSTN, ZNF207, NRP2, WISP2, ECM2, SLIT2, WISP1, SERPINC1, KNG1, APOE, APOH, FN1, PF4, ANG, VTN, APOB, APP, SERPINA5, MPO, CLEC3B, LPL, SERPINE2, THBS1, SOD3, CFH, FGF2, SAA1, PTPRF, FGFR1, BMP4, CCL2, PRG2, SELL, VEGFA, OGN, COL5A1, MDK, FGF7, FGFR2, TNXB, ANOS1, COL5A3, PCSK6, CTGF, LRPAP1, FGF9, RPL22, THBS4, FBN1, PLA2G5, RPL29, COMP, PGF, VEGFB, HDGF, CCL8, CXCL6, TGFBR3, APLP2, FMOD, FSTL1, PTCH1, GPNMB, POSTN, PCOLCE, HSD17B12, COL13A1, APOA5, CCDC80, NAV2, SFRP1, NDNF, ADAMTS15, LIPH, HBEGF, EPYC, SOST, LXN, RSPO3, CRISPLD2, SMOC2, GREM2, ADAMTS1, PCOLCE2, ADAMTS5, ADAMTS8, LIPG, ADGRG1 |
GO:0008202 | BP | steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
HSD17B6, CYP1A1, CYP17A1, CYP2E1, CYP3A4, CYP21A2, SULT1A3, CYP2D6, CYP2A6, CYP2C9, CYP2B6, CYP3A5, CYP3A7, TSPO, G6PC, AKR1C3, AKR1C2, SULT2A1, STARD3, MSMO1, CYP1B1, DHRS4 |
GO:0008203 | BP | cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
NPC1, LRP5, ERLIN2, ABCA1, CH25H, LDLR, APOA1, APOE, APOA2, APOC1, APOB, APP, CYP11A1, FDX1, CYP11B1, CYP11B2, TNFSF4, PON1, SOAT1, SREBF1, LEP, LEPR, STAR, NPC2, VLDLR, HDLBP, PPARD, LIPE, APOBR, SREBF2, STARD3, EBP, NR0B2, LDLRAP1, PCSK9, SORL1, APOL2, OSBPL1A, CLN6 |
GO:0008206 | BP | bile acid metabolic process | The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
NR5A2, NPC1, ATP8B1, LEP, FABP6, AKR1C1, NR1H4, GBA2 |
GO:0008209 | BP | androgen metabolic process | The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. |
ESR1, CYP3A4, CYP19A1, SRD5A2, ADM, HSD17B4, DHRS9, PPARGC1A |
GO:0008210 | BP | estrogen metabolic process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
HSD17B1, COMT, HSD17B4, CYP1B1 |
GO:0008211 | BP | glucocorticoid metabolic process | The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
APOA1, STAR |
GO:0008217 | BP | regulation of blood pressure | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
LRP5, AGT, POMC, SOD2, COL1A2, HMOX1, ACE, CYP11B1, GNB3, NPPB, NPR3, NPR2, PTGS1, EDNRA, NPY1R, NOS3, PTGS2, PPARG, LEP, AGTR2, ATP1A2, ACTA2, HBB, ACSM3, ERAP2, AGTRAP, P2RX4, ERAP1, LNPEP, NISCH |
GO:0008218 | BP | bioluminescence | The production of light by certain enzyme-catalyzed reactions in cells. |
SDC2 |
GO:0008219 | BP | cell death | Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
AXIN1, BRINP1, BCL10, HMOX1, FOSL2, NUP62, PTGER3, EMP1, EMP2, EMP3, TGFB2, PMP22, BNIP3, CLUL1, FBXO18, SUSD6, OPTN, ALS2, PRKD2, PNPLA8, ZAK, VAPA, FAF1, SNCAIP |
GO:0008228 | BP | opsonization | The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. |
CRP, C4A, C4B, MBL2, PTX3, CD47, FCN2, SPON2 |
GO:0008233 | MF | peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
MASP2, TPP1, DHH, CAPN15, CTSB, CTSH, FURIN, BMP1, UCHL3, CAPN3, PSMB5, CASP9, FGL2, CASP8, SPCS2, CLPP, DESI1, LONP2, MPND, HM13, APH1B, BAP1, PCSK5, USP25, MYRF |
GO:0008234 | MF | cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
CAPN15, CTSL, CTSB, CTSH, CAPN3, CTSK, CTSC, CASP6, BLMH, ESPL1, CASP8, OTUD7B, PIGK, PGPEP1, CTSZ |