| GO ID | Ontology | GO Term | Term Definition |
Proteins |
GO:0007338 | BP | single fertilization | The union of male and female gametes to form a zygote. |
UBXN8, DNALI1, CLGN, ADCY3, AR, CD46, HOXD10, HOXA10, GNPDA1, FOXL2, H3F3A, MFGE8, LRMP, SMAD4, TRPC3, SPA17, WDR48, TUBGCP3, SLIRP, KDM5B, FETUB, ADAM21, TRPC6 |
GO:0007339 | BP | binding of sperm to zona pellucida | The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. |
CLGN, B4GALT1, TCP1, ZP3, SPAM1, CCT3, CCT8, ZP1, CCT2, SPA17, CCT7, FETUB, ADAM21 |
GO:0007340 | BP | acrosome reaction | The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. |
ADCY3, STX2, GLRB |
GO:0007341 | BP | penetration of zona pellucida | The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. |
B4GALT1 |
GO:0007342 | BP | fusion of sperm to egg plasma membrane | The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. |
SERPINA5, CD9, SPAM1 |
GO:0007344 | BP | pronuclear fusion | The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome. |
CDK1 |
GO:0007346 | BP | regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
SDCBP, DAPK3, CDC123, RB1, CKS2, RPA3, CDKN1C, ASCL1, PLK1, SIK1, CKS1B, PTCH1, ZNF268, MAEA, AFAP1L2, NEK7, GBF1, NEK6, CYLD, RPRM, THAP1, AATF, SAE1, FBXO5 |
GO:0007352 | BP | zygotic specification of dorsal/ventral axis | The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote. |
SMAD6, SMAD2 |
GO:0007354 | BP | zygotic determination of anterior/posterior axis, embryo | The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. |
PCSK6 |
GO:0007356 | BP | thorax and anterior abdomen determination | Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. |
WT1 |
GO:0007368 | BP | determination of left/right symmetry | The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. |
AXIN1, TBX1, PSKH1, ACVR2A, PCSK6, NOTCH1, ACVR1, AP1B1, PKD2, ACVR2B, STIL, ARMC4, NPHP3, NEK8, BBS7, DYNC2LI1, DNAH5, PCSK5, DNAH11, DISP1, IFT74, DRC1, PITX2, CITED2, BICC1, MKKS, MKS1, CC2D2A, DNAI1 |
GO:0007369 | BP | gastrulation | A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. |
DLD, TGFBR2, HIRA, RPS6, RACK1, CUL3, SMAD2, EXT1, NR4A3 |
GO:0007379 | BP | segment specification | The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. |
HOXA2, MTF2, MAFB |
GO:0007386 | BP | compartment pattern specification | The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. |
NOTCH1 |
GO:0007389 | BP | pattern specification process | Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. |
MID1, TBX1, GLI2, APC, ZEB1, ZIC1, SOSTDC1, RNF111, SHROOM3, SYNGAP1 |
GO:0007398 | BP | ectoderm development | The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. |
STX2, CTNNB1, NF2, BMPR1A, ZBTB17 |
GO:0007399 | BP | nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
DPYSL4, ENC1, TPP1, DCLK1, RBFOX2, ITM2A, ZEB2, GAS7, SHOX2, SCRG1, CSPG5, GDF11, FGF19, FOS, APOB, INHA, CHRM2, INHBA, FGF2, CXCL1, VEGFA, NDUFV2, CHRM3, MDK, GAL, CBLN1, BDNF, EPHB2, ADORA1, SDHA, STAT3, NBL1, GLRB, PPT1, SMARCA2, SMARCA4, EFNA5, ATXN3, NAGLU, DLX5, HDAC4, PRPS1, FGF12, DLG4, JAG1, SIM1, VLDLR, PURA, NDP, SLC7A5, NRG1, APBA1, NOTCH2, MEF2C, PCDH1, EP300, DLG1, LSAMP, GPM6B, SEMA5A, ARHGEF7, SIM2, DCTN1, HES1, ELAVL3, PPP2R5D, MEF2D, PAFAH1B3, ERBB4, MPPED2, DPYSL2, CTF1, ZNF423, TMEM41B, CPLX2, GPSM1, RBM45, SIAH1, CNTN4, CHERP, NLGN1, ARID1B, CSGALNACT1, PHF10, GPR98, MYLIP, ST8SIA4, DPF3, FGF13, FGF11, FGF14, SMARCC1, SMARCD1, HES6, MARK4, ATOH8, FEZ1, MTR, SIGMAR1, OLFM1, PCDHAC1, SDCBP2, SEMA6A, BEX1, HES4, NRN1, MBNL1, RBFOX1, STMN3, CRIM1, DOK5, CNTN3, MBD5, ATXN10, EVL, MYT1L, INTU, PCDHA7, PCDHA6, PCDHA4, ARHGAP26, IGSF9B, ITM2B, PCDHB3, PCDHA8, PCDHA5, PCDHA3, PCDHA2, PCDHA11, PCDHA10, PCDHA1, PCDHAC2, MAFB, BZW2 |
GO:0007400 | BP | neuroblast fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. |
ASCL1 |
GO:0007403 | BP | glial cell fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. |
CTNNB1 |
GO:0007405 | BP | neuroblast proliferation | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. |
EML1, PLXNB2, ID4, ASCL1, KCNA1, DAGLB, FRS2, HHIP, RACGAP1, NDE1 |
GO:0007406 | BP | negative regulation of neuroblast proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. |
TGFB1, CTNNA1, KCTD11 |
GO:0007409 | BP | axonogenesis | De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon. |
APBB1, PAK3, FLOT1, ECM2, S100B, APP, CCK, S100A6, CNP, BCL2, NEFH, DRD2, STMN1, OGN, FGFR2, CTNNA2, NOTCH1, NUMB, GSK3B, PTPN11, FMOD, ANK3, PICALM, STK11, PLPPR4, SLITRK4, CNTN4, PARD3, NRCAM, DOCK7, ALS2, EPYC, PARD6B, SPTBN4, SEMA4A, SPAST |
GO:0007411 | BP | axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
MATN2, CHL1, NRP1, FLRT2, SIAH2, B4GAT1, KIF5C, NRP2, RPS6KA5, KLF7, SLIT2, UNC5C, NRAS, KRAS, NTRK1, FYN, CSF1R, NGFR, GLI2, GLI3, NCAM1, EZR, CREB1, EFNA1, ANOS1, BDNF, LAMA2, MAPK3, MAPK1, EPHB2, OTX2, GPC1, WNT5A, NKX2-1, CXCL12, LHX2, ETV1, EFNA4, EFNB2, EFNA5, EPHA5, EPHB1, DLX5, WNT3, TGFB2, GRB2, RAC1, SPTBN1, PRKCQ, PTK2, SOS1, ANK3, SEMA3B, SMAD4, TUBB3, SEMA3A, NECTIN1, EXT1, DPYSL2, PTPRO, ZNF280D, ZNF280B, SIAH1, CNTN4, ENAH, NR4A3, TNR, APBB2, ROBO3, RANBP9, FEZ1, SEMA3C, SPON2, SPTBN4, SEMA6A, NTN4, ROBO2, B3GNT2, FLRT3, EVL, NRXN1, MAPK8IP3 |
GO:0007412 | BP | axon target recognition | The process in which an axon recognizes and binds to a set of cells with which it may form stable connections. |
UCHL1, STXBP1 |
GO:0007413 | BP | axonal fasciculation | The collection of axons into a bundle of rods, known as a fascicle. |
NRP1, NCAM2, CNR1, EPHB2, SEMA5A, SEMA3A, CNTN4, NRCAM, CRTAC1, RTN4, CELSR3 |
GO:0007416 | BP | synapse assembly | The aggregation, arrangement and bonding together of a set of components to form a synapse. |
RAB29, GNPAT, DRD2, BDNF, PTEN, CDK5, NRG1, SDK2, SDK1, NLGN1, DNER, SPOCK2, NRCAM, ADGRL3, FLRT3, NRXN1, PLXND1, FARP1, PCDHB9, PCDHB3, PCDHB14, PCLO |
GO:0007417 | BP | central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
RNF103, NCAN, TPP1, DCLK1, PARK2, ADAM23, VNN1, S100B, FYN, LYN, GSTP1, HAPLN1, VCAN, ARSB, TIMP2, PAM, MAL, COX7B, ACVR1B, ZEB1, CSK, NES, ALDH3A2, RCAN1, ATN1, PTEN, ID3, ZBTB16, PAX8, STK4, ASIC2, CASZ1, ANKLE2, AHI1, DNER, NRCAM, BCAN, SERPINI1, NPAS2, SH3GL2, B3GNT5, WWP1, ELP3, ROBO2, PDGFC, VNN3, CHD7, HPCAL4, JRKL |
GO:0007418 | BP | ventral midline development | The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. |
GLI2 |
GO:0007420 | BP | brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
MACROD2, EML1, KCNK3, PLXNB2, PHGDH, NDUFS4, BCL2L11, TSPAN2, CTNND1, TULP3, CLN5, UNC5C, MBD3, CST3, APOD, SCT, EGR2, BCR, XRCC5, STMN1, ARF4, EPOR, ATP2B1, S1PR1, SYT1, CD9, PTPRG, FAS, MT3, CD27, AK4, SMARCA1, GABRA5, TGFBR2, ID1, CSK, NKX2-1, NES, STAR, SEPP1, AGTR2, HNMT, PPT1, BRCA2, AFF2, HRSP12, FOXG1, OXCT1, BID, ATP6V0D1, PAFAH1B2, PRKDC, H3F3A, HMGCS1, PTPN11, DLX2, FOXC1, ABR, PTCH1, SHROOM2, BMPR2, COX17, POU6F1, RAB3GAP1, PAFAH1B3, ZFHX3, ZIC1, PFKFB3, NIPBL, CNTN4, BBS7, TMEM57, PCDH19, PROX1, CITED1, PYGO2, CADM1, B3GNT5, ZNF335, ROBO2, CHD8, PCDH18, ABCB6, DDIT4, SPHK1, H2AFY2, CDH22, NDRG4, BOK, SLC7A11, IRS2, ADGRG1 |
GO:0007422 | BP | peripheral nervous system development | The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. |
ERBB2, EGR2, ERBB3, ALDH3A2, SOX8, PMP22, NRG1, EGR3, ASIC2, SERPINI1 |
GO:0007423 | BP | sensory organ development | The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. |
MAFB |
GO:0007431 | BP | salivary gland development | The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. |
CST3 |
GO:0007435 | BP | salivary gland morphogenesis | The process in which the anatomical structures of the salivary gland are generated and organized. |
EGFR, TGFB1, TGFB2 |
GO:0007440 | BP | foregut morphogenesis | The process in which the anatomical structures of the foregut are generated and organized. |
NOTCH1 |
GO:0007442 | BP | hindgut morphogenesis | The process in which the anatomical structures of the hindgut are generated and organized. |
GLI2, GLI3, WNT5A |
GO:0007492 | BP | endoderm development | The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. |
TGFB1, LAMC1, GATA4, NKX2-1, NOTCH1, SMAD3, HHEX, SMAD4, EXT1, ARC, MED12 |
GO:0007493 | BP | endodermal cell fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. |
GATA6, SOX17 |
GO:0007494 | BP | midgut development | The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. |
DAB1, ALDH1A2, EGFR, ASS1, WNT5A |
GO:0007498 | BP | mesoderm development | The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. |
TBX1, JAK2, GDF11, CTDNEP1, ETS2, VEGFA, ACVR2A, TIE1, LHX2, IRX3, TCF15, IKZF1, SMAD4, ACVR2B, EXT1, MEST, SECTM1 |
GO:0007500 | BP | mesodermal cell fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. |
KLF4, BMP4 |
GO:0007501 | BP | mesodermal cell fate specification | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. |
EYA2 |
GO:0007506 | BP | gonadal mesoderm development | The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. |
AMH, ZFPM2 |
GO:0007507 | BP | heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
SH3PXD2B, TBX1, SHOX2, MICAL2, HEXIM1, FGF19, MBD3, PDGFB, TGFB1, COL3A1, RBP4, RAF1, ERBB2, EDN1, TH, SPARC, GLI2, GLI3, MTHFD1, PSKH1, PCNA, BMP2, TDGF1, GYS1, GJA1, PAM, EPOR, TNNI3, WT1, ERBB3, EDNRA, ITGA3, CAD, LOX, GNA11, OXTR, SRI, ADM, FBN1, TGFBR1, TGFBR2, PPARG, ID1, ECE1, CRKL, NOTCH1, TSC2, GNAQ, OXCT1, PTEN, FGF12, TGFB2, CXADR, PRKDC, PKD1, MEF2A, ID3, MAP2K1, TEK, PPARD, PTPN11, MEF2C, SOX4, ZFP36L1, PPARA, EP300, AP1B1, AKAP13, FOXC1, MAP2K5, GAB1, PKD2, ACVR2B, CACNA1C, COX17, POU6F1, NFATC4, ERBB4, RPS6KA2, ARMC4, JMJD6, NEK8, ADIPOR2, BVES, OSR1, RB1CC1, DNAH5, PCSK5, MED12, DNAH11, IFT74, DRC1, PKP2, CITED2, HOPX, TCF25, ADAM19, BICC1, ADAP2, MKKS, FLRT3, CC2D2A, TRPS1, HDAC9, HSPB11 |
GO:0007512 | BP | adult heart development | The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. |
BMP10, GJA1, ADRA1A, MEF2D, SCUBE1, CHD7 |
GO:0007517 | BP | muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
CHD2, MSTN, TBX1, USP2, CRYAB, IGF1, DMD, COL6A3, XBP1, CAPN3, LAMA2, SRI, SOX6, CENPF, EMD, ETV1, FXR1, SMTN, EVC, FOXK1, FOXO4, TAGLN, MEF2A, ID3, CD164, MEF2C, EGR3, FHL1, MEF2D, POU6F1, TEAD4, TWIST1, ZFHX3, SGCB, CTF1, KMT5B, AEBP1, EID2, BVES, SGCD, SGCZ, HBEGF, TCF12, CHODL, ITGA11, MKL2, PAXBP1 |
GO:0007518 | BP | myoblast fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
IFRD1 |
GO:0007519 | BP | skeletal muscle tissue development | The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. |
FOXP2, CFLAR, CCNT2, SIN3B, FLNB, DCN, MYL6B, NR2F2, HOXD10, MYL6, CDK5, CAV1, MEF2C, EP300, MAPK14, BVES |
GO:0007520 | BP | myoblast fusion | A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
ADAM12, MYH9, GSK3B, PLEKHO1, PITX2 |
GO:0007521 | BP | muscle cell fate determination | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. |
MEF2C |
GO:0007528 | BP | neuromuscular junction development | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. |
MUSK, NRDC, ERBB2, TNC, CACNB3, ANK3, NTRK2, ALS2, PDZRN3 |
GO:0007529 | BP | establishment of synaptic specificity at neuromuscular junction | The biological process in which a synapse between a motor neuron and a muscle is initially formed. |
F2R |
GO:0007530 | BP | sex determination | Any process that establishes and transmits the specification of sexual status of an individual organism. |
TCF21, AMH, SRD5A1, WT1, CITED2 |
GO:0007548 | BP | sex differentiation | The establishment of the sex of an organism by physical differentiation. |
AMH, CYP17A1, AR, PBX1, AMHR2 |
GO:0007549 | BP | dosage compensation | Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes. |
H2AFY, H2AFY2 |
GO:0007565 | BP | female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
CLDN4, AGT, FOS, TGFB1, GNRH1, FSHB, PRL, AMBP, STS, BCL2, UMPS, PTHLH, ETS1, FOSL1, HPGD, ITGA2, IGFBP2, COMT, IGFBP5, CAD, OXTR, ADM, LEP, NAMPT, PGF, STAT5B, FOSB, UCP2, HSD11B2, DHODH, COL16A1, PSG7, PAPPA, PSG3, HFE, ADIPOR2, UPRT, TEAD3, EPYC, CLIC5, LNPEP, MAGED2 |
GO:0007566 | BP | embryo implantation | Attachment of the blastocyst to the uterine lining. |
STC2, RECK, CST3, IL1B, MMP2, SPP1, MMP9, LIF, PRLR, FBLN1, PTGS2, BSG, TGFBR2, RPL29, STC1, EMP2, NLRP5, H3F3A, FKBP4, PPARD, DDR1, TRIM28, IGFBP7, PTGIS, PCSK5, VMP1 |
GO:0007567 | BP | parturition | The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. |
HPGD, PTAFR, PTGFR, NRK, MAFF, PLA2G4C |
GO:0007568 | BP | aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
FOXO3, MBD3, ADA, ASS1, AGT, TIMP1, FOS, TGFB1, GNRH1, PENK, COL3A1, CRYAB, AMH, HMGCR, NTRK1, CYP1A1, TYMS, APOD, ITGB2, SERPING1, MPO, EIF2S1, IL6, JUN, DCN, KRT16, IGFBP1, CNP, DLD, CCL2, EEF2, ENO3, ADRB3, NQO1, TIMP2, CREB1, JUND, IGFBP2, ERCC2, VCAM1, ATP2B1, TNFRSF1B, CNR1, IL10, IGFBP5, CANX, CTGF, TSPO, AKT1, CTNNA1, ADM, ADRA1A, PCK1, NUDT1, SERPINF1, SREBF1, TGFBR2, SNCA, STAT3, GCLC, GCLM, NPY2R, CDKN1C, IRAK1, CTSC, POLG, SLC12A2, CASP9, FOXG1, UCP2, UCP3, PTEN, GRB2, ABAT, HAMP, FOXO4, RELA, PDE4D, EIF2B5, RGN, NPY5R, NAPEPLD, TPRA1, CARM1, AURKB, LITAF, CACYBP, RETN, GLRX2, PPARGC1A, KL, AMFR, TRPC6, LOXL2 |
GO:0007569 | BP | cell aging | An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). |
BGLAP, TP53, ICAM1, CDK1, NPM1, BCL2, MIF, NUP62, LIMS1, BRCA2, ILK, MORC3, PDCD4, MNT, NOX4, ZMIZ1 |
GO:0007584 | BP | response to nutrient | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. |
TNFRSF11B, GNPAT, OGT, ENSA, ACSL4, ABCA1, LDHA, ASS1, SERPINC1, APOA1, HMGCR, CYBB, GNAI2, ERCC1, NQO1, ARSB, IGFBP2, VCAM1, CNR1, AHCY, ADSL, SSTR1, ACSL1, HMGCL, TGFBR2, PPARG, AKR1C3, GCLC, GCLM, STAR, OXCT1, UCP3, PTEN, DAD1, HSF1, ADIPOQ, SLC27A4, AACS, ADIPOR2, TXN2, ABCG8, LIPG |
GO:0007585 | BP | respiratory gaseous exchange | The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. |
EDN1, BPGM, COX5B, SFTPC, CFTR, EDNRA, HNMT, NDST1, UCP3, FUT8, CHST11, DACH1, MAPK8IP3, MAFB, COX11 |
GO:0007586 | BP | digestion | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. |
PRSS1, AMY2B, SSTR1, CCKBR, PRSS3, NMU, AKR1C2, AKR1C1, SULT2A1, CTRB2, PPARGC1A |
GO:0007588 | BP | excretion | The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. |
NPHP1, AQP9, NFAT5, HMOX1, ADORA2B, AVPR2, AQP2, SCNN1G, CLCN5, CLCNKA, CLCNKB, AQP3, SLC22A18, NEDD4L, ABCG8, GRHPR |
GO:0007589 | BP | body fluid secretion | The controlled release of a fluid by a cell or tissue in an animal. |
EDN1, ANXA2, NPPB, GUCA1B |
GO:0007595 | BP | lactation | The secretion of milk by the mammary gland. |
SERPINC1, PRL, RPLP0, APRT, UMPS, VDR, VEGFA, CREB1, PRLR, PAM, CAD, OXTR, STAT5A, XDH, STAT5B, DHODH, CAV1, PPAT, DDR1, ERBB4, NCOA1, USF2, HIF1A, CDO1, GPAT4, UPRT, SLC29A1, APLN |
GO:0007596 | BP | blood coagulation | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
MAFG, RAD51C, AKAP10, KDM1A, JAK2, MFN2, PAPSS2, F8, F13A1, F2, PLG, PLAU, PLAT, SERPINC1, SERPINA1, IFNA1 , COL1A1, FGA, FGB, FGG, VWF, IFNA16, ITGB3, SERPINA5, F13B, FYN, SERPINE2, LYN, COL1A2, ANXA5, PRKAR1A, TFPI, IRF1, F5, GP1BB, PRKAR2A, CD36, ITGA2, PRKACA, RAB5A, F2R, PRKAR2B, GGCX, GATA4, CBX5, CAPZB, TFPI2, GNAQ, RAB27A, CAPZA1, F2RL1, CDC42, RAC1, HIST1H3D, HBB, HBG1, H3F3A, GNA12, PLAUR, MMRN1, HDAC1, ITPK1, JMJD1C, ANO6, DOCK11, LRRC16A, SCUBE1, CD177, DOCK8, ZFPM2, AKAP1, HDAC2, GATA6, DOCK6, CPB2, P2RX4, VKORC1, LNP, PDGFD, HPS4, PDGFC, SH2B1, EHD3, HMG20B, AK3, BLOC1S6, MAFF, PROCR, SH2B3, ENPP4 |
GO:0007597 | BP | blood coagulation, intrinsic pathway | A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. |
F8, F2, A2M, KNG1, APOH, VWF, SERPING1, GP1BB, C1QBP |
GO:0007598 | BP | blood coagulation, extrinsic pathway | A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X. |
TFPI |
GO:0007599 | BP | hemostasis | The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. |
VWF, GPI, AVPR2, HPS4 |
GO:0007600 | BP | sensory perception | The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. |
PENK, CCKBR, OPRL1, ASIC3, TRPV2 |
GO:0007601 | BP | visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
GRM8, ABLIM1, PDE6D, OPA1, AOC2, RP2, DHRS3, BEST1, EYA4, EML2, GUCA1C, COL1A1, RBP4, OPN1SW, TH, COL11A1, TYR, ATF6, PDC, CHM, CNGA1, MIP, TIMP3, GJC1, COL18A1, GLRB, PPT1, LUM, RABGGTB, PITPNA, NDP, GUCY2D, CRYZ, EFEMP1, PDCL, UNC119, TGFBI, CYP1B1, FAM161A, SFRP5, DRAM2, CYP4V2, BBS7, RDH10, ZNF513, BBS1, WDR36, BBS10, GPR98, RPGR, HPS1, DNAJC19, EPAS1, BBS2, MKKS, DLL4, CLN6, SPATA7, NOB1, GUCA1B, SLC45A2, MYO5A, OCLM, LAMC3 |
GO:0007602 | BP | phototransduction | The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. |
OPN1SW, PDC, UNC119, TRPC3, ASIC2, CDS1, OPN3, PLEKHB1, GUCA1B |
GO:0007603 | BP | phototransduction, visible light | The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. |
GNA11, GNAQ |
GO:0007605 | BP | sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
SOBP, COCH, TBX1, ATP8B1, SPRY2, SNAI2, TBL1X, WDR1, TECTA, LRIG2, EYA4, EML2, COL1A1, ICAM1, TH, GPX1, FGFR1, COL11A1, COL11A2, GABRA5, SLC1A3, CDKN1B, ALDH7A1, HOXA1, RPL38, NDP, COL4A3, TJP1, ASIC2, NIPBL, USP53, PGAP1, NAV2, CCDC50, CEMIP, GPR98, LRIG1, FAM107B, SPTBN4, SLC52A3, CLIC5, CHD7, DCDC2, FZD4, MYO6, FAM65B |
GO:0007606 | BP | sensory perception of chemical stimulus | The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. |
C5AR1, GNAS, GNAS |
GO:0007608 | BP | sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
GRM8, NCAM2, ADCY3, DRD2, UBR3, NAV2, OR2A5, MKKS, B3GNT2 |
GO:0007610 | BP | behavior | The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. |
CCL3, HTR2B, TRMT1L |
GO:0007611 | BP | learning or memory | The acquisition and processing of information and/or the storage and retrieval of this information over time. |
EGFR, PRNP, S100B, NTRK1, GPI, THRA, EGR2, GM2A, SLC11A2, AFF2, PTEN, MEF2C, GRIN2A, AMFR |
GO:0007612 | BP | learning | Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. |
UBA6, SYNJ1, PARK2, JUN, FYN, TH, FOSL1, ARF4, COMT, EPHB2, SLC6A1, PRKAR2B, PTGS2, DLG4, NTRK2, ARC, NLGN4X, ATAD1, FGF13, PAK7, EIF2AK4, NRXN1 |
GO:0007613 | BP | memory | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
MUSK, S100B, TH, ITGA5, NQO2, CREB1, CEBPB, CNR1, ITGA3, OXTR, PTGS2, HRH1, CHRNA7, FEN1, PSEN1, PTEN, VLDLR, GRIN2A, EIF4EBP2, ITPR3, ATAD1, FGF13, PAIP2, PLCB1, PLK2, PAK7, KMT2B |
GO:0007614 | BP | short-term memory | The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. |
MDK, COMT, SERPINF1 |
GO:0007616 | BP | long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
DRD2, CPEB3, BTBD9, EIF2AK4 |
GO:0007617 | BP | mating behavior | The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. |
APP, TH, MTNR1A, MAPK8IP2 |
GO:0007620 | BP | copulation | The act of sexual union between male and female, involving the transfer of sperm. |
ABAT |
GO:0007622 | BP | rhythmic behavior | The specific behavior of an organism that recur with measured regularity. |
EGR2 |
GO:0007623 | BP | circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
AGRP, ARNTL, CLDN4, HDAC3, PER1, PAX4, HNRNPR, NCOR1, EGFR, NTRK1, TYMS, SERPINE1, JUN, TOP1, CDK4, CREB1, JUND, NR1D1, FAS, HTR7, SREBF1, ID1, LEP, NAMPT, ID4, MTNR1A, NRIP1, MTNR1B, GSK3B, CPT1A, ID3, EGR3, EP300, KLF10, KLF9, NONO, ADIPOQ, NTRK2, NFIL3, SETX, TPH2, ARNTL2, PROX1, NPAS2, RBM4B, PPARGC1A, NOCT, TIMELESS, THRAP3 |
GO:0007625 | BP | grooming behavior | The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. |
APRT, DRD2, PPT1 |
GO:0007626 | BP | locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
UBA6, SOBP, MEIS1, GRM6, APP, TH, GAA, DRD2, TAL1, NPY1R, HTR2C, ETV5, NKX2-1, ALDH1A3, NPY2R, SEPP1, NOVA1, PTEN, SNAP25, ABAT, NRG1, APBA1, SLC18A2, NAV2, RASD2, ALS2, ANKH, GPRC5B, PAK7 |
GO:0007628 | BP | adult walking behavior | The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. |
NPC1, DAB1, UCHL1, MAPT, DRD2, TRH, GLRB, EPHA4, ZIC1, FXN, ABHD12, OXR1, SPTBN4, HIPK2, CHD7 |
GO:0007631 | BP | feeding behavior | Behavior associated with the intake of food. |
AGRP, GCG, FYN, DRD2, GAL, NPY1R, HTR2C, CCKBR, MC4R, NPY2R, NPY5R, NTRK2, GIGYF2, MRAP2 |
GO:0007632 | BP | visual behavior | The behavior of an organism in response to a visual stimulus. |
NPHP1, SLC1A2 |
GO:0007634 | BP | optokinetic behavior | The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus. |
HOXA1 |
GO:0007635 | BP | chemosensory behavior | Behavior that is dependent upon the sensation of chemicals. |
TRPV1 |
GO:0007638 | BP | mechanosensory behavior | Behavior that is dependent upon the sensation of a mechanical stimulus. |
ETV1, STRBP |
GO:0008009 | MF | chemokine activity | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
CXCL14, PPBP, PF4, CXCL1, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL2, CXCL5, CXCL12, CCL20, CCL8, CXCL6, CXCL16, CKLF |
GO:0008013 | MF | beta-catenin binding | Interacting selectively and non-covalently with the beta subunit of the catenin complex. |
TAX1BP3, SMAD7, AXIN1, KLF4, FOXO3, PARK2, TBL1X, ESR1, GLI3, AR, CDH2, APC, CDH5, CTNNA1, RORA, NR4A2, SOX9, NUMB, PSEN1, GSK3B, SKP1, CXADR, SMAD3, FOXO4, EP300, FOXO1, PTPRJ, SHROOM2, KANK1, PTPRK, CARM1, DLG5, LZIC, MED12, DACT3, TBL1XR1, SOX17, CHD8, TCF7L1, TCF7L2, DACT1, ASH2L, HDAC6, SUFU, BTRC |
GO:0008015 | BP | blood circulation | The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. |
TBC1D8, CYB5R3, SERPING1, F5, NPY1R, PLN, HTR7, ADM, MTHFR, CXCL12, RCAN1, OLR1, COL4A3, DLL4, CHD7 |
GO:0008016 | BP | regulation of heart contraction | Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
FXYD1, CELF2, TH, CHRM2, TPM1, THRA, DES, PLN, SRI, DMPK, CAMK2D, KCNJ12, HBEGF, HOPX, KCNIP2 |
GO:0008017 | MF | microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
EML1, KRIT1, DYNC1I1, MID1, BIRC5, BCL2L11, PRC1, ZNF207, KIF1C, KIF5C, OPA1, KIF1B, PEX14, TPPP, KIF20A, KIF4A, VAPB, EML2, CRYAB, PRNP, GAPDH, S100A8, S100A9, MAPT, MAP2, NEFH, TPT1, EZR, APC, CLIP1, SNCA, LRPPRC, MAP1B, KIF11, PLK1, GABARAPL2, RAB11A, RAE1, MAP1A, CENPE, KIF23, FMR1, GOLGA2, TIAM1, KIF22, CHD4, FAM175B, KIF14, CNN3, MAPRE2, DPYSL2, CCDC88A, CAMSAP1, SAXO2, MAST2, KLC3, PSRC1, HOOK3, GAS2L3, CEP57, KIF18B, KIF18A, MDM1, SKA2, NDRG1, FGF13, ARHGEF2, JAKMIP2, SKA1, MARK4, KIF20B, CHP1, KATNB1, KIFC1, KATNAL1, NUSAP1, NDEL1, MAP1LC3B, RACGAP1, MAP1LC3A, FAM83D, REEP1, TRPV4, EML4, KIF13B, KIF15, SYBU, NDE1, CRIPT, VAPA, STARD9, UXT, HDAC6, SPAST, SUN2, MACF1, MAPRE3, LZTS1, SBDS, HDGFRP3, KIF3A |
GO:0008020 | MF | G-protein coupled photoreceptor activity | Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
OPN1SW, ELOVL4, OPN3 |